AIM: To study the dynamic computed tomography (CT) features of hepatic angiomyolipoma (AML) in patients with or without tuberous sclerosis complex (TSC).METHODS: The clinical information, CT fi ndings and histopatholo...AIM: To study the dynamic computed tomography (CT) features of hepatic angiomyolipoma (AML) in patients with or without tuberous sclerosis complex (TSC).METHODS: The clinical information, CT fi ndings and histopathological results of hepatic AML were analyzed retrospectively in 10 patients.RESULTS: Hepatic AML was prone to occur in female patients (7/10), and most of the patients (8/10) had no specific symptoms. All tumors presented as well-def ined, unenveloped nodules in the liver. Six patients with sporadic hepatic AML had a solitary hepatic nodule with a definite fat component. Non-fat components of the hepatic lesions were enhanced earlier and persistently. Prominent central vessels were noted in the portal venous phase in three patients. In four patients with hepatic AML and TSC, most of the nodules were within the peripheral liver. Seven fat-deficient nodules were found with earlier contrast enhancement and rapid contrast material washout in two patients. Lymphangioleiomyomatosis was found in one patient.CONCLUSION: Imaging features of hepatic AML are characteristic. Correct diagnosis preoperatively can be made in combination with clinical features.展开更多
A method for preparing novel ceramics was developed in this study. Different ratios red muds were added to steel slags to optimize the preparation of novel ceramics by a traditional ceramic preparation process. The si...A method for preparing novel ceramics was developed in this study. Different ratios red muds were added to steel slags to optimize the preparation of novel ceramics by a traditional ceramic preparation process. The sintering mechanism, microstructure, and performance were studied by X-ray diffraction techniques, scanning electron microscopy, and combined experiments of linear shrinkage, water absorption, and flexural strength. The results confirmed that red mud can reduce the volumetric instabilities through the complementarity of red mud and ferroalloy slag. The crystal phases in the ceramics are all pyroxene group minerals, including diopside ferrian, augite, and diopside. The flexural strength of the ceramic that contains 40 wt% red mud and was prepared at the optimal sintering temperature(1140°C) is greater than 93 MPa; its corresponding water absorption is less than 0.05%.展开更多
Tuberous sclerosis complex (TSC) is a dominantly inherited disorder which characterized by the growth of harmatomatous in multiple organs. Unlike the common development of renal angiomyolipoma, hepatic angiomyolipoma ...Tuberous sclerosis complex (TSC) is a dominantly inherited disorder which characterized by the growth of harmatomatous in multiple organs. Unlike the common development of renal angiomyolipoma, hepatic angiomyolipoma rarely occur in patients with TSC. We report here a patient with hepatic angiomyolipomas and concurrent hepatocellular carcinoma in TSC. This represents the first reported case in English literature. In this patient, multiple hepatic angiomyolipomas were diagnosed with recognition of their fat components and typical clinical settings. Hepatocellular carcinoma in the left liver lobe was definitely diagnosed by US guided biopsy. In such clinical settings, fat containing lesions in liver can be reasonably treated as angiomyolipomas, but non fat containing lesions must be differentiated from hepatocellular carcinoma, imaging guided biopsy can be adopted to confirm the diagnosis.展开更多
Hydro-sodalites are zeolitic materials with a wide variety of applications.Fly ash is an abundant industrial solid waste,rich in silicon and aluminum,from which hydro-sodalite can be synthesized.However,traditional hy...Hydro-sodalites are zeolitic materials with a wide variety of applications.Fly ash is an abundant industrial solid waste,rich in silicon and aluminum,from which hydro-sodalite can be synthesized.However,traditional hydrothermal synthesis methods are complex and cannot produce high-purity products.Therefore,there is a demand for processing routes to obtain high-purity hydro-sodalites.In the present study,high-purity hydro-sodalite(90.2 wt%)was prepared from fly ash by applying a hydrothermal method to a submolten salt system.Samples were characterized by powder X-ray diffraction(XRD),scanning electron microscopy(SEM),thermogravimetry and differential thermal analysis(TG–DTA),and Fourier transform infrared spectroscopy(FTIR)to confirm and quantify conversion of the raw material into the product phase.Purity of the samples prepared with an H2O/Na OH mass ratio of 1.5 and an H2O/fly ash mass ratio of 10 was calculated and the conversion process of the product phase was studied.Crystallinity of the product was influenced more by the Na OH concentration,less by the H2O/fly ash mass ratio.The main reaction process of the system is that the Si O ions produced by dissolution of the vitreous body in the fly ash and Na+ions in the solution reacted on the destroyed mullite skeleton to produce hydro-sodalite.This processing route could help mitigate processing difficulties,while producing high-purity hydro-sodalite from fly ash.展开更多
