In this study,the design of a computational heuristic based on the nonlinear Liénard model is presented using the efficiency of artificial neural networks(ANNs)along with the hybridization procedures of global an...In this study,the design of a computational heuristic based on the nonlinear Liénard model is presented using the efficiency of artificial neural networks(ANNs)along with the hybridization procedures of global and local search approaches.The global search genetic algorithm(GA)and local search sequential quadratic programming scheme(SQPS)are implemented to solve the nonlinear Liénard model.An objective function using the differential model and boundary conditions is designed and optimized by the hybrid computing strength of the GA-SQPS.The motivation of the ANN procedures along with GA-SQPS comes to present reliable,feasible and precise frameworks to tackle stiff and highly nonlinear differentialmodels.The designed procedures of ANNs along with GA-SQPS are applied for three highly nonlinear differential models.The achieved numerical outcomes on multiple trials using the designed procedures are compared to authenticate the correctness,viability and efficacy.Moreover,statistical performances based on different measures are also provided to check the reliability of the ANN along with GASQPS.展开更多
AIM: To investigate the regulatory effect of electroacupuncture (EA) at Zusanli (ST36) on tumor necrosis factor-alpha (TNFα) in rats with ulcerative colitis (UC), and further elucidate the therapeutic mechanism of EA...AIM: To investigate the regulatory effect of electroacupuncture (EA) at Zusanli (ST36) on tumor necrosis factor-alpha (TNFα) in rats with ulcerative colitis (UC), and further elucidate the therapeutic mechanism of EA on UC.METHODS: Thirty-two male Sprague-Dawley (SD) rats were randomly divided into four groups (n=-8): normal control group, UC control group, UC+ST36 group and UC+nonacupoint group. A solution containing ethanol and 2,4,6-trinitrobenzenesulfonic acid (TNBS) was instilled into the distal colon in the rat (at a dose of 100 mg/kg) to set up UC rat model. Rats in wakefulness state of UC+ST36 group were stimulated at ST36 by EA once a day, while those of UC+nonacupoint group were done at 0.5 cm beside ST36. After 10d treatment, all rats were sacrificed simultaneously. Colon musocal inflammation and damage were assessed by measuring colon mass, morphologic damage score, colonic myeloperoxidase enzyme (MPO) activity, serum TNF-α and colonic TNF-α mRNA level. Morphologic damage score was examined under stereomicroscope. Colonic MPO activity was measured by spectrophotometer method. Serum TNF-αconcentration was determined by radioimmunoassay (RIA).Colonic TNF-α mRNA expression level was analyzed by semiquantitative reverse transcription polymerase chain reaction (RT-PCR).RESULTS: Ratio of colonic mass/body mass (mC/mB) and activity of colonic MPO (μkat/g tissue) markedly increased (8.5±2.6 vs 2.5±0.4; 145±25 vs 24±8, P＜0.01 vs normal control group). Compared with normal control rats, serum TNF-α and colonic TNF-α mRNA level in UC control group were increased 2.5 fold (2 278±170 vs 894±248, P＜0.01)and 4.3 fold (0.98±0.11 vs 0.23±0.11, P＜0.01)respectively. After EA at ST36, mc/mB and MPO activity were reduced significantly (5.3±2.0 vs 8.5±2.6; 104±36 vs145±25, P＜0.01, 0.05) compared with those of UC control group. Serum TNF-α and colonic TNF-α mRNA level were inhibited by EA stimulation at ST36 (P＜0.01). The inhibitory rate was 16 % and 44 % respectively.Morphologic damage score was also increased markedly in rat with UC (P＜0.01), whereas it was decreased by EA at ST36 (P＜0.05). There was no significant difference between UC control group and UC+EA at non-acupoint (P＞0.05). Furthermore, these parameters were highly correlated with each other (P＜0.01).CONCLUSION: Serum TNF-α concentration and colonic TNF-α mRNA expression level are increased significantly in UC rats in correlation with the severity of disease. It indicates that TNF-α is closely involved in the immune abnormalities and inflammatory responses in UC. EA at ST36 has therapeutic effect on UC by downregulating serum TNF-r and colonic TNF-r mRNA expression. High levels of TNF-αand its corresponding mRNA expression seem to be implicated in the pathogenesis of UC.展开更多
A new kind of conjugated polymer, acetylenic polysilazane was prepared by ammono- lysis of acetylenic dimethylchlorosilane. The polymer was characterized by 29Si、13C NMR and elemental analysis.
