目的应用Meta分析系统评价熊去氧胆酸单药与联合免疫抑制剂治疗原发性胆汁性胆管炎-自身免疫性肝炎重叠综合征(PBCAIH)的长期疗效及安全性。方法检索Pubmed、Embase、Cochrane图书馆、Web of Science、CBM、中国知网等数据库,检索时限...目的应用Meta分析系统评价熊去氧胆酸单药与联合免疫抑制剂治疗原发性胆汁性胆管炎-自身免疫性肝炎重叠综合征(PBCAIH)的长期疗效及安全性。方法检索Pubmed、Embase、Cochrane图书馆、Web of Science、CBM、中国知网等数据库,检索时限为建库至2020年4月22日,根据纳入及排除标准提取数据,应用Rev Man 5.3软件进行Meta分析。结果共纳入16篇文献,包括621例PBC-AIH患者,其中熊去氧胆酸单药治疗组268例。Meta分析结果显示,与熊去氧胆酸单药治疗相比较,通过联合免疫抑制剂治疗可提高PBC-AIH的生化指标复常率(OR=2.02,95%CI=1.43~2.86,P<0.001),且能有效稳定或减少肝脏纤维化(OR=3.54,95%CI=1.13~11.13,P=0.03)。但长期随访发现,单药治疗与联合治疗肝移植或肝相关死亡事件发生率比较差异无统计学意义(OR=0.64,95%CI=0.25~1.61,P=0.34)。进一步分析显示,两者在非肝硬化PBC-AIH患者不良事件发生率与肝硬化发生率比较差异均无统计学意义(OR=0.63,95%CI=0.30~1.33,P=0.22)(OR=1.31,95%CI=0.43~3.99,P=0.63)。结论熊去氧胆酸联合免疫抑制剂能显著提高PBC-AIH患者的生化指标复常率,有效稳定或减少肝脏纤维化,且不增加非肝硬化PBC-AIH患者不良事件的发生率,但肝硬化和终点事件的发生率与熊去氧胆酸单药治疗相同。展开更多
Along with the speedy development of the economic growth in China, the shortage of oil and gas becomes more and more serious. Based on summarizing some related research results, the prediction of China’s oil demand a...Along with the speedy development of the economic growth in China, the shortage of oil and gas becomes more and more serious. Based on summarizing some related research results, the prediction of China’s oil demand and supply in the year 2010 and the year 2020 has been given in the paper. The oil supply and demand situation is discussed on three different levels. Accordingly, suggestions about the oil supply safety and the national economy safety strategies have been given.展开更多
A method and system for automatically and simultaneously measuring the light output of multiple scintillators,or each scintillating unit of an array,were developed.Using a large area flat panel PSPMT H8500,the light o...A method and system for automatically and simultaneously measuring the light output of multiple scintillators,or each scintillating unit of an array,were developed.Using a large area flat panel PSPMT H8500,the light output and energy resolution were obtained automatically by comparing with reference scintillators or array using an Energy Table,Look-up Table and energy spectrum data.The aim of developing an efficient performance evaluation of scintillators was achieved.Using the method,a scintillator performance testing system was set up and six LYSO crystals and a 3×3 LYSO array were measured.The results showed that the light output and energy resolution were accurately measured automatically.The deviation of repeat measurements for the same sample was not more than 2%,and the nonlinear deviation of the system was not more than 3%.The system is suitable for measuring the performance of crystals,especially where the mass measurement of crystals and arrays is required.展开更多
PMI(privilege management infrastructure) is used to perform access control to resource in an E-commerce or E-government system. With the ever-increasing need for secure transaction, the need for systems that offer a w...PMI(privilege management infrastructure) is used to perform access control to resource in an E-commerce or E-government system. With the ever-increasing need for secure transaction, the need for systems that offer a wide variety of QoS (quality-of-service) features is also growing. In order to improve the QoS of PMI system, a cache based on RBAC(Role-based Access Control) and trust is proposed. Our system is realized based on Web service. How to design the cache based on RBAC and trust in the access control model is described in detail. The algorithm to query role permission in cache and to add records in cache is dealt with. The policy to update cache is introduced also.展开更多
