Stocks in the Chinese stock market can be divided into ST stocks and normal stocks, so to prevent investors from buying potential ST stocks, this paper first performs SMOTEENN oversampling data preprocessing for the S...Stocks in the Chinese stock market can be divided into ST stocks and normal stocks, so to prevent investors from buying potential ST stocks, this paper first performs SMOTEENN oversampling data preprocessing for the ST stock category, and selects 139 financial indicators and technical factor as predictive features. Then, it combines the Boruta algorithm and Copula entropy method for feature selection, effectively improving the machine learning model’s performance in ST stock classification, with the AUC values of the two models reaching 98% on the test set. In the model selection and optimization, this paper uses six major models, including logistic regression, XGBoost, AdaBoost, LightGBM, Catboost, and MLP, for modeling and optimizes them using the Optuna framework. Ultimately, XGBoost model is selected as the best model because its AUC value exceeds 95% and its running time is less. Finally, the XGBoost model is explained using the SHAP theory and the interaction between features is discovered, further improving the model’s accuracy and AUC value by about 0.6%, verifying the effectiveness of the model.展开更多
Purpose:We aimed to compare treatment efficacy,safety and material cost between tissue gel and coil regarding variceal embolization during transjugular intrahepatic portosystemic shunt(TIPS).Materials&Methods:This...Purpose:We aimed to compare treatment efficacy,safety and material cost between tissue gel and coil regarding variceal embolization during transjugular intrahepatic portosystemic shunt(TIPS).Materials&Methods:This retrospective study including cirrhotic patients with variceal bleeding treated with TIPS combined with variceal embolization between January 2016 and August 2017.Patients were divided into three groups according to embolic agents used in variceal embolization:tissue gel group(Group A),combination group(Group B),and coil group(Group C).The primary endpoint was 1-year rebleeding rate after TIPS creation.The secondary endpoints included shunt dysfunction,overt hepatic encephalopathy,liver function,and embolic agents-related expense.Results:A total of 60 patients(30,10,and 20 in Group A,B,and C)were included.Variceal rebleeding occurred in3(10%),0(0%),and 4(20%)patients within one year after TIPS creation in Group A,B,and C,respectively.Stent dysfunction occurred in 2(3.3%)patients and 9(15.0%)patients experienced overt hepatic encephalopathy.No significant differences were observed between three groups regarding primary and secondary endpoints except embolic agents-related expense,with a significantly lower cost in Group A when compared to the other two groups.Stent dysfunction occurred in two patients,with one patient in Group A developed acute occlusion caused by thrombus and another patient in Group C underwent stent stenosis during follow-up.Conclusions:Compares to coil alone or combines with coil,tissue gel has similar treatment efficacy and safety,but with significantly lower cost for variceal bleeding during TIPS.展开更多
Objectives:To present a case series of modified transjugular intrahepatic portosystemic shunts(TIPS) and percutaneous transhepatic intrahepatic portosystemic shunts(PTIPS) in cirrhotic patients with variceal bleeding(...Objectives:To present a case series of modified transjugular intrahepatic portosystemic shunts(TIPS) and percutaneous transhepatic intrahepatic portosystemic shunts(PTIPS) in cirrhotic patients with variceal bleeding(VB).In addition,the scientific literature pertaining to PTIPS was reviewed.Methods:This retrospective clinical case series included six cirrhotic patients with VB who were treated with PTIPS after the failure of endoscopic band ligation or endoscopic injection sclerotherapy combined with vasoactive drugs.The treatment was conducted between January 2017 and June 2019 at a single institution.Three patients suffered from severe atrophy of the right or left lobar of the liver as well as the main right or left branch of the portal vein.The remaining three patients showed severe atrophy of the whole liver and portal vein,resulting in widening of the liver fissure.A paired t-test was used to compare the changes in portal pressure gradient between before and after the PTIPS operation.The rebleeding rate,treatment efficacy,complications,and technical success rate were all assessed during follow-up.Results:All six PTIPS procedures were performed successfully,with no severe procedural-related complications observed.None of the patients experienced VB during a mean follow-up of 22.8(range,18.0-28.0) months.The mean portosystemic pressure gradient decreased from 28.3 ± 4.3 mmHg pre-procedure to 12.3 ± 2.6 mmHg immediately post-procedure(P <0.001).At follow-up,one patient was found to have developed grade 2 hepatic encephalopathy thrice during the first year,according to the West Haven criteria.However,this was resolved following medical treatment.Conclusions:When the patient’s portal venous anatomy is unconducive to the performance of TIPS using the transjugular approach,PTIPS can be considered as a safe,effective complementary surgical approach for patients with VB.展开更多
