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Microglial NLRP3 inflammasome-mediated neuroinflammation and therapeutic strategies in depression 被引量:4
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作者 Qiuqin Han wenhui li +5 位作者 Peiqing Chen lijuan Wang Xiwen Bao Renyan Huang Guobin liu Xiaorong Chen 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期1890-1898,共9页
Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containin... Previous studies have demonstrated a bidirectional relationship between inflammation and depression.Activation of the nucleotide-binding oligomerization domain,leucine-rich repeat,and NLR family pyrin domain-containing 3(NLRP3)inflammasomes is closely related to the pathogenesis of various neurological diseases.In patients with major depressive disorder,NLRP3 inflammasome levels are significantly elevated.Understanding the role that NLRP3 inflammasome-mediated neuroinflammation plays in the pathogenesis of depression may be beneficial for future therapeutic strategies.In this review,we aimed to elucidate the mechanisms that lead to the activation of the NLRP3 inflammasome in depression as well as to provide insight into therapeutic strategies that target the NLRP3 inflammasome.Moreover,we outlined various therapeutic strategies that target the NLRP3 inflammasome,including NLRP3 inflammatory pathway inhibitors,natural compounds,and other therapeutic compounds that have been shown to be effective in treating depression.Additionally,we summarized the application of NLRP3 inflammasome inhibitors in clinical trials related to depression.Currently,there is a scarcity of clinical trials dedicated to investigating the applications of NLRP3 inflammasome inhibitors in depression treatment.The modulation of NLRP3 inflammasomes in microglia holds promise for the management of depression.Further investigations are necessary to ascertain the efficacy and safety of these therapeutic approaches as potential novel antidepressant treatments. 展开更多
关键词 DEPRESSION MICROGLIA NEUROINFLAMMATION NLRP3 inflammasome
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Solar hydrogen production from electrochemical ammonia splitting powered by a single perovskite solar cell
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作者 Anna MBeiler wenhui li +2 位作者 Alisa Denisiuk Emilio Palomares Antoni Llobet 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第5期292-295,共4页
For carbon-free electrochemical fuel formation,the electrochemical cell must be powered by renewable energy.Obtaining solar-powered H_(2) fuel from water typically requires multiple photovoltaic cells and/or junctions... For carbon-free electrochemical fuel formation,the electrochemical cell must be powered by renewable energy.Obtaining solar-powered H_(2) fuel from water typically requires multiple photovoltaic cells and/or junctions to drive the water splitting reaction.Because of the lower thermodynamic requirements to oxidize ammonia compared to water,solar cells with smaller open circuit voltages can provide the required potential for ammonia splitting.In this work,a single perovskite solar cell with an open-circuit potential of 1.08 V is coupled to a 2-electrode electrochemical cell employing hybrid electroanodes functionalized with Ru-based molecular catalysts.The device is active for more than 30 min,producing N_(2) and H_(2) in a 1:2.9 ratio with 89%faradaic efficiency with no external applied bias.This work illustrates that hydrogen production from ammonia can be driven by conventional semiconductors. 展开更多
关键词 Ammonia oxidation Redox catalysis Perovskites Solarfuels Transitionmetal complexes
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Weak Fault Feature Extraction of the Rotating Machinery Using Flexible Analytic Wavelet Transform and Nonlinear Quantum Permutation Entropy
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作者 lili Bai wenhui li +3 位作者 He Ren Feng li TaoYan lirong Chen 《Computers, Materials & Continua》 SCIE EI 2024年第6期4513-4531,共19页
Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery,where weak fault characteristic signals hinder accurate fault state representation,we propose a novel feature extrac... Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery,where weak fault characteristic signals hinder accurate fault state representation,we propose a novel feature extraction method that combines the Flexible Analytic Wavelet Transform(FAWT)with Nonlinear Quantum Permutation Entropy.FAWT,leveraging fractional orders and arbitrary scaling and translation factors,exhibits superior translational invariance and adjustable fundamental oscillatory characteristics.This flexibility enables FAWT to provide well-suited wavelet shapes,effectively matching subtle fault components and avoiding performance degradation associated with fixed frequency partitioning and low-oscillation bases in detecting weak faults.In our approach,gearbox vibration signals undergo FAWT to obtain sub-bands.Quantum theory is then introduced into permutation entropy to propose Nonlinear Quantum Permutation Entropy,a feature that more accurately characterizes the operational state of vibration simulation signals.The nonlinear quantum permutation entropy extracted from sub-bands is utilized to characterize the operating state of rotating machinery.A comprehensive analysis of vibration signals from rolling bearings and gearboxes validates the feasibility of the proposed method.Comparative assessments with parameters derived from traditional permutation entropy,sample entropy,wavelet transform(WT),and empirical mode decomposition(EMD)underscore the superior effectiveness of this approach in fault detection and classification for rotating machinery. 展开更多
关键词 Rotating machinery quantum theory nonlinear quantum permutation entropy Flexible Analytic Wavelet Transform(FAWT) feature extraction
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A geographical similarity-based sampling method of non-fire point data for spatial prediction of forest fires 被引量:1
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作者 Quanli Xu wenhui li +1 位作者 Jing liu Xiao Wang 《Forest Ecosystems》 SCIE CSCD 2023年第2期195-214,共20页
Understanding the mechanisms and risks of forest fires by building a spatial prediction model is an important means of controlling forest fires.Non-fire point data are important training data for constructing a model,... Understanding the mechanisms and risks of forest fires by building a spatial prediction model is an important means of controlling forest fires.Non-fire point data are important training data for constructing a model,and their quality significantly impacts the prediction performance of the model.However,non-fire point data obtained using existing sampling methods generally suffer from low representativeness.Therefore,this study proposes a non-fire point data sampling method based on geographical similarity to improve the quality of non-fire point samples.The method is based on the idea that the less similar the geographical environment between a sample point and an already occurred fire point,the greater the confidence in being a non-fire point sample.Yunnan Province,China,with a high frequency of forest fires,was used as the study area.We compared the prediction performance of traditional sampling methods and the proposed method using three commonly used forest fire risk prediction models:logistic regression(LR),support vector machine(SVM),and random forest(RF).The results show that the modeling and prediction accuracies of the forest fire prediction models established based on the proposed sampling method are significantly improved compared with those of the traditional sampling method.Specifically,in 2010,the modeling and prediction accuracies improved by 19.1%and 32.8%,respectively,and in 2020,they improved by 13.1%and 24.3%,respectively.Therefore,we believe that collecting non-fire point samples based on the principle of geographical similarity is an effective way to improve the quality of forest fire samples,and thus enhance the prediction of forest fire risk. 展开更多
关键词 Spatial prediction of forest fires Data-driven models Geographic similarity Non-fire point data Data confidence
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OsNRAMP2 facilitates Cd efflux from vacuoles and contributes to the difference in grain Cd accumulation between japonica and indica rice 被引量:1
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作者 Wu Yang Luo Chen +14 位作者 Yamei Ma Rui Hu Jian Wang wenhui li Jingfang Dong Tifeng Yang lian Zhou Jiansong Chen Dilin liu Ning Yu Zhixia liu lingyan Zhou Shaohong Zhang Junliang Zhao Bin liu 《The Crop Journal》 SCIE CSCD 2023年第2期417-426,共10页
Cadmium(Cd)accumulation in rice grain is of health concern.Identifying genes involved in grain Cd accumulation and performing molecular breeding may reduce it.In this study,knockout of OsNRAMP2,a member of the NRAMP f... Cadmium(Cd)accumulation in rice grain is of health concern.Identifying genes involved in grain Cd accumulation and performing molecular breeding may reduce it.In this study,knockout of OsNRAMP2,a member of the NRAMP family,reduced grain Cd concentrations by more than 38%,and overexpressing OsNRAMP2 increased grain Cd concentrations by more than 50%.Physiological experiments showed that OsNRAMP2 facilitated Cd translocation from root to shoot by positively regulating Cd efflux from the vacuoles.At filling stage,OsNRAMP2 was highly expressed in all tissues except for husk,suggesting its role in Cd remobilization.Changes in OsNRAMP2 expression affected the concentrations of Fe,Mn,Zn,and Cu in grain and also affected rice growth.Phylogenetic analysis showed that the distribution of OsNRAMP2 haplotypes between japonica and indica was different.Among the four haplotypes of OsNRAMP2,Hap 1,with a 6-bp nucleotide insertion in exon 1,had grain Cd concentration at least 45.3%lower than any of the other three haplotypes.Almost all(99.3%)japonica accessions but rare indica accessions(4.44%)from the 3K sequenced rice genomes carry Hap 1 of OsNRAMP2.Our study sheds light on the molecular mechanism of grain Cd accumulation and provides a promising target for low-Cd rice breeding. 展开更多
