BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic i...BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic ingredients for mitigating MAFLD remain unclear.AIM To research the active ingredients of PM adjusting mitochondria to relieve highfat diet(HFD)-induced MAFLD in rats.METHODS Fat emulsion-induced L02 adipocyte model and HFD-induced MAFLD rat model were used to investigate the anti-MAFLD ability of PM and explore their action mechanisms.The adipocyte model was also applied to evaluate the activities of PM-derived constituents in liver mitochondria from HFD-fed rats(mitochondrial pharmacology).PM-derived constituents in liver mitochondria were confirmed by ultra-high-performance liquid chromatography/mass spectrometry(mitochondrial pharmacochemistry).The abilities of PM-derived monomer and monomer groups were evaluated by the adipocyte model and MAFLD mouse model,respectively.RESULTS PM repaired mitochondrial ultrastructure and prevented oxidative stress and energy production disorder of liver mitochondria to mitigate fat emulsion-induced cellular steatosis and HFD-induced MAFLD.PM-derived constituents that entered the liver mitochondria inhibited oxidative stress damage and improved energy production against cellular steatosis.Eight chemicals were found in the liver mitochondria of PM-administrated rats.The anti-steatosis ability of one monomer and the anti-MAFLD activity of the monomer group were validated.CONCLUSION PM restored mitochondrial structure and function and alleviated MAFLD,which may be associated with the remedy of oxidative stress and energy production.The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD.Thus,PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction.Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.展开更多
Biomass adhesive is conducive to decreasing the dependence of the wood adhesive industry on synthetic resin based on fossil resources and improving the market competitiveness of adhesives.It is also a critical breakth...Biomass adhesive is conducive to decreasing the dependence of the wood adhesive industry on synthetic resin based on fossil resources and improving the market competitiveness of adhesives.It is also a critical breakthrough to realize the goal of carbon peaking and carbon neutrality in the wood industry.In this study,a full biomass wood adhesive composed of tannin and sucrose was developed and applied successfully to the preparation of ply-wood.The preparation technique of plywood was optimized,and the chemical structure,curing performance,crystallization property and thermal performance of the adhesive were investigated.Results showed that:(1)hot-pressing temperature played a decisive role in the performances of tannin-sucrose composite adhesives and it also had a very significant influence on the water resistance of plywood.(2)The preparation of tannin-sucrose composite adhesive was a process in which sucrose was transformed into furan aldehydes and then made cross-linking reaction with tannin.These composite adhesives could only get good bonding performances when the curing temperature was above 210℃.(3)The optimal plywood preparation technique was:hot-pressing tem-perature of 220℃,hot-pressing time of 1.2 min/mm,m(tannin):m(sucrose)of 60:40,and adhesive loading of 160 g/m^(2).The wet bonding strength in boiling water of the prepared plywood was 0.83 MPa,meeting the strength requirements of Type-I plywood in the standard of GB/T 17657-2013.(4)The curing temperature of tannin-sucrose composite adhesive was further decreased by lowering the temperature during the transformation of sucrose into 5-HMF,which was a key in subsequent research.展开更多
AIM To identify the effects and mechanism of action of Polygonatum kingianum(P. kingianum) on dyslipidemia in rats using an integrated untargeted metabolomic method.METHODS A rat model of dyslipidemia was induced with...AIM To identify the effects and mechanism of action of Polygonatum kingianum(P. kingianum) on dyslipidemia in rats using an integrated untargeted metabolomic method.METHODS A rat model of dyslipidemia was induced with a high-fat diet(HFD) and rats were given P. kingianum [4 g/(kg·d)] intragastrically for 14 wk. Changes in serum and hepatic lipid parameters were evaluated. Metabolites in serum, urine and liver samples were profiled using ultra-highperformance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to identify potential biomarkers and metabolic pathways.RESULTS P. kingianum significantly inhibited the HFD-induced increase in total cholesterol and triglyceride in the liver and serum. P. kingianum also significantly regulated metabolites in the analyzed samples toward normal status. Nineteen, twenty-four and thirty-eight potential biomarkers were identified in serum, urine and liver samples, respectively. These biomarkers involved biosynthesis of phenylalanine, tyrosine, tryptophan, valine, leucine and isoleucine, along with metabolism of tryptophan, tyrosine, phenylalanine, starch, sucrose, glycerophospholipid, arachidonic acid, linoleic acid, nicotinate, nicotinamide and sphingolipid.CONCLUSION P. kingianum alleviates HFD-induced dyslipidemia by regulating many endogenous metabolites in serum, urine and liver samples. Collectively, our findings suggest that P. kingianum may be a promising lipid regulator to treat dyslipidemia and associated diseases.展开更多
BACKGROUND Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of nonalcoholic fatty liver disease(NAFLD).Polygonatum kin...BACKGROUND Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of nonalcoholic fatty liver disease(NAFLD).Polygonatum kingianum(PK)has been traditionally used in China as a medicinal and nutritional ingredient for centuries and can alleviate high-fat diet(HFD)-induced NAFLD by promoting mitochondrial functions.To date,the underlying molecular mechanism of PK for treating mitochondrial dysfunctions and thus alleviating NAFLD remains unclear.AIM To identify the molecular mechanism behind the mitochondrial regulatory action of PK against HFD-induced NAFLD in rats.METHODS NAFLD model was induced in rats with HFD.The rats were intragastrically administered PK(4 g/kg per day)for 14 wk.Metabolites in hepatic mitochondrial samples were profiled through ultra-high performance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to find the potential biomarkers and metabolic pathways.RESULTS PK significantly restored the metabolites’levels in the mitochondrial samples.Ten potential biomarkers were identified in the analyzed samples.These biomarkers are involved in riboflavin metabolism.CONCLUSION PK can alleviate HFD-induced NAFLD by regulating the riboflavin metabolism and further improving the mitochondrial functions.Thus,PK is a promising mitochondrial regulator/nutrient for alleviating NAFLD-associated diseases.展开更多
Access control is one of the core problems in data management system.In this paper,the system requirements were described in three aspects:the traditional access control model,the access control model in the Internet ...Access control is one of the core problems in data management system.In this paper,the system requirements were described in three aspects:the traditional access control model,the access control model in the Internet era and the access control model in the cloud computing environment.Meanwhile,the corresponding major models were listed and their characteristics and problems were analyzed.Finally,the development trend of the corresponding model was proposed.展开更多
