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HPLC切换波长法同时测定健脾止泻宁颗粒中盐酸小檗碱和黄芩苷的含量 被引量:2
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作者 黄传俊 杨莉 +11 位作者 梅勇 罗磊 吕姗珊 曾博程 龙涛 王凤 左娟 袁开超 唐攀 朱锋 陈波 谯志文 《中国药房》 CAS 北大核心 2018年第10期1324-1327,共4页
目的:建立同时测定健脾止泻宁颗粒中盐酸小檗碱和黄芩苷含量的方法。方法:采用高效液相色谱切换波长法。色谱柱为Hypersil BDS C18,流动相为甲醇-0.45%磷酸溶液-三乙胺(50∶49∶1,V/V/V),流速为1.0 mL/min,检测波长为265 nm(盐酸小檗碱)... 目的:建立同时测定健脾止泻宁颗粒中盐酸小檗碱和黄芩苷含量的方法。方法:采用高效液相色谱切换波长法。色谱柱为Hypersil BDS C18,流动相为甲醇-0.45%磷酸溶液-三乙胺(50∶49∶1,V/V/V),流速为1.0 mL/min,检测波长为265 nm(盐酸小檗碱)、280 nm(黄芩苷),柱温为30℃,进样量为10μL。结果:盐酸小檗碱和黄芩苷检测进样量线性范围分别为60.3~312.8 ng(r=0.999 7)、81.5~368.9 ng(r=0.999 9);定量限分别为0.666 8、0.774 0 ng,检测限分别为0.222 6、0.258 0 ng;中间精密度、稳定性、重复性试验的RSD均小于1.0%;加样回收率分别为96.48%~99.30%(RSD=1.06%,n=6)、95.20%~99.39%(RSD=1.66%,n=6);耐用性试验的RSD均小于2.0%。结论:该方法操作简便,精密度、稳定性、重复性、准确度、耐用性均较好,可用于健脾止泻宁颗粒中盐酸小檗碱和黄芩苷含量的同时测定。 展开更多
关键词 健脾止泻宁颗粒 高效液相色谱切换波长法 盐酸小檗碱 黄芩苷 含量测定
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智慧园区建设探索与应用实践 被引量:4
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作者 张巧月 蔡志平 +1 位作者 王峰 杨明川 《信息通信技术与政策》 2019年第6期8-12,共5页
随着物联网、云计算、人工智能、边缘计算等新技术的迅速发展与深入应用,园区的智慧化转型已成为未来发展的必然方向。本文通过分析智慧园区的建设需求,提出了融合“云—管—端”3个层面的智慧园区平台整体架构以及各个层面的建设方案,... 随着物联网、云计算、人工智能、边缘计算等新技术的迅速发展与深入应用,园区的智慧化转型已成为未来发展的必然方向。本文通过分析智慧园区的建设需求,提出了融合“云—管—端”3个层面的智慧园区平台整体架构以及各个层面的建设方案,并重点梳理了6类典型的智慧园区场景应用。最后,以视频数据分析为基础的智能安防为例,阐述了视频人脸识别等人工智能技术在智慧园区安防领域的应用实践。 展开更多
关键词 智慧园区 智能安防 人脸识别
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浅谈药剂科对医院不合理用药的药学干预 被引量:50
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作者 章考飞 凌艺兰 +1 位作者 汪峰 陈文娟 《安徽医药》 CAS 2019年第2期390-395,共6页
目的了解泾县医院药剂科对不合理用药管理的药学干预效果。方法对泾县医院2014年实施药学干预前后的药品使用数据进行比较分析,对比管理前后抗菌药物等使用指标变化,评价管理效果。结果通过对不合理用药的持续干预,该院药品使用情况更... 目的了解泾县医院药剂科对不合理用药管理的药学干预效果。方法对泾县医院2014年实施药学干预前后的药品使用数据进行比较分析,对比管理前后抗菌药物等使用指标变化,评价管理效果。结果通过对不合理用药的持续干预,该院药品使用情况更加合理。住院病人次均药品费用三年间下降581元,下降幅度30.8%,辅助用药总费用三年间下降至1 030.1万元,辅助用药总费用占比下降15.11%,抗菌药物临床使用指标逐步优化。结论通过药剂科对医院不合理用药的持续性干预,有效减少了病人在辅助用药上的支出,抑制了临床抗菌药物不合理使用行为。为医院临床路径工作的有序开展提供了药学支持,为新一轮公立医院医疗改革的有效落实提供了合理用药的有利环境。 展开更多
关键词 合理用药 辅助用药 重点监控药品 药学干预 次均住院药品费用 药占比
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SYSTEMATIC AND DYNAMIC PROPERTIES OF CASTING HOT SPOT 被引量:2
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作者 FanJinhui WeiBing wangfeng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2003年第2期153-155,共3页
The variation of casting hot spot with proceeding of solidification andcomponents of casting-mold system is studied by the technique of numerical simulation ofsolidification. The result shows that the thickest part of... The variation of casting hot spot with proceeding of solidification andcomponents of casting-mold system is studied by the technique of numerical simulation ofsolidification. The result shows that the thickest part of casting is not exactly the last part ofsolidification in the casting, while the last part of solidification is not exactly casting hot spotat the early stage of solidification. The location, size, shape and number of casting hot spotchange with geomitric, physical and technological factors of the casting-mold system such asthickness of the casting secondary wall and with the passage of time in the course of thesolidification. The former is known as the systematic property of hot spot and the latter, dynamicproperty. Only when the properties of hot spot are grasped completely and accurately, can it be fedmore effectively. By doing so, not only sound castings can be obtained, but also riser efficiencycan be improved. 展开更多
