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PM2.5-induced Alterations of Gene Expression in HBE Cells Revealed by Gene Chip Analysis 被引量:1
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作者 wang bing yu CAI Ying +3 位作者 ZHENG Kai HUANG Hai Yan QIN Xiao yun XU Xin yun 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2020年第3期213-216,共4页
PM2.5 are fine inhalable particles with diameters that are generally 2.5 micrometers and smaller and are characterized by a small particle size,a large surface area,and a strong toxin absorption ability[1-3].PM2.5 con... PM2.5 are fine inhalable particles with diameters that are generally 2.5 micrometers and smaller and are characterized by a small particle size,a large surface area,and a strong toxin absorption ability[1-3].PM2.5 contains heavy metals and organic pollutants that are harmful to human health and exert carcinogenic,teratogenic,and mutagenic effects[4-7].PM2.5 has been classified as a human carcinogen by the International Agency for Research on Cancer(IARC)[2].The economy has developed rapidly making air pollution a serious environmental health problem in China.The purpose of this study was to explore the differentially expressed genes and pathways after a PM2.5 exposure in the human bronchial epithelial(HBE)cells via gene chip technology and bioinformatics analysis. 展开更多
关键词 PM2.5 absorption ABILITY gene CHIP technology
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Di-2-Ethylhexyl Phthalate Induces Ovarian Toxicity and Alters Protein Expression of Hormone-regulated Receptors in Rats 被引量:1
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作者 QIN Xiao yun MA Quan +3 位作者 XU Xin yun TAN Qin ZHENG Kai wang bing yu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2019年第7期546-549,共4页
Phthalates are mult functional compo unds that are used in various commercial and in dustrial products, such as food packagings, toys, cosmetics, building materials, and personal care products, Di(2-ethylhexyl) phthal... Phthalates are mult functional compo unds that are used in various commercial and in dustrial products, such as food packagings, toys, cosmetics, building materials, and personal care products, Di(2-ethylhexyl) phthalate (DEHP), one of the most comm only used phthalates, is ubiquitously prese nt in humans.Studies have shown that DEHP has some potentially adverse effects on health, including abnormal timing of parturition, reproductive dysfunction, and low birth weight[5-7]. 展开更多
关键词 PROTEIN EXPRESSION Hormone-regulated
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Characteristics of Atmospheric Fine Particulate Matter(PM2.5)Induced Differentially Expressed Proteins Determined by Proteomics and Bioinformatics Analyses
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作者 ZHENG Kai CAI Ying +7 位作者 wang bing yu QIN Shuang Jian LI Bo Ru HUANG Hai Yan QIN Xiao yun LONG Ding Xin ZHANG Zhao Hui XU Xin yun 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2020年第8期583-592,共10页
Objective To screen the differentially expressed proteins(DEPs)in human bronchial epithelial cells(HBE)treated with atmospheric fine particulate matter(PM2.5).Methods HBE cells were treated with PM2.5 samples from She... Objective To screen the differentially expressed proteins(DEPs)in human bronchial epithelial cells(HBE)treated with atmospheric fine particulate matter(PM2.5).Methods HBE cells were treated with PM2.5 samples from Shenzhen and Taiyuan for 24 h.To detect overall protein expression,the Q Exactive mass spectrometer was used.Gene ontology(GO),Kyoto encyclopedia of genes and genomes(KEGG),and Perseus software were used to screen DEPs.Results Overall,67 DEPs were screened in the Shenzhen sample-treated group,of which 46 were upregulated and 21 were downregulated.In total,252 DEPs were screened in the Taiyuan sampletreated group,of which 134 were upregulated and 118 were downregulated.KEGG analysis demonstrated that DEPs were mainly enriched in ubiquitin-mediated proteolysis and HIF-1 signal pathways in Shenzhen PM2.5 samples-treated group.The GO analysis demonstrated that Shenzhen sample-induced DEPs were mainly involved in the biological process for absorption of various metal ions and cell components.The Taiyuan PM2.5-induced DEPs were mainly involved in biological processes of protein aggregation regulation and molecular function of oxidase activity.Additionally,three important DEPs,including ANXA2,DIABLO,and AIMP1,were screened.Conclusion Our findings provide a valuable basis for further evaluation of PM2.5-associated carcinogenesis. 展开更多
关键词 PM2.5 PROTEOMICS BIOINFORMATICS Differentially expressed proteins Weighted correlation network analysis
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