The assessment of the measurement error status of online Capacitor Voltage Transformers (CVT) within the power grid is of profound significance to the equitable trade of electric energy and the secure operation of the...The assessment of the measurement error status of online Capacitor Voltage Transformers (CVT) within the power grid is of profound significance to the equitable trade of electric energy and the secure operation of the power grid. This paper advances an online CVT error state evaluation method, anchored in the in-phase relationship and outlier detection. Initially, this method leverages the in-phase relationship to obviate the influence of primary side fluctuations in the grid on assessment accuracy. Subsequently, Principal Component Analysis (PCA) is employed to meticulously disentangle the error change information inherent in the CVT from the measured values and to compute statistics that delineate the error state. Finally, the Local Outlier Factor (LOF) is deployed to discern outliers in the statistics, with thresholds serving to appraise the CVT error state. Experimental results incontrovertibly demonstrate the efficacy of this method, showcasing its prowess in effecting online tracking of CVT error changes and conducting error state assessments. The discernible enhancements in reliability, accuracy, and sensitivity are manifest, with the assessment accuracy reaching an exemplary 0.01%.展开更多
Two-dimensional carbon/carbon(2D C/C)composites are a special class of carbon/carbon composites,generally obtained by combining resin-impregnated carbon fiber clothes,which are then cured and carbonized.This study dea...Two-dimensional carbon/carbon(2D C/C)composites are a special class of carbon/carbon composites,generally obtained by combining resin-impregnated carbon fiber clothes,which are then cured and carbonized.This study deals with the preparation of a protective coating for these materials.This coating,based on graphite,was prepared by the slurry method.The effect of graphite and phenolic resin powders with different weight ratios was examined.The results have shown that the coating slurry can fill the pores and cracks of the composite surface,thereby densifying the surface layer of the material.With the increase of the graphite powder/phenolic resin weight ratio,the coating density is enhanced while the coating surface flatness decreases;moreover,the protective ability of coating against erosion first increases(from 1:3 to 2:2)and then decreases(from 2:2 to 3:1).When the weight ratio is about 1:1,the coating for 2D C/C composites exhibits the best erosion resistance,which greatly aids these materials during gas quenching.In this case,the erosion rate is decreased by approximately 41.5%at the impact angle of 30°and 52.3%at normal impact,respectively.This can be attributed to the ability of the coating slurry to infiltrate into the substrate,thereby bonding the fibers together and increasing the compactness of the 2D C/C composites.展开更多
Based on the arable land situation in Gejiu City,upland dry planting of indica hybrid rice is being expanded in Karst mountain areas with a rainfall of over 1400 mm and an altitude of 1100-1600 m to develop grain prod...Based on the arable land situation in Gejiu City,upland dry planting of indica hybrid rice is being expanded in Karst mountain areas with a rainfall of over 1400 mm and an altitude of 1100-1600 m to develop grain production.This paper gives a specific description of hybrid rice upland dry seedling technology,upland transplanting technology,fertilization technology,field management,weed prevention and control technology,and disease and pest control.展开更多
Solid electrolytes for all solid sodium-ion batteries have been attracting much attention as an alternative energy storage system, which have the advantage of being extremely safe because it can be charged quickly and...Solid electrolytes for all solid sodium-ion batteries have been attracting much attention as an alternative energy storage system, which have the advantage of being extremely safe because it can be charged quickly and is nonflammable. We have synthesized anti-perovskite type Na<sub>3</sub>OX (X = Br, and I) electrolytes with high purity, by reactions of halogen mixtures with sodium oxides. After mixing, it was filled in an alumina crucible and heated for 6 hours at 330°C. It was confirmed that a large crystal strain was introduced by eutectication, which might reduce the activation energy of Na ion conduction and lead to an improvement of the conductivity. A relatively higher ionic conductivity of σ = 1.55 × 10<sup>-7</sup> S/cm at 60°C has been obtained for Na<sub>3</sub>OBr<sub>0.6</sub>I<sub>0.4</sub>, which is about three orders higher than that in literature. A different ratio of X (X = Br, I) ions was added into sodium oxide to make the Na<sub>3</sub>OX crystal. The influence of strain introduction on optimizing the bottleneck and improving the conductivity was discussed.展开更多
AIM: To assess the relationships of final best-corrected visual acuity(BCVA) and the optic nerve structural loss in varying age-cohorts of optic neuritis(ON) patients.METHODS: This is a retrospective, cross-sectional ...AIM: To assess the relationships of final best-corrected visual acuity(BCVA) and the optic nerve structural loss in varying age-cohorts of optic neuritis(ON) patients.METHODS: This is a retrospective, cross-sectional study.Totally 130 ON subjects(200 eyes) without ON onset within 6mo were included, who underwent BCVA assessment,peripapillary retinal nerve fibre layer(pRNFL) and macular segmented layers evaluation by optical coherence tomography(OCT).RESULTS: For the 0-18y cohort, the final BCVA(logMAR)was significantly better and less frequent recurrences than adult cohorts(P=0.000). The final BCVA(logMAR) in all age-cohorts of the ON patients had negative and linear correlations to the pRNFL thicknesses and macular retinal ganglion cell layer(mRGCL) volumes, when the pRNFL thicknesses were reduced to the thresholds of 57.2-67.5 μm or 0.691-0.737 mm;in mRGCL volumes, respectively, with the strongest interdependence in the 19-40y cohort. The ON patients from varying age cohorts would be threatened by blindness when their pRNFL thicknesses dropped 36.7-48.3 μm or the mRGCL volumes dropped to 0.495-0.613 mm;.CONCLUSION: The paediatric ON has best prognosis and young adult ON exhibits perfectly linear correlations of final vision and structural loss. The pRNFL and the mRGCL could be potential structural markers to predict the vision prognosis for varying-age ON patients.展开更多
