Agronomic measures are the key to promote the sustainable development of ratoon rice by reducing the damage from mechanical crushing to the residual stubble of the main crop, thereby mitigating the impact on axillary ...Agronomic measures are the key to promote the sustainable development of ratoon rice by reducing the damage from mechanical crushing to the residual stubble of the main crop, thereby mitigating the impact on axillary bud sprouting and yield formation in ratoon rice. This study used widely recommended conventional rice Jiafuzhan and hybrid rice Yongyou 2640 as the test materials to conduct a four-factor block design field experiment in a greenhouse of the experimental farm of Fujian Agricultural and Forestry University, China from 2018 to 2019.The treatments included fertilization and no fertilization, alternate wetting and drying irrigation and continuous water flooding irrigation, and plots with and without artificial crushing damage on the rice stubble. At the same time, a 13C stable isotope in-situ detection technology was used to fertilize the pot experiment. The results showed significant interactions among varieties, water management, nitrogen application and stubble status.Relative to the long-term water flooding treatment, the treatment with sequential application of nitrogen fertilizer coupled with moderate field drought for root-vigor and tiller promotion before and after harvesting of the main crop, significantly improved the effective tillers from low position nodes. This in turn increased the effective panicles per plant and grains per panicle by reducing the influence of artificial crushing damage on rice stubble and achieving a high yield of the regenerated rice. Furthermore, the partitioning of 13C assimilates to the residual stubble and its axillary buds were significantly improved at the mature stage of the main crop, while the translocation rate to roots and rhizosphere soil was reduced at the later growth stage of ratooning season rice. This was triggered by the metabolism of hormones and polyamines at the stem base regulated by the interaction of water and fertilizer at this time. We therefore suggest that to achieve a high yield of ratoon rice with low stubble height under mechanized harvesting, the timely application of nitrogen fertilizer is fundamental,coupled with moderate field drying for root-vigor preservation and tiller promotion before and after the mechanical harvesting of the main crop.展开更多
Nowadays,the rapid development of edge computing has driven an increasing number of deep learning applications deployed at the edge of the network,such as pedestrian and vehicle detection,to provide efficient intellig...Nowadays,the rapid development of edge computing has driven an increasing number of deep learning applications deployed at the edge of the network,such as pedestrian and vehicle detection,to provide efficient intelligent services to mobile users.However,as the accuracy requirements continue to increase,the components of deep learning models for pedestrian and vehicle detection,such as YOLOv4,become more sophisticated and the computing resources required for model training are increasing dramatically,which in turn leads to significant challenges in achieving effective deployment on resource-constrained edge devices while ensuring the high accuracy performance.For addressing this challenge,a cloud-edge collaboration-based pedestrian and vehicle detection framework is proposed in this paper,which enables sufficient training of models by utilizing the abundant computing resources in the cloud,and then deploying the well-trained models on edge devices,thus reducing the computing resource requirements for model training on edge devices.Furthermore,to reduce the size of the model deployed on edge devices,an automatic pruning method combines the convolution layer and BN layer is proposed to compress the pedestrian and vehicle detection model size.Experimental results show that the framework proposed in this paper is able to deploy the pruned model on a real edge device,Jetson TX2,with 6.72 times higher FPS.Meanwhile,the channel pruning reduces the volume and the number of parameters to 96.77%for the model,and the computing amount is reduced to 81.37%.展开更多