关键词 Rice(Oryza sativa L.) Cadmium OsNRAMP2 HAPLOTYPE
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Three-Dimensional Analytical Modeling of Axial-Flux Permanent Magnet Drivers
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作者 wenhui li Dazhi Wang +3 位作者 Shuo Cao Deshan Kong Sihan Wang Zhong Hua 《Computers, Materials & Continua》 SCIE EI 2023年第4期259-276,共18页
In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare co... In this paper, the axial-flux permanent magnet driver is modeledand analyzed in a simple and novel way under three-dimensional cylindricalcoordinates. The inherent three-dimensional characteristics of the deviceare comprehensively considered, and the governing equations are solved bysimplifying the boundary conditions. The axial magnetization of the sectorshapedpermanent magnets is accurately described in an algebraic form bythe parameters, which makes the physical meaning more explicit than thepurely mathematical expression in general series forms. The parameters of theBessel function are determined simply and the magnetic field distribution ofpermanent magnets and the air-gap is solved. Furthermore, the field solutionsare completely analytical, which provides convenience and satisfactoryaccuracy for modeling a series of electromagnetic performance parameters,such as the axial electromagnetic force density, axial electromagnetic force,and electromagnetic torque. The correctness and accuracy of the analyticalmodels are fully verified by three-dimensional finite element simulations and a15 kW prototype and the results of calculations, simulations, and experimentsunder three methods are highly consistent. The influence of several designparameters on magnetic field distribution and performance is studied and discussed.The results indicate that the modeling method proposed in this papercan calculate the magnetic field distribution and performance accurately andrapidly, which affords an important reference for the design and optimizationof axial-flux permanent magnet drivers. 展开更多
关键词 Three-dimensional analytical modeling cylindrical coordinates magnetic field distribution parameter sensitivity analysis performance measurement
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Relationship between the Ecological Livability and the Green Development of Agriculture
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作者 wenhui li Hongyang li Xingxing SUN 《Agricultural Biotechnology》 CAS 2023年第4期85-87,共3页
Ecological livability is one of the important tasks and objectives of the rural revitalization strategy proposed at the 19 th National Congress of the CPC.The most precious wealth of the countryside is the excellent e... Ecological livability is one of the important tasks and objectives of the rural revitalization strategy proposed at the 19 th National Congress of the CPC.The most precious wealth of the countryside is the excellent ecological environment,and China must unswervingly follow the route of green agricultural development.Based on current research on the relationship between ecological livable and agricultural green development,comprehensive policy documents,journal literature and related reports,this paper explored the background and connotation of ecological livable,the current situation of agricultural green development and existing problems,and profoundly analyzed ecological livable and the internal connection between agricultural green development,aiming to provide theoretical reference and scientific reference for the final realization of ecological livable goal. 展开更多
关键词 Ecological and livable Agricultural green agricultural development Rural revitalization
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Regeneration Characteristics and Spatial Pattern of <i>Platycladus orientalis</i>in Mount Tai, China
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作者 wenhui li Xiyue Zhao +2 位作者 Jinli Bian Ruiqiang liu Ruiqiang Ni 《Open Journal of Ecology》 2021年第3期276-286,共11页