Background:Multiple meta-analyses have found that acupuncture combined with drug treatment can effectively improve the efficacy of clinical treatment for ankylosing spondylitis.The efficacy of acupuncture is based on ...Background:Multiple meta-analyses have found that acupuncture combined with drug treatment can effectively improve the efficacy of clinical treatment for ankylosing spondylitis.The efficacy of acupuncture is based on nearby action and/or remote action,and there have been very few studies comparing the efficacy of these two actions in the treatment of active ankylosing spondylitis.Therefore,we designed this study to observe the clinical efficacy of different acupuncture methods combined with drug treatment for ankylosing spondylitis.Methods:Sixty patients with active ankylosing spondylitis were randomized into a test group and a control group.In addition to basic treatment with nonsteroidal anti-inflammatory drugs and empirical formula of Chinese medicine named heat-clearing,Yin-nourishing,and dehumidifying pills,the test group mainly adopted distal point acupuncture with needles manipulated once every 10 minutes and retained for 30 minutes at each of the nine acupoints,including Houxi(SI3),Shugu(BL65),Siguan(LI4),Quchi(LI11),Yanglingquan(GB34),Shenmai(BL62),Sanyinjiao(SP6),Taixi(KI3),and Zusanli(ST36),for five consecutive days per week(two days of rest per week)for two consecutive weeks.The control group mainly adopted proximal and local point acupuncture with needles manipulated once every 10 minutes and retained for 30 minutes at each of the six acupoints,including Jiaji(EX-B2),Dazhui(DU14),Tianzhu(BL10),Dachangshu(BL25),Shenshu(BL23),and Yaoyangguan(DU3),for five consecutive days per week(two days of rest per week)for two consecutive weeks.Changes between pretreatment and posttreatment ankylosing spondylitis disease activity score,McGill score,and Bath score were evaluated.Results:Ankylosing spondylitis,McGill,and Bath score were lower in both groups with a more significant drop in the test group.After the treatments were discontinued,ankylosing spondylitis,McGill,and Bath scores were lower for the test group compared to those immediately after the two-week treatment.For the control group,ankylosing spondylitis and McGill scores were higher compared to those immediately after the two-week treatment but lower than the pretreatment scores;the Bath score was lower compared to that immediately after the two-week treatment.The differences between the two groups were statistically significant(P<0.05).Conclusion:Though both distal point and proximal point acupuncture combined with drug treatment can improve disease symptoms in patients with ankylosing spondylitis,the distal acupoint group had higher and longer-lasting clinical efficacy.展开更多
High-quality AlN/sapphire templates were fabricated by the combination of sputtering and high-temperature(HT)annealing.The influence of sputtering parameters including nitrogen flux,radio frequency power,and substrate...High-quality AlN/sapphire templates were fabricated by the combination of sputtering and high-temperature(HT)annealing.The influence of sputtering parameters including nitrogen flux,radio frequency power,and substrate temperature on the crystalline quality and surface morphology of annealed AlN films were investigated.With lower substrate temperature,lower power,and lower N2 flux,the full width at half maximum of the X-ray rocking curve for AlN(0002)and(102)were improved to 97.2 and 259.2 arcsec after high-temperature annealing.This happens because the increased vacancy concentration of sputtered AlN films can facilitate the annihilation of dislocations by increasing the recovery rate during HT annealing.Step and step-bunching morphologies were clearly observed with optimized sputtering conditions.展开更多
Most cloud services are built with multi-tenancy which enables data and configuration segregation upon shared infrastructures.It offers tremendous advantages for enterprises and service providers.It is anticipated tha...Most cloud services are built with multi-tenancy which enables data and configuration segregation upon shared infrastructures.It offers tremendous advantages for enterprises and service providers.It is anticipated that this situation will evolve to foster cross-tenant collaboration supported by Authorization as a service.To realize access control in a multi-tenant cloud computing environment,this study proposes a multi-tenant cloud computing access control model based on the traditional usage access control model by building trust relations among tenants.The model consists of three sub-models,which achieve trust relationships between tenants with different granularities and satisfy the requirements of different application scenarios.With an established trust relation in MT-UCON(Multi-tenant Usage Access Control),the trustee can precisely authorize cross-tenant accesses to the trustor’s resources consistent with constraints over the trust relation and other components designated by the trustor.In addition,the security of the model is analyzed by an information flow method.The model adapts to the characteristics of a dynamic and open multi-tenant cloud computing environment and achieves fine-grained access control within and between tenants.展开更多
Background:The study was conducted with the interest of exploring the effects of Qingre Yangyin Chushi pill as anti-inflammatory agent in gout treatment based on the NLRP3/GSDMD coke death pathway.Methods:In this stud...Background:The study was conducted with the interest of exploring the effects of Qingre Yangyin Chushi pill as anti-inflammatory agent in gout treatment based on the NLRP3/GSDMD coke death pathway.Methods:In this study,48 male SD rats were randomly divided into 6 groups,namely model group,blank control group(BC),Qingre Yangyin Chushi pill low-dose treatment group(MSD1),medium-dose treatment group(MSD2),high-dose treatment group(MSD3),and colchicine group(PC),with eight members in each group.The BC and model groups were administered with saline twice a day.The MSD1,MSD2,and MSD3 groups were administered with Qingre Yangyin Chushi pill at a dose of 1.8 g·kg^?1,3.6 g·kg^?1,and 7.2 g·kg^?1 twice a day.The colchicine group was administered with a colchicine suspension at a dose of 0.6×10^?3 g kg^?1 twice a day for 7 days.After gavage of animals in each group for 4 days,the rats'ankle joints were injected with sodium urate suspension×3 days to induce a gouty arthritis model.Then,serum and tissue samples were collected on the third and seventh day after gavage.The synovial tissue from the rat ankle joints was taken,and immunohistochemical technique was used to detect NOD-like receptor protein 3(NLRP3),inflammatory bodies,cysteine protease-1(Caspase-1),and Gasdermin-D protein(GSDMD)expression.Image-Pro Plus image analysis system was used to measure the average integrated absorbance and calculate IHS.Integral enzyme-linked immunosorbent assay was used to determine the interleukin 1β(IL-1β)and interleukin 18(IL-18)expression of tumor necrosis