BACKGROUND:A combination of basic fibroblast growth factor(bFGF),platelet-derived growth factor(PDGF),human heregulin-beta-1,beta-mercaptoethanol retinoic acid and forskolin has been reported to induce the differentia...BACKGROUND:A combination of basic fibroblast growth factor(bFGF),platelet-derived growth factor(PDGF),human heregulin-beta-1,beta-mercaptoethanol retinoic acid and forskolin has been reported to induce the differentiation of rat bone marrow stromal cells into myelinating Schwann-like cells. OBJECTIVE:To investigate the inducing effects of a combination of bFGF,PDGF,human heregulin-beta-1,beta-mercaptoethanol retinoic acid and forskolin on neural stem cell differentiation by one- and two-step methods. DESIGN,TIME AND SETTING:A cytobiology experiment was performed at the Department of Histology and Embryology,Medical School of Nantong University,and Jiangsu Province Key Laboratory of Neuroregeneration,China,between August 2005 and January 2007. MATERIALS:A total of 30 healthy Sprague Dawley rat embryos at gestational days 14-16 were selected.bFGF,PDGF,human heregulin-beta-1,beta-mercaptoethanol,retinoic acid,and forskolin were purchased from Sigma,USA. METHODS:Passage 3 rat neural stem cells were cultured by a one-step method in serum-free medium plus 10 ng/mL bFGF,5 ng/mL PDGF,200 ng/mL heregulin-beta-1,35 ng/mL all-trans retinoic acid,and 5μmol/L forskolin or by a two-step method in serum-free medium plus 35 ng/mL all-trans retinoic acid for 72 hours,followed by serum-free medium plus 10 ng/mL bFGF,5 ng/mL PDGF,200 ng/mL heregulin-beta-1 and 5μmol/L forskolin.The control condition consisted of 10% fetal bovine serum alone or 20 ng/mL bFGF alone. MAIN OUTCOME MEASURES:Differentiated cells were identified by immunocytochemical staining for microtubule associate protein-2(MAP2) and S100 protein.Geometric parameters and sodium ion currents of the differentiated cells were measured by image analysis and whole-cell patch-clamp techniques,respectively. RESULTS:Compared with the two-step culture method,neuronal-like cells exhibited longer processes and a similar appearance to mature neurons using the one-step method.The percentage of MAP2 positive cells induced by the one-step method was significantly greater than the serum-alone group(P<0.05).Furthermore,the MAP2 positive cells induced by the one-step method had greater surface areas,cell body perimeters,and longer process than cells induced by serum-alone and bFGF-alone(P<0.05).There were no significant differences in these parameters between the one-step and two-step methods(P>0.05).In addition,80%of the induced neuronal-like cells from the one-step method and 20%from the two-step method displayed inwardly-evoked currents. CONCLUSION:The combination of bFGF,PDGF,human heregulin-beta-1,beta-mercaptoethanol retinoic acid and forskolin successfully induced neuronal differentiation from neural stem cells,with the one-step induction being more effective than the two-step method.展开更多
Alzheimer's disease(AD)represents the main form of dementia;however,valid diagnosis and treatment measures are lacking.The discovery of valuable biomarkers through omics technologies can help solve this problem.Fo...Alzheimer's disease(AD)represents the main form of dementia;however,valid diagnosis and treatment measures are lacking.The discovery of valuable biomarkers through omics technologies can help solve this problem.For this reason,metabolomic analysis using ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS)was carried out on plasma,hippocampus,and cortex samples of an AD rat model.Based on the metabolomic data,we report a multi-factor combined biomarker screening strategy to rapidly and accurately identify potential biomarkers.Compared with the usual procedure,our strategy can identify fewer biomarkers with higher diagnostic specificity and sensitivity.In addition to diagnosis,the potential biomarkers identified using our strategy were also beneficial for drug evaluation.Multi-factor combined biomarker screening strategy was used to identify differential metabolites from a rat model of amyloid beta peptide 1e40(Aβ_(1-40))plus ibotenic acid-induced AD(compared with the controls)for the first time;lysophosphatidylcholine(LysoPC)and intermediates of sphingolipid metabolism were screened as potential biomarkers.Subsequently,the effects of donepezil and pine nut were successfully reflected by regulating the levels of the abovementioned biomarkers and metabolic profile distribution in partial least squaresdiscriminant analysis(PLS-DA).This novel biomarker screening strategy can be used to analyze other metabolomic data to simultaneously enable disease diagnosis and drug evaluation.展开更多
