Background The World Health Organization and European Organization for Research and Treatment of Cancer （WHOEORTC） classification in 2005 promoted the comparisons of primary cutaneous lymphoma （PCL） subtypes betwe...Background The World Health Organization and European Organization for Research and Treatment of Cancer （WHOEORTC） classification in 2005 promoted the comparisons of primary cutaneous lymphoma （PCL） subtypes between different countries.The relative frequency of PCL varied according to geography.The study aimed to analyze the relative frequency and survival of PCLs in China and to compare the data with the published results from other countries.Methods We analyzed 98 patients with PCLs over a 6-year period and reclassified them according to the most recent WHO-EORTC classification （2005）.Disease-specific survival rate and curves according to specific subtypes such as mycosis fungoides,lymphomatoid papulosis,and primary cutaneous peripheral T-cell lymphoma,unspecified was also calculated.Results The relative rate of PCL in China was distinct from those in Western countries.Our study showed a higher frequency of cutaneous T-and NK-cell lymphomas （CTCLs） （94%）,and a lower frequency of cutaneous B-cell lymphomas （CBCLs） （6%）.The 5-year survival rate of the total PCLs was 82%.There was no significant difference in the 5-year survival rate （P 〉0.05 by Log-rank test） between CTCL （80%） and CBCL （100%）.Conclusions The higher percentage of CTCL in China may provide a clue to further study the etiological factors of PCLs.Racial variations in factors such as HLA determinants may play a role in the development of CTCL.展开更多
Kaposi＆#39;s sarcoma （KS） is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus （HIV）-positive patients.According to the clinical characteri...Kaposi＆#39;s sarcoma （KS） is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus （HIV）-positive patients.According to the clinical characteristics and the affected population,four clinical types of KS have been described successively：classic,endemic to Africa,acquired immunodeficiency syndrome （AIDS）-associated,and immunosuppression associated type.Bullous pemphigoid （BP） is an acquired autoimmune bullous skin disease that frequently occurs in the elderly and is characterized by intraepidermal blisters and immunoglobulin G （IgG） deposits on the basement membrane.A few cases of KS have occurred in immunosuppressed patients with BP.Here,we report a Chinese female patient diagnosed with immunosuppression associated KS that was induced by the short-term use of immunosuppressive agents for BP.We also present a review of the literature on immunosuppressed KS with BP and discuss the potential role of human herpesvirus-8 （HHV-8） in the pathogenic mechanism.展开更多
研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的...研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%.展开更多
文章报道了发现于西藏东南部芒康盆地上始新统的鼠李科植物叶化石标本.化石叶缘全缘或微波状,二级脉间距规则,弧曲向上并与其上的二级脉在叶缘处结合并与叶缘融合,形成真曲脉序;二级脉在中上部较为密集,三级脉密集相互平行,横贯二级脉之...文章报道了发现于西藏东南部芒康盆地上始新统的鼠李科植物叶化石标本.化石叶缘全缘或微波状,二级脉间距规则,弧曲向上并与其上的二级脉在叶缘处结合并与叶缘融合,形成真曲脉序;二级脉在中上部较为密集,三级脉密集相互平行,横贯二级脉之间,这些叶脉特征与美洲分布的灭绝类群——似勾儿茶叶属(Berhamniphyllum Jones and Dilcher)非常相似.百分之四十的二级脉集中于叶的上半部是当前化石的一个典型特征,未见于该属的其他类群,于是将当前化石定为君容似勾儿茶叶新种(Berhamniphyllum junrongiae Z. K. Zhou, T. X. Wang et J.Huang sp. nov.).进一步研究发现,仅凭叶脉特征不能将勾儿茶属(Berchemia)和Rhamnidium、Karwinskia等三个属区分开来,似勾儿茶叶属(Berhamniphyllum)代表了这几个属的一个灭绝的共同祖先,本文对产于云南和山东等地三种勾儿茶属化石进行了归并,并将其归并入似勾儿茶叶属中.根据形态学、分子系统证据和化石记录,将勾儿茶属、Rhamnidium、Karwinskia和似勾儿茶叶属定义为勾儿茶复合群(Berchemia complex).本文还讨论了勾儿茶复合群地理分布格局的演变历史,认为勾儿茶复合群于晚白垩世晚期起源于南美哥伦比亚,在始新世经中美洲扩散到北美,后又从北美经过北大西洋陆桥扩散至欧洲并从欧洲扩散至非洲.东亚的勾儿茶复合群是经白令陆桥扩散而来,时间不晚于始新世,这一类群在东亚最早出现于西藏芒康,其后再扩散至亚洲其他地区.展开更多
