Three-dimensional(3D)tumor models prepared from patient-derived cells have been reported to imitate some of the biological development processes of in situ tumors in vitro.These 3D tumor models share several important...Three-dimensional(3D)tumor models prepared from patient-derived cells have been reported to imitate some of the biological development processes of in situ tumors in vitro.These 3D tumor models share several important characteristics with their in vivo tumor counterparts.Accordingly,their applications in tumor modeling,drug screening,and precision-targeted treatment are promising.However,the establishment of tumormodels is subject to several challenges,including advancements in scale size,repeatability,structural precision in time and space,vascularization,and the tumor microenvironment.Recently,bioprinting technologies enabling the editorial arrangement of cells,factors,and materials have improved the simulation of tumormodels in vitro.Among the 3D bioprinted tumor models,the organoidmodel has been widely appreciated for its advantages of maintaining high heterogeneity and capacity for simulating the developmental process of tumor tissues.In this review,we outline approaches and potential prospects for tumor model bioprinting and discuss the existing bioprinting technologies and bioinks in tumor model construction.The multidisciplinary combination of tumor pathology,molecular biology,material science,and additive manufacturing will help overcome the barriers to tumor model construction by allowing consideration of the structural and functional characteristics of in vitro models and promoting the development of heterogeneous tumor precision therapies.展开更多
Potassium-based dual ion batteries(KDIBs)have attracted significant attention owing to high working voltage,high safety,low processing cost,and environmental friendliness.Nevertheless,one great challenge for practical...Potassium-based dual ion batteries(KDIBs)have attracted significant attention owing to high working voltage,high safety,low processing cost,and environmental friendliness.Nevertheless,one great challenge for practical KDIBs is to develop suitable anode materials with high specific capacity.Herein,we report an architecture of hierarchically porous antimony nanoparticles/carbon nanofibers(HPSb CNFs)as flexible,free-standing anode for high-performance KDIBs.The HPSb CNFs with hierarchically porous structure,and high-content nitrogen doping,not only offer sufficient free space to tolerate the repetitive volume expansion of Sb nanoparticles during long-term cycling,but also greatly facilitate the transport of electrons and ions within electrode,ensuring high material utilization ratio.Thus,the KDIBs,constituted by HPSb CNFs-700(calcined at 700°C)anode and graphite cathode,exhibited a high reversible capacity of 440 m Ah g^(-1)with high discharge medium voltage of 4.5 V at a specific current of 200 m A g^(-1)(the highest capacity for all KDIBs normalized by the mass of the anode),and excellent cyclic life.Outstanding electrochemical reversibility of the KDIBs was further demonstrated by ex situ XRD,ex situ Raman spectrum,and HRTEM.These results suggest the as-designed HPSb CNFs-700 with highcapacity and long-term cycling stability is a promising anode material for high-performance KDIBs.展开更多
Fibrous nanofluidic materials are ideal building blocks for implantable electrode,biomimetic actuator,wearable electronics due to their favorable features of intrinsic flexibility and unidirectional ion transport.Howe...Fibrous nanofluidic materials are ideal building blocks for implantable electrode,biomimetic actuator,wearable electronics due to their favorable features of intrinsic flexibility and unidirectional ion transport.However,the large-scale preparation of fibrous nanofluidic materials with desirable mechanical strength and good environment adaptability for practical use remains challenging.Herein,by fully taking advantage of the attractive mechanical,structural,chemical features of boron nitride(BN)nanosheet and nanofibrillated cellulose(NFC),a scalable and cost-effective three-dimensional(3D)printed macrofiber featuring abundant vertically aligned nanofluidic channels is demonstrated to exhibit a good combination of high tensile strength of 100 MPa,thermal stability of up to 230℃,ionic conductivity of 1.8×10^(−4)S/cm at low salt concentrations(<10^(−3)M).In addition,the versatile surface chemistry of cellulose allows us to stabilize the macrofiber at the molecular level via a facile postcross-linking method,which eventually enables the stable operation of the modified macrofiber in various extreme environments such as strong acidic,strong alkaline,high temperature.We believe this work implies a promising guideline for designing and manufacturing fibrous nanodevices towards extreme environment operations.展开更多