<em>Platycladus orientalis</em> is one of the main tree species in Mount Tai, and its sustainable development is of great significance to the protection and development of the forest ecological environment... <em>Platycladus orientalis</em> is one of the main tree species in Mount Tai, and its sustainable development is of great significance to the protection and development of the forest ecological environment of Mount Tai. In this study, a representative sample plot of <em>Platycladus orientalis</em> with a size of 30 m * 20 m was selected on Mount Tai. The growth and distribution of the parent trees and seedlings of <em>Platycladus orientalis</em> were investigated in the sample plots. The results showed that both the mother cypress trees and seedlings inside the plot present an aggregated distribution pattern within a certain scale, which conforms to the distribution of most natural communities;and the mother cypress can promote seedlings within a certain scale. Although <em>Platycladus orientalis</em> has good natural regeneration ability, it is difficult to succeed in understory regeneration solely relying on natural fertility, and it is not conducive to the long-term stable development of forest stands. Therefore, the thinning of <em>Platycladus orientalis</em> and the adjustment of the forest stand structure and artificial promotion of natural regeneration can not only reduce operating costs, but also conform to the idea of forest near-natural management and maintain sustainable forest development. 展开更多
关键词 Platycladus orientalis Understory Regeneration Point Pattern Analysis Community Structure Intraspecific Relationship
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Cyanidin-3-O-glucoside alleviates trimethyltin chloride-induced neurodegeneration by maintaining glutamate homeostasis through modulation of the gut microbiota
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作者 Yu Xi wenhui li +4 位作者 Junru Wang Meihong Yu Xiangquan Zeng He li Jian li 《Food Science and Human Wellness》 SCIE CSCD 2024年第2期1093-1107,共15页
Trimethyltin chloride(TMT)is a potent neurotoxin to cause neurodegeneration,especially in hippocampus.This study aimed to identify dietary components that can effectively attenuate TMT-induced neurodegeneration in hum... Trimethyltin chloride(TMT)is a potent neurotoxin to cause neurodegeneration,especially in hippocampus.This study aimed to identify dietary components that can effectively attenuate TMT-induced neurodegeneration in humans.The predominant anthocyanin in human diets,cyanidin-3-O-glucoside(C3G,5 or 50 mg/kg),was given to mice for 16 days,and TMT(2.7 mg/kg)was injected intraperitoneally once on the eighth day.C3G(50 mg/kg)significantly alleviated TMT-induced seizures and subsequent cognitive impairment by ameliorating hippocampal neurodegeneration and synaptic dysfunction.Furthermore,C3G treatment restored glutamate homeostasis in brain and reversed glutamine synthetase(GS)inhibition in reactive astrogliosis and neuroinflammation,which are critical for C3G's neuroprotective effects.Notably,C3G decreased the lipopolysaccharide,tumor necrosis factor-α,interleukin-6,and interleukin-1βlevels in the mice,which potentially by modulating the relative abundance of Atopobiaceae and Lachnospiraceae in the gut.C3G may be a promising and practical dietary component for reducing TMT-induced neurodegeneration. 展开更多
关键词 Cyanidin-3-O-glucoside TRIMETHYLTIN NEURODEGENERATION Glutamatergic pathway Gut microbiota
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Food-derived protein hydrolysates and peptides:anxiolytic and antidepressant activities,characteristics,and mechanisms
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作者 wenhui li Yu Xi +3 位作者 Junru Wang Yinxiao Zhang He li Xinqi liu 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1168-1185,共18页
Globally,the prevalence of anxiety and depression has reached epidemic proportions.Food-derived protein hydrolysates and peptides delivered through dietary supplementation can avoid the negative risks associated with ... Globally,the prevalence of anxiety and depression has reached epidemic proportions.Food-derived protein hydrolysates and peptides delivered through dietary supplementation can avoid the negative risks associated with traditional pharmaceuticals while delivering superior anxiolytic and antidepressant effects.This review summarizes current research on food-derived anxiolytic and antidepressant protein hydrolysates and peptides,and subsequently analyses their physicochemical characteristics and elaborates on their mechanisms.The aim of this work is to contribute to the in-depth study and provide a theoretical foundation for the development of related products to better serve patients with anxiety and depression. 展开更多
关键词 ANXIOLYTIC ANTIDEPRESSANT PEPTIDES Protein hydrolysates NEUROTRANSMITTER
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High-resolution crustal structure of the Yinchuan basin revealed by deep seismic reflection profiling:implications for deep processes of basin 被引量:8