AIM: To investigate the inhibitory efficacy of <sup>125</sup>I-labeled anti-basic fibroblast growth factor (bFGF) monoclonal antibody (mAb) in hepatocellular carcinoma (HCC).METHODS: bFGF mAb was prepared ...AIM: To investigate the inhibitory efficacy of <sup>125</sup>I-labeled anti-basic fibroblast growth factor (bFGF) monoclonal antibody (mAb) in hepatocellular carcinoma (HCC).METHODS: bFGF mAb was prepared by using the 1G9B9 hybridoma cell line with hybridization technology and extracted from ascites fluid through a Protein G Sepharose affinity column. After labeling with <sup>125</sup>I through the chloramine-T method, bFGF mAb was further purified by a Sephadex G-25 column. Gamma radiation counter GC-1200 detected radioactivity of <sup>125</sup>I-bFGF mAb. The murine H22 HCC xenograft model was established and randomized to interventions with control (phosphate-buffered saline), <sup>125</sup>I-bFGF mAb, <sup>125</sup>I plus bFGF mAb, bFGF mAb, or <sup>125</sup>I. The ratios of tumor inhibition were then calculated. Expression of bFGF, fibroblast growth factor receptor (FGFR), platelet-derived growth factor, and vascular endothelial growth factor (VEGF) mRNA was determined by quantitative reverse transcriptase real-time polymerase chain reaction.RESULTS: The purified bFGF mAb solution was 8.145 mg/mL with a titer of 1:2560000 and was stored at -20 °C. After coupling, <sup>125</sup>I-bFGF mAb was used at a 1: 1280000 dilution, stored at 4 °C, and its specific radioactivity was 37 MBq/mg. The corresponding tumor weight in the control, <sup>125</sup>I, bFGF mAb, <sup>125</sup>I plus bFGF mAb, and <sup>125</sup>I-bFGF mAb groups was 1.88 ± 0.25, 1.625 ± 0.21, 1.5 ± 0.18, 1.41 ± 0.16, and 0.98 ± 0.11 g, respectively. The tumor inhibition ratio in the <sup>125</sup>I, bFGF mAb, <sup>125</sup>I plus bFGF mAb, and <sup>125</sup>I-bFGF mAb groups was 13.6%, 20.2%, 25.1%, and 47.9%, respectively. Growth of HCC xenografts was inhibited significantly more in the <sup>125</sup>I-bFGF mAb group than in the other groups (P < 0.05). Expression of bFGF and FGFR mRNA in the <sup>125</sup>I-bFGF mAb group was significantly decreased in comparison with other groups (P < 0.05). Groups under interventions revealed increased expression of VEGF mRNA (except for <sup>125</sup>I group) compared with the control group.CONCLUSION: <sup>125</sup>I-bFGF mAb inhibits growth of HCC xenografts. The coupling effect of <sup>125</sup>I-bFGF mAb is more effective than the concomitant use of <sup>125</sup>I and bFGF mAb.展开更多
To the Editor: Appropriate donor-to-recipient size matching is of crucial importance in lung transplantation. Although tailoring of the lung has been described as a successful means of overcoming size disparities, its...To the Editor: Appropriate donor-to-recipient size matching is of crucial importance in lung transplantation. Although tailoring of the lung has been described as a successful means of overcoming size disparities, its merits and demerits remain unclear. Here, we present a case of recurrent hypoxemia after unmatched single lung transplantation.展开更多
To the Editor:The polymyxin antibiotics colistin(polymyxin E)and polymyxin B(PMB)became available in the 1950s;thus,they did not undergo contemporary drug development procedures.Their clinical use has recently resurge...To the Editor:The polymyxin antibiotics colistin(polymyxin E)and polymyxin B(PMB)became available in the 1950s;thus,they did not undergo contemporary drug development procedures.Their clinical use has recently resurged,assuming an important role as salvage therapv for otherwise untreatable gram-negative infection.[1]Multidrug-resistant(MDR)bacterial infections are primarily caused by gram-negative bacilli(GNB),such as Pseudomonas aeruginosa and Klebsiella pneumoniae^in lung transplant(LT)patients.[2]The increasing prevalence of MDR-GNB infections in LT patients has led to an upsurge in the use of these“older”drugs.During the treatment course,we should pay attention to severe and life-threatening respiratory paralysis caused by neuromuscular blockage associated with PMB.Herein,we report a rare case of a 67-year-old LT patient who suffered from respiratory arrest induced by PMB.展开更多