With unprecedented properties and functions,polymer-based hybrid materials hold extremely important position in many fields.Here in this review,we summarized applications of polymer-based hybrid materials toward perso...With unprecedented properties and functions,polymer-based hybrid materials hold extremely important position in many fields.Here in this review,we summarized applications of polymer-based hybrid materials toward personal health.Firstly,theoretical calculation and in-situ visualization used to explore the interfacial interaction and formation of hybrid materials are introduced.Secondly,applications of polymer-based hybrid materials in personal health from proactive protection(anti-bacteria and harmful gas removal),health condition monitoring(breathing and sleep)to disease diagnosis(magnetic resonance imaging),and tissue therapy(dental restoration)are discussed.Additionally,aggregation-induced emission(AIE)organic molecules based optical sensors for personal security and polymer semiconductor for organic thin film transistors are simply discussed.Finally,we present the future tendency for preparing polymer-based hybrid materials that related with personal health.展开更多
Capacitive deionization is an attractive approach to water desalination and treatment. To achieve efficient capacitative desalination, rationally designed electrodes with high specific capacitances, conductivities, an...Capacitive deionization is an attractive approach to water desalination and treatment. To achieve efficient capacitative desalination, rationally designed electrodes with high specific capacitances, conductivities, and stabilities are necessary. Here we report the construction of a three-dimensional （3D） holey graphene hydrogel （HGH）. This material contains abundant in-plane pores, offering efficient ion transport pathways. Furthermore, it forms a highly interconnected network of graphene sheets, providing efficient electron transport pathways, and its 3D hierarchical porous structure can provide a large specific surface area for the adsorption and storage of ions. Consequently, HGH serves as a binder-free electrode material with excellent electrical conductivity. Cyclic voltammetry （CV） measurements indicate that the optimized HGH can achieve specific capacitances of 358.4 F.g 1 in 6 M KOH solution and 148 F.g-1 in 0.5 M NaCl solution. Because of these high capacitances, HGH has a desalination capadty as high as 26.8 mg.g-1 （applied potential： 1.2 V; initial NaCI concentration： -5,000 mg.L-l）.展开更多
To explore the evolutionary relationships of Noctuoidea, the complete mitochondrial genome of Lemyra melli （Daniel） was sequenced and annotated. It was 15 418 bp in size, including 37 genes and one AT-rich region. T...To explore the evolutionary relationships of Noctuoidea, the complete mitochondrial genome of Lemyra melli （Daniel） was sequenced and annotated. It was 15 418 bp in size, including 37 genes and one AT-rich region. The nucleotide composition was biased towards A＋T （78.67%）. Most of the protein-coding genes are initiated by typical ATN codons, except for coxI, which uses a CGA. Nine are terminated with TAA or TAG, whereas four genes, cox1, cox11, nad4 and nad6, harbor incomplete termination codons of a single T. All of the tRNA genes have the typical clover-leaf structure, except trnS （AGN）. The A＋T-rich region is 338 bp, with a 93.38% AT content and several conserved structures, including a ATAGA ＋ poly T stretch, ATTTA ＋ （AT）n, a poly（A）, stem-and-loop structure with 5＇ flanking ＂TATA＂ and 3＇ flanking ＂GAAT＂ motifs and tandem-repeated elements. The phylogenetic relationship among the superfamily Noctuoidea is [Notodontidae ＋ （Erebidae ＋ （Nolidae ＋ （Euteliidae ＋ Noctuidae）））], and inside family Erebidae is [Arctiinae ＋ （Aganainae ＋ Lymantriidae）].展开更多
基金The authors appreciated the financial support from the National Key R&D Program of China(No.2018YFA0703000)the National Natural Science Foundation of China(No.82072412)+2 种基金the Translation Medicine National Key Science and Technology Infrastructure(Shanghai)Open Project(No.TMSK-2020-118)the Lingang Laboratory“Seeking Outstanding Youth Program”Open Project(No.LG-QS-202206-04)the Shanghai Municipal Natural Science Foundation(No.19ZR1429100).
