This paper is focused on the post-buckling behavior of the fixed laminated composite beams with effects of axial compression force and the shear deformation.The analytical solutions are established for the original co...This paper is focused on the post-buckling behavior of the fixed laminated composite beams with effects of axial compression force and the shear deformation.The analytical solutions are established for the original control equations(that is not simplified)by applying the Maclaurin series expansion,Chebyshev polynomials,the harmonic balance method and the Newton’s method.The validity of the present method is verified via comparing the analytical approximate solutions with the numerical ones which are obtained by the shooting method.The present third analytical approximate solutions can give excellent agreement with the numerical solutions for a wide range of the deformation amplitudes.What’s more,the effect of shear deformation on the post-bucking configuration of the sandwich beam is also proposed.It can be found that the shear angle has a great influence on the post-buckling load of composite beams.Therefore,the model simplifying the shear formation term as small quantity is not accurate for the case of sandwich beam with soft core.展开更多
Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is oft...Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC.展开更多
Developing dopant-free hole-transporting materials(HTMs)for high-performance perovskite solar cells(PVSCs)has been a very active research topic in recent years since HTMs play a critical role in optimizing interfacial...Developing dopant-free hole-transporting materials(HTMs)for high-performance perovskite solar cells(PVSCs)has been a very active research topic in recent years since HTMs play a critical role in optimizing interfacial charge carrier kinetics and in turn determining device performance.Here,a novel dendritic engineering strategy is first utilized to design HTMs with a D-A type molecular framework,and diphenylamine and/or carbazole is selected as the building block for constructing dendrons.All HTMs show good thermal stability and excellent film morphology,and the key optoelectronic properties could be fine-tuned by varying the dendron structure.Among them,MPA-Cz-BTI and MCz-Cz-BTI exhibit an improved interfacial contact with the perovskite active layer,and non-radiative recombination loss and charge transport loss can be effectively suppressed.Consequently,high power conversion efficiencies(PCEs)of 20.8%and 21.35%are achieved for MPA-Cz-BTI and MCz-Cz-BTI based devices,respectively,accompanied by excellent long-term storage stability.More encouragingly,ultrahigh fill factors of 85.2%and 83.5%are recorded for both devices,which are among the highest values reported to date.This work demonstrates the great potential of dendritic materials as a new type of dopant-free HTMs for high-performance PVSCs with excellent FF.展开更多
Background:Lymphocytic density in rectal cancer has been reported to be associated with therapeutic response,but the role of the lymphocytic distribution pattern remains to be determined.This study aimed to evaluate t...Background:Lymphocytic density in rectal cancer has been reported to be associated with therapeutic response,but the role of the lymphocytic distribution pattern remains to be determined.This study aimed to evaluate the association between the distribution and density of lymphocytes in rectal-cancer tissue with tumor response to neoadjuvant therapy.Methods:We retrospectively analysed 134 patients with rectal cancer receiving neoadjuvant therapy within a prospectively maintained cohort.Pretherapeutic biopsy samples were stained with immunohistochemistry(CD4 and CD8).Densities of intratumoral periglandular lymphocytes(IPLs)and tumor-infiltrating lymphocytes(TILs)were assessed separately.Logistic-regression analysis was used to assess associations of lymphocyte densities with tumor regression grade(TRG),controlling for clinicopathological,molecular,and regimen features.Results:Compared with cases in the lowest quartile of CD8^(+)TILs,those in the highest quartile were significantly associated with better TRG(multivariate odds ratio,0.23;95%confidence interval,0.07 to 0.76;P<0.001).In contrast,CD8^(+)IPLs,CD4^(+)IPLs,and CD4^(+)TILswere not significantly associatedwith TRG(P=0.033,0.156,and 0.170,respectively).Sensitivity analyses detected no interaction between CD8^(+)TILs and regimen of neoadjuvant radiation(Pinteraction=0.831)or chemotherapy(Pinteraction=0.879)on TRG.Conclusions:Our data suggest that CD8^(+)TILs,but not IPLs,are independently associated with response to neoadjuvant therapy,regardless of the regimen of radiation or chemotherapy.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.41972323 and 51991364)Science and Technology Project of the 13th Five-Year Plan of Jilin Provincial Department of Education(Grant No.JJKH20190126KJ)the Science and Technology Developing Plan Project of Jilin Province(Grant No.20160520021JH).
