Prolactinoma is an estrogen‐related tumor and leukemia‐related protein 16(LRP16)is correlated with the progression of estrogen‐related tumors,but the regulatory mechanism between LRP16 and prolactinoma remain uncle...Prolactinoma is an estrogen‐related tumor and leukemia‐related protein 16(LRP16)is correlated with the progression of estrogen‐related tumors,but the regulatory mechanism between LRP16 and prolactinoma remain unclear.This study demonstrates a variation in LRP16 with estrogen receptorα(ERα)in prolactinoma models and the up and downregulation effects of LRP16 on prolactin secretion of pituitary adenomas cells(GH_3cells).In our study,50 male SD rats(30‐day‐old)展开更多
基金financially supported by the National Natural Science Foundation of China and Hainan Province.[NSFC,Grant Nos.81570705 and 81270866NSFH,Grant No.20168353]
文摘Prolactinoma is an estrogen‐related tumor and leukemia‐related protein 16(LRP16)is correlated with the progression of estrogen‐related tumors,but the regulatory mechanism between LRP16 and prolactinoma remain unclear.This study demonstrates a variation in LRP16 with estrogen receptorα(ERα)in prolactinoma models and the up and downregulation effects of LRP16 on prolactin secretion of pituitary adenomas cells(GH_3cells).In our study,50 male SD rats(30‐day‐old)