This paper mainly discussed the operation benefits of fruit dealers in farm market. Taking fruit dealers in Shizishan Street Farm market in Wuhan City as the research object,this paper introduced current operation sit...This paper mainly discussed the operation benefits of fruit dealers in farm market. Taking fruit dealers in Shizishan Street Farm market in Wuhan City as the research object,this paper introduced current operation situation of fruit dealers and made a descriptive statistical analysis on characteristics of operators,operation situation,and cognitive status. Besides,it introduced the concept of net cost-benefit ratio to reflect the operation benefits. From further analysis on the operation benefits of fruit dealers,it found that there is little difference in the costbenefit ratio between dealers in the farm market. The average net cost-benefit ratio was 11. 94%. Specifically,if the total cost is 100 yuan,the dealer can obtain 12 yuan net profit. In order to find out how cost factors affect the operation benefits,it established a regression model for cost factors and net cost-benefit ratio. According to the survey results,when the wholesale cost increases 10000 yuan,the cost-benefit ratio will increase by 1. 454 percentage points,thus increasing the wholesale investment is helpful for increasing the net cost-benefit ratio; when the loss cost increases 10000 yuan,the cost-benefit ratio will increase by 7. 501 percentage points,thus the dealers can increase the operation benefits through controlling the loss cost and reducing the operation cost. Finally,it came up policy recommendations from the perspective of government and operators.展开更多
目的分析1990—2019年中国心肌炎疾病负担水平及其变化趋势。方法依据全球疾病负担(global burden of disease,GBD)2019数据库,利用心肌炎发病率、死亡率、伤残调整寿命年(DALY)、伤残损失寿命年(YLD)、过早死亡损失寿命年(YLL)及其年...目的分析1990—2019年中国心肌炎疾病负担水平及其变化趋势。方法依据全球疾病负担(global burden of disease,GBD)2019数据库,利用心肌炎发病率、死亡率、伤残调整寿命年(DALY)、伤残损失寿命年(YLD)、过早死亡损失寿命年(YLL)及其年龄标准化率和平均年度百分比变化率(AAPC)等指标比较分析1990—2019年我国和全球心肌炎水平,并阐述我国不同年龄、性别心肌炎疾病负担情况。结果与1990年相比,2019年中国心肌炎发病例数和死亡例数上涨幅度分别为47.47%和50.22%,DALY和YLL分别下降了25.59%、28.02%,而YLD上升了89.50%;2019年全球心肌炎的发病例数及死亡例数上升幅度分别为62.19%和65.40%,DALY和YLL分别下降了0.42%、2.53%,而YLD上升了64.21%。2019年,我国心肌炎的发病例数、死亡例数及DALY例数呈现双峰分布,均在小于20岁出现第一高峰。1990—2019年,我国心肌炎的标化发病率、标化死亡率及标化DALY率的AAPC分别为-0.223%(-0.233%,-0.213%)、-0.612%(-0.812%,-0.411%)和-1.759%(-1.909%,-1.609%),而全球则为-0.157%(-0.164%,-0.151%)、-0.257%(-0.395%,-0.117%)和-1.210%(-1.312%,-1.109%)。我国心肌炎的发病率、死亡率及DALY率表现为男性高于女性。结论相较于1990年,2019年我国心肌炎标化发病率、标化死亡率及标化DALY率均呈下降趋势,但对我国年轻人和老年群体仍有较大威胁,尤其是年轻男性和老年女性,应持续强化心肌炎的诊断流程及防治工作。展开更多
Although accumulating data demonstrate that dietary supplementation of bamboo vinegar and charcoal powder(BVC)can significantly strengthen the immunity and boost the growth of domestic animals,its application potency ...Although accumulating data demonstrate that dietary supplementation of bamboo vinegar and charcoal powder(BVC)can significantly strengthen the immunity and boost the growth of domestic animals,its application potency still awaits verification in commercial fish species such as the large-scale loach Paramisgurnus dabryanus.The impacts of 90-day dietary supplementation of 1%and 2%BVC on survival and growth performance of the loach,and on the intestinal morphological characteristics and gut microflora were analyzed.Our data show that the large-scale loach supplied with BVC at the experimental doses had significant higher survival rates and better growth performance(indicated by greater weight gain(1.13–1.14 times),higher specific growth rate(1.04 times),and lower feed conversion ratio(0.88–0.89 times))compared to that of the control(P<0.05).Histological examination revealed significant longer villus(3.22–5.54 times),deeper crypt(1.77–1.87 times),and thicker muscle(1.59–3.17 times)in the intestines of large-scale loach fed with BVC(P<0.05).Furthermore,we found that the gut microflora consisted of significantly fewer proportions of potential pathogenic bacterial species(Aeromonas veronii and Escherichia coli),but significantly greater proportions of beneficial microbes(Lactococus raffinolactis and Faecalibacterium prausnitzii).Therefore,dietary intake of BVC can promote intestinal tract development and optimize gut microflora,by which the survival and growth of large-scale loach may be improved.展开更多
As one of the pentlandites,Fe5Ni4S8(FNS) based materials have attracted increasing attention due to their excellent catalytic properties and promising applicability.The control over the catalyst surface structure ofte...As one of the pentlandites,Fe5Ni4S8(FNS) based materials have attracted increasing attention due to their excellent catalytic properties and promising applicability.The control over the catalyst surface structure often benefits its heterogeneous catalytic activity.However,this has not been investigated for FNS materials at the nanoscale regarding the catalytic activity related to high-index facets.Herein,FNS nanoparticles(FNSNPs) with enclosed continuous tunable high-index facets were prepared and studied to clarify the relationship between the structure and catalytic functionality.The results suggested strong dependence between exposed facets of FNSNPs and their sizes.The decline in the average size to5.8 nm led to enclosing by high-index facets(422) and(511) to yield optimal electrocatalytic activities toward the hydrogen evolution reaction.The catalytic activity of FNSNPs was closely related to the surface energy of the main exposed facets.These findings clarified the relationship between high-index-facet and high-surface-energy FNSNPs,as promising approaches in crystal surface control engineering.展开更多
