To improve the level of informatization of university library archives management,the problems existing in the information construction of university library archives management are analyzed and some practical solutio...To improve the level of informatization of university library archives management,the problems existing in the information construction of university library archives management are analyzed and some practical solutions are proposed in this paper.These solutions can effectively reduce the investment in human resources and equipment and facilities and improve the utilization rate of resources for computer application of university library archives management.展开更多
In order to better promote the digital and electronic development of libraries,this paper first analyzes the management requirements of library archives,constructs a management mode based on electronic technology,and ...In order to better promote the digital and electronic development of libraries,this paper first analyzes the management requirements of library archives,constructs a management mode based on electronic technology,and analyzes the management measures of electronic library archives for reference.展开更多
In the era of new media,people’s lifestyle,education and the like are inseparable from the Internet.At the same time,due to the emergence of smart devices such as mobile phones and tablet computers,people’s reading ...In the era of new media,people’s lifestyle,education and the like are inseparable from the Internet.At the same time,due to the emergence of smart devices such as mobile phones and tablet computers,people’s reading habits have changed.Fragmented reading has become an important form of reading for college students.College students themselves have the strong ability to accept change,so fragmented reading has gradually become an important form of student learning.This paper mainly analyses fragmented reading by college students and its impact on society in the era of new media.展开更多
University libraries have a great role in promoting the inheritance and innovation of excellent traditional culture,so it is necessary to integrate traditional culture into the process of university library developmen...University libraries have a great role in promoting the inheritance and innovation of excellent traditional culture,so it is necessary to integrate traditional culture into the process of university library development,so as to strengthen the efficiency of traditional culture in the process of inheritance,so that more university students will know and understand traditional culture,so as to clarify the excellence of traditional culture,and actively learn and inherit traditional culture,so as to contribute to the development of traditional culture.The article will propose effective strategies to address the dilemmas faced in the process of traditional cultural heritage in order to contribute to the innovative development of traditional culture.The article will propose effective strategies to address the dilemmas faced in the process of traditional culture inheritance in order to facilitate the innovative development of traditional culture.展开更多
Paper books and documents are the main media of information service in most university libraries.In order to study the main reasons for the decline of the utilization rate of paper books in university libraries,this p...Paper books and documents are the main media of information service in most university libraries.In order to study the main reasons for the decline of the utilization rate of paper books in university libraries,this paper takes a well-known university library in China as an example,discusses the current situation of its low utilization rate of paper books and the reasons for the problems,and puts forward relevant optimization strategies,so as to promote the improvement of the construction quality of university libraries in China.展开更多
With the vigorous development of network information technology,e-book borrowing service came into being and showed a vigorous development trend.Therefore,in order to strengthen the service function,the library needs ...With the vigorous development of network information technology,e-book borrowing service came into being and showed a vigorous development trend.Therefore,in order to strengthen the service function,the library needs to gradually improve the e-book borrowing service,so as to provide readers with high-quality service content,so that the library can give full play to its function of disseminating scientific and cultural knowledge.Therefore,in this article research,we first discuss the main reading methods of e-books,then investigate the current reading situation of e-books and traditional paper books in the library,and then put forward corresponding development strategies to effectively promote the rapid development of the library and strengthen the level of e-book borrowing service.展开更多
Quality of life and functional recovery after burn injury is the final goal of burn care,especially as most of burn patients survive the injury due to advanced medical science.However,dysfunction,disfigurement,contrac...Quality of life and functional recovery after burn injury is the final goal of burn care,especially as most of burn patients survive the injury due to advanced medical science.However,dysfunction,disfigurement,contractures,psychological problems and other discomforts due to burns and the consequent scars are common,and physical therapy and occupational therapy provide alternative treatments for these problems of burn patients.This guideline,organized by the Chinese Burn Association and Chinese Association of Burn Surgeons aims to emphasize the importance of team work in burn care and provide a brief introduction of the outlines of physical and occupational therapies during burn treatment,which is suitable for the current medical circumstances of China.It can be used as the start of the tools for burn rehabilitation.展开更多
