The vision of reaching a carbon peak and achieving carbon neutrality is guiding the low-carbon transition of China’s socioeconomic system.Currently,a research gap remains in the existing literature in terms of studie...The vision of reaching a carbon peak and achieving carbon neutrality is guiding the low-carbon transition of China’s socioeconomic system.Currently,a research gap remains in the existing literature in terms of studies that systematically identify opportunities to achieve carbon neutrality.To address this gap,this study comprehensively collates and investigates 1105 published research studies regarding carbon peaking and carbon neutrality.In doing so,the principles of development in this area are quantitively analyzed from a space–time perspective.At the same time,this study traces shifts and alterations in research hotspots.This systematic review summarizes the priorities and standpoints of key industries on carbon peaking and carbon neutrality.Furthermore,with an emphasis on five key management science topics,the scientific concerns and strategic demands for these two carbon emission-reduction goals are clarified.The paper ends with theoretical insights on and practical countermeasures for actions,priority tasks,and policy measures that will enable China to achieve a carbon-neutral future.This study provides a complete picture of the research status on carbon peaking and carbon neutrality,as well as the research directions worth investigating in this field,which are crucial to the formulation of carbon peak and carbon neutrality policies.展开更多
1.Introduction Carbon mitigation engineering,also known as climate engineering internationally,is an umbrella term of engineering measures targeted at combating climate change and achieving carbon neutrality.Climate o...1.Introduction Carbon mitigation engineering,also known as climate engineering internationally,is an umbrella term of engineering measures targeted at combating climate change and achieving carbon neutrality.Climate or mitigation engineering can be commonly divided into three categories based on technological principles[1]:(1)carbon dioxide removal(CDR),which has the potential to achieve negative emissions by removing atmospheric carbon dioxide[2].展开更多
Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g...Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.展开更多
The occurrence of high frequency resonances(HFRs)has been frequently observed in several MMC-HVDC projects.To avoid these HFRs,the controller design of an MMC must satisfy two requirements:1)The controller should rema...The occurrence of high frequency resonances(HFRs)has been frequently observed in several MMC-HVDC projects.To avoid these HFRs,the controller design of an MMC must satisfy two requirements:1)The controller should remain stable while in the high frequency range,and 2)MMC impedance should not possess a negative real part in the high frequency range.So far,majority of the related studies on MMC controller design have been unable to address these requirements precisely.This paper first describes the simplified high frequency MMC impedance model developed indigenously by the authors.Subsequently,the driving mechanism of two kinds of HFRs is revealed using the said developed model,including:1)MMC controller instability,and 2)Interaction instability between MMC and AC cables.Furthermore,the mathematical expressions outlining the controller stability constraint and positive damping constraint are proposed.Additionally,NSGA-III based multi-objective optimization algorithm is adopted,to identify the region most suitable for satisfying the proposed stability constraints under the MMC controller parameters.The proposed controller design method is capable of effectively evading the HFRs triggered by the incompatible MMC.The detailed time-domain simulations generated using PSCAD/EMTDC software validate the proposed designed method and endorse the improved results.展开更多
Objective:To describe the information technology and artificial intelligence support in management experiences of the pediatric designated hospital in the wave of COVID-19 in Shanghai.Methods:We retrospectively conclu...Objective:To describe the information technology and artificial intelligence support in management experiences of the pediatric designated hospital in the wave of COVID-19 in Shanghai.Methods:We retrospectively concluded the management experiences at the largest pediatric designated hospital from March 1st to May 11th in 2022 in Shanghai.We summarized the application of Internet hospital,face recognition technology in outpatient department,critical illness warning system and remote consultation system in the ward and the structed electronic medical record in the inpatient system.We illustrated the role of the information system through the number and prognosis of patients treated.Results:The COVID-19 designated hospitals were built particularly for critical patients requiring high-level medical care,responded quickly and scientifically to prevent and control the epidemic situation.From March 1st to May 11th,2022,we received and treated 768 children confirmed by positive RT-PCR and treated at our center.In our management,we use Internet Information on the Internet Hospital,face recognition technology in outpatient department,critical illness warning system and remote consultation system in the ward,structed electronic medical record in the inpatient system.No deaths or nosocomial infections occurred.The number of offline outpatient visits dropped,from March to May 2022,146,106,48,379,57,686 respectively.But the outpatient volume on the internet hospital increased significantly(3,347 in March 2022 vs.372 in March 2021;4,465 in April 2022 vs.409 in April 2021;4,677 in May 2022 vs.538 in May 2021).Conclusions:Information technology and artificial intelligence has provided significant supports in the management.The system might optimize the admission screening process,increases the communication inside and outside the ward,achieves early detection and diagnosis,timely isolates patients,and timely treatment of various types of children.展开更多
