In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycl...In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater.A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nanoscale or microscale.Under optimal conditions(pH=4,t=8 h,β-CD:NaAlg=9,adsorbent dosage = 1.5 g·L-1),the maximum removal rate of β-CD/NaAlg to tetracycline was 70%.The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model(R2=0.9977) and the pseudo-second-order kinetic model(R^(2)=0.9993).Moreover,the adsorbent still removed 55.3% of tetracycline after five cycles.Specially,the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater,and the removal rate of tetracycline reached 78.9% within 2 h.The existence of Cr(Ⅵ) had a negligible impact on tetracycline removal,while the presence of humic acid exhibited a promoting effect.The possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory analysis.In summary,β-CD/NaAlg represents an environmentally friendly,efficient,and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.展开更多
BACKGROUND This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome(AS)following coronavirus disease 2019(COVID-19)in a 33-year-old man diagnosed with Klinefelter syndrome(KS...BACKGROUND This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome(AS)following coronavirus disease 2019(COVID-19)in a 33-year-old man diagnosed with Klinefelter syndrome(KS).CASE SUMMARY A 33-year-old man with a diagnosis of KS was admitted to the Department of Pulmonary and Critical Care Medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of COVID-19.Computed tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs,accompanied by signs of partial bronchial inflation.Metagenomic next-generation sequencing of the bronchoalveolar lavage fluid suggested absence of pathogen.A biopsy specimen revealed organizing pneumonia with alveolar septal thickening.Additionally,extensive auto-antibody tests showed strong positivity for anti-SSA,anti-SSB,anti-Jo-1,and anti-Ro-52.Following multidisciplinary discussions,the patient received a final diagnosis of AS,leading to rapidly progressing respiratory failure.CONCLUSION This study underscores the clinical progression of AS-associated interstitial lung disease subsequent to viral infections such as COVID-19 in patients diagnosed with KS.展开更多
Groundwater serves as an important water source for residents in and around mining areas.To achieve scientific planning and efficient utilization of water resources in mining areas,it is essential to figure out the ch...Groundwater serves as an important water source for residents in and around mining areas.To achieve scientific planning and efficient utilization of water resources in mining areas,it is essential to figure out the chemical formation process and the ground water sulfur cycle that transpire after the coal mining activities.Based on studies of hydrochemistry and D,^(18)O-H_(2)O,^(34)S-SO_(4)isotopes,this study applied principal component analysis,ion ratio and other methods in its attempts to reveal the hydrogeochemical action and sulfur cycle in the subsidence area of Pingyu mining area.The study discovered that,in the studied area,precipitation provides the major supply of groundwater and the main water chemistry effects are dominated by oxidation dissolution of sulfide minerals as well as the dissolution of carbonate and silicate rocks.The sulfate in groundwater primarily originates from oxidation and dissolution of sulfide minerals in coal-bearing strata and human activities.The mixed sulfate formed by the oxidation of sulfide minerals and by human activities continuously recharges the groundwater,promoting the dissolution of carbonate rock and silicate rock in the process.展开更多
背景与目的癌痛严重影响患者体力活动、心理状态以及生活质量,甚至缩短患者生存时间,合理规范应用阿片类药物可有效控制癌痛。肺癌患者癌痛发病率高,需分析肺癌患者阿片类药物应用现状,以评估肺癌患者阿片类药物应用的合理性。方法回顾...背景与目的癌痛严重影响患者体力活动、心理状态以及生活质量,甚至缩短患者生存时间,合理规范应用阿片类药物可有效控制癌痛。肺癌患者癌痛发病率高,需分析肺癌患者阿片类药物应用现状,以评估肺癌患者阿片类药物应用的合理性。方法回顾性分析2018年6月-2019年6月北京协和医院呼吸与危重症医学科肺癌住院患者的临床资料,分析305例应用阿片类药物的肺癌癌痛患者的临床信息和用药信息。结果应用阿片类药物的肺癌患者影响因素分析中,年龄与阿片药物应用种类为主要影响因素。男性比例高于女性,且男性患者应用阿片药物种类多、年龄多集中在60岁-69岁之间。我院肺癌患者应用阿片类药物品种和结构符合要求,用药频率最高的为羟考酮缓释片,限定日费用(defined daily cost,DDC)排名第一位同时序号比为1,同步性好。吗啡片和吗啡注射液用量低,肺癌患者整体爆发痛(breakthrough cancer pain,BTcP)控制良好。阿片类药物整体应用合理(93.4%),不合理项目主要为爆发痛处置和用药频率不合理以及超剂量问题。结论应用阿片类药物的肺癌癌痛患者多为男性,老年男性癌痛更难于控制,需要加强关注。我院肺癌患者阿片类药物整体应用合理,但仍需关注BTcP处置、阿片类药物用药剂量和特殊人群用药等问题。展开更多
Transforming growth factor-β （TGF-β） binds with two transmembrane serine/threonine kinase receptors, type Ⅱ （TβRII） and type Ⅰ receptors （TβRⅠ）, and one accessory receptor, type Ⅲ receptor （TβRⅢ）, to...Transforming growth factor-β （TGF-β） binds with two transmembrane serine/threonine kinase receptors, type Ⅱ （TβRII） and type Ⅰ receptors （TβRⅠ）, and one accessory receptor, type Ⅲ receptor （TβRⅢ）, to transduce signals across cell membranes. Previous biochemical studies suggested that TβRI and TβRIII are preexisted homo-dimers. Using single-molecule microscopy to image green fluorescent protein-labeled membrane proteins, for the first time we have demonstrated that TβRI and TβRⅢ could exist as monomers at a low expression level. Upon TGF-β1 stimu- lation, TβRI follows the general ligand-induced receptor dimerization model for activation, but this process is TβRⅡ- dependent. The monomeric status of the non-kinase receptor TβRⅢ is unchanged in the presence of TGF-β1. With the increase of receptor expression, both TβRI and TβRIII can be assembled into dimers on cell surfaces.展开更多
BACKGROUND The prevalence of depression in patients with chronic obstructive pulmonary disease(COPD)ranges from 10%to 42%,but the diagnosis of depression in patients with COPD is often unrecognized and untreated.Unrec...BACKGROUND The prevalence of depression in patients with chronic obstructive pulmonary disease(COPD)ranges from 10%to 42%,but the diagnosis of depression in patients with COPD is often unrecognized and untreated.Unrecognized depression has major implications for compliance with medical treatment,prolonged lengths of stay,increased frequency of hospital admissions,and increased consultations with primary care physicians.Many studies have attempted to identify risk factors for progression,prognosis and response to therapy in patients with depression.However,few studies have examined the risk factors for depression in patients with COPD,and some results remain controversial.AIM To identify the potential risk factors to define patients with COPD who are at“high risk”of depression.METHODS The clinical data of 293 patients with COPD were reviewed from January 2017 to December 2018.The correlations between demographics,clinical characteristics and depression were analyzed.The risk factors for depression in patients with COPD were identified by multivariate logistic regression analysis.The cutoff value,sensitivity and specificity of the independent correlation factors were calculated with a receiver operating characteristic curve.RESULTS Of the 293 patients included,65(22.18%)individuals were identified to have depression.Significant differences were detected between patients with and without depression in terms of body mass index(BMI),forced expiratory volume in 1 s(FEV1),and COPD assessment test(CAT)score(all P<0.05).Low BMI,low FEV1,and high CAT were independent risk factors for depression in patients with COPD and the cutoff values of BMI,FEV1,and CAT scores were 21.373 kg/m2,0.855 L and 12.5,respectively.CONCLUSION Low BMI,low FEV1,and high CAT score were identified as independent risk factors for depression in patients with COPD.展开更多