A new kind of polytitanosilazane precursor PTSZ for Si/C/N/Ti-based ceramic was synthesized from the condensation reaction of silazane lithium salt and titanium tetrachloride (TiCl4). The results indicated that the c...A new kind of polytitanosilazane precursor PTSZ for Si/C/N/Ti-based ceramic was synthesized from the condensation reaction of silazane lithium salt and titanium tetrachloride (TiCl4). The results indicated that the ceramic yield of PTSZ was much higher than that of corresponding silazane oligomer.展开更多
文摘In this study,the design of a computational heuristic based on the nonlinear Liénard model is presented using the efficiency of artificial neural networks(ANNs)along with the hybridization procedures of global and local search approaches.The global search genetic algorithm(GA)and local search sequential quadratic programming scheme(SQPS)are implemented to solve the nonlinear Liénard model.An objective function using the differential model and boundary conditions is designed and optimized by the hybrid computing strength of the GA-SQPS.The motivation of the ANN procedures along with GA-SQPS comes to present reliable,feasible and precise frameworks to tackle stiff and highly nonlinear differentialmodels.The designed procedures of ANNs along with GA-SQPS are applied for three highly nonlinear differential models.The achieved numerical outcomes on multiple trials using the designed procedures are compared to authenticate the correctness,viability and efficacy.Moreover,statistical performances based on different measures are also provided to check the reliability of the ANN along with GASQPS.
基金the National Nature Science Foundation of China, No.39970888
文摘AIM: To investigate the regulatory effect of electroacupuncture (EA) at Zusanli (ST36) on tumor necrosis factor-alpha (TNFα) in rats with ulcerative colitis (UC), and further elucidate the therapeutic mechanism of EA on UC.METHODS: Thirty-two male Sprague-Dawley (SD) rats were randomly divided into four groups (n=-8): normal control group, UC control group, UC+ST36 group and UC+nonacupoint group. A solution containing ethanol and 2,4,6-trinitrobenzenesulfonic acid (TNBS) was instilled into the distal colon in the rat (at a dose of 100 mg/kg) to set up UC rat model. Rats in wakefulness state of UC+ST36 group were stimulated at ST36 by EA once a day, while those of UC+nonacupoint group were done at 0.5 cm beside ST36. After 10d treatment, all rats were sacrificed simultaneously. Colon musocal inflammation and damage were assessed by measuring colon mass, morphologic damage score, colonic myeloperoxidase enzyme (MPO) activity, serum TNF-α and colonic TNF-α mRNA level. Morphologic damage score was examined under stereomicroscope. Colonic MPO activity was measured by spectrophotometer method. Serum TNF-αconcentration was determined by radioimmunoassay (RIA).Colonic TNF-α mRNA expression level was analyzed by semiquantitative reverse transcription polymerase chain reaction (RT-PCR).RESULTS: Ratio of colonic mass/body mass (mC/mB) and activity of colonic MPO (μkat/g tissue) markedly increased (8.5±2.6 vs 2.5±0.4; 145±25 vs 24±8, P＜0.01 vs normal control group). Compared with normal control rats, serum TNF-α and colonic TNF-α mRNA level in UC control group were increased 2.5 fold (2 278±170 vs 894±248, P＜0.01)and 4.3 fold (0.98±0.11 vs 0.23±0.11, P＜0.01)respectively. After EA at ST36, mc/mB and MPO activity were reduced significantly (5.3±2.0 vs 8.5±2.6; 104±36 vs145±25, P＜0.01, 0.05) compared with those of UC control group. Serum TNF-α and colonic TNF-α mRNA level were inhibited by EA stimulation at ST36 (P＜0.01). The inhibitory rate was 16 % and 44 % respectively.Morphologic damage score was also increased markedly in rat with UC (P＜0.01), whereas it was decreased by EA at ST36 (P＜0.05). There was no significant difference between UC control group and UC+EA at non-acupoint (P＞0.05). Furthermore, these parameters were highly correlated with each other (P＜0.01).CONCLUSION: Serum TNF-α concentration and colonic TNF-α mRNA expression level are increased significantly in UC rats in correlation with the severity of disease. It indicates that TNF-α is closely involved in the immune abnormalities and inflammatory responses in UC. EA at ST36 has therapeutic effect on UC by downregulating serum TNF-r and colonic TNF-r mRNA expression. High levels of TNF-αand its corresponding mRNA expression seem to be implicated in the pathogenesis of UC.
文摘A new kind of conjugated polymer, acetylenic polysilazane was prepared by ammono- lysis of acetylenic dimethylchlorosilane. The polymer was characterized by 29Si、13C NMR and elemental analysis.
基金support of the National Natural Science Foundation of China(No.50072033)the Chinese Academy of Sciences(CXJJ-10).
文摘A new kind of polytitanosilazane precursor PTSZ for Si/C/N/Ti-based ceramic was synthesized from the condensation reaction of silazane lithium salt and titanium tetrachloride (TiCl4). The results indicated that the ceramic yield of PTSZ was much higher than that of corresponding silazane oligomer.