Objective Aberrant activating mutations in cyclin-dependent kinases 4 and 6(CDK4/6)are common in various cancers,including gastroesophageal malignancies.Although CDK4/6 inhibitors,such as abemaciclib and palbociclib,h...Objective Aberrant activating mutations in cyclin-dependent kinases 4 and 6(CDK4/6)are common in various cancers,including gastroesophageal malignancies.Although CDK4/6 inhibitors,such as abemaciclib and palbociclib,have been approved for breast cancer treatment,their effectiveness as a monotherapy remains limited for gastroesophageal tumors.The present study explored the underlying mechanism of abemaciclib resistance.Methods Abemaciclib-resistant gastric cancer cell lines were generated,and the phospho-eukaryotic translation initiation factor 4E(p-eIF4E)and eIF4E expression was compared between resistant and parental cell lines.In order to analyze the role of eIF4E in cell resistance,siRNA knockdown was employed.The effectiveness of ribavirin alone and its combination with abemaciclib was evaluated in the gastric cancer xenograft mouse model.Results The upregulation of eIF4E was a common feature in gastric cancer cells exposed to prolonged abemaciclib treatment.Gastric cancer cells with increased eIF4E levels exhibited a better response to eIF4E inhibition,especially those that were resistant to abemaciclib.Ribavirin,which is an approved anti-viral drug,significantly improved the efficacy of abemaciclib,both in vitro and in vivo,by inhibiting eIF4E.Importantly,ribavirin effectively suppressed the abemaciclib-resistant gastric cancer growth in mice without causing toxicity.Conclusion These findings suggest that targeting eIF4E can enhance the abemaciclib treatment for gastric cancer,proposing the potential combination therapy of CDK4/6 inhibitors with ribavirin for advanced gastric cancer.展开更多
Background:LncRNA DLX6-AS1 has been uncovered to exert effects on various cancers.Nevertheless,the impacts of DLX6-AS1 on endometrial cancer(EC)development remained obscure.The study explored the influence of DLX6-AS1...Background:LncRNA DLX6-AS1 has been uncovered to exert effects on various cancers.Nevertheless,the impacts of DLX6-AS1 on endometrial cancer(EC)development remained obscure.The study explored the influence of DLX6-AS1 on EC progression via the microRNA(miR)-374a-3p/zinc-finger protein(ZFX)axis.Methods:EC cell lines were collected and DLX6-AS1,miR-374a-3p,and ZFX levels in EC cell lines were detected.The EC cells were transfected with DLX6-AS1,miR-374a-3p,and ZFX constructs to examine the biological functions of EC cells.The xenograft model was established for detecting tumor growth.Rescue experiments were conducted to verify the interaction of DLX6-AS1,miR-374a-3p,and ZFX in EC cells.Results:DLX6-AS1 and ZFX levels were elevated,while miR-374a-3p exhibited a reduced level in EC cells.Silencing DLX6-AS1 and elevated miR-374a-3p expressions repressed the biological activities of EC cells.Reduced DLX6-AS1 repressed tumor development.MiR-374a-3p silencing reversed the impacts of DLX6-AS1 silencing,while ZFX overexpression abrogated the impacts of miR-374a-3p elevation on EC cell growth.Mechanically,DLX6-AS1 was found to bind to miR-374a-3p,and miR-374a-3p targeted ZFX.Conclusion:DLX6-AS1 depletion restricts the malignant phenotype of EC cells.The study might provide novel therapeutic biomarkers for EC treatment.展开更多
60 GHz millimeter wave(mmWave)system provides extremely high time resolution and multipath components(MPC)separation and has great potential to achieve high precision in the indoor positioning.However,the ranging data...60 GHz millimeter wave(mmWave)system provides extremely high time resolution and multipath components(MPC)separation and has great potential to achieve high precision in the indoor positioning.However,the ranging data is often contaminated by non-line-of-sight(NLOS)transmission.First,six features of 60GHz mm Wave signal under LOS and NLOS conditions are evaluated.Next,a classifier constructed by random forest(RF)algorithm is used to identify line-of-sight(LOS)or NLOS channel.The identification mechanism has excellent generalization performance and the classification accuracy is over 97%.Finally,based on the identification results,a residual weighted least squares positioning method is proposed.All ranging information including that under NLOS channels is fully utilized,positioning failure caused by insufficient LOS links can be avoided.Compared with the conventional least squares approach,the positioning error of the proposed algorithm is reduced by 49%.展开更多