In this paper,a cybersecurity threat warning model based on ant colony algorithm is designed to strengthen the accuracy of the cybersecurity threat warning model in the warning process and optimize its algorithm struc...In this paper,a cybersecurity threat warning model based on ant colony algorithm is designed to strengthen the accuracy of the cybersecurity threat warning model in the warning process and optimize its algorithm structure.Through the ant colony algorithm structure,the local global optimal solution is obtained;and the cybersecurity threat warning index system is established.Next,the above two steps are integrated to build the cybersecurity threat warning model based on ant colony algorithm,and comparative experiment is also designed.The experimental results show that,compared with the traditional qualitative differential game-based cybersecurity threat warning model,the cybersecurity threat warning model based on ant colony algorithm has a higher correct rate in the warning process,and the algorithm program is simpler with higher use value.展开更多
Rare earth co-doped phosphor for fluorescence intensity ratio(FIR) thermometer has gained increasing attention in recent years. Herein, the novel Tb^(3+)and Eu^(3+)co-doped K_(3)SrBi(P_(2)O_(7))_(2)(KSBP) phosphate ph...Rare earth co-doped phosphor for fluorescence intensity ratio(FIR) thermometer has gained increasing attention in recent years. Herein, the novel Tb^(3+)and Eu^(3+)co-doped K_(3)SrBi(P_(2)O_(7))_(2)(KSBP) phosphate phosphors were reported. The crystal structure of the title phosphor was determined using Rietveld refinement and proved to have a three-dimensional structure. The time-resolved spectroscopy reveals that there is almost no energy transfer between Tb^(3+)and Eu^(3+). More importantly, Tb^(3+)and Eu^(3+)emissions show different thermal quenching behaviors, which claims the potential of this material for application in optical thermometer. The FIR of the typical KSBP:0.02Tb^(3+),0.04Eu^(3+)sample demonstrates a polynomial relationship as a function of temperature and the absolute and relative sensitivity are0.025 K^(-1) and 0.59%/K, respectively. In general, our study reports a novel and potential KSBP:Tb^(3+),Eu^(3+)phosphate phosphor that is promising for use in high-sensitive FIR thermometers.展开更多
To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethan...To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes(PCPUs).Poly(e-caprolactone)(PCL)and poly(ethylene glycol)(PEG)are used as soft segments,and L-lysine ethyl ester diisocyanate(LDI),LAPC and L-lysine are used as hard segments.The obtained PCPUs exhibit appropriate mechanical properties with break elongation of 1000–1700%,tensile strength of 7–22 MPa,and relatively high elastic modulus of 11–18 MPa,which could admirably satisfy the requirement for soft tissue engineering scaffolds.The phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces,which effectively reduce protein adsorption and platelet adhesion while promoting the cell proliferation.In addition,the LAPC chain extender,PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity test.More interestingly,the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing phenotype.Thus,the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing.展开更多
Hexamethylenediamine(HMDA) is an important reagent for the synthesis of Nylon-6,6, and it is usually produced by the hydrogenation of adiponitrile using a toxic reagent of hydrocyanic acid. Herein, we developed an env...Hexamethylenediamine(HMDA) is an important reagent for the synthesis of Nylon-6,6, and it is usually produced by the hydrogenation of adiponitrile using a toxic reagent of hydrocyanic acid. Herein, we developed an environmental friendly route to produce HMDA via catalytic reductive amination of 1,6-hexanediol(HDO) in the presence of hydrogen. The activities of several heterogeneous metal catalysts such as supported Ni, Co, Ru, Pt, Pd catalysts were screened for the present reaction in supercritical ammonia without any additives. Among the catalysts examined, Ru/Al_2O_3 presented a high catalytic activity and highest selectivity for the desired product of HMDA. The high performance of Ru/Al_2O_3 was discussed based on the Ru dispersion and the surface properties like the acid-basicity. In addition, the reaction parameters such as reaction temperature,time, H_2 and NH_3 pressure were examined, and the reaction processes were discussed in detail.展开更多