Transarterial chemoembolization(TACE)is recommended as the first-line approach for intermediate hepatocellular carcinoma(HCC),and it is the most widely applied method for advanced HCC in real-world clinical practice.[...Transarterial chemoembolization(TACE)is recommended as the first-line approach for intermediate hepatocellular carcinoma(HCC),and it is the most widely applied method for advanced HCC in real-world clinical practice.[1,2]According to the China Liver Cancer(CNLC)staging system,TACE is recommended as the first-line therapy for stages IIb and IIIa,while it is also recommended as a major approach for stages Ib,IIa,and IIIb.[3]Despite its confirmed treatment efficacy and safety,repeated TACE is sometimes unbeneficial for some patients due to the high heterogenicity of HCC,manifesting as liver function deterioration and occupying the optimal occasion of other therapies.Accordingly,the concept of“TACE refractoriness”has been introduced by various societies around the world to avoid ineffective repeated TACE.[4]Nevertheless,there is no widely accepted consensus on the definitions of“TACE refractoriness”and some controversies have yet to be resolved.In addition,whether the existing definitions of“TACE refractoriness”are suitable for Chinese HCC patients is still doubtful.展开更多
Stability and global error bounds are studied for a class of stepsize-dependent linear multistep methods for nonlinear evolution equations governed by ω-dissipative vector fields in Banach space.To break through the ...Stability and global error bounds are studied for a class of stepsize-dependent linear multistep methods for nonlinear evolution equations governed by ω-dissipative vector fields in Banach space.To break through the order barrier p≤1 of unconditionally contractive linear multistep methods for dissipative systems,strongly dissipative systems are introduced.By employing the error growth function of the methods,new contractivity and convergence results of stepsize-dependent linear multistep methods on infinite integration intervals are provided for strictly dissipative systems(ω<0)and strongly dissipative systems.Some applications of the main results to several linear multistep methods,including the trapezoidal rule,are supplied.The theoretical results are also illustrated by a set of numerical experiments.展开更多
A two-grid method for solving the Cahn-Hilliard equation is proposed in this paper.This two-grid method consists of two steps.First,solve the Cahn-Hilliard equation with an implicit mixed finite element method on a co...A two-grid method for solving the Cahn-Hilliard equation is proposed in this paper.This two-grid method consists of two steps.First,solve the Cahn-Hilliard equation with an implicit mixed finite element method on a coarse grid.Second,solve two Poisson equations using multigrid methods on a fine grid.This two-grid method can also be combined with local mesh refinement to further improve the efficiency.Numerical results including two and three dimensional cases with linear or quadratic elements show that this two-grid method can speed up the existing mixed finite method while keeping the same convergence rate.展开更多
This paper is concerned with the numerical stability of implicit Runge-Kutta methods for nonlinear neutral Volterra delay-integro-differential equations with constant delay.Using a Halanay inequality generalized by Li...This paper is concerned with the numerical stability of implicit Runge-Kutta methods for nonlinear neutral Volterra delay-integro-differential equations with constant delay.Using a Halanay inequality generalized by Liz and Trofimchuk,we give two sufficient conditions for the stability of the true solution to this class of equations.Runge-Kutta methods with compound quadrature rule are considered.Nonlinear stability conditions for the proposed methods are derived.As an illustration of the application of these investigations,the asymptotic stability of the presented methods for Volterra delay-integro-differential equations are proved under some weaker conditions than those in the literature.An extension of the stability results to such equations with weakly singular kernel is also discussed.展开更多
文摘Stocks in the Chinese stock market can be divided into ST stocks and normal stocks, so to prevent investors from buying potential ST stocks, this paper first performs SMOTEENN oversampling data preprocessing for the ST stock category, and selects 139 financial indicators and technical factor as predictive features. Then, it combines the Boruta algorithm and Copula entropy method for feature selection, effectively improving the machine learning model’s performance in ST stock classification, with the AUC values of the two models reaching 98% on the test set. In the model selection and optimization, this paper uses six major models, including logistic regression, XGBoost, AdaBoost, LightGBM, Catboost, and MLP, for modeling and optimizes them using the Optuna framework. Ultimately, XGBoost model is selected as the best model because its AUC value exceeds 95% and its running time is less. Finally, the XGBoost model is explained using the SHAP theory and the interaction between features is discovered, further improving the model’s accuracy and AUC value by about 0.6%, verifying the effectiveness of the model.