A fractional nonlinear system with power damping term is introduced to study the forced vibration system in order to solve the resonance and bifurcation problems between grinding wheel and steel bar during robot grind...A fractional nonlinear system with power damping term is introduced to study the forced vibration system in order to solve the resonance and bifurcation problems between grinding wheel and steel bar during robot grinding.The robot,grinding wheel and steel bar are reduced to a spring-damping second-order system model.The implicit function equations of vibration amplitude of the dynamic system with coulomb friction damping,linear damping,square damping and cubic damping are obtained by average method.The stability of the system is analyzed and explained,and the stability condition of the system is proposed.Then,the amplitude-frequency characteristic curves of the system under different fractional differential orders,nonlinear stiffness parameters,fractional differential term coefficients and external excitation amplitude are analyzed.It is shown that the fractional differential term in the dynamic system is the damping characteristic.Then the influence of four kinds of damping on the vibration amplitude of the system under the same parameter is investigated and it is proved that the cubic damping suppresses the vibration of the system to the maximum extent.Finally,based on the idea that the equilibrium point of the system is the constant part of the Fourier series expansion term,the bifurcation behavior caused by the change of damping parameters in linear damping,square damping and cubic damping systems with different values of fractional differential order is investigated.展开更多
The treatment of wheat straw is very difficult,and its utilization rate is very low;accumulation causes air pollution and even fire.To make full use of wheat straw resources,we examined how using different physical an...The treatment of wheat straw is very difficult,and its utilization rate is very low;accumulation causes air pollution and even fire.To make full use of wheat straw resources,we examined how using different physical and chemical methods to treat the wheat straw which can improve its strength abilities,or enhance the activity of wheat straw ash.In terms of concrete additives,it can reduce the amount of cement used.In this paper,we found that alkali treatment can significantly improve the tensile strength of wheat straw fiber,but polyvinyl alcohol treatment has no obvious effect on the strength of wheat straw fiber after alkali treatment.At the same time,we analyzed the wheat straw fiber microstructure through scanning electron microscopy,and we also studied the wheat straw ash chemical composition after 600℃ high-temperature treatment.Through the compressive strength test,we found that the strength of concrete decreases with increasing of wheat straw fiber and wheat straw powder content,and the compressive strength of concrete with wheat straw ash instead of 5%cement decreases little,and the strength of the concrete also decreases with the increasing of wheat straw ash.Through the macroscopic observation of the failure form of concrete,we found that the failure form of concrete with wheat straw ash is similar to that of common concrete,while the failure degree of concrete with wheat straw fiber and wheat straw powder is weakened.Through the scanning electron microscope test of the concrete,it was found that wheat straw fiber has an effect on the cracking of concrete and the inner compactness of concrete can also be affected by adding wheat straw ash and wheat straw powder.展开更多
Dear Editor,Understanding the evolution and survival mechanisms of endangered wild medicinal herbs is crucial for their cultivation,utilization,and conservation.The snow lotus species Saussurea involucrata(Kar.&Ki...Dear Editor,Understanding the evolution and survival mechanisms of endangered wild medicinal herbs is crucial for their cultivation,utilization,and conservation.The snow lotus species Saussurea involucrata(Kar.&Kir.)Sch.Bip.(2n=32)(i.e.the well-known Tianshan snow lotus)which belongs to the eudicot family Asteraceae,is a famous traditional Chinese medicinal herb having anti-inflammatory.展开更多
[Objectives] To investigate the role of Eriocalyxin B (EriB) in promoting colon cancer cell apoptosis through ERK1/2 pathway in vitro, and to provide a natural candidate drug for colon cancer treatment. [Methods] Colo...[Objectives] To investigate the role of Eriocalyxin B (EriB) in promoting colon cancer cell apoptosis through ERK1/2 pathway in vitro, and to provide a natural candidate drug for colon cancer treatment. [Methods] Colon cancer cells treated with different concentrations of EriB were detected by CCK-8 assay;cell scratch assay and crystal violet staining were used to detect the invasion and migration of colon cancer cell;cell apoptosis was detected by Annexin V/PI double staining, and cell cycle was detected by PI staining;Western Blotting was used to detect epithelial-mesenchymal transition and apoptosis-related proteins in colon cancer cells treated with EriB. [Results] After EriB treatment, the proliferation, migration and apoptosis of colon cancer cells were significantly inhibited, and the ratio of P-ERK1/2 to ERK was significantly decreased. [Conclusions] EriB can effectively inhibit the proliferation of colon cancer cells and promote the apoptosis of colon cancer cells through ERK1/2 pathway.展开更多
文摘The assessment of the measurement error status of online Capacitor Voltage Transformers (CVT) within the power grid is of profound significance to the equitable trade of electric energy and the secure operation of the power grid. This paper advances an online CVT error state evaluation method, anchored in the in-phase relationship and outlier detection. Initially, this method leverages the in-phase relationship to obviate the influence of primary side fluctuations in the grid on assessment accuracy. Subsequently, Principal Component Analysis (PCA) is employed to meticulously disentangle the error change information inherent in the CVT from the measured values and to compute statistics that delineate the error state. Finally, the Local Outlier Factor (LOF) is deployed to discern outliers in the statistics, with thresholds serving to appraise the CVT error state. Experimental results incontrovertibly demonstrate the efficacy of this method, showcasing its prowess in effecting online tracking of CVT error changes and conducting error state assessments. The discernible enhancements in reliability, accuracy, and sensitivity are manifest, with the assessment accuracy reaching an exemplary 0.01%.