Background:Burns are life-threatening with high morbidity and mortality.Reliable diagnosis supported by accurate burn area and depth assessment is critical to the success of the treatment decision and,in some cases,ca...Background:Burns are life-threatening with high morbidity and mortality.Reliable diagnosis supported by accurate burn area and depth assessment is critical to the success of the treatment decision and,in some cases,can save the patient’s life.Current techniques such as straight-ruler method,aseptic film trimming method,and digital camera photography method are not repeatable and comparable,which lead to a great difference in the judgment of burn wounds and impede the establishment of the same evaluation criteria.Hence,in order to semi-automate the burn diagnosis process,reduce the impact of human error,and improve the accuracy of burn diagnosis,we include the deep learning technology into the diagnosis of burns.Method:This article proposes a novel method employing a state-of-the-art deep learning technique to segment the burn wounds in the images.We designed this deep learning segmentation framework based on the Mask Regions with Convolutional Neural Network(Mask R-CNN).For training our framework,we labeled 1150 pictures with the format of the Common Objects in Context(COCO)data set and trained our model on 1000 pictures.In the evaluation,we compared the different backbone networks in our framework.These backbone networks are Residual Network-101 with Atrous Convolution in Feature Pyramid Network(R101FA),Residual Network-101 with Atrous Convolution(R101A),and InceptionV2-Residual Network with Atrous Convolution(IV2RA).Finally,we used the Dice coefficient(DC)value to assess the model accuracy.Result:The R101FA backbone network gains the highest accuracy 84.51%in 150 pictures.Moreover,we chose different burn depth pictures to evaluate these three backbone networks.The R101FA backbone network gains the best segmentation effect in superficial,superficial thickness,and deep partial thickness.The R101A backbone network gains the best segmentation effect in full-thickness burn.Conclusion:This deep learning framework shows excellent segmentation in burn wound and extremely robust in different burn wound depths.Moreover,this framework just needs a suitable burn wound image when analyzing the burn wound.It is more convenient and more suitable when using in clinics compared with the traditional methods.And it also contributes more to the calculation of total body surface area(TBSA)burned.展开更多
Invasive fungal infection is one of the major complication of severe burns which can induce local or systemic inflammatory response and cause serious substantial damage to the patient. The incidence of fungal infectio...Invasive fungal infection is one of the major complication of severe burns which can induce local or systemic inflammatory response and cause serious substantial damage to the patient. The incidence of fungal infection for burn victims is increasing dramatically during recent years. This guideline, organized by Chinese Society of Burn Surgeons, aims to standardize the diagnosis, prevention and treatment of burn invasive fungal infection. It can be used as one of the tools for treatment of major burn patients.展开更多
Background: Severe burns injury is a serious pathology, leading to teratogenicity and significant mortality, and it also has a long-term social impact. The aim of this article is to describe the hospitalized populatio...Background: Severe burns injury is a serious pathology, leading to teratogenicity and significant mortality, and it also has a long-term social impact. The aim of this article is to describe the hospitalized population with severe burns injuries in eight burn centers in China between 2011 and 2015 and to suggest future preventive strategies. Methods: This 5-year retrospective review included all patients with severe burns in a database at eight institutions. The data collected included gender, age, month distribution, etiology, location, presence of inhalation injury, total burn surface area, depth of the burn, the length of hospitalization, and mortality. SPSS 19.0 software was used to analyze the data. Results: A total of 1126 patients were included: 803 (71.3%) male patients and 323 (28.7%) female patients. Scalds were the most common cause of burns (476, 42.27%), followed by fire (457, 40.59%). The extremities were the most frequently affected areas, followed by the trunk. The median length of hospitalization was 30 (15, 52) days. The overall mortality rate was 14.21%. Conclusions: Although medical centers have devoted intensive resources to improving the survival rates of burn patients, expenditures for prevention and education programs are minimal. Our findings suggest that more attention should be paid to the importance of prevention and the reduction of injury severity. This study may contribute to the establishment of a nationwide burn database and the elaboration of strategies to prevent severe burns injury.展开更多
Background:Diabetes significantly delays wound healing through oxidative stress,inflammation and impaired re-epithelialization that lead to defective regulation of the healing process,although the related mechanism re...Background:Diabetes significantly delays wound healing through oxidative stress,inflammation and impaired re-epithelialization that lead to defective regulation of the healing process,although the related mechanism remains unclear.Here,we aim to investigate the potential role and mechanism for the beneficial effect of betulinic acid(BA)on diabetic wound healing.Methods:The molecular effect of BA on hyperglycemia-mediated gene expression,oxidative stress,inflammation and glucose uptake was evaluated in endothelial,fibroblast and muscle cells.Burn injury was introduced to streptozotocin-induced diabetic rats and BA administration through either an intraperitoneal(IP)or topical(TOP)technique was used for wound treatment.Glucose tolerance was evaluated in both muscle tissue and fibroblasts,while oxidative stress and inflammation were determined in both the circulatory system and in wound tissues.The