Background:The treatment for spontaneous intracerebral hemorrhage(ICH)is still controversial,especially for hematomas in the basal ganglia.A retrospective case-control study with propensity score matching was performe...Background:The treatment for spontaneous intracerebral hemorrhage(ICH)is still controversial,especially for hematomas in the basal ganglia.A retrospective case-control study with propensity score matching was performed to compare the outcomes of conventional craniotomy and conservative treatment for patients with minor ICH in the basal ganglia.Methods:We retrospectively collected the data of consecutive patients with minor basal ganglia hemorrhage from January 2018 to August 2019.We compared clinical outcomes of two groups using propensity score matching.The extended Glasgow outcome scale obtained by phone interviews based on questionnaires at a 12-month follow-up was used as the primary outcome measure.According to a previous prognosis algorithm,patients were divided into good and poor prognosis groups to obtain a dichotomized(favorable or unfavorable)outcome as the primary outcome.Secondary outcomes included hospitalized complications,mortality,and modified Rankin score at 12 months.Results:A total of 54 patients were analyzed,and the baseline characteristics of patients in the surgery and conservative treatment groups were well matched.The primary favorable outcome at 12 months was significantly higher in the conservative treatment group than in the surgery group(81%vs 44%;OR 1.833,95%CI 1.159-2.900;P=0.005).The incidence of pneumonia in the surgery group was significantly higher than that in the conservative treatment group(P=0.005).Conclusions:It is not recommended to undertake conventional craniotomy for patients with a minor hematoma(25-40 ml)in the basal ganglia.An open craniotomy might induce worse long-term functional outcomes than the conservative treatment.展开更多
A green fabrication process(organic solvent-free)of artificial scaffolds is required in tissue engineering field.In this work,a series of aligned three-dimensional(3D)scaffolds are made from biodegradable waterborne p...A green fabrication process(organic solvent-free)of artificial scaffolds is required in tissue engineering field.In this work,a series of aligned three-dimensional(3D)scaffolds are made from biodegradable waterborne polyurethane(PU)emulsion via directional freeze–drying method to ensure no organic byproducts.After optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures,an aligned PUs scaffold(PU14)generated from 14wt%polymer content and processed at196C was selected based on the desired oriented porous structure(pore size of 32.569.3 lm,porosity of 92%)and balanced mechanical properties both in the horizontal direction(strength of 41.3 kPa,modulus of 72.3 kPa)and in the vertical direction(strength of 45.5 kPa,modulus of 139.3 kPa).The response of L929 cells and the regeneration of muscle tissue demonstrated that such pure material-based aligned 3D scaffold can facilitate the development of orientated cells and anisotropic tissue regeneration both in vitro and in vivo.Thus,these pure material-based scaffolds with ordered architecture have great potentials in tissue engineering for biological anisotropic tissue regeneration,such as muscle,nerve,spinal cord and so on.展开更多
As the power demand in data centers is increasing,the power capacity of the power supply system has become an essential resource to be optimized.Although many data centers use power oversubscription to make full use o...As the power demand in data centers is increasing,the power capacity of the power supply system has become an essential resource to be optimized.Although many data centers use power oversubscription to make full use of the power capacity,there are unavoidable power supply risks associated with it.Therefore,how to improve the data center power capacity utilization while ensuring power supply security has become an important issue.To solve this problem,we first define it and propose a risk evaluation metric called Weighted Power Supply Risk(WPSRisk).Then,a method,named Hybrid Genetic Algorithm with Ant Colony System(HGAACS),is proposed to improve power capacity utilization and reduce power supply risks by optimizing the server placement in the power supply system.HGAACS uses historical power data of each server to find a better placement solution by population iteration.HGAACS possesses not only the remarkable local search ability of Ant Colony System(ACS),but also enhances the global search capability by incorporating genetic operators from Genetic Algorithm(GA).To verify the performance of HGAACS,we experimentally compare it with five other placement algorithms.The experimental results show that HGAACS can perform better than other algorithms in both improving power utilization and reducing the riskof powersupply system.展开更多