基金This paper has obtained the support of the National Natural Science Foundation of China(No.51902039)High-Level Talents Innovation Support Plan of Dalian(No.2020RQ127)Scientific Research Project of Liaoning Provincial Department Education(No.LJKZ0722)。
文摘Two-dimensional carbon/carbon(2D C/C)composites are a special class of carbon/carbon composites,generally obtained by combining resin-impregnated carbon fiber clothes,which are then cured and carbonized.This study deals with the preparation of a protective coating for these materials.This coating,based on graphite,was prepared by the slurry method.The effect of graphite and phenolic resin powders with different weight ratios was examined.The results have shown that the coating slurry can fill the pores and cracks of the composite surface,thereby densifying the surface layer of the material.With the increase of the graphite powder/phenolic resin weight ratio,the coating density is enhanced while the coating surface flatness decreases;moreover,the protective ability of coating against erosion first increases(from 1:3 to 2:2)and then decreases(from 2:2 to 3:1).When the weight ratio is about 1:1,the coating for 2D C/C composites exhibits the best erosion resistance,which greatly aids these materials during gas quenching.In this case,the erosion rate is decreased by approximately 41.5%at the impact angle of 30°and 52.3%at normal impact,respectively.This can be attributed to the ability of the coating slurry to infiltrate into the substrate,thereby bonding the fibers together and increasing the compactness of the 2D C/C composites.
文摘Based on the arable land situation in Gejiu City,upland dry planting of indica hybrid rice is being expanded in Karst mountain areas with a rainfall of over 1400 mm and an altitude of 1100-1600 m to develop grain production.This paper gives a specific description of hybrid rice upland dry seedling technology,upland transplanting technology,fertilization technology,field management,weed prevention and control technology,and disease and pest control.
文摘Solid electrolytes for all solid sodium-ion batteries have been attracting much attention as an alternative energy storage system, which have the advantage of being extremely safe because it can be charged quickly and is nonflammable. We have synthesized anti-perovskite type Na<sub>3</sub>OX (X = Br, and I) electrolytes with high purity, by reactions of halogen mixtures with sodium oxides. After mixing, it was filled in an alumina crucible and heated for 6 hours at 330°C. It was confirmed that a large crystal strain was introduced by eutectication, which might reduce the activation energy of Na ion conduction and lead to an improvement of the conductivity. A relatively higher ionic conductivity of σ = 1.55 × 10<sup>-7</sup> S/cm at 60°C has been obtained for Na<sub>3</sub>OBr<sub>0.6</sub>I<sub>0.4</sub>, which is about three orders higher than that in literature. A different ratio of X (X = Br, I) ions was added into sodium oxide to make the Na<sub>3</sub>OX crystal. The influence of strain introduction on optimizing the bottleneck and improving the conductivity was discussed.
基金Supported by the National High Technology Research and Development Program of China(863 Programme,No.2015AA020511)Clinical Support Foundation of PLA General Hospital,China(No.2016FC-TSYS-I016)。
文摘AIM: To assess the relationships of final best-corrected visual acuity(BCVA) and the optic nerve structural loss in varying age-cohorts of optic neuritis(ON) patients.METHODS: This is a retrospective, cross-sectional study.Totally 130 ON subjects(200 eyes) without ON onset within 6mo were included, who underwent BCVA assessment,peripapillary retinal nerve fibre layer(pRNFL) and macular segmented layers evaluation by optical coherence tomography(OCT).RESULTS: For the 0-18y cohort, the final BCVA(logMAR)was significantly better and less frequent recurrences than adult cohorts(P=0.000). The final BCVA(logMAR) in all age-cohorts of the ON patients had negative and linear correlations to the pRNFL thicknesses and macular retinal ganglion cell layer(mRGCL) volumes, when the pRNFL thicknesses were reduced to the thresholds of 57.2-67.5 μm or 0.691-0.737 mm;in mRGCL volumes, respectively, with the strongest interdependence in the 19-40y cohort. The ON patients from varying age cohorts would be threatened by blindness when their pRNFL thicknesses dropped 36.7-48.3 μm or the mRGCL volumes dropped to 0.495-0.613 mm;.CONCLUSION: The paediatric ON has best prognosis and young adult ON exhibits perfectly linear correlations of final vision and structural loss. The pRNFL and the mRGCL could be potential structural markers to predict the vision prognosis for varying-age ON patients.