factor-α(TNF-α).Western blot was used to detect NLRP3,Caspase-1,GSDMD,and apoptosis-associated speck-like protein containing a CARD(ASC)expression levels.Results:After 48 hours of modeling,compared with the PC group,the arthritis indices of the MSD1,MSD2,and MSD3 groups were insignificant(P>0.05).The levels of IL-1β,IL-18,and TNF-αwere lower in the PC and MSD2 groups compared with the BC group.However,compared with the control group,MSD1,MSD2,and PC groups had lower levels of IL-1βand IL-18.Regarding TNF-αlevels(P<0.05);compared with the PC group,the levels of IL-1β,IL-18,and TNF-αin MSD2 decreased more significantly(P<0.05).The levels of NLRP3,Caspase-1,GSDMD,ASC,IHS score,and mRNA were lower in the PC and MSD2 groups(P<0.05)compared with the control group.The MSD1 and MSD2 groups had lower levels of NLRP3,Caspase-1,GSDMD,ASC protein levels,IHS points,and mRNA levels(P<0.05)compared with the PC group.Moreover,NLRP3,Caspase-1,GSDMD,ASC protein levels,IHS points,and mRNA levels were more reduced in the MSD2 group(P<0.05).Conclusion:Qingre Yangyin Chushi pill can inhibit the activation of the NLPR3 inflammatory complex,reduce the production of GSDMD protein,regulate the occurrence of pyroptosis,reduce the expression of inflammatory factors,and thus reduce arthritis.All these processes are achieved through the NLRP3/GSDMD pathway.展开更多
Post-stroke depression (PSD) is one of the most common affective disorders after acute cerebrovascular injury. It significantly increases the mortality, disability rate and recurrence rate of stroke, which places a he...Post-stroke depression (PSD) is one of the most common affective disorders after acute cerebrovascular injury. It significantly increases the mortality, disability rate and recurrence rate of stroke, which places a heavy burden on families and society. The etiology of PSD is not yet clear, involving a series of complex mechanisms. Inflammatory response, apoptosis, neurotrophic factors, neurotransmitters and many others may play important roles, and there is no effective treatment. Salvianolic acid for injection (SAFI) has the functions of anti-inflammatory, anti-oxidative stress, anti-apoptotic and can improve depressive behavior. It is expected to become a new antidepressant for the treatment of PSD.展开更多
Eleven tropical cyclones(TCs)affected Shanghai and crossed the same latitude as Shanghai from 2007 to 2018.According to similar tracks from best-track data,TCs that cause significant precipitation in Shanghai can be d...Eleven tropical cyclones(TCs)affected Shanghai and crossed the same latitude as Shanghai from 2007 to 2018.According to similar tracks from best-track data,TCs that cause significant precipitation in Shanghai can be divided into three types:landfall TCs,nearshore northward TCs,and western TCs.Based on ERA5 reanalysis data,the dynamic synthesis method was used to synthesize TC circulation situations to compare thermal,dynamic,water vapor,and stability conditions within TC circulations during the period when they affected Shanghai.The conclusions are as follows.1)When the three TC types are at the same latitude as Shanghai,they are all in the divergent field in the upper troposphere.For the landfall type,the subtropical high at 500 hPa is stronger and farther north than usual,and there is a high-pressure dam on the north side of the TCs.2)The warm advection of the three TC types at 925 hPa is located in the northern quadrant of the TCs.The dynamic and water vapor conditions are good in the north-western quadrant of landfall and western TCs,and more favorable in the eastern quadrant of nearshore northward TCs.3)The favorable effects of all three types on precipitation in Shanghai come from the boundary layer.Water vapor,upward motion,and instability conditions of landfall TCs are superior to the other two TC types.The best water vapor,dynamic,and convective instability conditions are at the northern boundary in Shanghai during landfall TCs,and the main sources of water vapor in Shanghai come from the eastern and northern boundaries.During nearshore northward TCs,the main contribution to precipitation is from the eastern boundary,while better dynamic and water vapor conditions come from the western and northern boundaries during western TCs.The above findings provide scientific and technical support for operational forecasting precipitation from TCs affecting mega-cities.展开更多
Accurate prediction of the convection initiation(CI)in urban areas is still a challenge.A heavy rainfall event,missed by the 9-km regional operational modeling system,occurred in the coastal urban area of the Shanghai...Accurate prediction of the convection initiation(CI)in urban areas is still a challenge.A heavy rainfall event,missed by the 9-km regional operational modeling system,occurred in the coastal urban area of the Shanghai metropolitan region(SMR)in the late morning on 28 July 2020 on the warm side to the south of the Meiyu front.In this study,observational analyses and convection-permitting simulations with a resolution of 3 km were conducted to investigate the CI mechanism of this rainfall event.The results showed that the CI was due to the interaction of urban heat island(UHI),northwesterly outflows from the Meiyu front precipitation system(MFPS),and northeasterly sea winds.First,the UHI created a lifting condition producing adiabatic cooling and the vertical moisture transport in the urban region.Then,the mesolow generated by the UHI induced and enhanced local low-level convergence near the CI region and accelerated the northwesterly outflows and the northeasterly sea winds as they converged to the UHI.The convection was triggered as a result of the strengthened low-level convergence when the enhanced northwesterly outflows and northeasterly sea winds approached the updraft zone caused by the UHI center.Sensitivity experiments with either the urban area of the SMR removed or the MFPS suppressed further revealed that the enhancement of the low-level convergence was mainly contributed by the UHI.The outflows and sea winds transported cold and moist air to the CI region and partly offset the negative contribution of the urban drying effect to the low-level relative humidity to facilitate the development of the deep moist absolute unstable layer during the CI.In addition,the MFPS also contributed to the enhancement of the northeasterly sea winds by influencing the land–sea pressure contrast on the north of the SMR.展开更多
The nanorod structure is an alternative scheme to develop high-efficiency deep ultraviolet light-emitting diodes(DUV LEDs). In this paper, we first report the electrically injected 274-nm AlGaN nanorod array DUV LEDs ...The nanorod structure is an alternative scheme to develop high-efficiency deep ultraviolet light-emitting diodes(DUV LEDs). In this paper, we first report the electrically injected 274-nm AlGaN nanorod array DUV LEDs fabricated by the nanosphere lithography and dry-etching technique. Nanorod DUV LED devices with good electrical properties are successfully realized. Compared to planar DUV LEDs, nanorod DUV LEDs present>2.5 times improvement in light output power and external quantum efficiency. The internal quantum efficiency of nanorod LEDs increases by 1.2 times due to the transformation of carriers from the exciton to the free electron–hole, possibly driven by the interface state effect of the nanorod sidewall surface. In addition, the nanorod array significantly facilitates photons escaping from the interior of LEDs along the vertical direction, contributing to improved light extraction efficiency. A three-dimensional finite-different time-domain simulation is performed to analyze further in detail the TE-and TM-polarized photon extraction mechanisms of the nanostructure. Our results demonstrate the nanorod structure is a good candidate for high-efficiency DUV emitters.展开更多