Chang＇e-3 （CE-3） landed on the Mare Imbrium basin in the east part of Sinus Iridum （19.51°W, 44.12°N）, which was China＇s first soft landing on the Moon and it started collecting data on the lunar surfa...Chang＇e-3 （CE-3） landed on the Mare Imbrium basin in the east part of Sinus Iridum （19.51°W, 44.12°N）, which was China＇s first soft landing on the Moon and it started collecting data on the lunar surface environment. To better understand the environment of this region, this paper utilizes the available high-resolution topography data, image data and geological data to carry out a detailed analysis and research on the area surrounding the landing site （Sinus Iridum and 45 km×70 km of the landing area） as well as on the topography, landform, geology and lunar dust of the area surrounding the landing site. A general topographic analysis of the surrounding area is based on a digital elevation model and digital elevation model data acquired by Chang＇e-2 that have high resolution; the geology analysis is based on lunar geological data published by USGS; the study on topographic factors and distribution of craters and rocks in the surrounding area covering 4km^4km or even smaller is based on images from the CE-3 landing camera and images from the topographic camera; an analysis is done of the effect of the CE-3 engine plume on the lunar surface by comparing images before and after the landing using data from the landing camera. A comprehensive analysis of the results shows that the landing site and its surrounding area are identified as typical lunar mare with flat topography. They are suitable for maneuvers by the rover, and are rich in geological phenomena and scientific targets, making it an ideal site for exploration.展开更多
This paper introduces a new method of small lunar craters’ automatic identification, using digital orthophoto map(DOM) data. The core of the approach is the fact that the lunar exploration DOM data reveal contrasting...This paper introduces a new method of small lunar craters’ automatic identification, using digital orthophoto map(DOM) data. The core of the approach is the fact that the lunar exploration DOM data reveal contrasting highlight and shadow characteristics of small craters under sunlight irradiation. This research effort combines image processing and mathematical modeling. Overall it proposes a new planetary data processing approach, to segment and extract the highlight and shadow regions of small craters,using the image gray frequency(IGF) statistical method.IGF can also be applied to identify the coupling relationships between small craters’ shape and their relative features. This paper presents the highlight and shadow pair matching(HSPM) model which manages to perform highprecision automatic recognition of small lunar craters.Testing was performed using the DOM data of Chang’E-2(CE-2). The results have shown that the proposed method has a high level of successful detection rate. The proposed methodology that uses DOM data can complement the drawbacks of the digital elevation model(DEM) that has a relatively high false detection rate. A hybrid fusion model(FUM) that combines both DOM and DEM data, was carried out to simultaneously identify small, medium, and large-sized craters. It has been proven that the FUM generally shows stronger recognition ability compared to previous approaches and it can be adapted for high precision identification of craters on the whole lunar surface.The results meet the requirements for a reliable and accurate exploration of the Moon and the planets.展开更多
The Moon-based Ultraviolet Telescope （MUVT） is one of the payloads on the Chang＇e-3 （CE-3） lunar lander. Because of the advantages of having no at- mospheric disturbances and the slow rotation of the Moon, we can...The Moon-based Ultraviolet Telescope （MUVT） is one of the payloads on the Chang＇e-3 （CE-3） lunar lander. Because of the advantages of having no at- mospheric disturbances and the slow rotation of the Moon, we can make long-term continuous observations of a series of important celestial objects in the near ultra- violet band （245-340 nm）, and perform a sky survey of selected areas, which can- not be completed on Earth. We can find characteristic changes in celestial brightness with time by analyzing image data from the MUVT, and deduce the radiation mech- anism and physical properties of these celestial objects after comparing with a phys- ical model. In order to explain the scientific purposes of MUVT, this article analyzes the preprocessing of MUVT image data and makes a preliminary evaluation of data quality. The results demonstrate that the methods used for data collection and prepro- cessing are effective, and the Level 2A and 2B image data satisfy the requirements of follow-up scientific researches.展开更多
The Chang＇e-3 Visible and Near-infrared Imaging Spectrometer （VNIS） is one of the four payloads on the Yutu rover. After traversing the landing site during the first two lunar days, four different areas are detecte...The Chang＇e-3 Visible and Near-infrared Imaging Spectrometer （VNIS） is one of the four payloads on the Yutu rover. After traversing the landing site during the first two lunar days, four different areas are detected, and Level 2A and 2B ra- diance data have been released to the scientific community. The released data have been processed by dark current subtraction, correction for the effect of temperature, radiometric calibration and geometric calibration. We emphasize approaches for re- flectance analysis and mineral identification for in-situ analysis with VNIS. Then the preliminary spectral and mineralogical results from the landing site are derived. After comparing spectral data from VNIS with data collected by the Ma instrument and samples of mare that were returned from the Apollo program, all the reflectance data have been found to have similar absorption features near 1000 nm except lunar sample 71061. In addition, there is also a weak absorption feature between 1750-2400nm on VNIS, but the slopes of VNIS and Ma reflectance at longer wavelengths are lower than data taken from samples of lunar mare. Spectral parameters such as Band Centers and Integrated Band Depth Ratios are used to analyze mineralogical features. The results show that detection points E and N205 are mixtures of high-Ca pyroxene and olivine, and the composition of olivineat point N205 is higher than that at point E, but the compositions of detection points S3 and N203 are mainly olivine-rich. Since there are no obvious absorption features near 1250 nm, plagioclase is not directly identified at the landing site.展开更多