effect of BA on the wound healing process was also evaluated.Results:BA treatment reversed hyperglycemia-induced glucose transporter type 4(GLUT4)sup-pression in both muscle and fibroblast cells.This treatment also partly reversed hyperglycemia-mediated suppression of endothelial nitric oxide synthase(eNOS),nuclear factor erythroid 2-related factor 2(Nrf2)signaling and nuclear factor NFκB p65 subunit(NFκB p65)activation in endothelial cells.An in vivo rat study showed that BA administration ameliorated diabetes-mediated glucose intolerance and partly attenuated diabetes-mediated oxidative stress and inflam-mation in both the circulatory system and wound tissues.BA administration by both IP and TOP techniques significantly accelerated diabetic wound healing,while BA administration by either IP or TOP methods alone had a significantly lower effect.Conclusions:BA treatment ameliorates hyperglycemia-mediated glucose intolerance,endothelial dysfunction,oxidative stress and inflammation.Administration of BA by both IP and TOP tech-niques was found to significantly accelerate diabetic wound healing,indicating that BA could be a potential therapeutic candidate for diabetic wound healing.展开更多
Background:Delayed wound healing is one of the major complications of diabetes mellitus and is characterized by prolonged inflammation,delayed re-epithelialization and consistent oxidative stress,although the detailed...Background:Delayed wound healing is one of the major complications of diabetes mellitus and is characterized by prolonged inflammation,delayed re-epithelialization and consistent oxidative stress,although the detailed mechanism remains unknown.In this study,we aimed to investigate the potential role and effect of pterostilbene(PTE)and hematopoietic stem cells(HSCs)on diabetic wound healing.Methods:Diabetic rats were used to measure the epigenetic changes in both HSCs and peripheral blood mononuclear cells(PBMCs).A cutaneous burn injury was induced in the rats and PTE-treated diabetic HSCs were transplanted for evaluation of wound healing.In addition,several biomedical parameters,including gene expression,oxidative stress,mitochondrial function and inflammation in macrophages,were also measured.Results:Our data showed that PTE had a much stronger effect than resveratrol on accelerating diabetic wound healing,likely because PTE can ameliorate diabetes-induced epigenetic changes to estrogen receptorβpromoter in HSCs,while resveratrol cannot.Further investigation showed that bone marrow transplantation of PTE-treated diabetic HSCs restores diabetes-induced suppression of estrogen receptorβand its target genes,including nuclear respiratory factor-1 and superoxide dismutase 2,and protects against diabetes-induced oxidative stress,mitochondrial dysfunction and elevated pro-inflammatory cytokines in both PBMCs and macrophages,subsequently accelerating cutaneous wound healing.Conclusions:HSC may play an important role in wound healing through transferring epigenetic modifications to subsequent PBMCs and macrophages by differentiation,while PTE accelerates diabetic wound healing by modulating diabetes-induced epigenetic changes in HSCs.Thus,PTE may be a novel therapeutic strategy for diabetic wound healing.展开更多
文摘To improve the level of informatization of university library archives management,the problems existing in the information construction of university library archives management are analyzed and some practical solutions are proposed in this paper.These solutions can effectively reduce the investment in human resources and equipment and facilities and improve the utilization rate of resources for computer application of university library archives management.
文摘In order to better promote the digital and electronic development of libraries,this paper first analyzes the management requirements of library archives,constructs a management mode based on electronic technology,and analyzes the management measures of electronic library archives for reference.
文摘In the era of new media,people’s lifestyle,education and the like are inseparable from the Internet.At the same time,due to the emergence of smart devices such as mobile phones and tablet computers,people’s reading habits have changed.Fragmented reading has become an important form of reading for college students.College students themselves have the strong ability to accept change,so fragmented reading has gradually become an important form of student learning.This paper mainly analyses fragmented reading by college students and its impact on society in the era of new media.
文摘University libraries have a great role in promoting the inheritance and innovation of excellent traditional culture,so it is necessary to integrate traditional culture into the process of university library development,so as to strengthen the efficiency of traditional culture in the process of inheritance,so that more university students will know and understand traditional culture,so as to clarify the excellence of traditional culture,and actively learn and inherit traditional culture,so as to contribute to the development of traditional culture.The article will propose effective strategies to address the dilemmas faced in the process of traditional cultural heritage in order to contribute to the innovative development of traditional culture.The article will propose effective strategies to address the dilemmas faced in the process of traditional culture inheritance in order to facilitate the innovative development of traditional culture.
文摘Paper books and documents are the main media of information service in most university libraries.In order to study the main reasons for the decline of the utilization rate of paper books in university libraries,this paper takes a well-known university library in China as an example,discusses the current situation of its low utilization rate of paper books and the reasons for the problems,and puts forward relevant optimization strategies,so as to promote the improvement of the construction quality of university libraries in China.