Flexible mechanosensors with a high sensitivity and fast response speed may advance the wearable and implantable applications of healthcare devices, such as real-time heart rate, pulse, and respiration monitoring. In ...Flexible mechanosensors with a high sensitivity and fast response speed may advance the wearable and implantable applications of healthcare devices, such as real-time heart rate, pulse, and respiration monitoring. In this paper, we introduce a novel flexible electronic eardrum （EE） based on single-walled carbon nanotubes, polyethylene, and polydimethylsiloxane with micro-structured pyramid arrays. The EE device shows a high sensitivity, high signal-to-noise ratio （approximately 55 dB）, and fast response time （76.9 μs） in detecting and recording sound within a frequency domain of 20-13,000 Hz. The mechanism for sound detection is investigated and the sensitivity is determined using the micro-structure, thickness, and strain state. We also demonstrated that the device is able to distinguish human voices. This unprecedented performance of the flexible electronic eardrum has implications for many applications such as implantable acoustical bioelectronics and personal voice recognition.展开更多
Thin-film polymer microelectrcxje arrays(MEAs)facilitate the high-resolution neural recording with its superior mechanical compliance.However,the densely packed electrodes and interconnects along with the ultra-thin p...Thin-film polymer microelectrcxje arrays(MEAs)facilitate the high-resolution neural recording with its superior mechanical compliance.However,the densely packed electrodes and interconnects along with the ultra-thin polymeric encapsulation/substrate layers give rise to non-negligible crosstalk,which could result in severe interference in the neural signal recording.Due to the lack of standardized characterization or modeling of crosstalk in neural electrode arrays,to date,crosstalk in polymer MEAs remains poorly understood.In this work,the crosstalk between two adjacent polymer microelectrodes is measured experimentally and modeled using equivalent circuits.Importantly,this study demonstrated a two-well measuring platform and systematically characterized the crosstalk in polymer microelectrodes with true isolation of the victim channel and precise control of its grounding condition.A simple,unified equation from detailed circuit modeling was proposed to calculate the crosstalk in different environments.Finite element analysis(FEA)analysis was conducted further to explore the crosstalk in more aggressively scaled polymer electrode threads.In addition to standardizing neural electrode array crosstalk characterization,this study not only reveals the dependence of the crosstalk in polymer MEAs on a variety of key device parameters but also provides general guidelines for the design of thin polymer MEAs for high-quality neural signal recording.展开更多
A new coordination polymer,[Co_(2)(L)_(2)(4,4'-bipy)]_(n)·3nH_(2)O(1)based on 5-(3-methyl-5-phenyl-4H-1,2,4-tri-azol-4-yl)isophthalic acid(H_(2)L)and 4,4'-bipyridine(4,4'-bipy)has been hydrothermally ...A new coordination polymer,[Co_(2)(L)_(2)(4,4'-bipy)]_(n)·3nH_(2)O(1)based on 5-(3-methyl-5-phenyl-4H-1,2,4-tri-azol-4-yl)isophthalic acid(H_(2)L)and 4,4'-bipyridine(4,4'-bipy)has been hydrothermally synthesized and character-ized by single-crystal X-ray diffraction,XRPD,IR,and elemental analysis.Temperature-dependent magnetic sus-ceptibility and thermal degradation for 1 were also studied.The asymmetric unit of compound 1 consists of two crystallographically independent Co(II)ion,two L^(2−)ligand,one 4,4'-bipy ligand,and three lattice water molecules.The 2D triangle networks were linked by the bridging 4,4'-bipy ligand to give rise to a 2-fold interpenetrated 3D architecture.The simplest cyclic motif of the 2D networks is a triangle ring consisting of three Co(II)cations and three L^(2−)ligands.So we can define Co(II)ions as 4-connected nodes and the L^(2−)ligands as 3-connected nodes.Thus,the 3D structure can be described as a 2-fold parallel interpenetrated ins InS 3,4-conn topology.展开更多
Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide（sH_2 bha）. Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with th...Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide（sH_2 bha）. Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis（TGA） and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells＇ proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology.展开更多
Based on the 16 historical tropical cyclones(TCs)affecting Shanghai from 2007 to 2019,the suitability of ERA5 for studying TCs affecting Shanghai is systematically evaluated from the perspective of TC track,intensity,...Based on the 16 historical tropical cyclones(TCs)affecting Shanghai from 2007 to 2019,the suitability of ERA5 for studying TCs affecting Shanghai is systematically evaluated from the perspective of TC track,intensity,10-m and upper-level wind,using TC best-track data of China Meteorological Administration and surface observations and sounding data.Corresponding to tropical storm(TS),strong tropical storm(STS),typhoon(TY),strong typhoon(STY)and super typhoon(SuperTY),the median TC track bias is 68.1,52.9,42.5,25.4,and 18.2 km,respectively,the median maximum 10-m wind speed(VMAX10m)bias is-3.7,-6.5,-11.4,-21.7,and-32.2 m·s-1,respectively,and the median minimum mean sea level pressure(MSLPmin)bias is 2.2,5.6,8.1,28.2,and 48.7 hPa,respectively.With the increase of TC intensity,the median TC track bias decreases,while the median VMAX10m and MSLPmin bias increase.In general,VMAX10m in ERA5 is lower than observed,and MSLPmin is larger than observed.Under influence of TS,STS,TY and STY,the median 10-m wind speed(V10m)bias in the city is 3.2,4.2,4.7,and 5.4 m·s-1,respectively,and is 4.4-5.2 m·s-1 near the east coast,respectively.V10m is mostly biased high,showing an"M"type pattern with the distance between TC and Shanghai.The median 10 m wind direction(WD10m)bias is in a range of-7° to+7°.The median upper-level wind speed(Vupper)bias decreases with height,with a maximum of~5 m·s-1 at 975 hPa.Below 900 hPa Vupperin ERA5 is typically larger than the radiosonde observation,and its mean bias error(MBE)increases with TC intensity.The upper-level wind direction(WDupper)matches the sounding data well,with a maximum bias of a few degrees only.The results provide a reference for the application of ERA5 to coastal cities affected by TCs.展开更多
基金the National Natural Science Foundation of China,No.82060707 and 82104381the Application and Basis Research Project of Yunnan China,No.202201AW070016,202001AZ070001-006,and 2019IB009the Young and Middle-aged Academic and Technological Leader of Yunnan,No.202005AC160059.
