Background Many psychotherapy theories emphasise the importance of self-schema and other-schema,but most previous studies focused on the explicit self-schema in major depressive disorder(MDD).However,the limited studi...Background Many psychotherapy theories emphasise the importance of self-schema and other-schema,but most previous studies focused on the explicit self-schema in major depressive disorder(MDD).However,the limited studies of implicit self-schema in MDD have shown inconsistencies in their findings.Furthermore,only a few studies have investigated the implicit other-schema,and the pathway illustrating how implicit schemas influence depression remains unclear.Aims The primary aim of our study was to explore the characteristics of implicit self-schema and otherschema in patients with MDD.We also examine the chain-mediating effect of attachment relationships and interpersonal trust.Methods The present study included 88 patients with MDD and 88 healthy controls(HCs).The Hamilton Depression Rating Scale-17,Experiences in Close Relationships Inventory—Revised Questionnaire,Trust Scale and the Extrinsic Affective Simon Task(EAST)were used to assess depressive symptoms,attachment relationships,interpersonal trust and implicit schemas,respectively.Paired sample t-test was used to compare the reaction time(RT)for positive and negative words within the two groups.Analysis of covariance was used to explore the difference between two groups from the perspective of implicit schemas and interpersonal patterns.The chain mediation model was verified by bootstrap.Results(1)For interpersonal patterns,patients with MDD scored significantly higher on attachment anxiety(F=82.150,p<0.001)and attachment avoidance(F=23.192,p<0.001)and scored significantly lower on the predictability(F=30.297,p<0.001),dependence(F=39.728,p<0.001)and faith(F=60.997,p<0.001)dimensions of interpersonal trust.(2)As for implicit schemas,no significant difference was found between the RT for positive self-words and negative self-words in patients with MDD(t=−1.056,p=0.294).However,the HC responded faster to positive self-words than negative self-words(t=−3.286,p=0.001).The RT for positive other-words and negative other-words were significantly different in both patients with MDD(t=2.943,p=0.004)and HCs(t=−2.482,p=0.015),with opposite directions.The EAST effect of other-schema in patients with MDD was significantly different from that in HCs(F=13.051,p<0.001).(3)For the total sample,the EAST effect of other-schema significantly correlated with attachment avoidance,interpersonal trust and depressive symptoms.Attachment avoidance and interpersonal trust were the chain mediators between the EAST effect of other-schema and depressive symptoms(95%CI:−0.090 to−0.008).However,no significant results were found for the EAST effect of other-schema when correlation and mediation analyses were performed for HCs and patients with MDD separately.Conclusions This study verified that patients with MDD have abnormal interpersonal patterns and negative implicit schemas.However,no mediating effect of attachment relationships and interpersonal trust was found.展开更多
Seeds establish dormancy to delay germination until the arrival of a favorable growing season.In this study,we identify a fate switch comprised of the MKK3–MPK7 kinase cascade and the ethylene response factor ERF4 th...Seeds establish dormancy to delay germination until the arrival of a favorable growing season.In this study,we identify a fate switch comprised of the MKK3–MPK7 kinase cascade and the ethylene response factor ERF4 that is responsible for the seed state transition from dormancy to germination.We show that dormancy-breaking factors activate the MKK3–MPK7 module,which affects the expression of some a-EXPANSIN(EXPA)genes to control seed dormancy.Furthermore,we identify a direct downstream substrate of this module,ERF4,which suppresses the expression of these EXPAs by directly binding to the GCC boxes in their exon regions.The activated MKK3–MPK7 module phosphorylates ERF4,leading to its rapid degradation and thereby releasing its inhibitory effect on the expression of these EXPAs.Collectively,our work identifies a signaling chain consisting of protein phosphorylation,degradation,and gene transcription,by which the germination promoters within the embryo sense and are activated by germination signals from ambient conditions.展开更多