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作者 Xing fuHuang Shaoying Feng +1 位作者 Rui Gao wenhui li 《Earthquake Science》 CSCD 2016年第2期83-92,共10页
The Yinchuan basin, located on the western margin of the Ordos block, has the characteristics of an active continental rift. A NW-striking deep seismic reflection profile across the center of Yinchuan basin precisely ... The Yinchuan basin, located on the western margin of the Ordos block, has the characteristics of an active continental rift. A NW-striking deep seismic reflection profile across the center of Yinchuan basin precisely revealed the fine structure of the crust. The images showed that the crust in the Yinchuan basin was characterized by vertical stratifications along a detachment located at a two-way travel time(TWT) of 8.0 s.The most outstanding feature of this seismic profile was the almost flat Mohorovicˇic′ discontinuity(Moho) and a high-reflection zone in the lower crust. This sub-horizontal Moho conflicts with the general assumption of an uplifted Moho under sedimentary basins and continental rifts, and may indicate the action of different processes at depth during the evolution of sedimentary basins or rifts.We present a possible interpretation of these deep processes and the sub-horizontal Moho. The high-reflection zone, which consists of sheets of high-density, mantlederived materials, may have compensated for crustal thinning in the Yinchuan basin, leading to the formation of a sub-horizontal Moho. These high-density materials may have been emplaced by underplating with mantlesourced magma. 展开更多
关键词 Yinchuan basin Deep seismic reflection section Deep process Magma underplating MOHO
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Application of active-source surface waves in urban underground space detection: A case study of Rongcheng County, Hebei, China 被引量:1
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作者 GuangWen Wang HaiYan Wang +3 位作者 HongQiang li ZhanWu Lu wenhui li TaiRan Xu 《Earth and Planetary Physics》 EI CSCD 2022年第4期385-398,共14页
Active-source surface wave exploration is advantageous because it has high imaging accuracy,is not affected by high-speed layers,and has a low cost;thus,it has unique advantages for investigating shallow surface struc... Active-source surface wave exploration is advantageous because it has high imaging accuracy,is not affected by high-speed layers,and has a low cost;thus,it has unique advantages for investigating shallow surface structures.For the development and utilization of urban underground space,two parameters in the shallow surface are important,namely,the shear wave velocity(V_(S))and the predominant period of the site,which determine the elevation and aseismic grade of the building design.The traditional method is mainly to obtain the two above-mentioned parameters through testing and measuring drilling samples.However,this method is extremely expensive and time consuming.Therefore,in this research,we used the multichannel surface wave acquisition method to extract the fundamental dispersion curve of single-shot data by using the phase shift method and obtain the V_(S) characteristics in the uppermost 40 m by inversion.We arrived at the following two conclusions based on the V_(S) profile.First,the study area can be roughly divided into five layers,among which the layers 0−8 m,14−20 m,and 20−30 m are low-velocity layers,corresponding to miscellaneous fill,a water-bearing sand layer,and a sand layer;therefore,the V_(S) is relatively low.In contrast,the layers at 8−14 m and 30−40 m are high-velocity layers that are mainly composed of clay,with a relatively better compactness and relatively high V_(S) values.In addition,a low-speed anomaly appears abruptly in the high-speed area at 20−40 m.This anomaly,when combined with geological data,suggests that it is an ancient river channel.Second,from the V_(S) value,the V_(Se)(equivalent shear wave velocity)was calculated.The construction site soil was categorized as class III,with good conditions for engineering geology.In addition,we calculated the predominant period of the site to be 0.56-0.77 s based on the V_(S).Therefore,in the overall structural design of the foundation engineering,the natural vibration period of the structure should be strictly controlled to avoid the predominant period of the site. 展开更多
关键词 Jizhong depression surface wave exploration shallow structure site category predominant period
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Using large dynamite shots to image the structure of the Moho from deep seismic reflection experiment between the Sichuan basin and Qinling orogen 被引量:1