Single atom catalysts(SACs)with metal_(1)-N_(x)sites have shown promising activity and selectivity in direct catalytic oxidation of benzene to phenol.The reaction pathway is considered to be involving two steps,includ...Single atom catalysts(SACs)with metal_(1)-N_(x)sites have shown promising activity and selectivity in direct catalytic oxidation of benzene to phenol.The reaction pathway is considered to be involving two steps,including a H_(2)O_(2)molecule dissociated on the metal single site to form the(metal_(1)-N_(x))=O active site,and followed by the dissociation of another H_(2)O_(2)on the other side of metal atom to form O=(metal_(1)-N_(x))=O intermediate center,which is active for the adsorption of benzene molecule via the formation of a C-O bond to form phenol.In this manuscript,we report a Cu SAC with nitrogen and oxygen dual-coordination(Cu1-N3O1 moiety)that doesn’t need the first H_(2)O_(2)activation process,as verified by both experimental and density function theory(DFT)calculations results.Compared with the counterpart nitrogen-coordinated Cu SAC(denoted as Cu1/NC),Cu SAC with nitrogen and oxygen dual-coordination(denoted as Cu1/NOC)exhibits 2.5 times higher turnover frequency(TOF)and 1.6 times higher utilization efficiency of H_(2)O_(2).Particularly,the coordination number(CN)of Cu atom in Cu1/NOC maintains four even after H_(2)O_(2)treatment and reaction.Combining DFT calculations,the dynamic evolution of single atomic Cu with nitrogen and oxygen dualcoordination in hydroxylation of benzene is proposed.These findings provide an efficient route to improve the catalytic performance through regulating the coordination environments of SACs and demonstrate a new reaction mechanism in hydroxylation of benzene to phenol reaction.展开更多
MXenes are promising supports for anchoring metal single atoms due to their versatile composition,well-defined nanostructures,and suitable conductivity.However,metal single atoms are usually coordinated with surface t...MXenes are promising supports for anchoring metal single atoms due to their versatile composition,well-defined nanostructures,and suitable conductivity.However,metal single atoms are usually coordinated with surface terminal groups(-O,-OH,-Cl,etc.)of MXenes via conventional wet-impregnation,resulting in limited electronic structure modification.Through a NiCl2 molten salt etching method,we observed that Ni single atoms could be in-situ doped in the lattice of MXenes analogue TiC_(0.5)N_(0.5) support(denoted as Ni1/TiC0.5N0.5),resulting in much larger charge transfer from Ni atoms to adjacent Ti atoms,and thus increasing the electronic density of these Ti atoms.When used for NO_(2) sensing,Ni_(1)/TiC_(0.5)N_(0.5) exhibited excellent response sensitivity(ultra-low limit of detection~10 ppb),selectivity,and good stability at room temperature.This study provides an effective strategy for producing MXenes analogue supported metal single atoms for potential application in gas sensing.展开更多
Detection of ppb-level NO_(2) gas under atmosphere is urgent to meet the requirements of the rapidly developing internet of things.Compared with traditional sensing methods,light illumination has been considered as a ...Detection of ppb-level NO_(2) gas under atmosphere is urgent to meet the requirements of the rapidly developing internet of things.Compared with traditional sensing methods,light illumination has been considered as a key approach for excellent gas sensor performance under moderate conditions.Herein,we developed a green-light-assisted gas sensor based on cadmium sulfide nanowires(CdS NWs)that has good NO_(2) sensing capability at ambient temperature.The response values of NO_(2) are 236%and 11%to 10 ppm and 12.5 ppb,respectively.Furthermore,the CdS NWs sensor has a high selectivity for NO_(2) over a variety of interference gases,as well as good stability.The cleaning light activation and the sulfur vacancy-trapped charge behavior of CdS NWs are observed,which suggest a light-assisted sensing mechanism.These results suggest that light-induced charge separation behavior might significantly improve gas-sensing characteristics.展开更多
基金the National Natural Science Foundation of China(71521002,72104025,and 72004011)China’s National Key Research and Development(R&D)Program(2016YFA0602603)China Post-doctoral Science Foundation(2021M690014)。
文摘The vision of reaching a carbon peak and achieving carbon neutrality is guiding the low-carbon transition of China’s socioeconomic system.Currently,a research gap remains in the existing literature in terms of studies that systematically identify opportunities to achieve carbon neutrality.To address this gap,this study comprehensively collates and investigates 1105 published research studies regarding carbon peaking and carbon neutrality.In doing so,the principles of development in this area are quantitively analyzed from a space–time perspective.At the same time,this study traces shifts and alterations in research hotspots.This systematic review summarizes the priorities and standpoints of key industries on carbon peaking and carbon neutrality.Furthermore,with an emphasis on five key management science topics,the scientific concerns and strategic demands for these two carbon emission-reduction goals are clarified.The paper ends with theoretical insights on and practical countermeasures for actions,priority tasks,and policy measures that will enable China to achieve a carbon-neutral future.This study provides a complete picture of the research status on carbon peaking and carbon neutrality,as well as the research directions worth investigating in this field,which are crucial to the formulation of carbon peak and carbon neutrality policies.