文摘Three-dimensional(3D)tumor models prepared from patient-derived cells have been reported to imitate some of the biological development processes of in situ tumors in vitro.These 3D tumor models share several important characteristics with their in vivo tumor counterparts.Accordingly,their applications in tumor modeling,drug screening,and precision-targeted treatment are promising.However,the establishment of tumormodels is subject to several challenges,including advancements in scale size,repeatability,structural precision in time and space,vascularization,and the tumor microenvironment.Recently,bioprinting technologies enabling the editorial arrangement of cells,factors,and materials have improved the simulation of tumormodels in vitro.Among the 3D bioprinted tumor models,the organoidmodel has been widely appreciated for its advantages of maintaining high heterogeneity and capacity for simulating the developmental process of tumor tissues.In this review,we outline approaches and potential prospects for tumor model bioprinting and discuss the existing bioprinting technologies and bioinks in tumor model construction.The multidisciplinary combination of tumor pathology,molecular biology,material science,and additive manufacturing will help overcome the barriers to tumor model construction by allowing consideration of the structural and functional characteristics of in vitro models and promoting the development of heterogeneous tumor precision therapies.
基金financially supported by the National Natural Science Foundation of China(Grant No.21673070)the Fundamental Research Funds of the Central Universities(No.531107051048)Hunan Key Laboratory of Two-Dimensional Materials(No.801200005)
文摘Potassium-based dual ion batteries(KDIBs)have attracted significant attention owing to high working voltage,high safety,low processing cost,and environmental friendliness.Nevertheless,one great challenge for practical KDIBs is to develop suitable anode materials with high specific capacity.Herein,we report an architecture of hierarchically porous antimony nanoparticles/carbon nanofibers(HPSb CNFs)as flexible,free-standing anode for high-performance KDIBs.The HPSb CNFs with hierarchically porous structure,and high-content nitrogen doping,not only offer sufficient free space to tolerate the repetitive volume expansion of Sb nanoparticles during long-term cycling,but also greatly facilitate the transport of electrons and ions within electrode,ensuring high material utilization ratio.Thus,the KDIBs,constituted by HPSb CNFs-700(calcined at 700°C)anode and graphite cathode,exhibited a high reversible capacity of 440 m Ah g^(-1)with high discharge medium voltage of 4.5 V at a specific current of 200 m A g^(-1)(the highest capacity for all KDIBs normalized by the mass of the anode),and excellent cyclic life.Outstanding electrochemical reversibility of the KDIBs was further demonstrated by ex situ XRD,ex situ Raman spectrum,and HRTEM.These results suggest the as-designed HPSb CNFs-700 with highcapacity and long-term cycling stability is a promising anode material for high-performance KDIBs.
文摘Fibrous nanofluidic materials are ideal building blocks for implantable electrode,biomimetic actuator,wearable electronics due to their favorable features of intrinsic flexibility and unidirectional ion transport.However,the large-scale preparation of fibrous nanofluidic materials with desirable mechanical strength and good environment adaptability for practical use remains challenging.Herein,by fully taking advantage of the attractive mechanical,structural,chemical features of boron nitride(BN)nanosheet and nanofibrillated cellulose(NFC),a scalable and cost-effective three-dimensional(3D)printed macrofiber featuring abundant vertically aligned nanofluidic channels is demonstrated to exhibit a good combination of high tensile strength of 100 MPa,thermal stability of up to 230℃,ionic conductivity of 1.8×10^(−4)S/cm at low salt concentrations(<10^(−3)M).In addition,the versatile surface chemistry of cellulose allows us to stabilize the macrofiber at the molecular level via a facile postcross-linking method,which eventually enables the stable operation of the modified macrofiber in various extreme environments such as strong acidic,strong alkaline,high temperature.We believe this work implies a promising guideline for designing and manufacturing fibrous nanodevices towards extreme environment operations.