文摘AIM: To study the dynamic computed tomography (CT) features of hepatic angiomyolipoma (AML) in patients with or without tuberous sclerosis complex (TSC).METHODS: The clinical information, CT fi ndings and histopathological results of hepatic AML were analyzed retrospectively in 10 patients.RESULTS: Hepatic AML was prone to occur in female patients (7/10), and most of the patients (8/10) had no specific symptoms. All tumors presented as well-def ined, unenveloped nodules in the liver. Six patients with sporadic hepatic AML had a solitary hepatic nodule with a definite fat component. Non-fat components of the hepatic lesions were enhanced earlier and persistently. Prominent central vessels were noted in the portal venous phase in three patients. In four patients with hepatic AML and TSC, most of the nodules were within the peripheral liver. Seven fat-deficient nodules were found with earlier contrast enhancement and rapid contrast material washout in two patients. Lymphangioleiomyomatosis was found in one patient.CONCLUSION: Imaging features of hepatic AML are characteristic. Correct diagnosis preoperatively can be made in combination with clinical features.
基金financially supported by the National Natural Science Foundation of China(No.51474028)the National Key Research and Development Program of China(No.2017YFC0210301)+2 种基金the China Postdoctoral Science Foundation(No.2017M621034)the Japan Society for the Promotion of Science(JSPS)the Alexander von Humboldt(AvH)Foundation for their financial support
文摘A method for preparing novel ceramics was developed in this study. Different ratios red muds were added to steel slags to optimize the preparation of novel ceramics by a traditional ceramic preparation process. The sintering mechanism, microstructure, and performance were studied by X-ray diffraction techniques, scanning electron microscopy, and combined experiments of linear shrinkage, water absorption, and flexural strength. The results confirmed that red mud can reduce the volumetric instabilities through the complementarity of red mud and ferroalloy slag. The crystal phases in the ceramics are all pyroxene group minerals, including diopside ferrian, augite, and diopside. The flexural strength of the ceramic that contains 40 wt% red mud and was prepared at the optimal sintering temperature(1140°C) is greater than 93 MPa; its corresponding water absorption is less than 0.05%.
文摘Tuberous sclerosis complex (TSC) is a dominantly inherited disorder which characterized by the growth of harmatomatous in multiple organs. Unlike the common development of renal angiomyolipoma, hepatic angiomyolipoma rarely occur in patients with TSC. We report here a patient with hepatic angiomyolipomas and concurrent hepatocellular carcinoma in TSC. This represents the first reported case in English literature. In this patient, multiple hepatic angiomyolipomas were diagnosed with recognition of their fat components and typical clinical settings. Hepatocellular carcinoma in the left liver lobe was definitely diagnosed by US guided biopsy. In such clinical settings, fat containing lesions in liver can be reasonably treated as angiomyolipomas, but non fat containing lesions must be differentiated from hepatocellular carcinoma, imaging guided biopsy can be adopted to confirm the diagnosis.
基金financially supported by the National Natural Science Foundation of China (No. 51474028)the National Key Research and Development Program of China (No. 2017YFC0210301)+1 种基金China Postdoctoral Science Foundation (No. 2017M621034)the Science and Technology Benefiting Citizens Program of Ningbo, China (No. 2015C50058)
文摘Hydro-sodalites are zeolitic materials with a wide variety of applications.Fly ash is an abundant industrial solid waste,rich in silicon and aluminum,from which hydro-sodalite can be synthesized.However,traditional hydrothermal synthesis methods are complex and cannot produce high-purity products.Therefore,there is a demand for processing routes to obtain high-purity hydro-sodalites.In the present study,high-purity hydro-sodalite(90.2 wt%)was prepared from fly ash by applying a hydrothermal method to a submolten salt system.Samples were characterized by powder X-ray diffraction(XRD),scanning electron microscopy(SEM),thermogravimetry and differential thermal analysis(TG–DTA),and Fourier transform infrared spectroscopy(FTIR)to confirm and quantify conversion of the raw material into the product phase.Purity of the samples prepared with an H2O/Na OH mass ratio of 1.5 and an H2O/fly ash mass ratio of 10 was calculated and the conversion process of the product phase was studied.Crystallinity of the product was influenced more by the Na OH concentration,less by the H2O/fly ash mass ratio.The main reaction process of the system is that the Si O ions produced by dissolution of the vitreous body in the fly ash and Na+ions in the solution reacted on the destroyed mullite skeleton to produce hydro-sodalite.This processing route could help mitigate processing difficulties,while producing high-purity hydro-sodalite from fly ash.
