Turbidity channels have been considered as one of the important types of deepwater reservoir, and the study of their architecture plays a key role in efficient development of an oil field. To better understand the res...Turbidity channels have been considered as one of the important types of deepwater reservoir, and the study of their architecture plays a key role in efficient development of an oil field. To better understand the reservoir architecture of the lower Congo Basin M oilfield, semiquantitative–quantitative study on turbidity channel depositional architecture patterns in the middle to lower slopes was conducted with the aid of abundant high quality materials（core, outcrop, logging and seismic data）,employing seismic stratigraphy, seismic sedimentology and sedimentary petrography methods. Then, its sedimentary evolution was analyzed accordingly. The results indicated that in the study area, grade 3 to grade 5 architecture units were single channel, complex channel and channel systems, respectively. Single channel sinuosity is negatively correlated with the slope, as internal grains became finer and thickness became thinner from bottom to top, axis to edge. The migration type of a single channel within one complex channel can be lateral migration and along paleocurrent migration horizontally, and lateral,indented and swing stacking in section view. Based on external morphological characteristics and boundaries,channel systems are comprised of a weakly confining type and a non-confining type. The O73 channel system can be divided into four complex channels named S1–S4, from bottom to top, with gradually less incision and more accretion. The study in this article will promote deeper understanding of turbidity channel theory, guide 3D geological modeling in reservoir development and contribute to efficient development of such reservoirs.展开更多
The flow dynamics of binary particle mixtures in the fluidized bed needs to be monitored in order to optimize the related industrial processes.In this paper,electrostatic sensing and high-speed imaging are applied to ...The flow dynamics of binary particle mixtures in the fluidized bed needs to be monitored in order to optimize the related industrial processes.In this paper,electrostatic sensing and high-speed imaging are applied to measure the velocities of polyethylene and sand particles in the binary particle mixtures in fluidization.Experimental studies were conducted on a lab-scale cold circulating fluidized bed.Correlation function between electrostatic signals from upstream and downstream electrodes placed along the riser shows two peaks that represent transit times for the two types of particles.To verify the above results,high-speed imaging was adopted to capture the flow images of particle mixtures.Particle Image Velocimetry and Particle Tracking Velocimetry algorithms were utilized to process the resulted images in order to measure the velocities of polyethylene and sand particles.The reasons for two-peak correlation functions are illustrated based on the frequency spectrums of the mono-solid-phase electrostatic signals and the velocity difference between polyethylene and sand particles.Finally,comparisons on the velocities obtained from electrostatic sensing and high-speed imaging demonstrate the electrostatic sensor can roughly estimate the particle velocity of binary particle mixtures in the near wall region of the circulating fluidized bed.展开更多
As a major kind of cell surface adhesion molecules with signal transduction function,integrins play a major role in tumorigenesis and tumor progression.The role of integrins in tumor cells and the tumor microenvironme...As a major kind of cell surface adhesion molecules with signal transduction function,integrins play a major role in tumorigenesis and tumor progression.The role of integrins in tumor cells and the tumor microenvironment has been extensively revealed.Among the integrin family,integrinαvβ3 is the most studied integrin in the past 20 years.Plenty of preclinical and clinical studies have been conducted,which showed clinical benefits of targeting integrinαvβ3 in tumor imaging and treatment.Currently,the focus of interest is gradually shifting from integrinαvβ3 toward other integrin subtypes.Integrinα6 is expressed in many malignant tumors,such as colorectal cancer,head and neck squamous cell carcinoma,breast cancer,pancreatic cancer,and liver cancer,and its expression is correlated with poor survival of the patients.Recent studies have shown that tumor molecular imaging agents and therapeutic drugs targeting integrinα6 have excellent safety and efficacy in preclinical mouse models,encouraging clinical translation of this promising target.In this review,we briefly overview the physiological and pathological function of integrinα6 and highlight the recent advances in integrinα6-targeted imaging and therapeutics in tumors.展开更多