文摘This paper mainly discussed the operation benefits of fruit dealers in farm market. Taking fruit dealers in Shizishan Street Farm market in Wuhan City as the research object,this paper introduced current operation situation of fruit dealers and made a descriptive statistical analysis on characteristics of operators,operation situation,and cognitive status. Besides,it introduced the concept of net cost-benefit ratio to reflect the operation benefits. From further analysis on the operation benefits of fruit dealers,it found that there is little difference in the costbenefit ratio between dealers in the farm market. The average net cost-benefit ratio was 11. 94%. Specifically,if the total cost is 100 yuan,the dealer can obtain 12 yuan net profit. In order to find out how cost factors affect the operation benefits,it established a regression model for cost factors and net cost-benefit ratio. According to the survey results,when the wholesale cost increases 10000 yuan,the cost-benefit ratio will increase by 1. 454 percentage points,thus increasing the wholesale investment is helpful for increasing the net cost-benefit ratio; when the loss cost increases 10000 yuan,the cost-benefit ratio will increase by 7. 501 percentage points,thus the dealers can increase the operation benefits through controlling the loss cost and reducing the operation cost. Finally,it came up policy recommendations from the perspective of government and operators.
文摘目的分析1990—2019年中国心肌炎疾病负担水平及其变化趋势。方法依据全球疾病负担(global burden of disease,GBD)2019数据库,利用心肌炎发病率、死亡率、伤残调整寿命年(DALY)、伤残损失寿命年(YLD)、过早死亡损失寿命年(YLL)及其年龄标准化率和平均年度百分比变化率(AAPC)等指标比较分析1990—2019年我国和全球心肌炎水平,并阐述我国不同年龄、性别心肌炎疾病负担情况。结果与1990年相比,2019年中国心肌炎发病例数和死亡例数上涨幅度分别为47.47%和50.22%,DALY和YLL分别下降了25.59%、28.02%,而YLD上升了89.50%;2019年全球心肌炎的发病例数及死亡例数上升幅度分别为62.19%和65.40%,DALY和YLL分别下降了0.42%、2.53%,而YLD上升了64.21%。2019年,我国心肌炎的发病例数、死亡例数及DALY例数呈现双峰分布,均在小于20岁出现第一高峰。1990—2019年,我国心肌炎的标化发病率、标化死亡率及标化DALY率的AAPC分别为-0.223%(-0.233%,-0.213%)、-0.612%(-0.812%,-0.411%)和-1.759%(-1.909%,-1.609%),而全球则为-0.157%(-0.164%,-0.151%)、-0.257%(-0.395%,-0.117%)和-1.210%(-1.312%,-1.109%)。我国心肌炎的发病率、死亡率及DALY率表现为男性高于女性。结论相较于1990年,2019年我国心肌炎标化发病率、标化死亡率及标化DALY率均呈下降趋势,但对我国年轻人和老年群体仍有较大威胁,尤其是年轻男性和老年女性,应持续强化心肌炎的诊断流程及防治工作。
基金Supported by the Key R&D Program of Zhejiang Province(No.2021C02048)the Science and Technology Project of Wenzhou(No.2019ZX002-02)+3 种基金the Natural Science Foundation of Zhejiang Province(No.LQ21C190003)the China Postdoctoral Science Foundation(No.2020M671743)the Zhejiang Provincial Key Laboratory Construction Plans(No.2020E10025)the Open Fund of Key Laboratory of Marine Ecosystem Dynamics,SIO(No.MED2020004)。
文摘Although accumulating data demonstrate that dietary supplementation of bamboo vinegar and charcoal powder(BVC)can significantly strengthen the immunity and boost the growth of domestic animals,its application potency still awaits verification in commercial fish species such as the large-scale loach Paramisgurnus dabryanus.The impacts of 90-day dietary supplementation of 1%and 2%BVC on survival and growth performance of the loach,and on the intestinal morphological characteristics and gut microflora were analyzed.Our data show that the large-scale loach supplied with BVC at the experimental doses had significant higher survival rates and better growth performance(indicated by greater weight gain(1.13–1.14 times),higher specific growth rate(1.04 times),and lower feed conversion ratio(0.88–0.89 times))compared to that of the control(P<0.05).Histological examination revealed significant longer villus(3.22–5.54 times),deeper crypt(1.77–1.87 times),and thicker muscle(1.59–3.17 times)in the intestines of large-scale loach fed with BVC(P<0.05).Furthermore,we found that the gut microflora consisted of significantly fewer proportions of potential pathogenic bacterial species(Aeromonas veronii and Escherichia coli),but significantly greater proportions of beneficial microbes(Lactococus raffinolactis and Faecalibacterium prausnitzii).Therefore,dietary intake of BVC can promote intestinal tract development and optimize gut microflora,by which the survival and growth of large-scale loach may be improved.
