BACKGROUND The incidence of colorectal cancer(CRC)is increasing annually.Laparoscopic radical resection of CRC is a minimally invasive procedure preferred in clinical practice.AIM To investigate the clinical effect of...BACKGROUND The incidence of colorectal cancer(CRC)is increasing annually.Laparoscopic radical resection of CRC is a minimally invasive procedure preferred in clinical practice.AIM To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching(PSM).METHODS The clinical data of 100 patients who received inpatient treatment for CRC at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)were analyzed retrospectively.The control group included patients who underwent open surgery(n=43),and those who underwent laparoscopic surgery formed the observation group(n=57).The baseline information of both groups was equipoised using 1×1 PSM.Differences in the perioperative parameters,inflammatory response,immune function,degree of pain,and physical status between the groups were analyzed.RESULTS Thirty patients from both groups were successfully matched.After PSM,baseline data showed no statistically significant differences between the groups:(1)Periop-erative parameters:The observation group had a longer surgery time,less intra-operative blood loss,earlier first ambulation and first anal exhaust times,and shorter gastric tube indwelling time than the control group;(2)Inflammatory response:24 h after surgery,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between groups were higher than preoperatively.IL-6,CRP,and TNF-αlevels in the observation group were lower than in the control group;(3)Immune function:At 24 h after surgery,counts of CD4-positive T-lymphocytes(CD4+)and CD4+/CD8-positive T-lymphocytes(CD8+)in both groups were lower than those before surgery,whereas CD8+was higher than that before surgery.At 24 h after surgery,both CD4+counts and CD4+/CD8+in the observation group were higher than those in the control group,whereas CD8+counts were lower;(4)Degree of pain:The visual analog scale scores in the observation group were lower than those in the control group at 24 and 72 h after surgery;and(5)Physical status:One month after surgery,the Karnofsky performance score in the observation group was higher than that in the control group.CONCLUSION Laparoscopic radical resection of CRC has significant benefits,such as reducing postoperative pain and postoperative inflammatory response,avoiding excessive immune inhibition,and contributing to postoperative recovery.展开更多
Prediction of seismic attenuation and dispersion that are inherently sensitive to hydraulic and elastic properties of the medium of interest in the presence of mesoscopic fractures and pores,is of great interest in th...Prediction of seismic attenuation and dispersion that are inherently sensitive to hydraulic and elastic properties of the medium of interest in the presence of mesoscopic fractures and pores,is of great interest in the characterization of fractured formations.This has been very difficult,however,considering that stress interactions between fractures and pores,related to their spatial distributions,tend to play a crucial role on affecting overall dynamic elastic properties that are largely unexplored.We thus choose to quantitatively investigate frequency-dependent P-wave characteristics in fractured porous rocks at the scale of a representative sample using a numerical scale-up procedure via performing finite element modelling.Based on 2-D numerical quasi-static experiments,effects of fracture and fluid properties on energy dissipation in response to wave-induced fluid flow at the mesoscopic scale are quantified via solving Biot's equations of consolidation.We show that numerical results are sensitive to some key characteristics of probed synthetic rocks containing unconnected and connected fractures,demonstrating that connectivity,aperture and inclination of fractures as well as fracture infills exhibit strong impacts on the two manifestations of WIFF mechanisms in the connected scenario,and on resulting total wave attenuation and phase velocity.This,in turn,illustrates the importance of these two WIFF mechanisms in fractured rocks and thus,a deeper understanding of them may eventually allow for a better characterization of fracture systems using seismic methods.Moreover,this presented work combines rock physics predictions with seismic numerical simulations in frequency domain to illustrate the sensitivity of seismic signatures on the monitoring of an idealized geologic CO_(2) sequestration in fractured reservoirs.The simulation demonstrates that these two WIFF mechanisms can strongly modify seismic records and hence,indicating that incorporating the two energy dissipation mechanisms in the geophysical interpretation can potentially improving the monitoring and surveying of fluid variations in fractured formations.展开更多
基金Supported by Scientific Research Project of Hunan Provincial Health Commission,No.202204114103.
文摘BACKGROUND The incidence of colorectal cancer(CRC)is increasing annually.Laparoscopic radical resection of CRC is a minimally invasive procedure preferred in clinical practice.AIM To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching(PSM).METHODS The clinical data of 100 patients who received inpatient treatment for CRC at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)were analyzed retrospectively.The control group included patients who underwent open surgery(n=43),and those who underwent laparoscopic surgery formed the observation group(n=57).The baseline information of both groups was equipoised using 1×1 PSM.Differences in the perioperative parameters,inflammatory response,immune function,degree of pain,and physical status between the groups were analyzed.RESULTS Thirty patients from both groups were successfully matched.After PSM,baseline data showed no statistically significant differences between the groups:(1)Periop-erative parameters:The observation group had a longer surgery time,less intra-operative blood loss,earlier first ambulation and first anal exhaust times,and shorter gastric tube indwelling time than the control group;(2)Inflammatory response:24 h after surgery,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between groups were higher than preoperatively.IL-6,CRP,and TNF-αlevels in the observation group were lower than in the control group;(3)Immune function:At 24 h after surgery,counts of CD4-positive T-lymphocytes(CD4+)and CD4+/CD8-positive T-lymphocytes(CD8+)in both groups were lower than those before surgery,whereas CD8+was higher than that before surgery.At 24 h after surgery,both CD4+counts and CD4+/CD8+in the observation group were higher than those in the control group,whereas CD8+counts were lower;(4)Degree of pain:The visual analog scale scores in the observation group were lower than those in the control group at 24 and 72 h after surgery;and(5)Physical status:One month after surgery,the Karnofsky performance score in the observation group was higher than that in the control group.CONCLUSION Laparoscopic radical resection of CRC has significant benefits,such as reducing postoperative pain and postoperative inflammatory response,avoiding excessive immune inhibition,and contributing to postoperative recovery.
文摘Prediction of seismic attenuation and dispersion that are inherently sensitive to hydraulic and elastic properties of the medium of interest in the presence of mesoscopic fractures and pores,is of great interest in the characterization of fractured formations.This has been very difficult,however,considering that stress interactions between fractures and pores,related to their spatial distributions,tend to play a crucial role on affecting overall dynamic elastic properties that are largely unexplored.We thus choose to quantitatively investigate frequency-dependent P-wave characteristics in fractured porous rocks at the scale of a representative sample using a numerical scale-up procedure via performing finite element modelling.Based on 2-D numerical quasi-static experiments,effects of fracture and fluid properties on energy dissipation in response to wave-induced fluid flow at the mesoscopic scale are quantified via solving Biot's equations of consolidation.We show that numerical results are sensitive to some key characteristics of probed synthetic rocks containing unconnected and connected fractures,demonstrating that connectivity,aperture and inclination of fractures as well as fracture infills exhibit strong impacts on the two manifestations of WIFF mechanisms in the connected scenario,and on resulting total wave attenuation and phase velocity.This,in turn,illustrates the importance of these two WIFF mechanisms in fractured rocks and thus,a deeper understanding of them may eventually allow for a better characterization of fracture systems using seismic methods.Moreover,this presented work combines rock physics predictions with seismic numerical simulations in frequency domain to illustrate the sensitivity of seismic signatures on the monitoring of an idealized geologic CO_(2) sequestration in fractured reservoirs.The simulation demonstrates that these two WIFF mechanisms can strongly modify seismic records and hence,indicating that incorporating the two energy dissipation mechanisms in the geophysical interpretation can potentially improving the monitoring and surveying of fluid variations in fractured formations.