关键词 hot spot systematic property dynamic property SOLIDIFICATION castingprocess
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Genetic Transformation of Brassica campestris L.ssp.pekinensis via Agrobacterium-with Bt Gene 被引量:2
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作者 wangfeng LiHanxia +1 位作者 YeZhibiao LuYong'en 《Hunan Agricultural Science & Technology Newsletter》 2002年第4期10-14,共5页
By means of Agrobacterium-mediated transformation, 43 kanamycin-resistant buds of Chinese cabbage were got. PCR, PCR-Southern blot and dot blot analysis were used to identify and characterize the putative transgenic p... By means of Agrobacterium-mediated transformation, 43 kanamycin-resistant buds of Chinese cabbage were got. PCR, PCR-Southern blot and dot blot analysis were used to identify and characterize the putative transgenic plants. 26 plants had the predicted bands of the fragment of npt Ⅱ gene. Insect bioassays of 4 transformants showed that toxic protein had been translated and the translation levels were different among these transformants. 展开更多
关键词 Chinese cabbage Bt gene genetic transformation cry IA(b)
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闽赣交界桃溪穹隆与外围印支期花岗岩岩石地球化学特征对比及地质意义 被引量:1
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作者 黄昌旗 张开毕 +3 位作者 曹明志 王林昌 王峰 赵举兴 《福建地质》 2022年第1期12-25,共14页
以桃溪穹隆与外围印支期花岗岩为研究对象,认为桃溪穹隆花岗岩更具壳源特征,表现为与壳源物质有关的矿物较多,岩石呈酸性和碱性程度更高,桃溪穹隆花岗岩高场强元素的亏损程度和亲石元素富集程度都大于穹隆外围,桃溪穹隆花岗岩δEu的亏... 以桃溪穹隆与外围印支期花岗岩为研究对象,认为桃溪穹隆花岗岩更具壳源特征,表现为与壳源物质有关的矿物较多,岩石呈酸性和碱性程度更高,桃溪穹隆花岗岩高场强元素的亏损程度和亲石元素富集程度都大于穹隆外围,桃溪穹隆花岗岩δEu的亏损程度远大于穹隆外围。Sr-Yb元素特征还显示,印支时期地壳部分重熔形成花岗岩时,桃溪穹隆应处于地壳更薄位置(<30 km或15 km),压力更低(<0.4~0.5 GPa或0.8~1GPa),更接近地表的位置。与桃溪穹隆花岗岩更具壳源特征和该时期穹隆的构造演化(地壳拉伸减薄,穹隆上隆)是一致的。 展开更多
关键词 桃溪穹隆 印支期花岗岩 岩石地球化学 Sr-Yb
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Super304H奥氏体不锈钢晶间腐蚀敏感性研究
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作者 陈浩 蒋奕锋 +4 位作者 左敦桂 李勇 王峰 王演铭 陈器 《电焊机》 2020年第4期95-99,I0007,共6页
针对Super304H钢管母材和焊接接头在高温运行过程中发生晶间腐蚀的问题,通过焊接试验、晶间腐蚀试验、金相检验等方法系统开展了Super304H钢管母材和焊接接头晶间腐蚀敏感性的研究。结果表明,随着C含量的减少和Nb/C比的增加,Super304H... 针对Super304H钢管母材和焊接接头在高温运行过程中发生晶间腐蚀的问题,通过焊接试验、晶间腐蚀试验、金相检验等方法系统开展了Super304H钢管母材和焊接接头晶间腐蚀敏感性的研究。结果表明,随着C含量的减少和Nb/C比的增加,Super304H钢管晶间腐蚀敏感性越低;焊接接头晶间腐蚀敏感性随着焊接热输入量和层间温度的增加呈上升趋势。 展开更多
关键词 SUPER304H钢 C含量和Nb/C比 晶间腐蚀敏感性 层间温度
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Terraces and Tectonic Uplifts at Yandantu and Changcaogou on the Northern Margin Fault of Altun
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作者 ZhengRongzhang XuXiwei +2 位作者 wangfeng LiJianping JiFengju 《Earthquake Research in China》 2004年第4期385-395,共11页
The formation of strath and strath terrace is closely related to tectonic uplift in the drainage basin. Based on the investigation of straths at Yandantu and Changcaogou on the eastern segment of the northern margin f... The formation of strath and strath terrace is closely related to tectonic uplift in the drainage basin. Based on the investigation of straths at Yandantu and Changcaogou on the eastern segment of the northern margin fault of Altun, and in combination with the paleoclimatic data, the tectonic uplift since late Epipleistocene as revealed by stream terraces at the two places is discussed. At Yandantu, three