Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced functionality.Mutation or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenes...Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced functionality.Mutation or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenesis can result in different types of ribosomopathies in clinic,collectively known as ribosomopathy genes.Emerging data suggest that ribosomopathy patients exhibit a significantly heightened susceptibility to cancer.Abnormal ribosome biogenesis and dysregulation of some ribosomopathy genes have also been found to be intimately associated with cancer development.The correlation between ribosome biogenesis or ribosomopathy and the development of malignancies has been well established.This work aims to review the recent advances in the research of ribosomopathy genes among human cancers and meanwhile,to excavate the potential role of these genes,which have not or rarely been reported in cancer,in the disease development across cancers.We plan to establish a theoretical framework between the ribosomopathy gene and cancer development,to further facilitate the potential of these genes as diagnostic biomarker as well as pharmaceutical targets for cancer treatment.展开更多
This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many ...This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many aspects,including anti-inflammation,anti-oxidation,anti-thrombosis,anti-tumor and so on.In particular,more than ten saponins have been found to have good anti-tumor activity and have potential research value,which can provide reference for the full development and utilization of Ardisia gigantifolia Stapf resources.展开更多
In recent years,with the modern development of traditional medicine,the research on the treatment of inflammatory bowel disease and bowel cancer is increasingly deep.This paper reviews the pharmacological research pro...In recent years,with the modern development of traditional medicine,the research on the treatment of inflammatory bowel disease and bowel cancer is increasingly deep.This paper reviews the pharmacological research progress of flavonoids,alkaloids,polyphenols,polysaccharides,steroids and saponins in the treatment of inflammatory bowel disease and canceration.展开更多
Investigating the bioaccessibility of harmful inorganic elements in soil is crucial for understanding their behavior in the environment and accurately assessing the environmental risks associated with soil.Traditional...Investigating the bioaccessibility of harmful inorganic elements in soil is crucial for understanding their behavior in the environment and accurately assessing the environmental risks associated with soil.Traditional batch experimental methods and linear models,however,are time-consuming and often fall short in precisely quantifying bioaccessibility.In this study,using 937 data points gathered from 56 journal articles,we developed machine learning models for three harmful inorganic elements,namely,Cd,Pb,and As.After thorough analysis,the model optimized through a boosting ensemble strategy demonstrated the best performance,with an average R2 of 0.95 and an RMSE of 0.25.We further employed SHAP values in conjunction with quantitative analysis to identify the key features that influence bioaccessibility.By utilizing the developed integrated models,we carried out predictions for 3002 data points across China,clarifying the bioaccessibility of cadmium(Cd),lead(Pb),and arsenic(As)in the soils of various sites and constructed a comprehensive spatial distribution map of China using the inverse distance weighting(IDW)interpolation method.Based on these findings,we further derived the soil environmental standards for metallurgical sites in China.Our observations from the collected data indicate a reduction in the number of sites exceeding the standard levels for Cd,Pb,and As in mining/smelting sites from 5,58,and 14 to 1,24,and 7,respectively.This research offers a precise and scientific approach for cross-regional risk assessment at the continental scale and lays a solid foundation for soil environmental management.展开更多
基金the National Natural Science Foundation of China(Grant No.:82360542)Jiangxi Provincial Natural Science Foundation,China(Grant Nos.:20224BAB214030 and 20224BAB216072)+2 种基金Doctoral Startup Fund of Gannan Medical University,China(Grant Nos.:QD202136 and QD202132)Science and Technology Planning Projects of Fuzhou,China(Grant No.:2021FZR0101)the Natural Science Foundation of Fujian Province,China(Grant No.:2022YZ0104).
文摘Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced functionality.Mutation or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenesis can result in different types of ribosomopathies in clinic,collectively known as ribosomopathy genes.Emerging data suggest that ribosomopathy patients exhibit a significantly heightened susceptibility to cancer.Abnormal ribosome biogenesis and dysregulation of some ribosomopathy genes have also been found to be intimately associated with cancer development.The correlation between ribosome biogenesis or ribosomopathy and the development of malignancies has been well established.This work aims to review the recent advances in the research of ribosomopathy genes among human cancers and meanwhile,to excavate the potential role of these genes,which have not or rarely been reported in cancer,in the disease development across cancers.We plan to establish a theoretical framework between the ribosomopathy gene and cancer development,to further facilitate the potential of these genes as diagnostic biomarker as well as pharmaceutical targets for cancer treatment.
基金Project of Guangdong Provincial Bureau of Chinese Medicine(20201371)Guangdong Medical Research Foundation(A2020170)Science and Technology Plan of Zhongshan City,Guangdong Province(2019B1014).
文摘This paper comprehensively reviews the research progress on the pharmacological effects of Ardisia gigantifolia Stapf in recent years,and finds that Ardisia gigantifolia Stapf has good pharmacological effects in many aspects,including anti-inflammation,anti-oxidation,anti-thrombosis,anti-tumor and so on.In particular,more than ten saponins have been found to have good anti-tumor activity and have potential research value,which can provide reference for the full development and utilization of Ardisia gigantifolia Stapf resources.
基金Guangdong Medical Research Foundation(A2020170,A2022479)Project of Guangdong Chinese Medicine Bureau(20201371)Zhongshan Science and Technology Plan(2019B1014).
文摘In recent years,with the modern development of traditional medicine,the research on the treatment of inflammatory bowel disease and bowel cancer is increasingly deep.This paper reviews the pharmacological research progress of flavonoids,alkaloids,polyphenols,polysaccharides,steroids and saponins in the treatment of inflammatory bowel disease and canceration.
基金supported by the National Key Research and Development Program of China(2019YFC1804604).
文摘Investigating the bioaccessibility of harmful inorganic elements in soil is crucial for understanding their behavior in the environment and accurately assessing the environmental risks associated with soil.Traditional batch experimental methods and linear models,however,are time-consuming and often fall short in precisely quantifying bioaccessibility.In this study,using 937 data points gathered from 56 journal articles,we developed machine learning models for three harmful inorganic elements,namely,Cd,Pb,and As.After thorough analysis,the model optimized through a boosting ensemble strategy demonstrated the best performance,with an average R2 of 0.95 and an RMSE of 0.25.We further employed SHAP values in conjunction with quantitative analysis to identify the key features that influence bioaccessibility.By utilizing the developed integrated models,we carried out predictions for 3002 data points across China,clarifying the bioaccessibility of cadmium(Cd),lead(Pb),and arsenic(As)in the soils of various sites and constructed a comprehensive spatial distribution map of China using the inverse distance weighting(IDW)interpolation method.Based on these findings,we further derived the soil environmental standards for metallurgical sites in China.Our observations from the collected data indicate a reduction in the number of sites exceeding the standard levels for Cd,Pb,and As in mining/smelting sites from 5,58,and 14 to 1,24,and 7,respectively.This research offers a precise and scientific approach for cross-regional risk assessment at the continental scale and lays a solid foundation for soil environmental management.