The Extreme Ultraviolet Camera （EUVC） onboard the Chang＇e-3 （CE-3） lander is used to observe the structure and dynamics of Earth＇s plasmasphere from the Moon. By detecting the resonance line emission of helium i...The Extreme Ultraviolet Camera （EUVC） onboard the Chang＇e-3 （CE-3） lander is used to observe the structure and dynamics of Earth＇s plasmasphere from the Moon. By detecting the resonance line emission of helium ions （He＋） at 30.4 nm, the EUVC images the entire plasmasphere with a time resolution of 10 min and a spatial resolution of about 0.1 Earth radius （RE） in a single frame. We first present details about the data processing from EUVC and the data acquisition in the commissioning phase, and then report some initial results, which reflect the basic features of the plas- masphere well. The photon count and emission intensity of EUVC are consistent with previous observations and models, which indicate that the EUVC works normally and can provide high quality data for future studies.展开更多
The Active Particle-induced X-ray Spectrometer （APXS） is an important payload mounted on the Yutu rover, which is part of the Chang＇e-3 mission. The sci- entific objective of APXS is to perform in-situ analysis of ...The Active Particle-induced X-ray Spectrometer （APXS） is an important payload mounted on the Yutu rover, which is part of the Chang＇e-3 mission. The sci- entific objective of APXS is to perform in-situ analysis of the chemical composition of lunar soil and rock samples. The radioactive sources, 55Fe and 109Cd, decay and produce a-particles and X-rays. When X-rays and a-particles interact with atoms in the surface material, they knock electrons out of their orbits, which release energy by emitting X-rays that can be measured by a silicon drift detector （SDD）. The elements and their concentrations can be determined by analyzing their peak energies and in- tensities. APXS has analyzed both the calibration target and lunar soil once during the first lunar day and again during the second lunar day. The total detection time lasted about 266 min and more than 2000 frames of data records have been acquired. APXS has three operating modes： calibration mode, distance sensing mode and detection mode. In detection mode, work distance can be calculated from the X-ray counting rate collected by SDD. Correction for the effect of temperature has been performed to convert the channel number for each spectrum to X-ray energy. Dead time correction is used to eliminate the systematic error in quantifying the activity of an X-ray pulse in a sample and derive the real count rate. We report APXS data and initial results during the first and second lunar days for the Yutu rover. In this study, we analyze the data from the calibration target and lunar soil on the first lunar day. Seven major elements, including Mg, A1, Si, K, Ca, Ti and Fe, have been identified. Comparing the peak areas and ratios of calibration basalt and lunar soil the landing site was found to be depleted in K, and have lower Mg and A1 but higher Ca, Ti, and Fe. In the future, we will obtain the elemental concentrations of lunar soil at the Chang＇e-3 landing site using APXS data.展开更多
The Chang＇e-3 （CE-3） mission is China＇s first exploration mission on the surface of the Moon that uses a lander and a rover. Eight instruments that form the scientific payloads have the following objectives： （1...The Chang＇e-3 （CE-3） mission is China＇s first exploration mission on the surface of the Moon that uses a lander and a rover. Eight instruments that form the scientific payloads have the following objectives： （1） investigate the morphological features and geological structures at the landing site; （2） integrated in-situ analysis of minerals and chemical compositions; （3） integrated exploration of the structure of the lunar interior; （4） exploration of the lunar-terrestrial space environment, lunar sur- face environment and acquire Moon-based ultraviolet astronomical observations. The Ground Research and Application System （GRAS） is in charge of data acquisition and pre-processing, management of the payload in orbit, and managing the data products and their applications. The Data Pre-processing Subsystem （DPS） is a part of GRAS. The task of DPS is the pre-processing of raw data from the eight instruments that are part of CE-3, including channel processing, unpacking, package sorting, calibration and correction, identification of geographical location, calculation of probe azimuth angle, probe zenith angle, solar azimuth angle, and solar zenith angle and so on, and conducting quality checks. These processes produce Level 0, Level 1 and Level 2 data. The computing platform of this subsystem is comprised of a high-performance computing cluster, including a real-time subsystem used for processing Level 0 data and a post-time subsystem for generating Level 1 and Level 2 data. This paper de- scribes the CE-3 data pre-processing method, the data pre-processing subsystem, data classification, data validity and data products that are used for scientific studies.展开更多
Developing highly efficient platinum‐group‐metal‐free electrocatalysts towards hydrogen oxidation reaction(HOR)under alkaline electrolyte is critical for the development of alkaline exchange member fuel cells.Herei...Developing highly efficient platinum‐group‐metal‐free electrocatalysts towards hydrogen oxidation reaction(HOR)under alkaline electrolyte is critical for the development of alkaline exchange member fuel cells.Herein,we reported the synthesis of boron doped Ni electrocatalyst(B‐Ni/C)and its remarkable alkaline HOR performance,with a 10‐fold mass activity enhancement compared with that of undoped Ni catalyst.Experimental results and density functional theory calculations indicate the d‐p hybridization between the p orbital of B and the d orbital of Ni via B‐doping could lead to promoted OH adsorption and optimized hydrogen binding energy on Ni surface,which together with the reduced formation energy of water species,contributes to the enhanced HOR performance under alkaline electrolyte.展开更多