基金supported by the National Key Research and Development Program of China(Nos.2021YFA1201301,2021YFA1201300,and 2021YFA1201304)the National Natural Science Foundation of China(Nos.51903042,52103298,51973030,and 22173017)+1 种基金the Science and Technology Commission of Shanghai Municipality(Nos.20JC1414900,21ZR1401400,and 19ZR1470600)the Fundamental Research Funds for the Central Universities(No.2232021A-06).
文摘With unprecedented properties and functions,polymer-based hybrid materials hold extremely important position in many fields.Here in this review,we summarized applications of polymer-based hybrid materials toward personal health.Firstly,theoretical calculation and in-situ visualization used to explore the interfacial interaction and formation of hybrid materials are introduced.Secondly,applications of polymer-based hybrid materials in personal health from proactive protection(anti-bacteria and harmful gas removal),health condition monitoring(breathing and sleep)to disease diagnosis(magnetic resonance imaging),and tissue therapy(dental restoration)are discussed.Additionally,aggregation-induced emission(AIE)organic molecules based optical sensors for personal security and polymer semiconductor for organic thin film transistors are simply discussed.Finally,we present the future tendency for preparing polymer-based hybrid materials that related with personal health.
基金This work was finally supported by the National Natural Science Foundation of China （No. 61528403）.
文摘Capacitive deionization is an attractive approach to water desalination and treatment. To achieve efficient capacitative desalination, rationally designed electrodes with high specific capacitances, conductivities, and stabilities are necessary. Here we report the construction of a three-dimensional （3D） holey graphene hydrogel （HGH）. This material contains abundant in-plane pores, offering efficient ion transport pathways. Furthermore, it forms a highly interconnected network of graphene sheets, providing efficient electron transport pathways, and its 3D hierarchical porous structure can provide a large specific surface area for the adsorption and storage of ions. Consequently, HGH serves as a binder-free electrode material with excellent electrical conductivity. Cyclic voltammetry （CV） measurements indicate that the optimized HGH can achieve specific capacitances of 358.4 F.g 1 in 6 M KOH solution and 148 F.g-1 in 0.5 M NaCl solution. Because of these high capacitances, HGH has a desalination capadty as high as 26.8 mg.g-1 （applied potential： 1.2 V; initial NaCI concentration： -5,000 mg.L-l）.
基金provided jointly by the Youth Science&Technology New Star Program(2013KJXX-96)the Educational Commission of Shaanxi Province of China(14JS003)
文摘To explore the evolutionary relationships of Noctuoidea, the complete mitochondrial genome of Lemyra melli （Daniel） was sequenced and annotated. It was 15 418 bp in size, including 37 genes and one AT-rich region. The nucleotide composition was biased towards A＋T （78.67%）. Most of the protein-coding genes are initiated by typical ATN codons, except for coxI, which uses a CGA. Nine are terminated with TAA or TAG, whereas four genes, cox1, cox11, nad4 and nad6, harbor incomplete termination codons of a single T. All of the tRNA genes have the typical clover-leaf structure, except trnS （AGN）. The A＋T-rich region is 338 bp, with a 93.38% AT content and several conserved structures, including a ATAGA ＋ poly T stretch, ATTTA ＋ （AT）n, a poly（A）, stem-and-loop structure with 5＇ flanking ＂TATA＂ and 3＇ flanking ＂GAAT＂ motifs and tandem-repeated elements. The phylogenetic relationship among the superfamily Noctuoidea is [Notodontidae ＋ （Erebidae ＋ （Nolidae ＋ （Euteliidae ＋ Noctuidae）））], and inside family Erebidae is [Arctiinae ＋ （Aganainae ＋ Lymantriidae）].