基金supported by the National Nature Science Foundation of China,the National Key Research and Development Program of China(302001109,2016YFD0300508,2017YFD0301602,2018YFD0301105)the Fujian and Taiwan Cultivation Resources Development and Green Cultivation Coordination Innovation Center,China(Fujian 2011 Project,2015-75)the Natural Science Foundation of Fujian Province,China(2022J01142)。
文摘Agronomic measures are the key to promote the sustainable development of ratoon rice by reducing the damage from mechanical crushing to the residual stubble of the main crop, thereby mitigating the impact on axillary bud sprouting and yield formation in ratoon rice. This study used widely recommended conventional rice Jiafuzhan and hybrid rice Yongyou 2640 as the test materials to conduct a four-factor block design field experiment in a greenhouse of the experimental farm of Fujian Agricultural and Forestry University, China from 2018 to 2019.The treatments included fertilization and no fertilization, alternate wetting and drying irrigation and continuous water flooding irrigation, and plots with and without artificial crushing damage on the rice stubble. At the same time, a 13C stable isotope in-situ detection technology was used to fertilize the pot experiment. The results showed significant interactions among varieties, water management, nitrogen application and stubble status.Relative to the long-term water flooding treatment, the treatment with sequential application of nitrogen fertilizer coupled with moderate field drought for root-vigor and tiller promotion before and after harvesting of the main crop, significantly improved the effective tillers from low position nodes. This in turn increased the effective panicles per plant and grains per panicle by reducing the influence of artificial crushing damage on rice stubble and achieving a high yield of the regenerated rice. Furthermore, the partitioning of 13C assimilates to the residual stubble and its axillary buds were significantly improved at the mature stage of the main crop, while the translocation rate to roots and rhizosphere soil was reduced at the later growth stage of ratooning season rice. This was triggered by the metabolism of hormones and polyamines at the stem base regulated by the interaction of water and fertilizer at this time. We therefore suggest that to achieve a high yield of ratoon rice with low stubble height under mechanized harvesting, the timely application of nitrogen fertilizer is fundamental,coupled with moderate field drying for root-vigor preservation and tiller promotion before and after the mechanical harvesting of the main crop.
基金supported by Key-Area Research and Development Program of Guangdong Province(2021B0101420002)the Major Key Project of PCL(PCL2021A09)+3 种基金National Natural Science Foundation of China(62072187)Guangdong Major Project of Basic and Applied Basic Research(2019B030302002)Guangdong Marine Economic Development Special Fund Project(GDNRC[2022]17)Guangzhou Development Zone Science and Technology(2021GH10,2020GH10).
文摘Nowadays,the rapid development of edge computing has driven an increasing number of deep learning applications deployed at the edge of the network,such as pedestrian and vehicle detection,to provide efficient intelligent services to mobile users.However,as the accuracy requirements continue to increase,the components of deep learning models for pedestrian and vehicle detection,such as YOLOv4,become more sophisticated and the computing resources required for model training are increasing dramatically,which in turn leads to significant challenges in achieving effective deployment on resource-constrained edge devices while ensuring the high accuracy performance.For addressing this challenge,a cloud-edge collaboration-based pedestrian and vehicle detection framework is proposed in this paper,which enables sufficient training of models by utilizing the abundant computing resources in the cloud,and then deploying the well-trained models on edge devices,thus reducing the computing resource requirements for model training on edge devices.Furthermore,to reduce the size of the model deployed on edge devices,an automatic pruning method combines the convolution layer and BN layer is proposed to compress the pedestrian and vehicle detection model size.Experimental results show that the framework proposed in this paper is able to deploy the pruned model on a real edge device,Jetson TX2,with 6.72 times higher FPS.Meanwhile,the channel pruning reduces the volume and the number of parameters to 96.77%for the model,and the computing amount is reduced to 81.37%.