Nomenclatures for lunar features always accompany the progresses of human lunar exploration,which has an important dual meaning in culture and science. The naming of lunar features not only can commemorate the outstan...Nomenclatures for lunar features always accompany the progresses of human lunar exploration,which has an important dual meaning in culture and science. The naming of lunar features not only can commemorate the outstanding contributions of academics,masters in various fields, and popularize the traditional cultures of ethnic groups all over the world, but also have a critical function of providing accurate indicative information on features with special morphology, origin, nature and scientific value. However, nomenclature for features at the Chang'e-3 landing site, which has a more arbitrary form without many constrains posed by a uniformed system, is unlike the features for other morphological units.This paper originated from the actual needs for the description of scientific exploration activities, interpretation of scientific research and dissemination of scientific results. Some prominent morphological units with great scientific importance and identification purpose were chosen from the images taken by the terrain camera, panorama cameras and landing camera onboard the Chang'e lander and Yutu rover. A nomenclature system was established under the three enclosures, four quadrants and twenty-eight lunar lodges' system of the Chinese ancient sky division method. Finally, a standard feature names set waspublished after some necessary approval procedures by the International Astronomical Union.展开更多
Anomaly detection has practical significance for finding unusual patterns in time series.However,most existing algorithms may lose some important information in time series presentation and have high time complexity.A...Anomaly detection has practical significance for finding unusual patterns in time series.However,most existing algorithms may lose some important information in time series presentation and have high time complexity.Another problem is that privacy-preserving was not taken into account in these algorithms.In this paper,we propose a new data structure named Interval Hash Table(IHTable)to capture more original information of time series and design a fast anomaly detection algorithm based on Interval Hash Table(ADIHT).The key insight of ADIHT is distributions of normal subsequences are always similar while distributions of anomaly subsequences are different and random by contrast.Furthermore,to make our proposed algorithm fit for anomaly detection under multiple participation,we propose a privacy-preserving anomaly detection scheme named OP-ADIHT based on ADIHT and homomorphic encryption.Compared with existing anomaly detection schemes with privacy-preserving,OP-ADIHT needs less communication cost and calculation cost.Security analysis of different circumstances also shows that OP-ADIHT will not leak the privacy information of participants.Extensive experiments results show that ADIHT can outperform most anomaly detection algorithms and perform close to the best results in terms of AUC-ROC,and ADIHT needs the least time.展开更多
We provide an investigation of the spectroscopic factor of resonance states in A=5-8 nuclei,utilizing the Gamow shell model(GSM).Within the GSM,the configuration mixing is taken into account exactly with the shell mod...We provide an investigation of the spectroscopic factor of resonance states in A=5-8 nuclei,utilizing the Gamow shell model(GSM).Within the GSM,the configuration mixing is taken into account exactly with the shell model framework,and the continuum coupling is addressed via the complex-energy Berggren ensemble,which treats bound,resonance,and non-resonant continuum single-particle states on an equal footing.As a result,both the configuration mixing and continuum coupling are meticulously considered in the GSM.We first calculate the low-lying states of helium isotopes and isotones with the GSM,and the results are compared with that of ab initio no-core shell model(NCSM)calculations.The results indicate that GSM can reproduce the low-lying resonance states more accurately than the NCSM.Following this,we delve into the spectroscopic factors of the resonance states as computed through both GSM and NCSM,concurrently conducting systematic calculations of overlap functions pertinent to these resonance states.Finally,the calculated overlap function and spectroscopic factor of6He(01+)■νp3/2→^(7)He(3/2_(1)-)with GSM are compared with the results from ab initio NCSM,variational Monte Carlo,and Green’s function Monte Carlo calculations,as well as available experimental data.The results assert that wave function asymptotes can only be reproduced in GSM,where resonance and continuum coupling are precisely addressed.展开更多
Fe-N-C materials have received increasing attention,due to its distinctive catalytic activity.However,the Fe-N coordination number dependence of catalytic ability and mechanism for H_(2)O_(2)activation remain elusive....Fe-N-C materials have received increasing attention,due to its distinctive catalytic activity.However,the Fe-N coordination number dependence of catalytic ability and mechanism for H_(2)O_(2)activation remain elusive.Herein,a series of Fe-N-C heterogeneous Fenton-like catalysts with different Fe-N coordination number were prepared for tetracycline degradation.The results demonstrated that samples with Fe-N4 structure exhibited high activity.The excellent performance was mainly ascribed to the high adsorption capacity and the formation of superoxide radicals(•O_(2)^(−))catalyzed by Fe linked to pyridinic nitrogen.The intermediates and degradation pathways of tetracycline degradation by Fe-N-C/H_(2)O_(2)system were analyzed by liquid chromatography coupled to tandem mass spectrometry(LC-MS/MS).Furthermore,we applied our Fe-N-C catalysts to treat simulated pharmaceutical wastewater with high tetracycline degradation capacity despite high concentrations of organic matter such as oxalic acid and various ionic interferences.Our work reveals the dependence of the activation H_(2)O_(2)on the Fe-N coordination environment and the degradation mechanism of these catalysts.It provides insights into the prospects for tuning the catalyst in practical applications.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC3801101)National Natural Science Foundation of China(52170028)+1 种基金the State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology(2023DX11)National Engineering Research Center for Safe Sludge Disposal and Resource Recovery(2021A003).
