目的筛选夏枯草的质量标志物,并建立其含量测定的方法。方法利用UPLC Q Exactive Plus Orbitrap高分辨液质联用仪进行全成分分析,采用高效液相色谱(HPLC)法建立夏枯草的指纹图谱,对20批次夏枯草药材进行化学计量学分析,筛选夏枯草的质...目的筛选夏枯草的质量标志物,并建立其含量测定的方法。方法利用UPLC Q Exactive Plus Orbitrap高分辨液质联用仪进行全成分分析,采用高效液相色谱(HPLC)法建立夏枯草的指纹图谱,对20批次夏枯草药材进行化学计量学分析,筛选夏枯草的质量标志物并测定含量。综合分析相关的文献数据,研究不同产地夏枯草的迷迭香酸含量变化,进而评价药材质量。结果从夏枯草中共鉴定出72个化合物,其中有机酸类化合物36个,占总数的50%;20批次夏枯草的指纹图谱中共标记了8个共有峰,指认出咖啡酸、芦丁、金丝桃苷和迷迭香酸4个成分,各批次之间的相似度大于0.900。化学计量学分析结果表明,迷迭香酸可能是夏枯草的潜在质量标志物。测定20批次夏枯草中迷迭香酸含量,发现有5个批次不合格。综合文献分析了158批次夏枯草,发现迷迭香酸含量的整体合格率为59.77%。结论迷迭香酸是夏枯草的潜在质量标志物,其含量能有效地评价不同产地夏枯草药材的质量。展开更多
Isotopic abundances and ratios of He and Ar found in inclusion fluids in pyrites formed in the Yaoling-Meiziwo tungsten miner-alization epoch show that the concentration of 4He varies widely,from 1.54×10-7 cm3 ST...Isotopic abundances and ratios of He and Ar found in inclusion fluids in pyrites formed in the Yaoling-Meiziwo tungsten miner-alization epoch show that the concentration of 4He varies widely,from 1.54×10-7 cm3 STP/g to 2609×10-7 cm3 STP/g.3He is 0.759×10-12 cm3 STP/g-3.463×10-12 cm3 STP/g.3He/4He is 0.0043-4.362 Ra,varying from crustal to mantle values.The concen-tration of 40Ar ranges from 0.624×10-7 cm3 STP/g to 8.89×10-7 cm3 STP/g.The 40Ar/36Ar varies extensively,from 330 to 2952,between atmospheric and crustal or mantle radiogenic values.Mantle-derived He is present in ore-forming fluids and the calcu-lated average proportion of the mantle He is 22%;the maximum is 67%.Our research results show that mantle-derived fluids play a significant role in tungsten mineralization.The fractionation of He and Ar indicate that there was 4He-enriched air-saturated water(MSAW) in the ore-forming fluid.The ore-forming fluid was a mixture of mantle fluid,crustal magmatic fluid and MSAW.The occurrence of a mantle component in ore-forming fluid indicates the large-scale W and Sn mineralization,including Yaol-ing-Meiziwo,in southeastern China was the result of crust and mantle interaction.The underplating or intrusion of voluminous basaltic magma formed by partial melting of the upper mantle provided the necessary heat to cause partial melting of the crust and the generation of voluminous S-type granitic magmas.Crustal magmatic fluid and mantle fluid with high 3He/4He were released from magma crystallization and fractionation,mixed with the circulating modified air-saturated water,and filled the extensional tectonic fractures,leading to the formation of world-class W and Sn deposits in southeastern China.展开更多
文摘目的筛选夏枯草的质量标志物,并建立其含量测定的方法。方法利用UPLC Q Exactive Plus Orbitrap高分辨液质联用仪进行全成分分析,采用高效液相色谱(HPLC)法建立夏枯草的指纹图谱,对20批次夏枯草药材进行化学计量学分析,筛选夏枯草的质量标志物并测定含量。综合分析相关的文献数据,研究不同产地夏枯草的迷迭香酸含量变化,进而评价药材质量。结果从夏枯草中共鉴定出72个化合物,其中有机酸类化合物36个,占总数的50%;20批次夏枯草的指纹图谱中共标记了8个共有峰,指认出咖啡酸、芦丁、金丝桃苷和迷迭香酸4个成分,各批次之间的相似度大于0.900。化学计量学分析结果表明,迷迭香酸可能是夏枯草的潜在质量标志物。测定20批次夏枯草中迷迭香酸含量,发现有5个批次不合格。综合文献分析了158批次夏枯草,发现迷迭香酸含量的整体合格率为59.77%。结论迷迭香酸是夏枯草的潜在质量标志物,其含量能有效地评价不同产地夏枯草药材的质量。
基金the National Basic Research Program of China (2007CB411404)the National Natural Science Foundation of China (40873034)the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2011)
文摘Isotopic abundances and ratios of He and Ar found in inclusion fluids in pyrites formed in the Yaoling-Meiziwo tungsten miner-alization epoch show that the concentration of 4He varies widely,from 1.54×10-7 cm3 STP/g to 2609×10-7 cm3 STP/g.3He is 0.759×10-12 cm3 STP/g-3.463×10-12 cm3 STP/g.3He/4He is 0.0043-4.362 Ra,varying from crustal to mantle values.The concen-tration of 40Ar ranges from 0.624×10-7 cm3 STP/g to 8.89×10-7 cm3 STP/g.The 40Ar/36Ar varies extensively,from 330 to 2952,between atmospheric and crustal or mantle radiogenic values.Mantle-derived He is present in ore-forming fluids and the calcu-lated average proportion of the mantle He is 22%;the maximum is 67%.Our research results show that mantle-derived fluids play a significant role in tungsten mineralization.The fractionation of He and Ar indicate that there was 4He-enriched air-saturated water(MSAW) in the ore-forming fluid.The ore-forming fluid was a mixture of mantle fluid,crustal magmatic fluid and MSAW.The occurrence of a mantle component in ore-forming fluid indicates the large-scale W and Sn mineralization,including Yaol-ing-Meiziwo,in southeastern China was the result of crust and mantle interaction.The underplating or intrusion of voluminous basaltic magma formed by partial melting of the upper mantle provided the necessary heat to cause partial melting of the crust and the generation of voluminous S-type granitic magmas.Crustal magmatic fluid and mantle fluid with high 3He/4He were released from magma crystallization and fractionation,mixed with the circulating modified air-saturated water,and filled the extensional tectonic fractures,leading to the formation of world-class W and Sn deposits in southeastern China.