文摘With the vigorous development of network information technology,e-book borrowing service came into being and showed a vigorous development trend.Therefore,in order to strengthen the service function,the library needs to gradually improve the e-book borrowing service,so as to provide readers with high-quality service content,so that the library can give full play to its function of disseminating scientific and cultural knowledge.Therefore,in this article research,we first discuss the main reading methods of e-books,then investigate the current reading situation of e-books and traditional paper books in the library,and then put forward corresponding development strategies to effectively promote the rapid development of the library and strengthen the level of e-book borrowing service.
文摘Quality of life and functional recovery after burn injury is the final goal of burn care,especially as most of burn patients survive the injury due to advanced medical science.However,dysfunction,disfigurement,contractures,psychological problems and other discomforts due to burns and the consequent scars are common,and physical therapy and occupational therapy provide alternative treatments for these problems of burn patients.This guideline,organized by the Chinese Burn Association and Chinese Association of Burn Surgeons aims to emphasize the importance of team work in burn care and provide a brief introduction of the outlines of physical and occupational therapies during burn treatment,which is suitable for the current medical circumstances of China.It can be used as the start of the tools for burn rehabilitation.
基金supported by the National Natural Science Foundation of China(Grant No.61772379)the National Technological Action of Major Disease Prevention and Control(2018-ZX-01S-001).
文摘Background:Burns are life-threatening with high morbidity and mortality.Reliable diagnosis supported by accurate burn area and depth assessment is critical to the success of the treatment decision and,in some cases,can save the patient’s life.Current techniques such as straight-ruler method,aseptic film trimming method,and digital camera photography method are not repeatable and comparable,which lead to a great difference in the judgment of burn wounds and impede the establishment of the same evaluation criteria.Hence,in order to semi-automate the burn diagnosis process,reduce the impact of human error,and improve the accuracy of burn diagnosis,we include the deep learning technology into the diagnosis of burns.Method:This article proposes a novel method employing a state-of-the-art deep learning technique to segment the burn wounds in the images.We designed this deep learning segmentation framework based on the Mask Regions with Convolutional Neural Network(Mask R-CNN).For training our framework,we labeled 1150 pictures with the format of the Common Objects in Context(COCO)data set and trained our model on 1000 pictures.In the evaluation,we compared the different backbone networks in our framework.These backbone networks are Residual Network-101 with Atrous Convolution in Feature Pyramid Network(R101FA),Residual Network-101 with Atrous Convolution(R101A),and InceptionV2-Residual Network with Atrous Convolution(IV2RA).Finally,we used the Dice coefficient(DC)value to assess the model accuracy.Result:The R101FA backbone network gains the highest accuracy 84.51%in 150 pictures.Moreover,we chose different burn depth pictures to evaluate these three backbone networks.The R101FA backbone network gains the best segmentation effect in superficial,superficial thickness,and deep partial thickness.The R101A backbone network gains the best segmentation effect in full-thickness burn.Conclusion:This deep learning framework shows excellent segmentation in burn wound and extremely robust in different burn wound depths.Moreover,this framework just needs a suitable burn wound image when analyzing the burn wound.It is more convenient and more suitable when using in clinics compared with the traditional methods.And it also contributes more to the calculation of total body surface area(TBSA)burned.
文摘Invasive fungal infection is one of the major complication of severe burns which can induce local or systemic inflammatory response and cause serious substantial damage to the patient. The incidence of fungal infection for burn victims is increasing dramatically during recent years. This guideline, organized by Chinese Society of Burn Surgeons, aims to standardize the diagnosis, prevention and treatment of burn invasive fungal infection. It can be used as one of the tools for treatment of major burn patients.
基金the Key Program National Natural Science Foundation of China(81430042)Special Foundation for Scientific Research of Health Care Industry of China(201202002)+1 种基金Project of Technology Innovation in Priority Research Field of the First Affiliated Hospital of Third Military Medical University(Army Medical University)(SWH2016ZDCX4201)New Clinical Technology of Military Medicine and Medical Care of War Injury Program of the First Affiliated Hospital of Third Military Medical University(Army Medical University)(SWH2016YSCXYB-06).