文摘In this work,a novel composite material based on β-cyclodextrin-immobilized sodium alginate aerogel(β-CD/NaAlg) was developed utilizing cross-linker of epichlorohydrin and applied as an adsorbent to remove tetracycline antibiotics from reclaimed wastewater.A series of characterizations were utilized to confirm the successful synthesis of the adsorbent and this β-CD/NaAlg presented a three-dimensional network at the nanoscale or microscale.Under optimal conditions(pH=4,t=8 h,β-CD:NaAlg=9,adsorbent dosage = 1.5 g·L-1),the maximum removal rate of β-CD/NaAlg to tetracycline was 70%.The adsorption behavior of tetracycline on β-CD/NaAlg conformed to the Freundlich isotherm model(R2=0.9977) and the pseudo-second-order kinetic model(R^(2)=0.9993).Moreover,the adsorbent still removed 55.3% of tetracycline after five cycles.Specially,the adsorbent was integrated with ultrafiltration to adsorb tetracycline antibiotics from simulated reclaimed wastewater,and the removal rate of tetracycline reached 78.9% within 2 h.The existence of Cr(Ⅵ) had a negligible impact on tetracycline removal,while the presence of humic acid exhibited a promoting effect.The possible adsorption mechanisms were also elucidated through X-ray photoelectron spectroscopy and density functional theory analysis.In summary,β-CD/NaAlg represents an environmentally friendly,efficient,and sustainable adsorbent for removing tetracycline antibiotics from reclaimed water.
基金Supported by the Natural Science Foundation of Jiangxi Province,No.20202BAB206002 and No.20224BAB216084.
文摘BACKGROUND This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome(AS)following coronavirus disease 2019(COVID-19)in a 33-year-old man diagnosed with Klinefelter syndrome(KS).CASE SUMMARY A 33-year-old man with a diagnosis of KS was admitted to the Department of Pulmonary and Critical Care Medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of COVID-19.Computed tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs,accompanied by signs of partial bronchial inflation.Metagenomic next-generation sequencing of the bronchoalveolar lavage fluid suggested absence of pathogen.A biopsy specimen revealed organizing pneumonia with alveolar septal thickening.Additionally,extensive auto-antibody tests showed strong positivity for anti-SSA,anti-SSB,anti-Jo-1,and anti-Ro-52.Following multidisciplinary discussions,the patient received a final diagnosis of AS,leading to rapidly progressing respiratory failure.CONCLUSION This study underscores the clinical progression of AS-associated interstitial lung disease subsequent to viral infections such as COVID-19 in patients diagnosed with KS.
基金supported by Geological Research Project of the Construction Management Bureau of the Middle Route of the South to North Water Diversion Project(ZXJ/HN/YW/GC-2020037)。
文摘Groundwater serves as an important water source for residents in and around mining areas.To achieve scientific planning and efficient utilization of water resources in mining areas,it is essential to figure out the chemical formation process and the ground water sulfur cycle that transpire after the coal mining activities.Based on studies of hydrochemistry and D,^(18)O-H_(2)O,^(34)S-SO_(4)isotopes,this study applied principal component analysis,ion ratio and other methods in its attempts to reveal the hydrogeochemical action and sulfur cycle in the subsidence area of Pingyu mining area.The study discovered that,in the studied area,precipitation provides the major supply of groundwater and the main water chemistry effects are dominated by oxidation dissolution of sulfide minerals as well as the dissolution of carbonate and silicate rocks.The sulfate in groundwater primarily originates from oxidation and dissolution of sulfide minerals in coal-bearing strata and human activities.The mixed sulfate formed by the oxidation of sulfide minerals and by human activities continuously recharges the groundwater,promoting the dissolution of carbonate rock and silicate rock in the process.
文摘背景与目的癌痛严重影响患者体力活动、心理状态以及生活质量,甚至缩短患者生存时间,合理规范应用阿片类药物可有效控制癌痛。肺癌患者癌痛发病率高,需分析肺癌患者阿片类药物应用现状,以评估肺癌患者阿片类药物应用的合理性。方法回顾性分析2018年6月-2019年6月北京协和医院呼吸与危重症医学科肺癌住院患者的临床资料,分析305例应用阿片类药物的肺癌癌痛患者的临床信息和用药信息。结果应用阿片类药物的肺癌患者影响因素分析中,年龄与阿片药物应用种类为主要影响因素。男性比例高于女性,且男性患者应用阿片药物种类多、年龄多集中在60岁-69岁之间。我院肺癌患者应用阿片类药物品种和结构符合要求,用药频率最高的为羟考酮缓释片,限定日费用(defined daily cost,DDC)排名第一位同时序号比为1,同步性好。吗啡片和吗啡注射液用量低,肺癌患者整体爆发痛(breakthrough cancer pain,BTcP)控制良好。阿片类药物整体应用合理(93.4%),不合理项目主要为爆发痛处置和用药频率不合理以及超剂量问题。结论应用阿片类药物的肺癌癌痛患者多为男性,老年男性癌痛更难于控制,需要加强关注。我院肺癌患者阿片类药物整体应用合理,但仍需关注BTcP处置、阿片类药物用药剂量和特殊人群用药等问题。
基金This work was supported by the National Natural Science Foundation of China （90713024, 20821003, 30921004）, the National Basic Research Program of China （2007CB935601, 2010CB833706） and the Chinese Academy of Sciences.