文摘Background The World Health Organization and European Organization for Research and Treatment of Cancer （WHOEORTC） classification in 2005 promoted the comparisons of primary cutaneous lymphoma （PCL） subtypes between different countries.The relative frequency of PCL varied according to geography.The study aimed to analyze the relative frequency and survival of PCLs in China and to compare the data with the published results from other countries.Methods We analyzed 98 patients with PCLs over a 6-year period and reclassified them according to the most recent WHO-EORTC classification （2005）.Disease-specific survival rate and curves according to specific subtypes such as mycosis fungoides,lymphomatoid papulosis,and primary cutaneous peripheral T-cell lymphoma,unspecified was also calculated.Results The relative rate of PCL in China was distinct from those in Western countries.Our study showed a higher frequency of cutaneous T-and NK-cell lymphomas （CTCLs） （94%）,and a lower frequency of cutaneous B-cell lymphomas （CBCLs） （6%）.The 5-year survival rate of the total PCLs was 82%.There was no significant difference in the 5-year survival rate （P 〉0.05 by Log-rank test） between CTCL （80%） and CBCL （100%）.Conclusions The higher percentage of CTCL in China may provide a clue to further study the etiological factors of PCLs.Racial variations in factors such as HLA determinants may play a role in the development of CTCL.
文摘Kaposi＆#39;s sarcoma （KS） is a rare,malignant vascular.tumor of the skin,mucosa,and viscera with an increased incidence in human immunodeficiency virus （HIV）-positive patients.According to the clinical characteristics and the affected population,four clinical types of KS have been described successively：classic,endemic to Africa,acquired immunodeficiency syndrome （AIDS）-associated,and immunosuppression associated type.Bullous pemphigoid （BP） is an acquired autoimmune bullous skin disease that frequently occurs in the elderly and is characterized by intraepidermal blisters and immunoglobulin G （IgG） deposits on the basement membrane.A few cases of KS have occurred in immunosuppressed patients with BP.Here,we report a Chinese female patient diagnosed with immunosuppression associated KS that was induced by the short-term use of immunosuppressive agents for BP.We also present a review of the literature on immunosuppressed KS with BP and discuss the potential role of human herpesvirus-8 （HHV-8） in the pathogenic mechanism.
文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%.
文摘文章报道了发现于西藏东南部芒康盆地上始新统的鼠李科植物叶化石标本.化石叶缘全缘或微波状,二级脉间距规则,弧曲向上并与其上的二级脉在叶缘处结合并与叶缘融合,形成真曲脉序;二级脉在中上部较为密集,三级脉密集相互平行,横贯二级脉之间,这些叶脉特征与美洲分布的灭绝类群——似勾儿茶叶属(Berhamniphyllum Jones and Dilcher)非常相似.百分之四十的二级脉集中于叶的上半部是当前化石的一个典型特征,未见于该属的其他类群,于是将当前化石定为君容似勾儿茶叶新种(Berhamniphyllum junrongiae Z. K. Zhou, T. X. Wang et J.Huang sp. nov.).进一步研究发现,仅凭叶脉特征不能将勾儿茶属(Berchemia)和Rhamnidium、Karwinskia等三个属区分开来,似勾儿茶叶属(Berhamniphyllum)代表了这几个属的一个灭绝的共同祖先,本文对产于云南和山东等地三种勾儿茶属化石进行了归并,并将其归并入似勾儿茶叶属中.根据形态学、分子系统证据和化石记录,将勾儿茶属、Rhamnidium、Karwinskia和似勾儿茶叶属定义为勾儿茶复合群(Berchemia complex).本文还讨论了勾儿茶复合群地理分布格局的演变历史,认为勾儿茶复合群于晚白垩世晚期起源于南美哥伦比亚,在始新世经中美洲扩散到北美,后又从北美经过北大西洋陆桥扩散至欧洲并从欧洲扩散至非洲.东亚的勾儿茶复合群是经白令陆桥扩散而来,时间不晚于始新世,这一类群在东亚最早出现于西藏芒康,其后再扩散至亚洲其他地区.