基金financial support from the National Natural Science Foundation of China(71521002)National Key Research and Development Program of China(2016YFA0602603)。
文摘1.Introduction Carbon mitigation engineering,also known as climate engineering internationally,is an umbrella term of engineering measures targeted at combating climate change and achieving carbon neutrality.Climate or mitigation engineering can be commonly divided into three categories based on technological principles[1]:(1)carbon dioxide removal(CDR),which has the potential to achieve negative emissions by removing atmospheric carbon dioxide[2].
基金supported by the National Natural Science Foundation of China(Nos.82173668,82260676)Jiangxi Provincial Natural Science Foundation(20232BAB216131,China)+2 种基金the Scientific and Technological Key Projects of Guangdong Province(Nos.2021B1111110003,2019B020202002,China)the Science and Technology Projects of Ganzhou(202101094462,China)the Start-Up Foundation of Gannan Medical University(No.QD202144-2067,China).
文摘Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.
基金supported by the National Natural Science Foundation of China (52207099).
文摘The occurrence of high frequency resonances(HFRs)has been frequently observed in several MMC-HVDC projects.To avoid these HFRs,the controller design of an MMC must satisfy two requirements:1)The controller should remain stable while in the high frequency range,and 2)MMC impedance should not possess a negative real part in the high frequency range.So far,majority of the related studies on MMC controller design have been unable to address these requirements precisely.This paper first describes the simplified high frequency MMC impedance model developed indigenously by the authors.Subsequently,the driving mechanism of two kinds of HFRs is revealed using the said developed model,including:1)MMC controller instability,and 2)Interaction instability between MMC and AC cables.Furthermore,the mathematical expressions outlining the controller stability constraint and positive damping constraint are proposed.Additionally,NSGA-III based multi-objective optimization algorithm is adopted,to identify the region most suitable for satisfying the proposed stability constraints under the MMC controller parameters.The proposed controller design method is capable of effectively evading the HFRs triggered by the incompatible MMC.The detailed time-domain simulations generated using PSCAD/EMTDC software validate the proposed designed method and endorse the improved results.
基金Evaluation Study on Fudan Pediatric Medical Consortium's Response to Public Health Emergencies Based on the Prevention and Control of COVID-19 of Shanghai Municipal Health Commission under Grant No.202150028Practical Research on Medical Management of Integrated Paediatric COVID-19 Designated Hospital in peacetime and wartime of Shanghai Shenkang Hospital Development Center under Grant No.2022SKMR-17Research on the Exploration and Application of the"4s"Management Mode of Pediatric Medical Safety under the Normalized Epidemic Prevention and Control of Shanghai Shenkang Hospital Development Center under Grant No.SHDC12021620.
文摘Objective:To describe the information technology and artificial intelligence support in management experiences of the pediatric designated hospital in the wave of COVID-19 in Shanghai.Methods:We retrospectively concluded the management experiences at the largest pediatric designated hospital from March 1st to May 11th in 2022 in Shanghai.We summarized the application of Internet hospital,face recognition technology in outpatient department,critical illness warning system and remote consultation system in the ward and the structed electronic medical record in the inpatient system.We illustrated the role of the information system through the number and prognosis of patients treated.Results:The COVID-19 designated hospitals were built particularly for critical patients requiring high-level medical care,responded quickly and scientifically to prevent and control the epidemic situation.From March 1st to May 11th,2022,we received and treated 768 children confirmed by positive RT-PCR and treated at our center.In our management,we use Internet Information on the Internet Hospital,face recognition technology in outpatient department,critical illness warning system and remote consultation system in the ward,structed electronic medical record in the inpatient system.No deaths or nosocomial infections occurred.The number of offline outpatient visits dropped,from March to May 2022,146,106,48,379,57,686 respectively.But the outpatient volume on the internet hospital increased significantly(3,347 in March 2022 vs.372 in March 2021;4,465 in April 2022 vs.409 in April 2021;4,677 in May 2022 vs.538 in May 2021).Conclusions:Information technology and artificial intelligence has provided significant supports in the management.The system might optimize the admission screening process,increases the communication inside and outside the ward,achieves early detection and diagnosis,timely isolates patients,and timely treatment of various types of children.