基金the National Natural Science Foundation of China,No.30870643Natural Science Foundation of Jiangsu Province,No. BK2002036
文摘BACKGROUND:A combination of basic fibroblast growth factor(bFGF),platelet-derived growth factor(PDGF),human heregulin-beta-1,beta-mercaptoethanol retinoic acid and forskolin has been reported to induce the differentiation of rat bone marrow stromal cells into myelinating Schwann-like cells. OBJECTIVE:To investigate the inducing effects of a combination of bFGF,PDGF,human heregulin-beta-1,beta-mercaptoethanol retinoic acid and forskolin on neural stem cell differentiation by one- and two-step methods. DESIGN,TIME AND SETTING:A cytobiology experiment was performed at the Department of Histology and Embryology,Medical School of Nantong University,and Jiangsu Province Key Laboratory of Neuroregeneration,China,between August 2005 and January 2007. MATERIALS:A total of 30 healthy Sprague Dawley rat embryos at gestational days 14-16 were selected.bFGF,PDGF,human heregulin-beta-1,beta-mercaptoethanol,retinoic acid,and forskolin were purchased from Sigma,USA. METHODS:Passage 3 rat neural stem cells were cultured by a one-step method in serum-free medium plus 10 ng/mL bFGF,5 ng/mL PDGF,200 ng/mL heregulin-beta-1,35 ng/mL all-trans retinoic acid,and 5μmol/L forskolin or by a two-step method in serum-free medium plus 35 ng/mL all-trans retinoic acid for 72 hours,followed by serum-free medium plus 10 ng/mL bFGF,5 ng/mL PDGF,200 ng/mL heregulin-beta-1 and 5μmol/L forskolin.The control condition consisted of 10% fetal bovine serum alone or 20 ng/mL bFGF alone. MAIN OUTCOME MEASURES:Differentiated cells were identified by immunocytochemical staining for microtubule associate protein-2(MAP2) and S100 protein.Geometric parameters and sodium ion currents of the differentiated cells were measured by image analysis and whole-cell patch-clamp techniques,respectively. RESULTS:Compared with the two-step culture method,neuronal-like cells exhibited longer processes and a similar appearance to mature neurons using the one-step method.The percentage of MAP2 positive cells induced by the one-step method was significantly greater than the serum-alone group(P<0.05).Furthermore,the MAP2 positive cells induced by the one-step method had greater surface areas,cell body perimeters,and longer process than cells induced by serum-alone and bFGF-alone(P<0.05).There were no significant differences in these parameters between the one-step and two-step methods(P>0.05).In addition,80%of the induced neuronal-like cells from the one-step method and 20%from the two-step method displayed inwardly-evoked currents. CONCLUSION:The combination of bFGF,PDGF,human heregulin-beta-1,beta-mercaptoethanol retinoic acid and forskolin successfully induced neuronal differentiation from neural stem cells,with the one-step induction being more effective than the two-step method.
基金supported by the National Natural Science Foundation of China(Grant No.:81673392).
文摘Alzheimer's disease(AD)represents the main form of dementia;however,valid diagnosis and treatment measures are lacking.The discovery of valuable biomarkers through omics technologies can help solve this problem.For this reason,metabolomic analysis using ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF-MS)was carried out on plasma,hippocampus,and cortex samples of an AD rat model.Based on the metabolomic data,we report a multi-factor combined biomarker screening strategy to rapidly and accurately identify potential biomarkers.Compared with the usual procedure,our strategy can identify fewer biomarkers with higher diagnostic specificity and sensitivity.In addition to diagnosis,the potential biomarkers identified using our strategy were also beneficial for drug evaluation.Multi-factor combined biomarker screening strategy was used to identify differential metabolites from a rat model of amyloid beta peptide 1e40(Aβ_(1-40))plus ibotenic acid-induced AD(compared with the controls)for the first time;lysophosphatidylcholine(LysoPC)and intermediates of sphingolipid metabolism were screened as potential biomarkers.Subsequently,the effects of donepezil and pine nut were successfully reflected by regulating the levels of the abovementioned biomarkers and metabolic profile distribution in partial least squaresdiscriminant analysis(PLS-DA).This novel biomarker screening strategy can be used to analyze other metabolomic data to simultaneously enable disease diagnosis and drug evaluation.
基金This work was supported by the Natural Science Foundation of Fujian Province,ChinaResearch on Network Risk Assessment Method Based on Dynamic Attack Behavior(Grant No.2019J01889)+1 种基金the Education-Scientific research Project for Middle-Aged and Young of Fujian Province,ChinaResearch on Analysis System of Malicious Code Based on API Relevance(Grant No.JT180626).
文摘In this paper,a cybersecurity threat warning model based on ant colony algorithm is designed to strengthen the accuracy of the cybersecurity threat warning model in the warning process and optimize its algorithm structure.Through the ant colony algorithm structure,the local global optimal solution is obtained;and the cybersecurity threat warning index system is established.Next,the above two steps are integrated to build the cybersecurity threat warning model based on ant colony algorithm,and comparative experiment is also designed.The experimental results show that,compared with the traditional qualitative differential game-based cybersecurity threat warning model,the cybersecurity threat warning model based on ant colony algorithm has a higher correct rate in the warning process,and the algorithm program is simpler with higher use value.
