BACKGROUND Juvenile polyps are the most common type of polyps in children but are rare in adults.Inflammatory bowel disease(IBD)patients have a similar spectrum of symptoms as patients with juvenile polyps.Both patien...BACKGROUND Juvenile polyps are the most common type of polyps in children but are rare in adults.Inflammatory bowel disease(IBD)patients have a similar spectrum of symptoms as patients with juvenile polyps.Both patients with juvenile polyps and those with active IBD have high fecal calprotectin levels.Four cases of children with ulcerative colitis(UC)with solitary juvenile polyps and one case of an adult with UC with juvenile polyposis syndrome have been reported upon diagnosis of UC,while there have been no cases of adults with UC with solitary juvenile polyp reported in the literature.CASE SUMMARY A 37-year-old man with a 12-year history of UC was admitted to our clinic because of increased stool frequency.UC was diagnosed at the age of 25.As the lesion was confined to the rectum,sulfasalazine suppositories or mesalazine suppositories were used.The patient was followed in an outpatient clinic,and colonoscopy was performed every one or two years.The latest examination was undertaken three years prior in the presence of proctitis.Recently,the patient complained of three to five bowel movements a day.There was mucus in the stool but no visible blood.Colonoscopy revealed a solitary polyp,about 1.5 cm in diameter,with a short and broad peduncle in the transverse colon surrounded by congestive and edematous mucosa.The patient had no family history of colorectal polyps or cancer.The polyp was successfully removed by endoscopic mucosal resection.Histopathological examination revealed that the polyp was a juvenile polyp without any malignant signs.Immunohistochemical staining for p53 showed wild-type expression and p53 overexpression was not detected.Ki67 labeling index was 3%.CONCLUSION This is the first case of an adult UC patient with a solitary juvenile polyp at the 12-year follow-up.The correlation between juvenile polyps and the activity of IBD needs further study.展开更多
angiosarcoma is a vascular neoplasm that is among the most aggressive subtypes of sarcomas.Its involvement in the gastrointestinal tract is rare.We here report a case of multifocal gastrointestinal epithelioid angiosa...angiosarcoma is a vascular neoplasm that is among the most aggressive subtypes of sarcomas.Its involvement in the gastrointestinal tract is rare.We here report a case of multifocal gastrointestinal epithelioid angiosarcomas presenting with gastrointestinal bleeding.CASE SUMMARY A 77-year-old woman was admitted because of melena and dizziness for three months.Gastroscopy and colonoscopy were performed,revealing a centrally ulcerated hemorrhagic polypoid lesion in the gastric body and multiple polypoid lesions with blood clots and hemorrhagic tendency in the colon.Histopathological examination of routine endoscopic biopsy samples showed inflammation in the gastric mucosa and tubular adenomas in the colon.The polypoid lesions were removed by endoscopic mucosal resection.Immunohistochemistry suggested a final diagnosis of epithelioid angiosarcomas.The patient refused chemotherapy and died after three months.CONCLUSION Epithelioid angiosarcomas are characterized by highly vascular nature and tendency to cause gastrointestinal bleeding.Efforts to obtain histological findings using endoscopic mucosal resection are of great importance.展开更多
Colorectal cancer(CRC)is presently the second most prevalent global mortalityinducing cancer.CRC carcinogenesis is a multifactorial process involving internal genetic mutations and the external environment.In addition...Colorectal cancer(CRC)is presently the second most prevalent global mortalityinducing cancer.CRC carcinogenesis is a multifactorial process involving internal genetic mutations and the external environment.In addition,non-neoplastic cell activities within tumor microenvironments for CRC development have been established.However,interleukin(IL)-33,secreted by such cell types,plays a pivotal role in cancer progression due to interaction with cellular constituents within the tumor-inflammation microenvironment.IL-33 belongs to the IL-1 cytokine family and acts as binding attachments for the suppressor of tumorigenicity(ST)2 receptor.Therefore,how to coordinate tumor microenvironment,design and optimize treatment strategies suitable for CRC,based on IL-33/ST2 signal is a challenge.Even though it has established influences upon immunitylinked conditions,IL-33 effects on CRC progression and prevention and related mechanisms are still controversial.Our review depicts controversial activities for IL-33/ST2 within carcinogenesis and cancer prevention.Moreover,IL-33/ST2 signaling is a potential therapeutic target for CRC.展开更多