基金Supported by the National Natural Science Foundation of China,No.81273814Guangdong Province Key Scientific Research Grant,No.2013A022100031
文摘AIM: To investigate the inhibitory efficacy of <sup>125</sup>I-labeled anti-basic fibroblast growth factor (bFGF) monoclonal antibody (mAb) in hepatocellular carcinoma (HCC).METHODS: bFGF mAb was prepared by using the 1G9B9 hybridoma cell line with hybridization technology and extracted from ascites fluid through a Protein G Sepharose affinity column. After labeling with <sup>125</sup>I through the chloramine-T method, bFGF mAb was further purified by a Sephadex G-25 column. Gamma radiation counter GC-1200 detected radioactivity of <sup>125</sup>I-bFGF mAb. The murine H22 HCC xenograft model was established and randomized to interventions with control (phosphate-buffered saline), <sup>125</sup>I-bFGF mAb, <sup>125</sup>I plus bFGF mAb, bFGF mAb, or <sup>125</sup>I. The ratios of tumor inhibition were then calculated. Expression of bFGF, fibroblast growth factor receptor (FGFR), platelet-derived growth factor, and vascular endothelial growth factor (VEGF) mRNA was determined by quantitative reverse transcriptase real-time polymerase chain reaction.RESULTS: The purified bFGF mAb solution was 8.145 mg/mL with a titer of 1:2560000 and was stored at -20 °C. After coupling, <sup>125</sup>I-bFGF mAb was used at a 1: 1280000 dilution, stored at 4 °C, and its specific radioactivity was 37 MBq/mg. The corresponding tumor weight in the control, <sup>125</sup>I, bFGF mAb, <sup>125</sup>I plus bFGF mAb, and <sup>125</sup>I-bFGF mAb groups was 1.88 ± 0.25, 1.625 ± 0.21, 1.5 ± 0.18, 1.41 ± 0.16, and 0.98 ± 0.11 g, respectively. The tumor inhibition ratio in the <sup>125</sup>I, bFGF mAb, <sup>125</sup>I plus bFGF mAb, and <sup>125</sup>I-bFGF mAb groups was 13.6%, 20.2%, 25.1%, and 47.9%, respectively. Growth of HCC xenografts was inhibited significantly more in the <sup>125</sup>I-bFGF mAb group than in the other groups (P < 0.05). Expression of bFGF and FGFR mRNA in the <sup>125</sup>I-bFGF mAb group was significantly decreased in comparison with other groups (P < 0.05). Groups under interventions revealed increased expression of VEGF mRNA (except for <sup>125</sup>I group) compared with the control group.CONCLUSION: <sup>125</sup>I-bFGF mAb inhibits growth of HCC xenografts. The coupling effect of <sup>125</sup>I-bFGF mAb is more effective than the concomitant use of <sup>125</sup>I and bFGF mAb.
文摘To the Editor: Appropriate donor-to-recipient size matching is of crucial importance in lung transplantation. Although tailoring of the lung has been described as a successful means of overcoming size disparities, its merits and demerits remain unclear. Here, we present a case of recurrent hypoxemia after unmatched single lung transplantation.
基金This work was supported by the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(No.2019PT320020).
文摘To the Editor:The polymyxin antibiotics colistin(polymyxin E)and polymyxin B(PMB)became available in the 1950s;thus,they did not undergo contemporary drug development procedures.Their clinical use has recently resurged,assuming an important role as salvage therapv for otherwise untreatable gram-negative infection.[1]Multidrug-resistant(MDR)bacterial infections are primarily caused by gram-negative bacilli(GNB),such as Pseudomonas aeruginosa and Klebsiella pneumoniae^in lung transplant(LT)patients.[2]The increasing prevalence of MDR-GNB infections in LT patients has led to an upsurge in the use of these“older”drugs.During the treatment course,we should pay attention to severe and life-threatening respiratory paralysis caused by neuromuscular blockage associated with PMB.Herein,we report a rare case of a 67-year-old LT patient who suffered from respiratory arrest induced by PMB.