基金supported by the National Major Scientific and Technological Special Project during the Thirteenth Five-year Plan Period (2016ZX05033-003-002)the Project of Sinopec Science and Technology Development Department (G580015-ZS-KJB016)
文摘Turbidity channels have been considered as one of the important types of deepwater reservoir, and the study of their architecture plays a key role in efficient development of an oil field. To better understand the reservoir architecture of the lower Congo Basin M oilfield, semiquantitative–quantitative study on turbidity channel depositional architecture patterns in the middle to lower slopes was conducted with the aid of abundant high quality materials（core, outcrop, logging and seismic data）,employing seismic stratigraphy, seismic sedimentology and sedimentary petrography methods. Then, its sedimentary evolution was analyzed accordingly. The results indicated that in the study area, grade 3 to grade 5 architecture units were single channel, complex channel and channel systems, respectively. Single channel sinuosity is negatively correlated with the slope, as internal grains became finer and thickness became thinner from bottom to top, axis to edge. The migration type of a single channel within one complex channel can be lateral migration and along paleocurrent migration horizontally, and lateral,indented and swing stacking in section view. Based on external morphological characteristics and boundaries,channel systems are comprised of a weakly confining type and a non-confining type. The O73 channel system can be divided into four complex channels named S1–S4, from bottom to top, with gradually less incision and more accretion. The study in this article will promote deeper understanding of turbidity channel theory, guide 3D geological modeling in reservoir development and contribute to efficient development of such reservoirs.
基金financial supports from the National Natural Science Foundation of China (No.61403138)Beijing Natural Science Foundation (No.3202028)+1 种基金funded by the National Research Foundation (NRF), Prime Minister’s Offce, Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) programmeGrant Number R-706-001-102–281, National University of Singapore。
文摘The flow dynamics of binary particle mixtures in the fluidized bed needs to be monitored in order to optimize the related industrial processes.In this paper,electrostatic sensing and high-speed imaging are applied to measure the velocities of polyethylene and sand particles in the binary particle mixtures in fluidization.Experimental studies were conducted on a lab-scale cold circulating fluidized bed.Correlation function between electrostatic signals from upstream and downstream electrodes placed along the riser shows two peaks that represent transit times for the two types of particles.To verify the above results,high-speed imaging was adopted to capture the flow images of particle mixtures.Particle Image Velocimetry and Particle Tracking Velocimetry algorithms were utilized to process the resulted images in order to measure the velocities of polyethylene and sand particles.The reasons for two-peak correlation functions are illustrated based on the frequency spectrums of the mono-solid-phase electrostatic signals and the velocity difference between polyethylene and sand particles.Finally,comparisons on the velocities obtained from electrostatic sensing and high-speed imaging demonstrate the electrostatic sensor can roughly estimate the particle velocity of binary particle mixtures in the near wall region of the circulating fluidized bed.
基金National Natural Science Foundation of China(81972531)。
文摘As a major kind of cell surface adhesion molecules with signal transduction function,integrins play a major role in tumorigenesis and tumor progression.The role of integrins in tumor cells and the tumor microenvironment has been extensively revealed.Among the integrin family,integrinαvβ3 is the most studied integrin in the past 20 years.Plenty of preclinical and clinical studies have been conducted,which showed clinical benefits of targeting integrinαvβ3 in tumor imaging and treatment.Currently,the focus of interest is gradually shifting from integrinαvβ3 toward other integrin subtypes.Integrinα6 is expressed in many malignant tumors,such as colorectal cancer,head and neck squamous cell carcinoma,breast cancer,pancreatic cancer,and liver cancer,and its expression is correlated with poor survival of the patients.Recent studies have shown that tumor molecular imaging agents and therapeutic drugs targeting integrinα6 have excellent safety and efficacy in preclinical mouse models,encouraging clinical translation of this promising target.In this review,we briefly overview the physiological and pathological function of integrinα6 and highlight the recent advances in integrinα6-targeted imaging and therapeutics in tumors.