文摘BACKGROUND Metabolic dysfunction-associated fatty liver disease(MAFLD)is a severe threat to human health.Polygonum multiflorum(PM)has been proven to remedy mitochondria and relieve MAFLD,but the main pharmacodynamic ingredients for mitigating MAFLD remain unclear.AIM To research the active ingredients of PM adjusting mitochondria to relieve highfat diet(HFD)-induced MAFLD in rats.METHODS Fat emulsion-induced L02 adipocyte model and HFD-induced MAFLD rat model were used to investigate the anti-MAFLD ability of PM and explore their action mechanisms.The adipocyte model was also applied to evaluate the activities of PM-derived constituents in liver mitochondria from HFD-fed rats(mitochondrial pharmacology).PM-derived constituents in liver mitochondria were confirmed by ultra-high-performance liquid chromatography/mass spectrometry(mitochondrial pharmacochemistry).The abilities of PM-derived monomer and monomer groups were evaluated by the adipocyte model and MAFLD mouse model,respectively.RESULTS PM repaired mitochondrial ultrastructure and prevented oxidative stress and energy production disorder of liver mitochondria to mitigate fat emulsion-induced cellular steatosis and HFD-induced MAFLD.PM-derived constituents that entered the liver mitochondria inhibited oxidative stress damage and improved energy production against cellular steatosis.Eight chemicals were found in the liver mitochondria of PM-administrated rats.The anti-steatosis ability of one monomer and the anti-MAFLD activity of the monomer group were validated.CONCLUSION PM restored mitochondrial structure and function and alleviated MAFLD,which may be associated with the remedy of oxidative stress and energy production.The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD.Thus,PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction.Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.
文摘Biomass adhesive is conducive to decreasing the dependence of the wood adhesive industry on synthetic resin based on fossil resources and improving the market competitiveness of adhesives.It is also a critical breakthrough to realize the goal of carbon peaking and carbon neutrality in the wood industry.In this study,a full biomass wood adhesive composed of tannin and sucrose was developed and applied successfully to the preparation of ply-wood.The preparation technique of plywood was optimized,and the chemical structure,curing performance,crystallization property and thermal performance of the adhesive were investigated.Results showed that:(1)hot-pressing temperature played a decisive role in the performances of tannin-sucrose composite adhesives and it also had a very significant influence on the water resistance of plywood.(2)The preparation of tannin-sucrose composite adhesive was a process in which sucrose was transformed into furan aldehydes and then made cross-linking reaction with tannin.These composite adhesives could only get good bonding performances when the curing temperature was above 210℃.(3)The optimal plywood preparation technique was:hot-pressing tem-perature of 220℃,hot-pressing time of 1.2 min/mm,m(tannin):m(sucrose)of 60:40,and adhesive loading of 160 g/m^(2).The wet bonding strength in boiling water of the prepared plywood was 0.83 MPa,meeting the strength requirements of Type-I plywood in the standard of GB/T 17657-2013.(4)The curing temperature of tannin-sucrose composite adhesive was further decreased by lowering the temperature during the transformation of sucrose into 5-HMF,which was a key in subsequent research.
基金Supported by the National Natural Science Foundation of China,No.81660596 and No.81760733the Application and Basis Research Project of Yunnan,China,No.2016FD050 and No.2017FF117-013the Fund for Young and Middle-aged Academic and Technological Leaders of Yunnan,No.2015HB053
文摘AIM To identify the effects and mechanism of action of Polygonatum kingianum(P. kingianum) on dyslipidemia in rats using an integrated untargeted metabolomic method.METHODS A rat model of dyslipidemia was induced with a high-fat diet(HFD) and rats were given P. kingianum [4 g/(kg·d)] intragastrically for 14 wk. Changes in serum and hepatic lipid parameters were evaluated. Metabolites in serum, urine and liver samples were profiled using ultra-highperformance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to identify potential biomarkers and metabolic pathways.RESULTS P. kingianum significantly inhibited the HFD-induced increase in total cholesterol and triglyceride in the liver and serum. P. kingianum also significantly regulated metabolites in the analyzed samples toward normal status. Nineteen, twenty-four and thirty-eight potential biomarkers were identified in serum, urine and liver samples, respectively. These biomarkers involved biosynthesis of phenylalanine, tyrosine, tryptophan, valine, leucine and isoleucine, along with metabolism of tryptophan, tyrosine, phenylalanine, starch, sucrose, glycerophospholipid, arachidonic acid, linoleic acid, nicotinate, nicotinamide and sphingolipid.CONCLUSION P. kingianum alleviates HFD-induced dyslipidemia by regulating many endogenous metabolites in serum, urine and liver samples. Collectively, our findings suggest that P. kingianum may be a promising lipid regulator to treat dyslipidemia and associated diseases.
基金the National Natural Science Foundation of China,No.81660596the National Natural Science Foundation of China,No.81760733+2 种基金the Science and Technology Project of Yunnan China,No.2017FF117-013the Science and Technology Project of Yunnan China,No.2016FD050the Application and Basis Research Project of Yunnan China,No.201801CH00227
文摘BACKGROUND Developing mitochondrial regulators/nutrients from natural products to remedy mitochondrial dysfunction represent attractive strategies for therapy of nonalcoholic fatty liver disease(NAFLD).Polygonatum kingianum(PK)has been traditionally used in China as a medicinal and nutritional ingredient for centuries and can alleviate high-fat diet(HFD)-induced NAFLD by promoting mitochondrial functions.To date,the underlying molecular mechanism of PK for treating mitochondrial dysfunctions and thus alleviating NAFLD remains unclear.AIM To identify the molecular mechanism behind the mitochondrial regulatory action of PK against HFD-induced NAFLD in rats.METHODS NAFLD model was induced in rats with HFD.The rats were intragastrically administered PK(4 g/kg per day)for 14 wk.Metabolites in hepatic mitochondrial samples were profiled through ultra-high performance liquid chromatography/mass spectrometry followed by multivariate statistical analysis to find the potential biomarkers and metabolic pathways.RESULTS PK significantly restored the metabolites’levels in the mitochondrial samples.Ten potential biomarkers were identified in the analyzed samples.These biomarkers are involved in riboflavin metabolism.CONCLUSION PK can alleviate HFD-induced NAFLD by regulating the riboflavin metabolism and further improving the mitochondrial functions.Thus,PK is a promising mitochondrial regulator/nutrient for alleviating NAFLD-associated diseases.
文摘Access control is one of the core problems in data management system.In this paper,the system requirements were described in three aspects:the traditional access control model,the access control model in the Internet era and the access control model in the cloud computing environment.Meanwhile,the corresponding major models were listed and their characteristics and problems were analyzed.Finally,the development trend of the corresponding model was proposed.