levels of stream terraces(T 1, T 2 and T 3)have developed since 16ka BP, where T 1, T 3 and T 2 are fill terraces and the buried major straths are exposed. The ages of three treads are dated to be about 16.1ka BP, 12.8ka BP and 6.2ka BP, respectively. The three terraces reflect three tectonic uplift events, while the ages of the treads represent the occurrence time of these events. The stream is still beveling the bedrock and widening the channel at present, and the modern strath is being generated. The uplift rate is 4.8~4.5mm/a since 16.1 ka BP in this area. From 12.8ka B.P to 6.2ka BP, The uplift rate was 6.4mm/a. The uplift rate is 3.1mm/a since 6.2ka BP. At Changcaogou, four levels of stream terraces(T 1, T 2, T 3 and T 1′)have developed since 7ka BP. All of them are fill terraces. There are buried straths under the deposits. The buried major strath is exposed on T 3 and T 2 and the minor strath on T 1′and T 1. The ages of treads of the three terraces (T 3, T 2 and T 1′) are 7 ka BP, 3 ka BP and 2.5 ka BP, respectively. The four terraces reflect two uplift events induced by tectonic activities. One occurred in about 7 ka BP, and the other in 3ka BP. The uplift rate is 5.9mm/a since 7.0 ka BP at Changcaogou. From 7ka BP to 3ka BP, the uplift rate was 7.0mm/a, and since 3ka BP till now, the uplift rate is 4.7 mm/a. 展开更多
关键词 Strath Tectonic uplift Northern margin fault of Altun Yandantu Changcaogou
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马克思主义的社会革命思想及其现实意义——基于对《共产党宣言》的时代性解读
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作者 王凤 李昕羽 《中共伊犁州委党校学报》 2022年第1期5-10,共6页
《共产党宣言》作为马克思主义社会革命思想的宣言书,对马克思主义社会革命思想的发展起到了承上启下的重要作用。在新的历史条件和时代背景下深入解读和挖掘《共产党宣言》中马克思主义社会革命思想的丰富内涵,对正确认识和理解中国的... 《共产党宣言》作为马克思主义社会革命思想的宣言书,对马克思主义社会革命思想的发展起到了承上启下的重要作用。在新的历史条件和时代背景下深入解读和挖掘《共产党宣言》中马克思主义社会革命思想的丰富内涵,对正确认识和理解中国的社会革命问题、继续推进中国特色社会主义进程中新的伟大革命具有十分重要的现实意义。 展开更多
关键词 马克思主义 《共产党宣言》 社会革命 现实意义
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Slip-Rate on the Middle Altyn Tagh Fault since the Holocene Period
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作者 wangfeng LiMing +1 位作者 XuXiwei ZhengRongzhang 《Earthquake Research in China》 2005年第1期64-73,共10页
By analyzing high-resolution SPOT images and in combination with fieldwork and chronometry, three typical fault-offset sites on the south-middle Altyn Tagh strike-slip fault were studied to obtain the sinistral horizo... By analyzing high-resolution SPOT images and in combination with fieldwork and chronometry, three typical fault-offset sites on the south-middle Altyn Tagh strike-slip fault were studied to obtain the sinistral horizontal slip rate of the fault. At Annanba, the left-lateral strike-slip rate on a branch of the south Altyn Tagh fault is 7.5±1.7 mm/a since 9.36±0.73ka BP. At Seven Spring, the fault has four branches and the left-lateral strike-slip rate on one of them is 2.3±0.5mm/a since 13.86±1.07ka BP, and it is deduced that the total slip-rate of all the four branches is 6.9±1.5~ 9.2±2.0 mm/a since Holocene. At Yuemakeqi, the left-lateral strike-slip rate of the fault is 10.6±3.0mm/a since 4.73±0.38 ka BP. A slip-rate of 7~11mm/a on the middle segment of the Altyn Tagh fault (between 88°30’E and 93°05’E) since Holocene can be deduced from the three sites mentioned above and the result is similar to the latest GPS observation. 展开更多