文摘Background: Severe burns injury is a serious pathology, leading to teratogenicity and significant mortality, and it also has a long-term social impact. The aim of this article is to describe the hospitalized population with severe burns injuries in eight burn centers in China between 2011 and 2015 and to suggest future preventive strategies. Methods: This 5-year retrospective review included all patients with severe burns in a database at eight institutions. The data collected included gender, age, month distribution, etiology, location, presence of inhalation injury, total burn surface area, depth of the burn, the length of hospitalization, and mortality. SPSS 19.0 software was used to analyze the data. Results: A total of 1126 patients were included: 803 (71.3%) male patients and 323 (28.7%) female patients. Scalds were the most common cause of burns (476, 42.27%), followed by fire (457, 40.59%). The extremities were the most frequently affected areas, followed by the trunk. The median length of hospitalization was 30 (15, 52) days. The overall mortality rate was 14.21%. Conclusions: Although medical centers have devoted intensive resources to improving the survival rates of burn patients, expenditures for prevention and education programs are minimal. Our findings suggest that more attention should be paid to the importance of prevention and the reduction of injury severity. This study may contribute to the establishment of a nationwide burn database and the elaboration of strategies to prevent severe burns injury.
基金supported by The National Natural Science Foundation of China,Project#:81772097Revival Program of Growth Factors,Project#:SZYZ-TR-10.
文摘Background:Diabetes significantly delays wound healing through oxidative stress,inflammation and impaired re-epithelialization that lead to defective regulation of the healing process,although the related mechanism remains unclear.Here,we aim to investigate the potential role and mechanism for the beneficial effect of betulinic acid(BA)on diabetic wound healing.Methods:The molecular effect of BA on hyperglycemia-mediated gene expression,oxidative stress,inflammation and glucose uptake was evaluated in endothelial,fibroblast and muscle cells.Burn injury was introduced to streptozotocin-induced diabetic rats and BA administration through either an intraperitoneal(IP)or topical(TOP)technique was used for wound treatment.Glucose tolerance was evaluated in both muscle tissue and fibroblasts,while oxidative stress and inflammation were determined in both the circulatory system and in wound tissues.The effect of BA on the wound healing process was also evaluated.Results:BA treatment reversed hyperglycemia-induced glucose transporter type 4(GLUT4)sup-pression in both muscle and fibroblast cells.This treatment also partly reversed hyperglycemia-mediated suppression of endothelial nitric oxide synthase(eNOS),nuclear factor erythroid 2-related factor 2(Nrf2)signaling and nuclear factor NFκB p65 subunit(NFκB p65)activation in endothelial cells.An in vivo rat study showed that BA administration ameliorated diabetes-mediated glucose intolerance and partly attenuated diabetes-mediated oxidative stress and inflam-mation in both the circulatory system and wound tissues.BA administration by both IP and TOP techniques significantly accelerated diabetic wound healing,while BA administration by either IP or TOP methods alone had a significantly lower effect.Conclusions:BA treatment ameliorates hyperglycemia-mediated glucose intolerance,endothelial dysfunction,oxidative stress and inflammation.Administration of BA by both IP and TOP tech-niques was found to significantly accelerate diabetic wound healing,indicating that BA could be a potential therapeutic candidate for diabetic wound healing.
基金supported by the National Natural Science Foundation of China Project(81772097)the National Key Disease Preventive Project for Wound Healing(2018-ZX-01S-001).
文摘Background:Delayed wound healing is one of the major complications of diabetes mellitus and is characterized by prolonged inflammation,delayed re-epithelialization and consistent oxidative stress,although the detailed mechanism remains unknown.In this study,we aimed to investigate the potential role and effect of pterostilbene(PTE)and hematopoietic stem cells(HSCs)on diabetic wound healing.Methods:Diabetic rats were used to measure the epigenetic changes in both HSCs and peripheral blood mononuclear cells(PBMCs).A cutaneous burn injury was induced in the rats and PTE-treated diabetic HSCs were transplanted for evaluation of wound healing.In addition,several biomedical parameters,including gene expression,oxidative stress,mitochondrial function and inflammation in macrophages,were also measured.Results:Our data showed that PTE had a much stronger effect than resveratrol on accelerating diabetic wound healing,likely because PTE can ameliorate diabetes-induced epigenetic changes to estrogen receptorβpromoter in HSCs,while resveratrol cannot.Further investigation showed that bone marrow transplantation of PTE-treated diabetic HSCs restores diabetes-induced suppression of estrogen receptorβand its target genes,including nuclear respiratory factor-1 and superoxide dismutase 2,and protects against diabetes-induced oxidative stress,mitochondrial dysfunction and elevated pro-inflammatory cytokines in both PBMCs and macrophages,subsequently accelerating cutaneous wound healing.Conclusions:HSC may play an important role in wound healing through transferring epigenetic modifications to subsequent PBMCs and macrophages by differentiation,while PTE accelerates diabetic wound healing by modulating diabetes-induced epigenetic changes in HSCs.Thus,PTE may be a novel therapeutic strategy for diabetic wound healing.