文摘Transforming growth factor-β （TGF-β） binds with two transmembrane serine/threonine kinase receptors, type Ⅱ （TβRII） and type Ⅰ receptors （TβRⅠ）, and one accessory receptor, type Ⅲ receptor （TβRⅢ）, to transduce signals across cell membranes. Previous biochemical studies suggested that TβRI and TβRIII are preexisted homo-dimers. Using single-molecule microscopy to image green fluorescent protein-labeled membrane proteins, for the first time we have demonstrated that TβRI and TβRⅢ could exist as monomers at a low expression level. Upon TGF-β1 stimu- lation, TβRI follows the general ligand-induced receptor dimerization model for activation, but this process is TβRⅡ- dependent. The monomeric status of the non-kinase receptor TβRⅢ is unchanged in the presence of TGF-β1. With the increase of receptor expression, both TβRI and TβRIII can be assembled into dimers on cell surfaces.
基金Supported by Horizontal Projects of National Key Research and Development Plan Projects,No.1210053010.
文摘BACKGROUND The prevalence of depression in patients with chronic obstructive pulmonary disease(COPD)ranges from 10%to 42%,but the diagnosis of depression in patients with COPD is often unrecognized and untreated.Unrecognized depression has major implications for compliance with medical treatment,prolonged lengths of stay,increased frequency of hospital admissions,and increased consultations with primary care physicians.Many studies have attempted to identify risk factors for progression,prognosis and response to therapy in patients with depression.However,few studies have examined the risk factors for depression in patients with COPD,and some results remain controversial.AIM To identify the potential risk factors to define patients with COPD who are at“high risk”of depression.METHODS The clinical data of 293 patients with COPD were reviewed from January 2017 to December 2018.The correlations between demographics,clinical characteristics and depression were analyzed.The risk factors for depression in patients with COPD were identified by multivariate logistic regression analysis.The cutoff value,sensitivity and specificity of the independent correlation factors were calculated with a receiver operating characteristic curve.RESULTS Of the 293 patients included,65(22.18%)individuals were identified to have depression.Significant differences were detected between patients with and without depression in terms of body mass index(BMI),forced expiratory volume in 1 s(FEV1),and COPD assessment test(CAT)score(all P<0.05).Low BMI,low FEV1,and high CAT were independent risk factors for depression in patients with COPD and the cutoff values of BMI,FEV1,and CAT scores were 21.373 kg/m2,0.855 L and 12.5,respectively.CONCLUSION Low BMI,low FEV1,and high CAT score were identified as independent risk factors for depression in patients with COPD.
基金Supported by the National Natural Science Foundation of China
文摘Chang＇e-3 （CE-3） landed on the Mare Imbrium basin in the east part of Sinus Iridum （19.51°W, 44.12°N）, which was China＇s first soft landing on the Moon and it started collecting data on the lunar surface environment. To better understand the environment of this region, this paper utilizes the available high-resolution topography data, image data and geological data to carry out a detailed analysis and research on the area surrounding the landing site （Sinus Iridum and 45 km×70 km of the landing area） as well as on the topography, landform, geology and lunar dust of the area surrounding the landing site. A general topographic analysis of the surrounding area is based on a digital elevation model and digital elevation model data acquired by Chang＇e-2 that have high resolution; the geology analysis is based on lunar geological data published by USGS; the study on topographic factors and distribution of craters and rocks in the surrounding area covering 4km^4km or even smaller is based on images from the CE-3 landing camera and images from the topographic camera; an analysis is done of the effect of the CE-3 engine plume on the lunar surface by comparing images before and after the landing using data from the landing camera. A comprehensive analysis of the results shows that the landing site and its surrounding area are identified as typical lunar mare with flat topography. They are suitable for maneuvers by the rover, and are rich in geological phenomena and scientific targets, making it an ideal site for exploration.
基金Funding was provided by National Major Projects-GRAS Construction of China Lunar Exploration Project and Nation Science Foundation Project (No. 41671458)
文摘This paper introduces a new method of small lunar craters’ automatic identification, using digital orthophoto map(DOM) data. The core of the approach is the fact that the lunar exploration DOM data reveal contrasting highlight and shadow characteristics of small craters under sunlight irradiation. This research effort combines image processing and mathematical modeling. Overall it proposes a new planetary data processing approach, to segment and extract the highlight and shadow regions of small craters,using the image gray frequency(IGF) statistical method.IGF can also be applied to identify the coupling relationships between small craters’ shape and their relative features. This paper presents the highlight and shadow pair matching(HSPM) model which manages to perform highprecision automatic recognition of small lunar craters.Testing was performed using the DOM data of Chang’E-2(CE-2). The results have shown that the proposed method has a high level of successful detection rate. The proposed methodology that uses DOM data can complement the drawbacks of the digital elevation model(DEM) that has a relatively high false detection rate. A hybrid fusion model(FUM) that combines both DOM and DEM data, was carried out to simultaneously identify small, medium, and large-sized craters. It has been proven that the FUM generally shows stronger recognition ability compared to previous approaches and it can be adapted for high precision identification of craters on the whole lunar surface.The results meet the requirements for a reliable and accurate exploration of the Moon and the planets.
文摘The Moon-based Ultraviolet Telescope （MUVT） is one of the payloads on the Chang＇e-3 （CE-3） lunar lander. Because of the advantages of having no at- mospheric disturbances and the slow rotation of the Moon, we can make long-term continuous observations of a series of important celestial objects in the near ultra- violet band （245-340 nm）, and perform a sky survey of selected areas, which can- not be completed on Earth. We can find characteristic changes in celestial brightness with time by analyzing image data from the MUVT, and deduce the radiation mech- anism and physical properties of these celestial objects after comparing with a phys- ical model. In order to explain the scientific purposes of MUVT, this article analyzes the preprocessing of MUVT image data and makes a preliminary evaluation of data quality. The results demonstrate that the methods used for data collection and prepro- cessing are effective, and the Level 2A and 2B image data satisfy the requirements of follow-up scientific researches.