文摘BACKGROUND Juvenile polyps are the most common type of polyps in children but are rare in adults.Inflammatory bowel disease(IBD)patients have a similar spectrum of symptoms as patients with juvenile polyps.Both patients with juvenile polyps and those with active IBD have high fecal calprotectin levels.Four cases of children with ulcerative colitis(UC)with solitary juvenile polyps and one case of an adult with UC with juvenile polyposis syndrome have been reported upon diagnosis of UC,while there have been no cases of adults with UC with solitary juvenile polyp reported in the literature.CASE SUMMARY A 37-year-old man with a 12-year history of UC was admitted to our clinic because of increased stool frequency.UC was diagnosed at the age of 25.As the lesion was confined to the rectum,sulfasalazine suppositories or mesalazine suppositories were used.The patient was followed in an outpatient clinic,and colonoscopy was performed every one or two years.The latest examination was undertaken three years prior in the presence of proctitis.Recently,the patient complained of three to five bowel movements a day.There was mucus in the stool but no visible blood.Colonoscopy revealed a solitary polyp,about 1.5 cm in diameter,with a short and broad peduncle in the transverse colon surrounded by congestive and edematous mucosa.The patient had no family history of colorectal polyps or cancer.The polyp was successfully removed by endoscopic mucosal resection.Histopathological examination revealed that the polyp was a juvenile polyp without any malignant signs.Immunohistochemical staining for p53 showed wild-type expression and p53 overexpression was not detected.Ki67 labeling index was 3%.CONCLUSION This is the first case of an adult UC patient with a solitary juvenile polyp at the 12-year follow-up.The correlation between juvenile polyps and the activity of IBD needs further study.
文摘angiosarcoma is a vascular neoplasm that is among the most aggressive subtypes of sarcomas.Its involvement in the gastrointestinal tract is rare.We here report a case of multifocal gastrointestinal epithelioid angiosarcomas presenting with gastrointestinal bleeding.CASE SUMMARY A 77-year-old woman was admitted because of melena and dizziness for three months.Gastroscopy and colonoscopy were performed,revealing a centrally ulcerated hemorrhagic polypoid lesion in the gastric body and multiple polypoid lesions with blood clots and hemorrhagic tendency in the colon.Histopathological examination of routine endoscopic biopsy samples showed inflammation in the gastric mucosa and tubular adenomas in the colon.The polypoid lesions were removed by endoscopic mucosal resection.Immunohistochemistry suggested a final diagnosis of epithelioid angiosarcomas.The patient refused chemotherapy and died after three months.CONCLUSION Epithelioid angiosarcomas are characterized by highly vascular nature and tendency to cause gastrointestinal bleeding.Efforts to obtain histological findings using endoscopic mucosal resection are of great importance.
基金Natural Science Foundation of China,No.81803069Zhejiang Medical Technology Plan Project,No.2019RC007,No.2019KY007 and No.2021KY047Funds of Science Technology Department of Zhejiang Province,No.LGF21H160033.
文摘Colorectal cancer(CRC)is presently the second most prevalent global mortalityinducing cancer.CRC carcinogenesis is a multifactorial process involving internal genetic mutations and the external environment.In addition,non-neoplastic cell activities within tumor microenvironments for CRC development have been established.However,interleukin(IL)-33,secreted by such cell types,plays a pivotal role in cancer progression due to interaction with cellular constituents within the tumor-inflammation microenvironment.IL-33 belongs to the IL-1 cytokine family and acts as binding attachments for the suppressor of tumorigenicity(ST)2 receptor.Therefore,how to coordinate tumor microenvironment,design and optimize treatment strategies suitable for CRC,based on IL-33/ST2 signal is a challenge.Even though it has established influences upon immunitylinked conditions,IL-33 effects on CRC progression and prevention and related mechanisms are still controversial.Our review depicts controversial activities for IL-33/ST2 within carcinogenesis and cancer prevention.Moreover,IL-33/ST2 signaling is a potential therapeutic target for CRC.