基金financially supported by the Scientific and Technological Development Program of Jilin Province(Grant No.20220201138GX)the Project for Self-innovation Ability Construction of Jilin Province Development and Reform Commission(Grant No.2021C026)the Project Supported by Graduate Innovation Fund of Jilin University。
文摘As one of the pentlandites,Fe5Ni4S8(FNS) based materials have attracted increasing attention due to their excellent catalytic properties and promising applicability.The control over the catalyst surface structure often benefits its heterogeneous catalytic activity.However,this has not been investigated for FNS materials at the nanoscale regarding the catalytic activity related to high-index facets.Herein,FNS nanoparticles(FNSNPs) with enclosed continuous tunable high-index facets were prepared and studied to clarify the relationship between the structure and catalytic functionality.The results suggested strong dependence between exposed facets of FNSNPs and their sizes.The decline in the average size to5.8 nm led to enclosing by high-index facets(422) and(511) to yield optimal electrocatalytic activities toward the hydrogen evolution reaction.The catalytic activity of FNSNPs was closely related to the surface energy of the main exposed facets.These findings clarified the relationship between high-index-facet and high-surface-energy FNSNPs,as promising approaches in crystal surface control engineering.
基金supported by the Nature Science Foundation of Hubei Province(No.2017CFB606).
文摘Objective Aberrant activating mutations in cyclin-dependent kinases 4 and 6(CDK4/6)are common in various cancers,including gastroesophageal malignancies.Although CDK4/6 inhibitors,such as abemaciclib and palbociclib,have been approved for breast cancer treatment,their effectiveness as a monotherapy remains limited for gastroesophageal tumors.The present study explored the underlying mechanism of abemaciclib resistance.Methods Abemaciclib-resistant gastric cancer cell lines were generated,and the phospho-eukaryotic translation initiation factor 4E(p-eIF4E)and eIF4E expression was compared between resistant and parental cell lines.In order to analyze the role of eIF4E in cell resistance,siRNA knockdown was employed.The effectiveness of ribavirin alone and its combination with abemaciclib was evaluated in the gastric cancer xenograft mouse model.Results The upregulation of eIF4E was a common feature in gastric cancer cells exposed to prolonged abemaciclib treatment.Gastric cancer cells with increased eIF4E levels exhibited a better response to eIF4E inhibition,especially those that were resistant to abemaciclib.Ribavirin,which is an approved anti-viral drug,significantly improved the efficacy of abemaciclib,both in vitro and in vivo,by inhibiting eIF4E.Importantly,ribavirin effectively suppressed the abemaciclib-resistant gastric cancer growth in mice without causing toxicity.Conclusion These findings suggest that targeting eIF4E can enhance the abemaciclib treatment for gastric cancer,proposing the potential combination therapy of CDK4/6 inhibitors with ribavirin for advanced gastric cancer.
基金supported by Shanghai Municipal Health Commission(Grant/Award No.20194Y0050).
文摘Background:LncRNA DLX6-AS1 has been uncovered to exert effects on various cancers.Nevertheless,the impacts of DLX6-AS1 on endometrial cancer(EC)development remained obscure.The study explored the influence of DLX6-AS1 on EC progression via the microRNA(miR)-374a-3p/zinc-finger protein(ZFX)axis.Methods:EC cell lines were collected and DLX6-AS1,miR-374a-3p,and ZFX levels in EC cell lines were detected.The EC cells were transfected with DLX6-AS1,miR-374a-3p,and ZFX constructs to examine the biological functions of EC cells.The xenograft model was established for detecting tumor growth.Rescue experiments were conducted to verify the interaction of DLX6-AS1,miR-374a-3p,and ZFX in EC cells.Results:DLX6-AS1 and ZFX levels were elevated,while miR-374a-3p exhibited a reduced level in EC cells.Silencing DLX6-AS1 and elevated miR-374a-3p expressions repressed the biological activities of EC cells.Reduced DLX6-AS1 repressed tumor development.MiR-374a-3p silencing reversed the impacts of DLX6-AS1 silencing,while ZFX overexpression abrogated the impacts of miR-374a-3p elevation on EC cell growth.Mechanically,DLX6-AS1 was found to bind to miR-374a-3p,and miR-374a-3p targeted ZFX.Conclusion:DLX6-AS1 depletion restricts the malignant phenotype of EC cells.The study might provide novel therapeutic biomarkers for EC treatment.
基金supported by National Natural Science Foundation of China(No.62101298)Collaborative Education Project between Industry and Academia,China(22050609312501)。
文摘60 GHz millimeter wave(mmWave)system provides extremely high time resolution and multipath components(MPC)separation and has great potential to achieve high precision in the indoor positioning.However,the ranging data is often contaminated by non-line-of-sight(NLOS)transmission.First,six features of 60GHz mm Wave signal under LOS and NLOS conditions are evaluated.Next,a classifier constructed by random forest(RF)algorithm is used to identify line-of-sight(LOS)or NLOS channel.The identification mechanism has excellent generalization performance and the classification accuracy is over 97%.Finally,based on the identification results,a residual weighted least squares positioning method is proposed.All ranging information including that under NLOS channels is fully utilized,positioning failure caused by insufficient LOS links can be avoided.Compared with the conventional least squares approach,the positioning error of the proposed algorithm is reduced by 49%.