基金Scientific Research and Cultivation Plan project of Beijing Municipal Hospital(No.PZ2019018).
文摘Background:Multiple meta-analyses have found that acupuncture combined with drug treatment can effectively improve the efficacy of clinical treatment for ankylosing spondylitis.The efficacy of acupuncture is based on nearby action and/or remote action,and there have been very few studies comparing the efficacy of these two actions in the treatment of active ankylosing spondylitis.Therefore,we designed this study to observe the clinical efficacy of different acupuncture methods combined with drug treatment for ankylosing spondylitis.Methods:Sixty patients with active ankylosing spondylitis were randomized into a test group and a control group.In addition to basic treatment with nonsteroidal anti-inflammatory drugs and empirical formula of Chinese medicine named heat-clearing,Yin-nourishing,and dehumidifying pills,the test group mainly adopted distal point acupuncture with needles manipulated once every 10 minutes and retained for 30 minutes at each of the nine acupoints,including Houxi(SI3),Shugu(BL65),Siguan(LI4),Quchi(LI11),Yanglingquan(GB34),Shenmai(BL62),Sanyinjiao(SP6),Taixi(KI3),and Zusanli(ST36),for five consecutive days per week(two days of rest per week)for two consecutive weeks.The control group mainly adopted proximal and local point acupuncture with needles manipulated once every 10 minutes and retained for 30 minutes at each of the six acupoints,including Jiaji(EX-B2),Dazhui(DU14),Tianzhu(BL10),Dachangshu(BL25),Shenshu(BL23),and Yaoyangguan(DU3),for five consecutive days per week(two days of rest per week)for two consecutive weeks.Changes between pretreatment and posttreatment ankylosing spondylitis disease activity score,McGill score,and Bath score were evaluated.Results:Ankylosing spondylitis,McGill,and Bath score were lower in both groups with a more significant drop in the test group.After the treatments were discontinued,ankylosing spondylitis,McGill,and Bath scores were lower for the test group compared to those immediately after the two-week treatment.For the control group,ankylosing spondylitis and McGill scores were higher compared to those immediately after the two-week treatment but lower than the pretreatment scores;the Bath score was lower compared to that immediately after the two-week treatment.The differences between the two groups were statistically significant(P<0.05).Conclusion:Though both distal point and proximal point acupuncture combined with drug treatment can improve disease symptoms in patients with ankylosing spondylitis,the distal acupoint group had higher and longer-lasting clinical efficacy.
基金This work was supported by the National Key R&D Program of China(Nos.2016YFB0400800 and 2017YFB0404202)the National Natural Sciences Foundation of China(Grant Nos.61527814,61674147,61904176,U1505253)+1 种基金Beijing Nova Program Z181100006218007Youth Innovation Promotion Association CAS 2017157.
文摘High-quality AlN/sapphire templates were fabricated by the combination of sputtering and high-temperature(HT)annealing.The influence of sputtering parameters including nitrogen flux,radio frequency power,and substrate temperature on the crystalline quality and surface morphology of annealed AlN films were investigated.With lower substrate temperature,lower power,and lower N2 flux,the full width at half maximum of the X-ray rocking curve for AlN(0002)and(102)were improved to 97.2 and 259.2 arcsec after high-temperature annealing.This happens because the increased vacancy concentration of sputtered AlN films can facilitate the annihilation of dislocations by increasing the recovery rate during HT annealing.Step and step-bunching morphologies were clearly observed with optimized sputtering conditions.
文摘Most cloud services are built with multi-tenancy which enables data and configuration segregation upon shared infrastructures.It offers tremendous advantages for enterprises and service providers.It is anticipated that this situation will evolve to foster cross-tenant collaboration supported by Authorization as a service.To realize access control in a multi-tenant cloud computing environment,this study proposes a multi-tenant cloud computing access control model based on the traditional usage access control model by building trust relations among tenants.The model consists of three sub-models,which achieve trust relationships between tenants with different granularities and satisfy the requirements of different application scenarios.With an established trust relation in MT-UCON(Multi-tenant Usage Access Control),the trustee can precisely authorize cross-tenant accesses to the trustor’s resources consistent with constraints over the trust relation and other components designated by the trustor.In addition,the security of the model is analyzed by an information flow method.The model adapts to the characteristics of a dynamic and open multi-tenant cloud computing environment and achieves fine-grained access control within and between tenants.
基金This study was supported by the General Project of Beijing Natural Science Foundation(No.7172101)the Beijing Municipal Hospital Research and Cultivation Project(No.PZ2017015)the Beijing Hospital of Traditional Chinese Medicine Gospital-Level Project(No.YJ-201807).
文摘Background:The study was conducted with the interest of exploring the effects of Qingre Yangyin Chushi pill as anti-inflammatory agent in gout treatment based on the NLRP3/GSDMD coke death pathway.Methods:In this study,48 male SD rats were randomly divided into 6 groups,namely model group,blank control group(BC),Qingre Yangyin Chushi pill low-dose treatment group(MSD1),medium-dose treatment group(MSD2),high-dose treatment group(MSD3),and colchicine group(PC),with eight members in each group.The BC and model groups were administered with saline twice a day.The MSD1,MSD2,and MSD3 groups were administered with Qingre Yangyin Chushi pill at a dose of 1.8 g·kg^?1,3.6 g·kg^?1,and 7.2 g·kg^?1 twice a day.The colchicine group was administered with a colchicine suspension at a dose of 0.6×10^?3 g kg^?1 twice a day for 7 days.After gavage of animals in each group for 4 days,the rats'ankle joints were injected with sodium urate suspension×3 days to induce a gouty arthritis model.Then,serum and tissue samples were collected on the third and seventh day after gavage.The synovial tissue from the rat ankle joints was taken,and immunohistochemical technique was used to detect NOD-like receptor protein 3(NLRP3),inflammatory bodies,cysteine protease-1(Caspase-1),and Gasdermin-D protein(GSDMD)expression.Image-Pro Plus image analysis system was used to measure the average integrated absorbance and calculate IHS.Integral enzyme-linked immunosorbent assay was used to determine the interleukin 1β(IL-1β)and interleukin 18(IL-18)expression of tumor necrosis factor-α(TNF-α).Western blot was used to detect NLRP3,Caspase-1,GSDMD,and apoptosis-associated speck-like protein containing a CARD(ASC)expression levels.Results:After 48 hours of modeling,compared with the PC group,the arthritis indices of the MSD1,MSD2,and MSD3 groups were insignificant(P>0.05).The levels of IL-1β,IL-18,and TNF-αwere lower in the PC and MSD2 groups compared with the BC group.However,compared with the control group,MSD1,MSD2,and PC groups had lower levels of IL-1βand IL-18.Regarding TNF-αlevels(P<0.05);compared with the PC group,the levels of IL-1β,IL-18,and TNF-αin MSD2 decreased more significantly(P<0.05).The levels of NLRP3,Caspase-1,GSDMD,ASC,IHS score,and mRNA were lower in the PC and MSD2 groups(P<0.05)compared with the control group.The MSD1 and MSD2 groups had lower levels of NLRP3,Caspase-1,GSDMD,ASC protein levels,IHS points,and mRNA levels(P<0.05)compared with the PC group.Moreover,NLRP3,Caspase-1,GSDMD,ASC protein levels,IHS points,and mRNA levels were more reduced in the MSD2 group(P<0.05).Conclusion:Qingre Yangyin Chushi pill can inhibit the activation of the NLPR3 inflammatory complex,reduce the production of GSDMD protein,regulate the occurrence of pyroptosis,reduce the expression of inflammatory factors,and thus reduce arthritis.All these processes are achieved through the NLRP3/GSDMD pathway.