文摘This paper is focused on the post-buckling behavior of the fixed laminated composite beams with effects of axial compression force and the shear deformation.The analytical solutions are established for the original control equations(that is not simplified)by applying the Maclaurin series expansion,Chebyshev polynomials,the harmonic balance method and the Newton’s method.The validity of the present method is verified via comparing the analytical approximate solutions with the numerical ones which are obtained by the shooting method.The present third analytical approximate solutions can give excellent agreement with the numerical solutions for a wide range of the deformation amplitudes.What’s more,the effect of shear deformation on the post-bucking configuration of the sandwich beam is also proposed.It can be found that the shear angle has a great influence on the post-buckling load of composite beams.Therefore,the model simplifying the shear formation term as small quantity is not accurate for the case of sandwich beam with soft core.
基金This work was supported by the grants of the National Key R&D Program of China(2017YFC1309001)Guangzhou Science and Technology Plan Projects(Health Medical Collaborative Innovation Program of Guangzhou,201803040019)+3 种基金National Natural Science Foundation of China(81730072,81672407 and 81872001,81902411)Guangdong Natural Science Funds for Distinguished Young Scholar(No.2015A030306001)National Postdoctoral Program for Innovative Talents(BX201700299)China Postdoctoral Science Foundation(2018M643342).
文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC.
基金the National Natural Science Foundation of China(21805128,21774055,61775091)Shenzhen Key Laboratory Project(ZDSYS201602261933302)+2 种基金Shenzhen Innovation Committee(JCYJ20180504165851864)Shenzhen Innovation Committee(JCYJ20170818141216288)the Seed Funding for Strategic Interdisciplinary Research Scheme of the University of Hong Kong。
文摘Developing dopant-free hole-transporting materials(HTMs)for high-performance perovskite solar cells(PVSCs)has been a very active research topic in recent years since HTMs play a critical role in optimizing interfacial charge carrier kinetics and in turn determining device performance.Here,a novel dendritic engineering strategy is first utilized to design HTMs with a D-A type molecular framework,and diphenylamine and/or carbazole is selected as the building block for constructing dendrons.All HTMs show good thermal stability and excellent film morphology,and the key optoelectronic properties could be fine-tuned by varying the dendron structure.Among them,MPA-Cz-BTI and MCz-Cz-BTI exhibit an improved interfacial contact with the perovskite active layer,and non-radiative recombination loss and charge transport loss can be effectively suppressed.Consequently,high power conversion efficiencies(PCEs)of 20.8%and 21.35%are achieved for MPA-Cz-BTI and MCz-Cz-BTI based devices,respectively,accompanied by excellent long-term storage stability.More encouragingly,ultrahigh fill factors of 85.2%and 83.5%are recorded for both devices,which are among the highest values reported to date.This work demonstrates the great potential of dendritic materials as a new type of dopant-free HTMs for high-performance PVSCs with excellent FF.
基金supported by a National Natural Scientific Foundation of China grant[No.31601077 to R.D.]a Guangzhou Science and Technology Plan[No.201604020005 to J.W.].
文摘Background:Lymphocytic density in rectal cancer has been reported to be associated with therapeutic response,but the role of the lymphocytic distribution pattern remains to be determined.This study aimed to evaluate the association between the distribution and density of lymphocytes in rectal-cancer tissue with tumor response to neoadjuvant therapy.Methods:We retrospectively analysed 134 patients with rectal cancer receiving neoadjuvant therapy within a prospectively maintained cohort.Pretherapeutic biopsy samples were stained with immunohistochemistry(CD4 and CD8).Densities of intratumoral periglandular lymphocytes(IPLs)and tumor-infiltrating lymphocytes(TILs)were assessed separately.Logistic-regression analysis was used to assess associations of lymphocyte densities with tumor regression grade(TRG),controlling for clinicopathological,molecular,and regimen features.Results:Compared with cases in the lowest quartile of CD8^(+)TILs,those in the highest quartile were significantly associated with better TRG(multivariate odds ratio,0.23;95%confidence interval,0.07 to 0.76;P<0.001).In contrast,CD8^(+)IPLs,CD4^(+)IPLs,and CD4^(+)TILswere not significantly associatedwith TRG(P=0.033,0.156,and 0.170,respectively).Sensitivity analyses detected no interaction between CD8^(+)TILs and regimen of neoadjuvant radiation(Pinteraction=0.831)or chemotherapy(Pinteraction=0.879)on TRG.Conclusions:Our data suggest that CD8^(+)TILs,but not IPLs,are independently associated with response to neoadjuvant therapy,regardless of the regimen of radiation or chemotherapy.