文摘目的应用Meta分析系统评价熊去氧胆酸单药与联合免疫抑制剂治疗原发性胆汁性胆管炎-自身免疫性肝炎重叠综合征(PBCAIH)的长期疗效及安全性。方法检索Pubmed、Embase、Cochrane图书馆、Web of Science、CBM、中国知网等数据库,检索时限为建库至2020年4月22日,根据纳入及排除标准提取数据,应用Rev Man 5.3软件进行Meta分析。结果共纳入16篇文献,包括621例PBC-AIH患者,其中熊去氧胆酸单药治疗组268例。Meta分析结果显示,与熊去氧胆酸单药治疗相比较,通过联合免疫抑制剂治疗可提高PBC-AIH的生化指标复常率(OR=2.02,95%CI=1.43~2.86,P<0.001),且能有效稳定或减少肝脏纤维化(OR=3.54,95%CI=1.13~11.13,P=0.03)。但长期随访发现,单药治疗与联合治疗肝移植或肝相关死亡事件发生率比较差异无统计学意义(OR=0.64,95%CI=0.25~1.61,P=0.34)。进一步分析显示,两者在非肝硬化PBC-AIH患者不良事件发生率与肝硬化发生率比较差异均无统计学意义(OR=0.63,95%CI=0.30~1.33,P=0.22)(OR=1.31,95%CI=0.43~3.99,P=0.63)。结论熊去氧胆酸联合免疫抑制剂能显著提高PBC-AIH患者的生化指标复常率,有效稳定或减少肝脏纤维化,且不增加非肝硬化PBC-AIH患者不良事件的发生率,但肝硬化和终点事件的发生率与熊去氧胆酸单药治疗相同。
文摘Along with the speedy development of the economic growth in China, the shortage of oil and gas becomes more and more serious. Based on summarizing some related research results, the prediction of China’s oil demand and supply in the year 2010 and the year 2020 has been given in the paper. The oil supply and demand situation is discussed on three different levels. Accordingly, suggestions about the oil supply safety and the national economy safety strategies have been given.
基金Supported by National Natural Science Foundation of China (10805049,11175200)Knowledge Innovation Program of the Chinese Academy of Sciences,Grant (KJCX2-EW-N06)Special-funded Programme on National Key Scientific Instruments and Equipment Development (2011YQ120096)
文摘A method and system for automatically and simultaneously measuring the light output of multiple scintillators,or each scintillating unit of an array,were developed.Using a large area flat panel PSPMT H8500,the light output and energy resolution were obtained automatically by comparing with reference scintillators or array using an Energy Table,Look-up Table and energy spectrum data.The aim of developing an efficient performance evaluation of scintillators was achieved.Using the method,a scintillator performance testing system was set up and six LYSO crystals and a 3×3 LYSO array were measured.The results showed that the light output and energy resolution were accurately measured automatically.The deviation of repeat measurements for the same sample was not more than 2%,and the nonlinear deviation of the system was not more than 3%.The system is suitable for measuring the performance of crystals,especially where the mass measurement of crystals and arrays is required.
基金Supported by the National Tenth Five-rear Planfor Scientific and Technological Development of China (413160501)the National Natural Science Foundation of China (50477038)
文摘PMI(privilege management infrastructure) is used to perform access control to resource in an E-commerce or E-government system. With the ever-increasing need for secure transaction, the need for systems that offer a wide variety of QoS (quality-of-service) features is also growing. In order to improve the QoS of PMI system, a cache based on RBAC(Role-based Access Control) and trust is proposed. Our system is realized based on Web service. How to design the cache based on RBAC and trust in the access control model is described in detail. The algorithm to query role permission in cache and to add records in cache is dealt with. The policy to update cache is introduced also.