基金supported by the National Key Research and Development Program of China(No.2018YFB1308702)the Graduate Education Innovation Program of Shanxi Provence(No.2020BY142)+1 种基金the National Natural Science Foundation of China(Nos.51905367,51905372,52105557)the Specipal Funding for Guiding Local Scientific and Technological Development of the Central(No.YDZX20191400002149).
文摘A fractional nonlinear system with power damping term is introduced to study the forced vibration system in order to solve the resonance and bifurcation problems between grinding wheel and steel bar during robot grinding.The robot,grinding wheel and steel bar are reduced to a spring-damping second-order system model.The implicit function equations of vibration amplitude of the dynamic system with coulomb friction damping,linear damping,square damping and cubic damping are obtained by average method.The stability of the system is analyzed and explained,and the stability condition of the system is proposed.Then,the amplitude-frequency characteristic curves of the system under different fractional differential orders,nonlinear stiffness parameters,fractional differential term coefficients and external excitation amplitude are analyzed.It is shown that the fractional differential term in the dynamic system is the damping characteristic.Then the influence of four kinds of damping on the vibration amplitude of the system under the same parameter is investigated and it is proved that the cubic damping suppresses the vibration of the system to the maximum extent.Finally,based on the idea that the equilibrium point of the system is the constant part of the Fourier series expansion term,the bifurcation behavior caused by the change of damping parameters in linear damping,square damping and cubic damping systems with different values of fractional differential order is investigated.
基金Supported by the Opening Project of Tunnel and Underground Engineering Research Center of Jiangsu Province (TERC) (2021-SDJJ-08).
文摘The treatment of wheat straw is very difficult,and its utilization rate is very low;accumulation causes air pollution and even fire.To make full use of wheat straw resources,we examined how using different physical and chemical methods to treat the wheat straw which can improve its strength abilities,or enhance the activity of wheat straw ash.In terms of concrete additives,it can reduce the amount of cement used.In this paper,we found that alkali treatment can significantly improve the tensile strength of wheat straw fiber,but polyvinyl alcohol treatment has no obvious effect on the strength of wheat straw fiber after alkali treatment.At the same time,we analyzed the wheat straw fiber microstructure through scanning electron microscopy,and we also studied the wheat straw ash chemical composition after 600℃ high-temperature treatment.Through the compressive strength test,we found that the strength of concrete decreases with increasing of wheat straw fiber and wheat straw powder content,and the compressive strength of concrete with wheat straw ash instead of 5%cement decreases little,and the strength of the concrete also decreases with the increasing of wheat straw ash.Through the macroscopic observation of the failure form of concrete,we found that the failure form of concrete with wheat straw ash is similar to that of common concrete,while the failure degree of concrete with wheat straw fiber and wheat straw powder is weakened.Through the scanning electron microscope test of the concrete,it was found that wheat straw fiber has an effect on the cracking of concrete and the inner compactness of concrete can also be affected by adding wheat straw ash and wheat straw powder.
基金This work was supported by grants from the National Natural Science Foundation of China(U2003122)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(2019QZKK0502).Sequencing service was provided by Bioyi Biotechnology Co.,Ltd.Wuhan,China。
文摘Dear Editor,Understanding the evolution and survival mechanisms of endangered wild medicinal herbs is crucial for their cultivation,utilization,and conservation.The snow lotus species Saussurea involucrata(Kar.&Kir.)Sch.Bip.(2n=32)(i.e.the well-known Tianshan snow lotus)which belongs to the eudicot family Asteraceae,is a famous traditional Chinese medicinal herb having anti-inflammatory.
基金Supported by Natural Science Research Project of Colleges and Universities in Anhui Province(KJ2019A1110,KJ2020A0863)Innovation Team Research Fund Project of Anhui Medical College(WJH202007t,WJH202008t)2021 Anhui Provincial Production-Education Integration Training Base Project for Quality Engineering(2021cjrh020).
文摘[Objectives] To investigate the role of Eriocalyxin B (EriB) in promoting colon cancer cell apoptosis through ERK1/2 pathway in vitro, and to provide a natural candidate drug for colon cancer treatment. [Methods] Colon cancer cells treated with different concentrations of EriB were detected by CCK-8 assay;cell scratch assay and crystal violet staining were used to detect the invasion and migration of colon cancer cell;cell apoptosis was detected by Annexin V/PI double staining, and cell cycle was detected by PI staining;Western Blotting was used to detect epithelial-mesenchymal transition and apoptosis-related proteins in colon cancer cells treated with EriB. [Results] After EriB treatment, the proliferation, migration and apoptosis of colon cancer cells were significantly inhibited, and the ratio of P-ERK1/2 to ERK was significantly decreased. [Conclusions] EriB can effectively inhibit the proliferation of colon cancer cells and promote the apoptosis of colon cancer cells through ERK1/2 pathway.