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作者 Hongqiang li Rui Gao +2 位作者 Haiyan Wang wenhui li Xiaosong Xiong 《Earthquake Science》 CSCD 2016年第6期321-326,共6页
The Qinling orogen was formed as a result of the collision between the North and South China blocks. The Qinling orogen represents the location at which the southern and northern parts of the Chinese mainland col- lid... The Qinling orogen was formed as a result of the collision between the North and South China blocks. The Qinling orogen represents the location at which the southern and northern parts of the Chinese mainland col- lided, and it's also the intersection of the Central China orogen and the north-south tectonic belt. There is evidence of strong deformation in this orogen, and it has had a long and complex geological history. We investigated the structure of the Moho in the southern Qinling orogen using large dynamite shot imaging techniques. By integrating the analysis of the single-shot and the move-out corrections profile, we determined the structure of the Moho beneath the northern Dabashan thrust belt and the southern Qinling orogen, including the mantle suture beneath Fenghuang mountain. The Moho is divided into two parts by the mantle suture zone beneath Fenghuang mountain: (1) from Ziyang to Hanyin, the north-dipping Moho is at about 45-55 km depth and the depth increases rapidly; and (2) from Hanyin to Ningshan, the south-dipping Moho is at about 40-45 km depth and shallows slowly. The mantle suture is located beneath Fenghuang mountain, and the Moho overlaps at this location: the shallower Moho is connected to the northern part of China, and the deeper Moho is connected to the southern part. This may indicate that the lithosphere in the Sichuan basin subducts to the Qinling block and that the subduction frontier reaches at least as far as Fenghuang mountain. 展开更多
关键词 Moho . Deep seismic reflection profiles . Largedynamite shots .Qinling Orogen China
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Oxaliplatin combined with S-1 capsule in the treatment of 62 cases with advanced gastric cancer
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作者 wenhui li Qiuju lin 《The Chinese-German Journal of Clinical Oncology》 CAS 2013年第9期416-418,共3页
Objective: The aim of this study was to evaluate the efficacy and safety profile of DeFazio (S-l) combined with oxaliplatin against unresectable advanced or metastatic gastric cancer. Methods: Oxaliplatin was give... Objective: The aim of this study was to evaluate the efficacy and safety profile of DeFazio (S-l) combined with oxaliplatin against unresectable advanced or metastatic gastric cancer. Methods: Oxaliplatin was given intravenously at 130 mg/m2 for 2 h on dl and S-1 was administered bid. at 80 mg/m2/day on d1-14 followed by a 7-day rest during the 3-week schedule. Results: All 62 patients were assessed for efficacy and adverse events. The response and disease control rates were 47.3% and 80.8%, respectively. The median time to progression was 7.8 months, and the median overall survival was 11.6 months. The grade 3/4 adverse events were hematological toxicities, including neutropenia (11.3%), thrombocytopenia (9.7%) and gastrointestinal reactions (6.5%). Conclusion: The SOX regimen (oxaliplatin, 130 mg/m2 d l; S-1, 80 mg/m2/day, bid. d1-14, q3w) provide a favorable efficacy and safety profile in patients with advanced gastric cancer. 展开更多
关键词 gastric carcinoma OXALIPLATIN DeFazio (S-1) combination chemotherapy
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The Clinical Anatomy of the Cavernous Sinus
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作者 Pengfei Zhang Huanjiu Xi wenhui li 《Forensic Medicine and Anatomy Research》 2015年第2期66-75,共10页
Introduction: The cavernous sinus (CS) is a very important concept because it is not only interesting to anatomical theory but also useful to clinical medicine, especially in the field of surgery. This paper described... Introduction: The cavernous sinus (CS) is a very important concept because it is not only interesting to anatomical theory but also useful to clinical medicine, especially in the field of surgery. This paper described the microsurgical anatomy of the CS with special attention to its concept that the CS was really venous sinus or plexus. Materials and Methods: Fifty CSs from 25 Chinese adult cadaver heads fixed in 10% methanal, whose artery and vein were injected with red and blue latex, respectively, dissected stepwise under the operating microscope. Results: Asymmetric and nonintegral blue latex distributed in the cavity of the CS to form a retina with various diameters and repeatedly diverged and converged were observed under the surgical microscope with magnification 5 - 25, after the lateral wall of the CS was opened by maxillary approach. Measurement of sinus included length, diameter and triangular structure of the CS. It is very important to understand the microsurgical anatomy of the CS for neurosurgeons. Conclusion: The CS was venous plexus rather than sinus. The lateral wall of the sinus had two layers, and the lateral cavity of the sinus really did exist even though it was very small. The triangles where maxillary approach passed were more important for neurosurgeons. 展开更多
