Correction to:Signal Transduction and Targeted Therapy https:/l doi.org/10.1038/s41392-022-00948-6,publishedonline18 April2022 In the process of collating the raw data,the authors noticed an inadvertent error occurred...Correction to:Signal Transduction and Targeted Therapy https:/l doi.org/10.1038/s41392-022-00948-6,publishedonline18 April2022 In the process of collating the raw data,the authors noticed an inadvertent error occurred in Supplementary Fig.5d that needs to be corrected after online publication of the article 1.展开更多
B cells secreting IL-10 functionally are recognized as functional regulatory B(B_(reg))cells;however,direct evidence concerning the phenotype,regulation,and functional and clinical relevance of IL-10-secreting B_(reg)...B cells secreting IL-10 functionally are recognized as functional regulatory B(B_(reg))cells;however,direct evidence concerning the phenotype,regulation,and functional and clinical relevance of IL-10-secreting B_(reg)cells in humans is still lacking.Here,we demonstrate that,although IL-10 itself is anti-inflammatory,IL-10+functional B_(reg)cells in patients with systemic lupus erythematosus(SLE)display aggressive inflammatory features;these features shift their functions away from inducing CD8^(+)T cell tolerance and cause them to induce a pathogenic CD4^(+)T cell response.展开更多
文摘Correction to:Signal Transduction and Targeted Therapy https:/l doi.org/10.1038/s41392-022-00948-6,publishedonline18 April2022 In the process of collating the raw data,the authors noticed an inadvertent error occurred in Supplementary Fig.5d that needs to be corrected after online publication of the article 1.
基金The study was supported by project grants from the National Natural Science Foundation of China(82071767,82025016,31830025,81901585,and 81802403)the Natural Science Foundation of Guangdong Province,China(2018B030308010 and 2019A1515011770).
文摘B cells secreting IL-10 functionally are recognized as functional regulatory B(B_(reg))cells;however,direct evidence concerning the phenotype,regulation,and functional and clinical relevance of IL-10-secreting B_(reg)cells in humans is still lacking.Here,we demonstrate that,although IL-10 itself is anti-inflammatory,IL-10+functional B_(reg)cells in patients with systemic lupus erythematosus(SLE)display aggressive inflammatory features;these features shift their functions away from inducing CD8^(+)T cell tolerance and cause them to induce a pathogenic CD4^(+)T cell response.
