Background: Osteoporosis (OP) is a common clinical manifestation of multiple myeloma (MM). The aim of this study was to investigate the possible molecular pathways and shared genes in the co-occurrence of OP and MM. M...Background: Osteoporosis (OP) is a common clinical manifestation of multiple myeloma (MM). The aim of this study was to investigate the possible molecular pathways and shared genes in the co-occurrence of OP and MM. Methods: The Gene Expression Omnibus database was used to retrieve gene expression information. Use WGCNA and differential analysis to screen out Hub genes. The GENEMANIA was used to build protein-protein interaction (PPI) networks. Enrichment analyses were performed to explore the functions. Validation datasets were selected to verify the diagnostic marker reliability of PLAGL1. The immune microenvironment of diseases was analyzed by immune infiltration analyses. Results: We confirmed a hub gene called PLAGL1, which is significantly under-expressed in both OP and MM. We found hub genes were associated with glucose and energy metabolism. Subsequently, the reliability of PLAGL1 for diagnosing OP and MM was verified using ROC curves, with all areas under the curve > 0.75. Moreover, PLAGL1 regulates t lymphocytes and may participate in the occurrence of OP in MM through immune pathways. Conclusions: PLAGL1 is a hub gene for the co-occurrence of OP and MM. It can regulate T-lymphocyte involvement in disease development. PLAGL1 may be a novel diagnostic marker for the co-occurrence of OP and MM.展开更多
Multi-direction impact forging(MDIF)was applied to the as-extruded ZK60 Mg alloy,and the microstructure,texture evolution and yield strength symmetry were investigated in the current study.The results showed that the ...Multi-direction impact forging(MDIF)was applied to the as-extruded ZK60 Mg alloy,and the microstructure,texture evolution and yield strength symmetry were investigated in the current study.The results showed that the average grain size of forged piece was greatly refined to 5.3μm after 120 forging passes,which was ascribed to the segmenting effect of{10–12}twins and the subsequent multiple rounds of dynamic recrystallization(DRX).A great deal of{10–12}twins were activated at the beginning of MDIF process,which played an important role in grain refinement.With forging proceeding,continuous and discontinuous DRX were successively activated,resulting in the fully DRXed microstructure.Meanwhile,the forged piece exhibited a unique four-peak texture,and the initial<10-10>//ED fiber texture component gradually evolved into multiple texture components composed of<0001>//FFD(first forging direction)and<11–20>//FFD texture.The special strain path was the key to the formation of the unique four-peak texture.The{10–12}twinning and basal slip were two dominant factors to the evolution of texture during MDIF process.Grain strengthening and dislocation strengthening were two main strengthening mechanisms of the forged piece.Besides,the symmetry of yield strength was greatly improved by MDIF process.展开更多
The rolling direction(RD) and the transverse direction(TD) samples were obtained from an as-rolled ZK60 magnesium alloy sheet with strong anisotropy of initial texture and their mechanical properties were tested at va...The rolling direction(RD) and the transverse direction(TD) samples were obtained from an as-rolled ZK60 magnesium alloy sheet with strong anisotropy of initial texture and their mechanical properties were tested at various deformation temperatures. Meanwhile, the microstructure and texture of these samples after fracture were investigated. Results revealed that a higher flow stress along the RD than that along the TD at room temperature were ascribed to the strong anisotropy of transitional texture, and this texture effect was remarkably weakened with the increase of deformation temperature. Deformation structure was dominant at 100?C, and was replaced by dynamic recrystallization structure when the deformation temperature increased to 200?C and 300?C. The texture presented a strong texture(transitional texture in the RD sample and basal texture in the TD sample) at 100?C, but its intensity visibly decreased and texture components became more disperse at 200?C and 300?C. These microstructure and texture results were employed in conjunction with calculated results to argue that raising deformation temperature could increase the activity of non-basal slip by tailoring the relative critical resolved shear stress of each deformation mode and finally result in low texture effect on mechanical anisotropy.展开更多
Tubes of 3.5 vol.%TiB whiskers reinforced Ti6AI4 V matrix composites(TiBw/Ti6AI4V) were successfully fabricated by a two-step hot-hydrostatic extrusion process:β extrusion at 1100 ℃ and subsequent near-βextrusion a...Tubes of 3.5 vol.%TiB whiskers reinforced Ti6AI4 V matrix composites(TiBw/Ti6AI4V) were successfully fabricated by a two-step hot-hydrostatic extrusion process:β extrusion at 1100 ℃ and subsequent near-βextrusion at 950 ℃.The dimensions of tubes were about 7 mm in diameter and 2 mm in thickness.A refined basket-weave structure in Ti6AI4 V matrix was achieved at ambient temperature after the extrusion process.Besides,the original network structure formed by TiB whiskers synthesized was broken,while the TiB whiskers were preferentially aligned in the extruding direction.Meanwhile,a fibrous texture was evolved finally,resulting from partial dynamic recrystallization during the β extrusion and the involvement of a phase during the near-β extrusion.The tensile and compressive tests results showed that both the strength and ductility of the tubes were significantly improved.In particular,the tubes exhibited good mechanical properties at elevated temperatures.展开更多
文摘Background: Osteoporosis (OP) is a common clinical manifestation of multiple myeloma (MM). The aim of this study was to investigate the possible molecular pathways and shared genes in the co-occurrence of OP and MM. Methods: The Gene Expression Omnibus database was used to retrieve gene expression information. Use WGCNA and differential analysis to screen out Hub genes. The GENEMANIA was used to build protein-protein interaction (PPI) networks. Enrichment analyses were performed to explore the functions. Validation datasets were selected to verify the diagnostic marker reliability of PLAGL1. The immune microenvironment of diseases was analyzed by immune infiltration analyses. Results: We confirmed a hub gene called PLAGL1, which is significantly under-expressed in both OP and MM. We found hub genes were associated with glucose and energy metabolism. Subsequently, the reliability of PLAGL1 for diagnosing OP and MM was verified using ROC curves, with all areas under the curve > 0.75. Moreover, PLAGL1 regulates t lymphocytes and may participate in the occurrence of OP in MM through immune pathways. Conclusions: PLAGL1 is a hub gene for the co-occurrence of OP and MM. It can regulate T-lymphocyte involvement in disease development. PLAGL1 may be a novel diagnostic marker for the co-occurrence of OP and MM.