基金funded by the Jiangsu Provincial Medical Talent Funding(ZDRCA2016038)the Suzhou Special Diagnosis and Treatment Technology of Clinical Key Diseases(LCZX201704)+2 种基金the National Natural Science Foundation of China(81771945,81901847)the Natural Science Foundation of Jiangsu Province(BK20190177)the Suzhou Science and Technology Youth Plan(KJXW2018003).
文摘Purpose:We aimed to compare treatment efficacy,safety and material cost between tissue gel and coil regarding variceal embolization during transjugular intrahepatic portosystemic shunt(TIPS).Materials&Methods:This retrospective study including cirrhotic patients with variceal bleeding treated with TIPS combined with variceal embolization between January 2016 and August 2017.Patients were divided into three groups according to embolic agents used in variceal embolization:tissue gel group(Group A),combination group(Group B),and coil group(Group C).The primary endpoint was 1-year rebleeding rate after TIPS creation.The secondary endpoints included shunt dysfunction,overt hepatic encephalopathy,liver function,and embolic agents-related expense.Results:A total of 60 patients(30,10,and 20 in Group A,B,and C)were included.Variceal rebleeding occurred in3(10%),0(0%),and 4(20%)patients within one year after TIPS creation in Group A,B,and C,respectively.Stent dysfunction occurred in 2(3.3%)patients and 9(15.0%)patients experienced overt hepatic encephalopathy.No significant differences were observed between three groups regarding primary and secondary endpoints except embolic agents-related expense,with a significantly lower cost in Group A when compared to the other two groups.Stent dysfunction occurred in two patients,with one patient in Group A developed acute occlusion caused by thrombus and another patient in Group C underwent stent stenosis during follow-up.Conclusions:Compares to coil alone or combines with coil,tissue gel has similar treatment efficacy and safety,but with significantly lower cost for variceal bleeding during TIPS.
基金supported by the Jiangsu Provincial Medical Talent Funding (ZDRCA2016038)the Suzhou Special Diagnosis and Treatment Technology of Clinical Key Diseases (LCZX201704)+2 种基金the National Natural Science Foundation of China (81771945, 81901847)the Natural Science Foundation of Jiangsu Province (BK20190177)the Suzhou Science and Technology Youth Plan (KJXW2018003)。
文摘Objectives:To present a case series of modified transjugular intrahepatic portosystemic shunts(TIPS) and percutaneous transhepatic intrahepatic portosystemic shunts(PTIPS) in cirrhotic patients with variceal bleeding(VB).In addition,the scientific literature pertaining to PTIPS was reviewed.Methods:This retrospective clinical case series included six cirrhotic patients with VB who were treated with PTIPS after the failure of endoscopic band ligation or endoscopic injection sclerotherapy combined with vasoactive drugs.The treatment was conducted between January 2017 and June 2019 at a single institution.Three patients suffered from severe atrophy of the right or left lobar of the liver as well as the main right or left branch of the portal vein.The remaining three patients showed severe atrophy of the whole liver and portal vein,resulting in widening of the liver fissure.A paired t-test was used to compare the changes in portal pressure gradient between before and after the PTIPS operation.The rebleeding rate,treatment efficacy,complications,and technical success rate were all assessed during follow-up.Results:All six PTIPS procedures were performed successfully,with no severe procedural-related complications observed.None of the patients experienced VB during a mean follow-up of 22.8(range,18.0-28.0) months.The mean portosystemic pressure gradient decreased from 28.3 ± 4.3 mmHg pre-procedure to 12.3 ± 2.6 mmHg immediately post-procedure(P <0.001).At follow-up,one patient was found to have developed grade 2 hepatic encephalopathy thrice during the first year,according to the West Haven criteria.However,this was resolved following medical treatment.Conclusions:When the patient’s portal venous anatomy is unconducive to the performance of TIPS using the transjugular approach,PTIPS can be considered as a safe,effective complementary surgical approach for patients with VB.