基金the financial support from the National Key R&D Program of China(2018YFA0208504 and 2018YFA0703503)the National Natural Science Foundation of China(21932006)the Youth Innovation Promotion Association of CAS(2017049).
基金We thank the National Key R&D Program of China(Nos.2018YFA0703503 and 2018YFA0208504)the National Natural Science Foundation of China(No.21932006)the Youth Innovation Promotion Association of CAS(No.2017049)for financial support.
文摘Single atom catalysts(SACs)with metal_(1)-N_(x)sites have shown promising activity and selectivity in direct catalytic oxidation of benzene to phenol.The reaction pathway is considered to be involving two steps,including a H_(2)O_(2)molecule dissociated on the metal single site to form the(metal_(1)-N_(x))=O active site,and followed by the dissociation of another H_(2)O_(2)on the other side of metal atom to form O=(metal_(1)-N_(x))=O intermediate center,which is active for the adsorption of benzene molecule via the formation of a C-O bond to form phenol.In this manuscript,we report a Cu SAC with nitrogen and oxygen dual-coordination(Cu1-N3O1 moiety)that doesn’t need the first H_(2)O_(2)activation process,as verified by both experimental and density function theory(DFT)calculations results.Compared with the counterpart nitrogen-coordinated Cu SAC(denoted as Cu1/NC),Cu SAC with nitrogen and oxygen dual-coordination(denoted as Cu1/NOC)exhibits 2.5 times higher turnover frequency(TOF)and 1.6 times higher utilization efficiency of H_(2)O_(2).Particularly,the coordination number(CN)of Cu atom in Cu1/NOC maintains four even after H_(2)O_(2)treatment and reaction.Combining DFT calculations,the dynamic evolution of single atomic Cu with nitrogen and oxygen dualcoordination in hydroxylation of benzene is proposed.These findings provide an efficient route to improve the catalytic performance through regulating the coordination environments of SACs and demonstrate a new reaction mechanism in hydroxylation of benzene to phenol reaction.
基金National Key R&D Program of China(No.2018YFA0208504)the National Natural Science Foundation of China(Nos.21932006 and 92161112)+1 种基金the National Science Basic Research Program of Shaanxi(Nos.S2020-JC-WT-0001 and 2021JCW-20)the Youth Innovation Promotion Association of CAS(No.Y2017049)for financial support.
文摘MXenes are promising supports for anchoring metal single atoms due to their versatile composition,well-defined nanostructures,and suitable conductivity.However,metal single atoms are usually coordinated with surface terminal groups(-O,-OH,-Cl,etc.)of MXenes via conventional wet-impregnation,resulting in limited electronic structure modification.Through a NiCl2 molten salt etching method,we observed that Ni single atoms could be in-situ doped in the lattice of MXenes analogue TiC_(0.5)N_(0.5) support(denoted as Ni1/TiC0.5N0.5),resulting in much larger charge transfer from Ni atoms to adjacent Ti atoms,and thus increasing the electronic density of these Ti atoms.When used for NO_(2) sensing,Ni_(1)/TiC_(0.5)N_(0.5) exhibited excellent response sensitivity(ultra-low limit of detection~10 ppb),selectivity,and good stability at room temperature.This study provides an effective strategy for producing MXenes analogue supported metal single atoms for potential application in gas sensing.
基金The authors are thankful for the financial support from the National Key Research and Development Program of China(Grant No.2018YFA0208504)National Natural Science Foundation of China(NSFC 21932006)the Youth Innovation Promotion Association of CAS(2017049).
文摘Detection of ppb-level NO_(2) gas under atmosphere is urgent to meet the requirements of the rapidly developing internet of things.Compared with traditional sensing methods,light illumination has been considered as a key approach for excellent gas sensor performance under moderate conditions.Herein,we developed a green-light-assisted gas sensor based on cadmium sulfide nanowires(CdS NWs)that has good NO_(2) sensing capability at ambient temperature.The response values of NO_(2) are 236%and 11%to 10 ppm and 12.5 ppb,respectively.Furthermore,the CdS NWs sensor has a high selectivity for NO_(2) over a variety of interference gases,as well as good stability.The cleaning light activation and the sulfur vacancy-trapped charge behavior of CdS NWs are observed,which suggest a light-assisted sensing mechanism.These results suggest that light-induced charge separation behavior might significantly improve gas-sensing characteristics.