基金Project supported by the National Natural Science Foundation of China(52072348 and 52104272)Scientific Research Start-up Fund of Anhui Polytechnic University(2020YQQ053)+1 种基金Scientific Research Project of Anhui Polytechnic University(Xjky2020083)Innovation and Entrepreneurship Education and Training Project for Anhui Provincial College Students(S202110363258)。
文摘Rare earth co-doped phosphor for fluorescence intensity ratio(FIR) thermometer has gained increasing attention in recent years. Herein, the novel Tb^(3+)and Eu^(3+)co-doped K_(3)SrBi(P_(2)O_(7))_(2)(KSBP) phosphate phosphors were reported. The crystal structure of the title phosphor was determined using Rietveld refinement and proved to have a three-dimensional structure. The time-resolved spectroscopy reveals that there is almost no energy transfer between Tb^(3+)and Eu^(3+). More importantly, Tb^(3+)and Eu^(3+)emissions show different thermal quenching behaviors, which claims the potential of this material for application in optical thermometer. The FIR of the typical KSBP:0.02Tb^(3+),0.04Eu^(3+)sample demonstrates a polynomial relationship as a function of temperature and the absolute and relative sensitivity are0.025 K^(-1) and 0.59%/K, respectively. In general, our study reports a novel and potential KSBP:Tb^(3+),Eu^(3+)phosphate phosphor that is promising for use in high-sensitive FIR thermometers.
基金This work was supported by the National Natural Science Foundation of China(51273124,51333003 and 51573114)the National Science Fund for Distinguished Young Scholars of China(51425305).
文摘To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes(PCPUs).Poly(e-caprolactone)(PCL)and poly(ethylene glycol)(PEG)are used as soft segments,and L-lysine ethyl ester diisocyanate(LDI),LAPC and L-lysine are used as hard segments.The obtained PCPUs exhibit appropriate mechanical properties with break elongation of 1000–1700%,tensile strength of 7–22 MPa,and relatively high elastic modulus of 11–18 MPa,which could admirably satisfy the requirement for soft tissue engineering scaffolds.The phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces,which effectively reduce protein adsorption and platelet adhesion while promoting the cell proliferation.In addition,the LAPC chain extender,PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity test.More interestingly,the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing phenotype.Thus,the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing.
基金Guidance Project of Fujian Science and Technology Department(Grant No.2017Y0033)Fujian Medical Innovation Project(Grant No.2017-CX-31)+1 种基金Sail Project of Fujian Medical University(Grant No.2017XQ1068)“Weak Discipline Construction Project” of Shanghai Municipal Commission of Health and Family Planning(Grant No.2016ZB0301-01).
基金supported by the National Basic Research Program of China(2016YFA0602900)Youth Innovation Promotion Association CAS(2016206)Jilin Provincial Science and Technology Program of China(20150301012GX)
文摘Hexamethylenediamine(HMDA) is an important reagent for the synthesis of Nylon-6,6, and it is usually produced by the hydrogenation of adiponitrile using a toxic reagent of hydrocyanic acid. Herein, we developed an environmental friendly route to produce HMDA via catalytic reductive amination of 1,6-hexanediol(HDO) in the presence of hydrogen. The activities of several heterogeneous metal catalysts such as supported Ni, Co, Ru, Pt, Pd catalysts were screened for the present reaction in supercritical ammonia without any additives. Among the catalysts examined, Ru/Al_2O_3 presented a high catalytic activity and highest selectivity for the desired product of HMDA. The high performance of Ru/Al_2O_3 was discussed based on the Ru dispersion and the surface properties like the acid-basicity. In addition, the reaction parameters such as reaction temperature,time, H_2 and NH_3 pressure were examined, and the reaction processes were discussed in detail.