文摘Transarterial chemoembolization(TACE)is recommended as the first-line approach for intermediate hepatocellular carcinoma(HCC),and it is the most widely applied method for advanced HCC in real-world clinical practice.[1,2]According to the China Liver Cancer(CNLC)staging system,TACE is recommended as the first-line therapy for stages IIb and IIIa,while it is also recommended as a major approach for stages Ib,IIa,and IIIb.[3]Despite its confirmed treatment efficacy and safety,repeated TACE is sometimes unbeneficial for some patients due to the high heterogenicity of HCC,manifesting as liver function deterioration and occupying the optimal occasion of other therapies.Accordingly,the concept of“TACE refractoriness”has been introduced by various societies around the world to avoid ineffective repeated TACE.[4]Nevertheless,there is no widely accepted consensus on the definitions of“TACE refractoriness”and some controversies have yet to be resolved.In addition,whether the existing definitions of“TACE refractoriness”are suitable for Chinese HCC patients is still doubtful.
基金supported by the Natural Science Foundation of China(Grant Nos.12271367,11771060)by the Science and Technology Innovation Plan of Shanghai,China(Grant No.20JC1414200)sponsored by the Natural Science Foundation of Shanghai,China(Grant No.20ZR1441200).
文摘Stability and global error bounds are studied for a class of stepsize-dependent linear multistep methods for nonlinear evolution equations governed by ω-dissipative vector fields in Banach space.To break through the order barrier p≤1 of unconditionally contractive linear multistep methods for dissipative systems,strongly dissipative systems are introduced.By employing the error growth function of the methods,new contractivity and convergence results of stepsize-dependent linear multistep methods on infinite integration intervals are provided for strictly dissipative systems(ω<0)and strongly dissipative systems.Some applications of the main results to several linear multistep methods,including the trapezoidal rule,are supplied.The theoretical results are also illustrated by a set of numerical experiments.
基金The research of J.Zhou was supported by Graduate innovation program of Hunan province in China(Grant No.CX2012B240)China Scholarship Council and Natural Science Foundation of China(Grant No.11201159)+6 种基金L.Chen was supported by NSF Grant DMS-1115961,and in part by Department of Energy prime award#DE-SC0006903The research of Y.Q.Huang was partially supported by the National Natural Science Foundation of China(Grant No.91430213)Program for Changjiang Scholars and Innovative Research Team in University(Grant No.IRT1179)International Science and Technology Cooperation Program of China(Grant No.2010DFR00700)The research of W.S.Wang was supported by Ky and Yu-Fen Fan Fund Travel Grant from the AMS,the National Natural Science Foundation of China(Grant No.11001033,11371074)the Natural Science Foundation for Distinguished Young scholars in Hunan Province,China(Grant No.13JJ1020)the Research Foundation of Education Bureau of Hunan Province,China(Grant No.13A108).
文摘A two-grid method for solving the Cahn-Hilliard equation is proposed in this paper.This two-grid method consists of two steps.First,solve the Cahn-Hilliard equation with an implicit mixed finite element method on a coarse grid.Second,solve two Poisson equations using multigrid methods on a fine grid.This two-grid method can also be combined with local mesh refinement to further improve the efficiency.Numerical results including two and three dimensional cases with linear or quadratic elements show that this two-grid method can speed up the existing mixed finite method while keeping the same convergence rate.
基金supported by NSF of China(Grant No.11001033)Natural Science Foundation of Hunan Province(Grant No.10JJ4003)Chinese Society for Electrical Engineering,and Graduates’innovation fund of HUST(No.HF-08-02-2011-011).
文摘This paper is concerned with the numerical stability of implicit Runge-Kutta methods for nonlinear neutral Volterra delay-integro-differential equations with constant delay.Using a Halanay inequality generalized by Liz and Trofimchuk,we give two sufficient conditions for the stability of the true solution to this class of equations.Runge-Kutta methods with compound quadrature rule are considered.Nonlinear stability conditions for the proposed methods are derived.As an illustration of the application of these investigations,the asymptotic stability of the presented methods for Volterra delay-integro-differential equations are proved under some weaker conditions than those in the literature.An extension of the stability results to such equations with weakly singular kernel is also discussed.