关键词 altyn tagh fault strike-slip fault offset landforms slip-rate
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Design is Omnipresent in Our Life
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作者 wangfeng 《China & The World Cultural Exchange》 2004年第1期20-23,共4页
It is true that design influences every facet of our life, Today, designis no longer a novelty for Chinese people. Maybe many of us cannot define what design means to our life, but it is having ubiquitous Impact on ou... It is true that design influences every facet of our life, Today, designis no longer a novelty for Chinese people. Maybe many of us cannot define what design means to our life, but it is having ubiquitous Impact on our ways of life and the environment are becoming the focus of 展开更多
关键词 中国 封面设计 图案设计 设计师
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Slip Rate on the Altyn Tagh Fault on the West of the Cherchen River (Between 85°~ 85°45′E) Since Late Quaternary
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作者 wangfeng LiMing +2 位作者 XuXiwei ZhengRongzhang ChenWenbin 《Earthquake Research in China》 2004年第4期396-405,共10页
Because of the significance to the formation and evolution of the Tibetan plateau, the displacement and slip rate of the Altyn Tagh fault have been topics full of disputation. Scientists who hold different opinions on... Because of the significance to the formation and evolution of the Tibetan plateau, the displacement and slip rate of the Altyn Tagh fault have been topics full of disputation. Scientists who hold different opinions on the evolution of Tibet insist on different slip rates and displacements of the fault zone. In the article, study is focused on the late Quaternary slip rate of the Altyn Tagh fault west of the Cherchen River (between 85°E and 85°45’E). On the basis of high resolution SPOT images of the region, three sites, namely Koramlik, Aqqan pasture and Dalakuansay, were chosen for field investigation. To calculate the slip rate of the fault, displacement of terraces was measured on SPOT satellite images or in situ during fieldwork and thermo-luminescence (TL) dating method was used. To get the ages of terraces, samples of sand were collected from the uppermost sand beds that lie just under loess. The method for calculating slip rate of fault is to divide the displacement of terrace risers by the age of its neighboring lower terrace. The displacement of rivers is not considered in this article because of its uncertainties. At Koramlik, the slip rate of the Altyn Tagh fault is 11.6±2.6mm/a since 6.02±0.47ka B.P and 9.6±2.6mm/a since 15.76±1.19ka B.P. At Aqqan pasture, about 30km west of Koramlik, the slip rate is 12.1±1.9mm/a since 2.06±0.16 ka B.P. At Dalakuansayi, the slip rate of the fault is 12.2±3.0mm/a since 4.91±0.39ka B.P. Hence, we get the average slip rate of 11.4±2.5mm/a for the western part of the Altyn Tagh Fault since Holocene. This result is close to the latest results from GPS research. 展开更多
关键词 The Altyn Tagh fault Strike-slip fault Offset landform Slip rate
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Theoretical Analysis of Time-Dependent Wave-Packet Dynamics: Proton Impact Excitation (2s - 2p) with Li Atom
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作者 CHENShao-Hao wangfeng LIJia-Ming 《Chinese Physics Letters》 SCIE CAS CSCD 2004年第7期1251-1254,共4页