Ultrasonic-stationary shoulder assisted friction stir welding(U-SSFSW)is a novel hybrid welding technique,which reveals promising prospect in joining Al/Mg dissimilar alloys.A thorough understanding of U-SSFSW process...Ultrasonic-stationary shoulder assisted friction stir welding(U-SSFSW)is a novel hybrid welding technique,which reveals promising prospect in joining Al/Mg dissimilar alloys.A thorough understanding of U-SSFSW process is imperative for the further application of this technique.Pigeon-inspired optimization(PIO)is a swarm intelligent optimization algorithm and is proposed in mathematical modeling and process optimization by artificial intelligence.In this study,PIO optimized artificial neural network(PIOANN)was firstly established to acquire the relationships between the inputs and output of the Al/Mg welding process by U-SSFSW technique.A reliable PIO-ANN was achieved and the joint with a tensile strength of 161 MPa was acquired under the PIO optimized parameters.This tensile strength is higher than any ever-reported results with the similar welding condition.The joint formation,microstructure,microhardness and fracture behaviors were systemically investigated based on the reported studies and the confirmation experiment of this study to explore the enhancing mechanism of U-SSFSW Al/Mg joint.展开更多
Brillouin gain spectra(BGS)in an As2Se3 photonic crystal fiber(PCF)are investigated numerically.The profiles of the BGS are simulated by calculating the characteristics of different-order optical and acoustic waves in...Brillouin gain spectra(BGS)in an As2Se3 photonic crystal fiber(PCF)are investigated numerically.The profiles of the BGS are simulated by calculating the characteristics of different-order optical and acoustic waves in the PCFs with different core diameters.For the small-core PCF,there are two peaks in BGS,but there is only one peak for the large-core PCF.We also reveal that in the small-core PCF,the difference of Brillouin frequency shift between the LP01 and LP11 modes is obvious,while it is not obvious in the large-core PCF.The Brillouin threshold increases with the core diameter increasing.展开更多
基金supported by grants from the Shanghai Mental Health Center(No.CRC2017YB01)and from Science and Technology Commission of Shanghai Municipality(No.21Y11905400).
文摘Background Many psychotherapy theories emphasise the importance of self-schema and other-schema,but most previous studies focused on the explicit self-schema in major depressive disorder(MDD).However,the limited studies of implicit self-schema in MDD have shown inconsistencies in their findings.Furthermore,only a few studies have investigated the implicit other-schema,and the pathway illustrating how implicit schemas influence depression remains unclear.Aims The primary aim of our study was to explore the characteristics of implicit self-schema and otherschema in patients with MDD.We also examine the chain-mediating effect of attachment relationships and interpersonal trust.Methods The present study included 88 patients with MDD and 88 healthy controls(HCs).The Hamilton Depression Rating Scale-17,Experiences in Close Relationships Inventory—Revised Questionnaire,Trust Scale and the Extrinsic Affective Simon Task(EAST)were used to assess depressive symptoms,attachment relationships,interpersonal trust and implicit schemas,respectively.Paired sample t-test was used to compare the reaction time(RT)for positive and negative words within the two groups.Analysis of covariance was used to explore the difference between two groups from the perspective of implicit schemas and interpersonal patterns.The chain mediation model was verified by bootstrap.Results(1)For interpersonal patterns,patients with MDD scored significantly higher on attachment anxiety(F=82.150,p<0.001)and attachment avoidance(F=23.192,p<0.001)and scored significantly lower on the predictability(F=30.297,p<0.001),dependence(F=39.728,p<0.001)and faith(F=60.997,p<0.001)dimensions of interpersonal trust.(2)As for implicit schemas,no significant difference was found between the RT for positive self-words and negative self-words in patients with MDD(t=−1.056,p=0.294).However,the HC responded faster to positive self-words than negative self-words(t=−3.286,p=0.001).The RT for positive other-words and negative other-words were significantly different in both patients with MDD(t=2.943,p=0.004)and HCs(t=−2.482,p=0.015),with opposite directions.The EAST effect of other-schema in patients with MDD was significantly different from that in HCs(F=13.051,p<0.001).(3)For the total sample,the EAST effect of other-schema significantly correlated with attachment avoidance,interpersonal trust and depressive symptoms.Attachment avoidance and interpersonal trust were the chain mediators between the EAST effect of other-schema and depressive symptoms(95%CI:−0.090 to−0.008).However,no significant results were found for the EAST effect of other-schema when correlation and mediation analyses were performed for HCs and patients with MDD separately.Conclusions This study verified that patients with MDD have abnormal interpersonal patterns and negative implicit schemas.However,no mediating effect of attachment relationships and interpersonal trust was found.