基金Natural Science Foundation of Shanxi Provinc(201801D121219)Shanxi Provincial Health and Family Planning Commission project(2017065)
文摘Post-stroke depression (PSD) is one of the most common affective disorders after acute cerebrovascular injury. It significantly increases the mortality, disability rate and recurrence rate of stroke, which places a heavy burden on families and society. The etiology of PSD is not yet clear, involving a series of complex mechanisms. Inflammatory response, apoptosis, neurotrophic factors, neurotransmitters and many others may play important roles, and there is no effective treatment. Salvianolic acid for injection (SAFI) has the functions of anti-inflammatory, anti-oxidative stress, anti-apoptotic and can improve depressive behavior. It is expected to become a new antidepressant for the treatment of PSD.
基金supported by the National Natural Science Foundation of China(Grant Nos.41875059,41875071,41875051,42005077,and U2142206)the Natural Science Foundation of Shanghai Science and Technology Committee(Nos.21ZR1457700 and 22ZR1456100)East China Phased Array Weather Radar Application Joint Laboratory.
文摘Eleven tropical cyclones(TCs)affected Shanghai and crossed the same latitude as Shanghai from 2007 to 2018.According to similar tracks from best-track data,TCs that cause significant precipitation in Shanghai can be divided into three types:landfall TCs,nearshore northward TCs,and western TCs.Based on ERA5 reanalysis data,the dynamic synthesis method was used to synthesize TC circulation situations to compare thermal,dynamic,water vapor,and stability conditions within TC circulations during the period when they affected Shanghai.The conclusions are as follows.1)When the three TC types are at the same latitude as Shanghai,they are all in the divergent field in the upper troposphere.For the landfall type,the subtropical high at 500 hPa is stronger and farther north than usual,and there is a high-pressure dam on the north side of the TCs.2)The warm advection of the three TC types at 925 hPa is located in the northern quadrant of the TCs.The dynamic and water vapor conditions are good in the north-western quadrant of landfall and western TCs,and more favorable in the eastern quadrant of nearshore northward TCs.3)The favorable effects of all three types on precipitation in Shanghai come from the boundary layer.Water vapor,upward motion,and instability conditions of landfall TCs are superior to the other two TC types.The best water vapor,dynamic,and convective instability conditions are at the northern boundary in Shanghai during landfall TCs,and the main sources of water vapor in Shanghai come from the eastern and northern boundaries.During nearshore northward TCs,the main contribution to precipitation is from the eastern boundary,while better dynamic and water vapor conditions come from the western and northern boundaries during western TCs.The above findings provide scientific and technical support for operational forecasting precipitation from TCs affecting mega-cities.
基金Supported by the National Key Research and Development Program of China(2017YFC1501902)Natural Science Foundation of Shanghai Science and Technology Committee(21ZR1457700)。
文摘Accurate prediction of the convection initiation(CI)in urban areas is still a challenge.A heavy rainfall event,missed by the 9-km regional operational modeling system,occurred in the coastal urban area of the Shanghai metropolitan region(SMR)in the late morning on 28 July 2020 on the warm side to the south of the Meiyu front.In this study,observational analyses and convection-permitting simulations with a resolution of 3 km were conducted to investigate the CI mechanism of this rainfall event.The results showed that the CI was due to the interaction of urban heat island(UHI),northwesterly outflows from the Meiyu front precipitation system(MFPS),and northeasterly sea winds.First,the UHI created a lifting condition producing adiabatic cooling and the vertical moisture transport in the urban region.Then,the mesolow generated by the UHI induced and enhanced local low-level convergence near the CI region and accelerated the northwesterly outflows and the northeasterly sea winds as they converged to the UHI.The convection was triggered as a result of the strengthened low-level convergence when the enhanced northwesterly outflows and northeasterly sea winds approached the updraft zone caused by the UHI center.Sensitivity experiments with either the urban area of the SMR removed or the MFPS suppressed further revealed that the enhancement of the low-level convergence was mainly contributed by the UHI.The outflows and sea winds transported cold and moist air to the CI region and partly offset the negative contribution of the urban drying effect to the low-level relative humidity to facilitate the development of the deep moist absolute unstable layer during the CI.In addition,the MFPS also contributed to the enhancement of the northeasterly sea winds by influencing the land–sea pressure contrast on the north of the SMR.
基金National Key R&D Program of China(2016YFB0400800)National Natural Science Foundation of China(61875187,61527814,61674147,U1505253)+1 种基金Beijing Nova Program(Z181100006218007)Youth Innovation Promotion Association of the Chinese Academy of Sciences(2017157)
文摘The nanorod structure is an alternative scheme to develop high-efficiency deep ultraviolet light-emitting diodes(DUV LEDs). In this paper, we first report the electrically injected 274-nm AlGaN nanorod array DUV LEDs fabricated by the nanosphere lithography and dry-etching technique. Nanorod DUV LED devices with good electrical properties are successfully realized. Compared to planar DUV LEDs, nanorod DUV LEDs present>2.5 times improvement in light output power and external quantum efficiency. The internal quantum efficiency of nanorod LEDs increases by 1.2 times due to the transformation of carriers from the exciton to the free electron–hole, possibly driven by the interface state effect of the nanorod sidewall surface. In addition, the nanorod array significantly facilitates photons escaping from the interior of LEDs along the vertical direction, contributing to improved light extraction efficiency. A three-dimensional finite-different time-domain simulation is performed to analyze further in detail the TE-and TM-polarized photon extraction mechanisms of the nanostructure. Our results demonstrate the nanorod structure is a good candidate for high-efficiency DUV emitters.