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基于铁死亡探究牛磺酸对鱼藤酮致神经细胞损伤的保护作用 被引量:1
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作者 陈迪 美合日妮萨·莫合塔尔 +5 位作者 布海迪且·麦麦提敏 图尔荪古丽·如则 王锋 徐南 古丽苏木古丽·亚克甫 孙威 《营养学报》 CAS CSCD 北大核心 2023年第1期51-56,62,共7页
目的采用鱼藤酮诱导SH-SY5Y细胞损伤建立帕金森病(Parkinson’s disease,PD)样病变细胞模型,基于铁死亡探讨牛磺酸的保护作用及机制。方法实验分为对照组、鱼藤酮组、鱼藤酮+牛磺酸组、牛磺酸组;对照组、鱼藤酮组、鱼藤酮+铁死亡抑制剂... 目的采用鱼藤酮诱导SH-SY5Y细胞损伤建立帕金森病(Parkinson’s disease,PD)样病变细胞模型,基于铁死亡探讨牛磺酸的保护作用及机制。方法实验分为对照组、鱼藤酮组、鱼藤酮+牛磺酸组、牛磺酸组;对照组、鱼藤酮组、鱼藤酮+铁死亡抑制剂组、铁死亡抑制剂组。通过Western blot、MTT细胞毒性检测试剂盒、乳酸脱氢酶细胞毒性检测试剂盒检测SH-SY5Y细胞损伤状况;运用Westernblot和铁含量检测试剂盒检测铁死亡水平;运用总谷胱甘肽检测试剂盒、脂质氧化(MDA)检测试剂盒、活性氧检测试剂盒、总SOD活性检测试剂盒检测氧化应激水平;运用Westernblot检测Nrf2/Keap1/SLC7A11信号通路活化水平。结果结果显示,与对照组比较,鱼藤酮组酪氨酸羟化酶表达量降低、细胞存活率降低、细胞死亡率升高、铁死亡和氧化应激水平升高以及Nrf2/Keap1/SLC7A11通路活化水平降低,P<0.05,差异具有统计学意义;与鱼藤酮组比较,鱼藤酮+牛磺酸组酪氨酸羟化酶表达量增加、细胞存活率升高、细胞死亡率降低、铁死亡和氧化应激水平降低以及Nrf2/Keap1/SLC7A11通路活化水平升高,P<0.05,差异具有统计学意义;与鱼藤酮+牛磺酸组比较,牛磺酸组上述各项指标变化无显著差异。运用铁死亡抑制剂显著降低了鱼藤酮致SH-SY5Y细胞损伤和氧化应激水平。结论在鱼藤酮诱导PD样病变细胞模型中,牛磺酸可通过Nrf2/Keap1/SLC7A11信号通路抑制铁死亡及氧化应激,发挥神经保护作用。 展开更多
关键词 SH-SY5Y细胞 鱼藤酮 牛磺酸 铁死亡
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Gene expression profiles of the developing human retina 被引量:1
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作者 wangfeng LIHuiming +5 位作者 LIUWenwen XUPing HUGengxi CHENGYidong JIALibin HUANGQian 《Chinese Science Bulletin》 SCIE EI CAS 2004年第21期2277-2284,共8页
Retina is a multilayer and highly specialized tissue important in converting light into neural signals. In humans, the critical period for the formation of complex multiplayer structure takes place during embryogenesi... Retina is a multilayer and highly specialized tissue important in converting light into neural signals. In humans, the critical period for the formation of complex multiplayer structure takes place during embryogenesis be- tween 12 and 28 weeks. The morphologic changes during retinal development in humans have been studied but little is known about the molecular events essential for the formation of the retina. To gain further insights into this process, cDNA microarrays containing 16361 human gene probes were used to measure the gene expression levels in retinas. Of the 16361 genes, 68.7%, 71.4% and 69.7% showed positive hybridiza- tion with cDNAs made from 12—16 week fetal, 22—26 week fetal and adult retinas. A total of 814 genes showed a mini- mum of 3-fold changes between the lowest and highest ex- pression levels among three time points and among them, 106 genes had expression levels with the hybridization intensity above 100 at one or more time points. The clustering analysis suggested that the majority of differentially expressed genes were down-regulated during the retinal development. The differentially expressed genes were further classified accord- ing to functions of known genes, and were ranked in de- creasing order according to frequency: development, differ- entiation, signal transduction, protein synthesis and transla- tion, metabolism, DNA binding and transcription, DNA syn- thesis-repair-recombination, immuno-response, ion channel- transport, cell receptor, cytoskeleton, cell cycle, pro-oncogene, stress and apoptosis related genes. Among these 106 differen- tially expressed genes, 60 are already present in NEI retina cDNA or EST Databank but the remaining 46 genes are ab- sent and thus identified as “function