基金supported by the National Natural Science Foundation of China(grant nos.32000250 and 32170364)the China Postdoctoral Science Foundation(grant no.2020M682997)+2 种基金the Key Area Research and Development Program of Guangdong Province(grant no.2021B0707010006)the Science,Technology and Innovation Commission of Shenzhen Municipality(grant nos.KCXFZ-20201221173203009 and KCXFZ20211020164207012)the Dapeng New District Science and Technology Program(grant nos.KJYF202101-09 and RCTD20180102)。
文摘Seeds establish dormancy to delay germination until the arrival of a favorable growing season.In this study,we identify a fate switch comprised of the MKK3–MPK7 kinase cascade and the ethylene response factor ERF4 that is responsible for the seed state transition from dormancy to germination.We show that dormancy-breaking factors activate the MKK3–MPK7 module,which affects the expression of some a-EXPANSIN(EXPA)genes to control seed dormancy.Furthermore,we identify a direct downstream substrate of this module,ERF4,which suppresses the expression of these EXPAs by directly binding to the GCC boxes in their exon regions.The activated MKK3–MPK7 module phosphorylates ERF4,leading to its rapid degradation and thereby releasing its inhibitory effect on the expression of these EXPAs.Collectively,our work identifies a signaling chain consisting of protein phosphorylation,degradation,and gene transcription,by which the germination promoters within the embryo sense and are activated by germination signals from ambient conditions.
基金supported by the National Natural Science Foundation of China(No.51874201)the Science Technology Major Project of Liaoning Province,China(No.2019JH1/10100028)。
文摘Ultrasonic-stationary shoulder assisted friction stir welding(U-SSFSW)is a novel hybrid welding technique,which reveals promising prospect in joining Al/Mg dissimilar alloys.A thorough understanding of U-SSFSW process is imperative for the further application of this technique.Pigeon-inspired optimization(PIO)is a swarm intelligent optimization algorithm and is proposed in mathematical modeling and process optimization by artificial intelligence.In this study,PIO optimized artificial neural network(PIOANN)was firstly established to acquire the relationships between the inputs and output of the Al/Mg welding process by U-SSFSW technique.A reliable PIO-ANN was achieved and the joint with a tensile strength of 161 MPa was acquired under the PIO optimized parameters.This tensile strength is higher than any ever-reported results with the similar welding condition.The joint formation,microstructure,microhardness and fracture behaviors were systemically investigated based on the reported studies and the confirmation experiment of this study to explore the enhancing mechanism of U-SSFSW Al/Mg joint.
基金supported by the National Key R&D Program of China(No.2018YFB0504500)the National Natural Science Foundation of China(NSFC)(Nos.61875052,61905059,and 11374084)+1 种基金the Anhui Provincial Natural Science Foundation(No.1908085QF273)the Fundamental Research Funds for the Central Universities(Nos.PA2019GDQT0007 and JZ2019HGTA0037).
文摘Brillouin gain spectra(BGS)in an As2Se3 photonic crystal fiber(PCF)are investigated numerically.The profiles of the BGS are simulated by calculating the characteristics of different-order optical and acoustic waves in the PCFs with different core diameters.For the small-core PCF,there are two peaks in BGS,but there is only one peak for the large-core PCF.We also reveal that in the small-core PCF,the difference of Brillouin frequency shift between the LP01 and LP11 modes is obvious,while it is not obvious in the large-core PCF.The Brillouin threshold increases with the core diameter increasing.