基金Supported by the National Natural Science Foundation of China
文摘The Chang＇e-3 Visible and Near-infrared Imaging Spectrometer （VNIS） is one of the four payloads on the Yutu rover. After traversing the landing site during the first two lunar days, four different areas are detected, and Level 2A and 2B ra- diance data have been released to the scientific community. The released data have been processed by dark current subtraction, correction for the effect of temperature, radiometric calibration and geometric calibration. We emphasize approaches for re- flectance analysis and mineral identification for in-situ analysis with VNIS. Then the preliminary spectral and mineralogical results from the landing site are derived. After comparing spectral data from VNIS with data collected by the Ma instrument and samples of mare that were returned from the Apollo program, all the reflectance data have been found to have similar absorption features near 1000 nm except lunar sample 71061. In addition, there is also a weak absorption feature between 1750-2400nm on VNIS, but the slopes of VNIS and Ma reflectance at longer wavelengths are lower than data taken from samples of lunar mare. Spectral parameters such as Band Centers and Integrated Band Depth Ratios are used to analyze mineralogical features. The results show that detection points E and N205 are mixtures of high-Ca pyroxene and olivine, and the composition of olivineat point N205 is higher than that at point E, but the compositions of detection points S3 and N203 are mainly olivine-rich. Since there are no obvious absorption features near 1250 nm, plagioclase is not directly identified at the landing site.
文摘The Extreme Ultraviolet Camera （EUVC） onboard the Chang＇e-3 （CE-3） lander is used to observe the structure and dynamics of Earth＇s plasmasphere from the Moon. By detecting the resonance line emission of helium ions （He＋） at 30.4 nm, the EUVC images the entire plasmasphere with a time resolution of 10 min and a spatial resolution of about 0.1 Earth radius （RE） in a single frame. We first present details about the data processing from EUVC and the data acquisition in the commissioning phase, and then report some initial results, which reflect the basic features of the plas- masphere well. The photon count and emission intensity of EUVC are consistent with previous observations and models, which indicate that the EUVC works normally and can provide high quality data for future studies.
基金Supported by the National Natural Science Foundation of China
文摘The Active Particle-induced X-ray Spectrometer （APXS） is an important payload mounted on the Yutu rover, which is part of the Chang＇e-3 mission. The sci- entific objective of APXS is to perform in-situ analysis of the chemical composition of lunar soil and rock samples. The radioactive sources, 55Fe and 109Cd, decay and produce a-particles and X-rays. When X-rays and a-particles interact with atoms in the surface material, they knock electrons out of their orbits, which release energy by emitting X-rays that can be measured by a silicon drift detector （SDD）. The elements and their concentrations can be determined by analyzing their peak energies and in- tensities. APXS has analyzed both the calibration target and lunar soil once during the first lunar day and again during the second lunar day. The total detection time lasted about 266 min and more than 2000 frames of data records have been acquired. APXS has three operating modes： calibration mode, distance sensing mode and detection mode. In detection mode, work distance can be calculated from the X-ray counting rate collected by SDD. Correction for the effect of temperature has been performed to convert the channel number for each spectrum to X-ray energy. Dead time correction is used to eliminate the systematic error in quantifying the activity of an X-ray pulse in a sample and derive the real count rate. We report APXS data and initial results during the first and second lunar days for the Yutu rover. In this study, we analyze the data from the calibration target and lunar soil on the first lunar day. Seven major elements, including Mg, A1, Si, K, Ca, Ti and Fe, have been identified. Comparing the peak areas and ratios of calibration basalt and lunar soil the landing site was found to be depleted in K, and have lower Mg and A1 but higher Ca, Ti, and Fe. In the future, we will obtain the elemental concentrations of lunar soil at the Chang＇e-3 landing site using APXS data.
文摘The Chang＇e-3 （CE-3） mission is China＇s first exploration mission on the surface of the Moon that uses a lander and a rover. Eight instruments that form the scientific payloads have the following objectives： （1） investigate the morphological features and geological structures at the landing site; （2） integrated in-situ analysis of minerals and chemical compositions; （3） integrated exploration of the structure of the lunar interior; （4） exploration of the lunar-terrestrial space environment, lunar sur- face environment and acquire Moon-based ultraviolet astronomical observations. The Ground Research and Application System （GRAS） is in charge of data acquisition and pre-processing, management of the payload in orbit, and managing the data products and their applications. The Data Pre-processing Subsystem （DPS） is a part of GRAS. The task of DPS is the pre-processing of raw data from the eight instruments that are part of CE-3, including channel processing, unpacking, package sorting, calibration and correction, identification of geographical location, calculation of probe azimuth angle, probe zenith angle, solar azimuth angle, and solar zenith angle and so on, and conducting quality checks. These processes produce Level 0, Level 1 and Level 2 data. The computing platform of this subsystem is comprised of a high-performance computing cluster, including a real-time subsystem used for processing Level 0 data and a post-time subsystem for generating Level 1 and Level 2 data. This paper de- scribes the CE-3 data pre-processing method, the data pre-processing subsystem, data classification, data validity and data products that are used for scientific studies.
