【据Journal of Hepatology 2020年9月报道】题:多代母系肥胖通过miR-27a-3p增加子代肝细胞癌的发病率(作者Sun Y等)肥胖是影响肝细胞癌(HCC)等恶性肿瘤发生发展的独立危险因素。来自武汉大学生命科学学院的Sun等团队前期在Journal of H...【据Journal of Hepatology 2020年9月报道】题:多代母系肥胖通过miR-27a-3p增加子代肝细胞癌的发病率(作者Sun Y等)肥胖是影响肝细胞癌(HCC)等恶性肿瘤发生发展的独立危险因素。来自武汉大学生命科学学院的Sun等团队前期在Journal of Hepatology(2012年)发表研究发现母系肥胖可使子代脂肪肝病变发生传代性累积,但目前领域内尚不清楚母系肥胖是否会影响子代HCC的发生发展。因此,本研究设计有关实验旨在研究这其中的联系及其潜在机制。展开更多
INTRODUCTIONAmino acid consumption test (AACT) has a highsensitivity and specificity in evaluating exocrinepancreatic insufficiency,but its diagnostic valueto exocrine pancreatic insufficiency in Chinese hasnot been w...INTRODUCTIONAmino acid consumption test (AACT) has a highsensitivity and specificity in evaluating exocrinepancreatic insufficiency,but its diagnostic valueto exocrine pancreatic insufficiency in Chinese hasnot been well understood.In this study,the oralreagent stimulating pancreatic secretion (O-AACT)was used instead of cerulein(I-AACT) for amidoacid consumption test and the dignostic efficiency ofO-AACT was evaluated and compared with I-AACTon the exocrine pancreatic insufficiency in Chinese.展开更多
Background Radiofrequency catheter ablation （RFCA） for atrial fibrillation （AF） has developed rapidly,and is a commonly performed ablation in many major hospitals throughout the world,due to its satisfactory resul...Background Radiofrequency catheter ablation （RFCA） for atrial fibrillation （AF） has developed rapidly,and is a commonly performed ablation in many major hospitals throughout the world,due to its satisfactory results.The aim of this study was to detect the effect of RFCA on C-reactive protein （CRP）,brain natriuretic peptide （BNP）,and echocardiograph in patients with persistent and permanent AF.Methods A total of 120 patients （71 males,mean age （50.8＆#177;12.0） years） with persistent and permanent AF undergoing RFCA under guidance of the Carto merge technique were studied.Left atrial diameter （LAD）,right atrial diameter （RAD）,left ventricular ejection fraction （LVEF）,CRP,and BNP were observed 3,6 and 12 months after RFCA and compared with results before RFCA.The recurrence of atrial arrhythmias was observed 3 and 12 months after the procedure.Results Compared with that before RFCA,LAD and RAD decreased and LVEF increased significantly after RFCA.Meanwhile,the levels of CRP and BNP were reduced significantly at 3,6,and 12 months after RFCA （P〈0.05）.In the non-recurrent patients,LVEF was increased significantly compared with the recurrent patients at 3,6,and 12 months after RFCA （P〈0.05）.CRP and BNP levels were decreased significantly in the non-recurrent patients compared with the recurrent patients at 3,6,and 12 months after RFCA （P〈0.05）.After one or two applications of RFCA,during a follow-up of 12 months,12 patients （10.0%） had AF,10 patients （8.3%） had atrial flutter,and 5 patients had atrial tachycardia （4.2%）.Conclusions Conversion of AF to sinus rhythm by RFCA,has been shown to reduce LA size and improve LVEF.It can also significantly decrease the levels of CRP and BNP in patients with persistent and permanent AF and reduce the risk of inflammation and developing heart failure.展开更多
文摘【据Journal of Hepatology 2020年9月报道】题:多代母系肥胖通过miR-27a-3p增加子代肝细胞癌的发病率(作者Sun Y等)肥胖是影响肝细胞癌(HCC)等恶性肿瘤发生发展的独立危险因素。来自武汉大学生命科学学院的Sun等团队前期在Journal of Hepatology(2012年)发表研究发现母系肥胖可使子代脂肪肝病变发生传代性累积,但目前领域内尚不清楚母系肥胖是否会影响子代HCC的发生发展。因此,本研究设计有关实验旨在研究这其中的联系及其潜在机制。
基金the Science Fund of Department of Health,Sichuan Province,No.9241-920054
文摘INTRODUCTIONAmino acid consumption test (AACT) has a highsensitivity and specificity in evaluating exocrinepancreatic insufficiency,but its diagnostic valueto exocrine pancreatic insufficiency in Chinese hasnot been well understood.In this study,the oralreagent stimulating pancreatic secretion (O-AACT)was used instead of cerulein(I-AACT) for amidoacid consumption test and the dignostic efficiency ofO-AACT was evaluated and compared with I-AACTon the exocrine pancreatic insufficiency in Chinese.
文摘Background Radiofrequency catheter ablation （RFCA） for atrial fibrillation （AF） has developed rapidly,and is a commonly performed ablation in many major hospitals throughout the world,due to its satisfactory results.The aim of this study was to detect the effect of RFCA on C-reactive protein （CRP）,brain natriuretic peptide （BNP）,and echocardiograph in patients with persistent and permanent AF.Methods A total of 120 patients （71 males,mean age （50.8＆#177;12.0） years） with persistent and permanent AF undergoing RFCA under guidance of the Carto merge technique were studied.Left atrial diameter （LAD）,right atrial diameter （RAD）,left ventricular ejection fraction （LVEF）,CRP,and BNP were observed 3,6 and 12 months after RFCA and compared with results before RFCA.The recurrence of atrial arrhythmias was observed 3 and 12 months after the procedure.Results Compared with that before RFCA,LAD and RAD decreased and LVEF increased significantly after RFCA.Meanwhile,the levels of CRP and BNP were reduced significantly at 3,6,and 12 months after RFCA （P〈0.05）.In the non-recurrent patients,LVEF was increased significantly compared with the recurrent patients at 3,6,and 12 months after RFCA （P〈0.05）.CRP and BNP levels were decreased significantly in the non-recurrent patients compared with the recurrent patients at 3,6,and 12 months after RFCA （P〈0.05）.After one or two applications of RFCA,during a follow-up of 12 months,12 patients （10.0%） had AF,10 patients （8.3%） had atrial flutter,and 5 patients had atrial tachycardia （4.2%）.Conclusions Conversion of AF to sinus rhythm by RFCA,has been shown to reduce LA size and improve LVEF.It can also significantly decrease the levels of CRP and BNP in patients with persistent and permanent AF and reduce the risk of inflammation and developing heart failure.