unknown”. To validate gene expression data from the microarray, real-time RT-PCR was performed for 46 “function unknown” genes and 6 known retina specific expression genes, and β-actin was used as internal control. Twenty-seven of these genes showed very similar expression profiles between the microarray and real-time RT-PCR data. In situ hybridization revealed both expression level and cellular distribution of NNAT in retina. Finally, the chromosomal locations of 106 differentially ex- pressed genes were also searched and one of these genes is associated with autosomal dominant cone or cone-rod dys- trophy. The data from present study provide insights into understanding genetic programs during human retinal de- velopment and help identify additional retinal disease genes. 展开更多
关键词 基因表达 视网膜 疾病识别 多层结构 CDNA 微排列 基因调节
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X-ray magnetic circular dichroism:Orbital and spin moments of iron single-crystal thin film deposited on MgO substrate 被引量:1
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作者 LIHonghong WANGJie +3 位作者 LIRuipeng GUOYuxian wangfeng HUZhiwei 《Chinese Science Bulletin》 SCIE EI CAS 2005年第10期950-953,共4页
X-ray magnetic circular dichroism in absorp- tion of the single-crystal iron layer deposited epitaxially on MgO substrate is studied. Spin and orbital moment, 0.069 and 2.33 μB, respectively, are calculated in terms ... X-ray magnetic circular dichroism in absorp- tion of the single-crystal iron layer deposited epitaxially on MgO substrate is studied. Spin and orbital moment, 0.069 and 2.33 μB, respectively, are calculated in terms of the XMCD sum rules. Our results are accordant to those pub- lished. Experiments show that the orbital moment would be decreased to that in bulk materials as iron film is thinned down, but spin moment changes little. 展开更多
关键词 X射线 磁性环 分色性 光学特性
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A multilevel preconditioner for the C-R FEM for elliptic problems with discontinuous coefficients
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作者 wangfeng CHENJinRu HUANGpeiQi 《Science China Mathematics》 SCIE 2012年第7期1513-1526,共14页
In this paper, we propose a multilevel preconditioner for the Crouzeix-Raviart finite element approximation of second-order elliptic partial differential equations with discontinuous coefficients. Since the finite ele... In this paper, we propose a multilevel preconditioner for the Crouzeix-Raviart finite element approximation of second-order elliptic partial differential equations with discontinuous coefficients. Since the finite element spaces are nonnested, weighted intergrid transfer operators, which are stable under the weighted L2 norm, are introduced to exchange information between different meshes. By analyzing the eigenvalue distribution of the preconditioned system, we prove that except a few small eigenvalues, all the other eigenvalues are bounded below and above nearly uniformly with respect to the jump and the mesh size. As a result, we get that the convergence rate of the preconditioned conjugate gradient method is quasi-uniform with respect to the jump and the mesh size. Numerical experiments are presented to confirm our theoretical analysis. 展开更多
关键词 multilevel method Crouzeix-Raviart element discontinuous coefficients
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