文摘Developing highly efficient platinum‐group‐metal‐free electrocatalysts towards hydrogen oxidation reaction(HOR)under alkaline electrolyte is critical for the development of alkaline exchange member fuel cells.Herein,we reported the synthesis of boron doped Ni electrocatalyst(B‐Ni/C)and its remarkable alkaline HOR performance,with a 10‐fold mass activity enhancement compared with that of undoped Ni catalyst.Experimental results and density functional theory calculations indicate the d‐p hybridization between the p orbital of B and the d orbital of Ni via B‐doping could lead to promoted OH adsorption and optimized hydrogen binding energy on Ni surface,which together with the reduced formation energy of water species,contributes to the enhanced HOR performance under alkaline electrolyte.
基金provided by National Major Projects-GRAS Construction of China Lunar Exploration Project
文摘Nomenclatures for lunar features always accompany the progresses of human lunar exploration,which has an important dual meaning in culture and science. The naming of lunar features not only can commemorate the outstanding contributions of academics,masters in various fields, and popularize the traditional cultures of ethnic groups all over the world, but also have a critical function of providing accurate indicative information on features with special morphology, origin, nature and scientific value. However, nomenclature for features at the Chang'e-3 landing site, which has a more arbitrary form without many constrains posed by a uniformed system, is unlike the features for other morphological units.This paper originated from the actual needs for the description of scientific exploration activities, interpretation of scientific research and dissemination of scientific results. Some prominent morphological units with great scientific importance and identification purpose were chosen from the images taken by the terrain camera, panorama cameras and landing camera onboard the Chang'e lander and Yutu rover. A nomenclature system was established under the three enclosures, four quadrants and twenty-eight lunar lodges' system of the Chinese ancient sky division method. Finally, a standard feature names set waspublished after some necessary approval procedures by the International Astronomical Union.
基金supported by Natural Science Foundation of Guangdong Province,China(Grant No.2020A1515010970)Shenzhen Research Council(Grant No.JCYJ20200109113427092,GJHZ20180928155209705).
文摘Anomaly detection has practical significance for finding unusual patterns in time series.However,most existing algorithms may lose some important information in time series presentation and have high time complexity.Another problem is that privacy-preserving was not taken into account in these algorithms.In this paper,we propose a new data structure named Interval Hash Table(IHTable)to capture more original information of time series and design a fast anomaly detection algorithm based on Interval Hash Table(ADIHT).The key insight of ADIHT is distributions of normal subsequences are always similar while distributions of anomaly subsequences are different and random by contrast.Furthermore,to make our proposed algorithm fit for anomaly detection under multiple participation,we propose a privacy-preserving anomaly detection scheme named OP-ADIHT based on ADIHT and homomorphic encryption.Compared with existing anomaly detection schemes with privacy-preserving,OP-ADIHT needs less communication cost and calculation cost.Security analysis of different circumstances also shows that OP-ADIHT will not leak the privacy information of participants.Extensive experiments results show that ADIHT can outperform most anomaly detection algorithms and perform close to the best results in terms of AUC-ROC,and ADIHT needs the least time.
基金supported by the National Natural Science Foundation of China(Grant Nos.12205340,12175281,and 11975282)the Gansu Natural Science Foundation(Grant No.22JR5RA123)+3 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB34000000)the Key Research Program of the Chinese Academy of Sciences(Grant No.XDPB15)the State Key Laboratory of Nuclear Physics and TechnologyPeking University(Grant No.NPT2020KFY13)。
文摘We provide an investigation of the spectroscopic factor of resonance states in A=5-8 nuclei,utilizing the Gamow shell model(GSM).Within the GSM,the configuration mixing is taken into account exactly with the shell model framework,and the continuum coupling is addressed via the complex-energy Berggren ensemble,which treats bound,resonance,and non-resonant continuum single-particle states on an equal footing.As a result,both the configuration mixing and continuum coupling are meticulously considered in the GSM.We first calculate the low-lying states of helium isotopes and isotones with the GSM,and the results are compared with that of ab initio no-core shell model(NCSM)calculations.The results indicate that GSM can reproduce the low-lying resonance states more accurately than the NCSM.Following this,we delve into the spectroscopic factors of the resonance states as computed through both GSM and NCSM,concurrently conducting systematic calculations of overlap functions pertinent to these resonance states.Finally,the calculated overlap function and spectroscopic factor of6He(01+)■νp3/2→^(7)He(3/2_(1)-)with GSM are compared with the results from ab initio NCSM,variational Monte Carlo,and Green’s function Monte Carlo calculations,as well as available experimental data.The results assert that wave function asymptotes can only be reproduced in GSM,where resonance and continuum coupling are precisely addressed.
基金supported by the National Key Research and Development Program of China(No.2019YFC1906401-03)the Harbin Institute of Technology National Engineering Research Center of Urban Water Resources Co.,Ltd.(No.GJS-YFLX202207280002)。
文摘Fe-N-C materials have received increasing attention,due to its distinctive catalytic activity.However,the Fe-N coordination number dependence of catalytic ability and mechanism for H_(2)O_(2)activation remain elusive.Herein,a series of Fe-N-C heterogeneous Fenton-like catalysts with different Fe-N coordination number were prepared for tetracycline degradation.The results demonstrated that samples with Fe-N4 structure exhibited high activity.The excellent performance was mainly ascribed to the high adsorption capacity and the formation of superoxide radicals(•O_(2)^(−))catalyzed by Fe linked to pyridinic nitrogen.The intermediates and degradation pathways of tetracycline degradation by Fe-N-C/H_(2)O_(2)system were analyzed by liquid chromatography coupled to tandem mass spectrometry(LC-MS/MS).Furthermore,we applied our Fe-N-C catalysts to treat simulated pharmaceutical wastewater with high tetracycline degradation capacity despite high concentrations of organic matter such as oxalic acid and various ionic interferences.Our work reveals the dependence of the activation H_(2)O_(2)on the Fe-N coordination environment and the degradation mechanism of these catalysts.It provides insights into the prospects for tuning the catalyst in practical applications.