基金supported by National Natural Science Foundation of China(Grant No.51975146)Key Research and Development Plan in Shandong Province(Grant No.2018JMRH0412,2019JZZY010364)National Defense Basic Scientific Research of China(Grant no.JCK2018603C017)。
文摘Multi-direction impact forging(MDIF)was applied to the as-extruded ZK60 Mg alloy,and the microstructure,texture evolution and yield strength symmetry were investigated in the current study.The results showed that the average grain size of forged piece was greatly refined to 5.3μm after 120 forging passes,which was ascribed to the segmenting effect of{10–12}twins and the subsequent multiple rounds of dynamic recrystallization(DRX).A great deal of{10–12}twins were activated at the beginning of MDIF process,which played an important role in grain refinement.With forging proceeding,continuous and discontinuous DRX were successively activated,resulting in the fully DRXed microstructure.Meanwhile,the forged piece exhibited a unique four-peak texture,and the initial<10-10>//ED fiber texture component gradually evolved into multiple texture components composed of<0001>//FFD(first forging direction)and<11–20>//FFD texture.The special strain path was the key to the formation of the unique four-peak texture.The{10–12}twinning and basal slip were two dominant factors to the evolution of texture during MDIF process.Grain strengthening and dislocation strengthening were two main strengthening mechanisms of the forged piece.Besides,the symmetry of yield strength was greatly improved by MDIF process.
基金supported financially by the National Natural Science Foundation of China (No. 51401064)the Sci-tech Development Project in Shandong Province (No. 2014GGX10211)+1 种基金the Sci-tech Major Project in Shandong Province (No. 2015ZDJQ02002)the Fundamental Research Funds for the Central Universities (No. HIT.NSRIF.2016109)
文摘The rolling direction(RD) and the transverse direction(TD) samples were obtained from an as-rolled ZK60 magnesium alloy sheet with strong anisotropy of initial texture and their mechanical properties were tested at various deformation temperatures. Meanwhile, the microstructure and texture of these samples after fracture were investigated. Results revealed that a higher flow stress along the RD than that along the TD at room temperature were ascribed to the strong anisotropy of transitional texture, and this texture effect was remarkably weakened with the increase of deformation temperature. Deformation structure was dominant at 100?C, and was replaced by dynamic recrystallization structure when the deformation temperature increased to 200?C and 300?C. The texture presented a strong texture(transitional texture in the RD sample and basal texture in the TD sample) at 100?C, but its intensity visibly decreased and texture components became more disperse at 200?C and 300?C. These microstructure and texture results were employed in conjunction with calculated results to argue that raising deformation temperature could increase the activity of non-basal slip by tailoring the relative critical resolved shear stress of each deformation mode and finally result in low texture effect on mechanical anisotropy.
基金financially supported by the National HighTech Research and Development Program of China("863 Program",No.2013AA031202)
文摘Tubes of 3.5 vol.%TiB whiskers reinforced Ti6AI4 V matrix composites(TiBw/Ti6AI4V) were successfully fabricated by a two-step hot-hydrostatic extrusion process:β extrusion at 1100 ℃ and subsequent near-βextrusion at 950 ℃.The dimensions of tubes were about 7 mm in diameter and 2 mm in thickness.A refined basket-weave structure in Ti6AI4 V matrix was achieved at ambient temperature after the extrusion process.Besides,the original network structure formed by TiB whiskers synthesized was broken,while the TiB whiskers were preferentially aligned in the extruding direction.Meanwhile,a fibrous texture was evolved finally,resulting from partial dynamic recrystallization during the β extrusion and the involvement of a phase during the near-β extrusion.The tensile and compressive tests results showed that both the strength and ductility of the tubes were significantly improved.In particular,the tubes exhibited good mechanical properties at elevated temperatures.