基金We acknowledge the funding support from the National Natural Science Foundation of China （No. 61574163）, the China Postdoctoral Science Foundation （No. 2015M571837） and the Foundation Research Project of Jiangsu Province （No. BK20150364）.
文摘Flexible mechanosensors with a high sensitivity and fast response speed may advance the wearable and implantable applications of healthcare devices, such as real-time heart rate, pulse, and respiration monitoring. In this paper, we introduce a novel flexible electronic eardrum （EE） based on single-walled carbon nanotubes, polyethylene, and polydimethylsiloxane with micro-structured pyramid arrays. The EE device shows a high sensitivity, high signal-to-noise ratio （approximately 55 dB）, and fast response time （76.9 μs） in detecting and recording sound within a frequency domain of 20-13,000 Hz. The mechanism for sound detection is investigated and the sensitivity is determined using the micro-structure, thickness, and strain state. We also demonstrated that the device is able to distinguish human voices. This unprecedented performance of the flexible electronic eardrum has implications for many applications such as implantable acoustical bioelectronics and personal voice recognition.
基金supported by National Science Foundation award 1847215,National Institute of Neurological Disorders and Stroke award 1RFINS 118301-01 and Samsung Global Research Outreach Award.
文摘Thin-film polymer microelectrcxje arrays(MEAs)facilitate the high-resolution neural recording with its superior mechanical compliance.However,the densely packed electrodes and interconnects along with the ultra-thin polymeric encapsulation/substrate layers give rise to non-negligible crosstalk,which could result in severe interference in the neural signal recording.Due to the lack of standardized characterization or modeling of crosstalk in neural electrode arrays,to date,crosstalk in polymer MEAs remains poorly understood.In this work,the crosstalk between two adjacent polymer microelectrodes is measured experimentally and modeled using equivalent circuits.Importantly,this study demonstrated a two-well measuring platform and systematically characterized the crosstalk in polymer microelectrodes with true isolation of the victim channel and precise control of its grounding condition.A simple,unified equation from detailed circuit modeling was proposed to calculate the crosstalk in different environments.Finite element analysis(FEA)analysis was conducted further to explore the crosstalk in more aggressively scaled polymer electrode threads.In addition to standardizing neural electrode array crosstalk characterization,this study not only reveals the dependence of the crosstalk in polymer MEAs on a variety of key device parameters but also provides general guidelines for the design of thin polymer MEAs for high-quality neural signal recording.
基金This work was supported by the National Natural Science Foundation of China(Nos.21071083 and 20771062).
文摘A new coordination polymer,[Co_(2)(L)_(2)(4,4'-bipy)]_(n)·3nH_(2)O(1)based on 5-(3-methyl-5-phenyl-4H-1,2,4-tri-azol-4-yl)isophthalic acid(H_(2)L)and 4,4'-bipyridine(4,4'-bipy)has been hydrothermally synthesized and character-ized by single-crystal X-ray diffraction,XRPD,IR,and elemental analysis.Temperature-dependent magnetic sus-ceptibility and thermal degradation for 1 were also studied.The asymmetric unit of compound 1 consists of two crystallographically independent Co(II)ion,two L^(2−)ligand,one 4,4'-bipy ligand,and three lattice water molecules.The 2D triangle networks were linked by the bridging 4,4'-bipy ligand to give rise to a 2-fold interpenetrated 3D architecture.The simplest cyclic motif of the 2D networks is a triangle ring consisting of three Co(II)cations and three L^(2−)ligands.So we can define Co(II)ions as 4-connected nodes and the L^(2−)ligands as 3-connected nodes.Thus,the 3D structure can be described as a 2-fold parallel interpenetrated ins InS 3,4-conn topology.
基金Project supported by State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Guangxi Normal University)(CMEMR2016-B12)the National Natural Science Foundation of China(31572492,21401031,21371103,31372482)+3 种基金the Innovative and Entrepreneurial Training Plan for Tianjin College Students(201710061035)the Natural Science Foundation of Tianjin(12JCZDJC22100)the General Fund of Application Foundation and Advanced Technology Program of Tianjin(14JCYBJC30000)the Veterinary Biotechnology Scientific Research Innovation Team of Tianjin,China(TD12-5019)
文摘Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide（sH_2 bha）. Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis（TGA） and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells＇ proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology.
基金supported by the National Natural Science Foundation of China(Grant Nos.41875059,41875071,and 4175049)Shanghai Natural Science Foundation(No.21ZR1457700).
文摘Based on the 16 historical tropical cyclones(TCs)affecting Shanghai from 2007 to 2019,the suitability of ERA5 for studying TCs affecting Shanghai is systematically evaluated from the perspective of TC track,intensity,10-m and upper-level wind,using TC best-track data of China Meteorological Administration and surface observations and sounding data.Corresponding to tropical storm(TS),strong tropical storm(STS),typhoon(TY),strong typhoon(STY)and super typhoon(SuperTY),the median TC track bias is 68.1,52.9,42.5,25.4,and 18.2 km,respectively,the median maximum 10-m wind speed(VMAX10m)bias is-3.7,-6.5,-11.4,-21.7,and-32.2 m·s-1,respectively,and the median minimum mean sea level pressure(MSLPmin)bias is 2.2,5.6,8.1,28.2,and 48.7 hPa,respectively.With the increase of TC intensity,the median TC track bias decreases,while the median VMAX10m and MSLPmin bias increase.In general,VMAX10m in ERA5 is lower than observed,and MSLPmin is larger than observed.Under influence of TS,STS,TY and STY,the median 10-m wind speed(V10m)bias in the city is 3.2,4.2,4.7,and 5.4 m·s-1,respectively,and is 4.4-5.2 m·s-1 near the east coast,respectively.V10m is mostly biased high,showing an"M"type pattern with the distance between TC and Shanghai.The median 10 m wind direction(WD10m)bias is in a range of-7° to+7°.The median upper-level wind speed(Vupper)bias decreases with height,with a maximum of~5 m·s-1 at 975 hPa.Below 900 hPa Vupperin ERA5 is typically larger than the radiosonde observation,and its mean bias error(MBE)increases with TC intensity.The upper-level wind direction(WDupper)matches the sounding data well,with a maximum bias of a few degrees only.The results provide a reference for the application of ERA5 to coastal cities affected by TCs.