基金the key research and development program of Zhejiang province(2017C03027)National Natural Science Foundation of China(No.81771262)+1 种基金Natural Science Foundation of Zhejiang Province(LQ20H090005)Wenzhou Municipal Science and Technology Bureau Project of China(Y20190568)
文摘Background:The treatment for spontaneous intracerebral hemorrhage(ICH)is still controversial,especially for hematomas in the basal ganglia.A retrospective case-control study with propensity score matching was performed to compare the outcomes of conventional craniotomy and conservative treatment for patients with minor ICH in the basal ganglia.Methods:We retrospectively collected the data of consecutive patients with minor basal ganglia hemorrhage from January 2018 to August 2019.We compared clinical outcomes of two groups using propensity score matching.The extended Glasgow outcome scale obtained by phone interviews based on questionnaires at a 12-month follow-up was used as the primary outcome measure.According to a previous prognosis algorithm,patients were divided into good and poor prognosis groups to obtain a dichotomized(favorable or unfavorable)outcome as the primary outcome.Secondary outcomes included hospitalized complications,mortality,and modified Rankin score at 12 months.Results:A total of 54 patients were analyzed,and the baseline characteristics of patients in the surgery and conservative treatment groups were well matched.The primary favorable outcome at 12 months was significantly higher in the conservative treatment group than in the surgery group(81%vs 44%;OR 1.833,95%CI 1.159-2.900;P=0.005).The incidence of pneumonia in the surgery group was significantly higher than that in the conservative treatment group(P=0.005).Conclusions:It is not recommended to undertake conventional craniotomy for patients with a minor hematoma(25-40 ml)in the basal ganglia.An open craniotomy might induce worse long-term functional outcomes than the conservative treatment.
基金This work was supported by the National Natural Science Foundation of China(51573114,51673126,51733005)the National Science Fund for Distinguished Young Scholars of China(51425305).
文摘A green fabrication process(organic solvent-free)of artificial scaffolds is required in tissue engineering field.In this work,a series of aligned three-dimensional(3D)scaffolds are made from biodegradable waterborne polyurethane(PU)emulsion via directional freeze–drying method to ensure no organic byproducts.After optimizing the concentration of polymer in the emulsion and investigating different freezing temperatures,an aligned PUs scaffold(PU14)generated from 14wt%polymer content and processed at196C was selected based on the desired oriented porous structure(pore size of 32.569.3 lm,porosity of 92%)and balanced mechanical properties both in the horizontal direction(strength of 41.3 kPa,modulus of 72.3 kPa)and in the vertical direction(strength of 45.5 kPa,modulus of 139.3 kPa).The response of L929 cells and the regeneration of muscle tissue demonstrated that such pure material-based aligned 3D scaffold can facilitate the development of orientated cells and anisotropic tissue regeneration both in vitro and in vivo.Thus,these pure material-based scaffolds with ordered architecture have great potentials in tissue engineering for biological anisotropic tissue regeneration,such as muscle,nerve,spinal cord and so on.
基金This work was supported by the National Natural Science Foundation of China(No.62072187)the Guangdong Major Project of Basic and Applied Basic Research(No.2019B030302002)+2 种基金the Guangzhou Science and Technology Program Key Projects(No.202007040002)the Guangdong Marine Economic Development Special Fund Project(No.GDNRC[2022]17)the Guangzhou Development Zone Science and Technology Project(Nos.2021GH10 and 2020GH10).
文摘As the power demand in data centers is increasing,the power capacity of the power supply system has become an essential resource to be optimized.Although many data centers use power oversubscription to make full use of the power capacity,there are unavoidable power supply risks associated with it.Therefore,how to improve the data center power capacity utilization while ensuring power supply security has become an important issue.To solve this problem,we first define it and propose a risk evaluation metric called Weighted Power Supply Risk(WPSRisk).Then,a method,named Hybrid Genetic Algorithm with Ant Colony System(HGAACS),is proposed to improve power capacity utilization and reduce power supply risks by optimizing the server placement in the power supply system.HGAACS uses historical power data of each server to find a better placement solution by population iteration.HGAACS possesses not only the remarkable local search ability of Ant Colony System(ACS),but also enhances the global search capability by incorporating genetic operators from Genetic Algorithm(GA).To verify the performance of HGAACS,we experimentally compare it with five other placement algorithms.The experimental results show that HGAACS can perform better than other algorithms in both improving power utilization and reducing the riskof powersupply system.