关键词 CAVERNOUS SINUS ANATOMY CONCEPT
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Two material removal modes in chemical mechanical polishing:mechanical plowing vs.chemical bonding 被引量:1
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作者 Yuan WU liang JIANG +3 位作者 wenhui li Jiaxin ZHENG Yushan CHEN linmao QIAN 《Friction》 SCIE EI CAS CSCD 2024年第5期897-905,共9页
With the rapid development of semiconductors,the number of materials needed to be polished sharply increases.The material properties vary significantly,posing challenges to chemical mechanical polishing(CMP).According... With the rapid development of semiconductors,the number of materials needed to be polished sharply increases.The material properties vary significantly,posing challenges to chemical mechanical polishing(CMP).Accordingly,the study aimed to classify the material removal mechanism.Based on the CMP and atomic force microscopy results,the six representative metals can be preliminarily classified into two groups,presumably due to different material removal modes.From the tribology perspective,the first group of Cu,Co,and Ni may mainly rely on the mechanical plowing effect.After adding H_(2)O_(2),corrosion can be first enhanced and then suppressed,affecting the surface mechanical strength.Consequently,the material removal rate(MRR)and the surface roughness increase and decrease.By comparison,the second group of Ta,Ru,and Ti may primarily depend on the chemical bonding effect.Adding H_(2)O_(2)can promote oxidation,increasing interfacial chemical bonds.Therefore,the MRR increases,and the surface roughness decreases and levels off.In addition,CMP can be regulated by tuning the synergistic effect of oxidation,complexation,and dissolution for mechanical plowing,while tuning the synergistic effect of oxidation and ionic strength for chemical bonding.The findings provide mechanistic insight into the material removal mechanism in CMP. 展开更多
关键词 Chemical mechanical polishing corrosion wear material removal mode mechanical plowing chemical bonding
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Electrochemical Biosensor for Detection of Staphylococcus aureus Based on Nucleic Acid Aptamers
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作者 Xuejun liang wenhui li 《Journal of Biosciences and Medicines》 2023年第11期133-140,共8页
Staphylococcus aureus is a gram-staining positive cocci bacillus baterium and also one of the foodborne pathogens, which is a serious potential hazard to human health and food safety. We constructed an electroche... Staphylococcus aureus is a gram-staining positive cocci bacillus baterium and also one of the foodborne pathogens, which is a serious potential hazard to human health and food safety. We constructed an electrochemical biosensor for the detection of S. aureus based on nucleic acid aptamers to achieve highly specific detection of S. aureus. The detection of S. aureus was realized by using Aptamer (Apt) to capture S. aureus, which resulted in a change in the spatial conformation of Apt and a decrease in the electrochemical signal. Under the optimized experimental conditions, the detected electrochemical signals were positively correlated with the concentration of S. aureus with a linear range of 1 × 10<sup>1</sup> - 1 × 10<sup>5</sup> CFU/mL, a detection limit of 4.76 CFU/mL, and an experimental recovery of 97.43% - 99.37%. Therefore, we successfully constructed an electrochemical biosensor for the specific detection of S. aureus, which has the advantages of high specificity, sensitive detection and convenient operation. 展开更多
关键词 S. aureus Nucleic Acid Aptamer ELECTROCHEMISTRY
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Exploration of Nature Education Path for Teenagers:A Case Study of Yancheng Wetland Nature Education Based on the World Natural Heritage Site
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作者 wenhui li Xiejuan TANG +1 位作者 Hongyang li Xingxing SUN 《Asian Agricultural Research》 2023年第10期40-44,共5页
Nature education is the trend of the current social development.By gradually improving the awareness of ecological civilization among the whole people,the achievements in ecological civilization are jointly built and ... Nature education is the trend of the current social development.By gradually improving the awareness of ecological civilization among the whole people,the achievements in ecological civilization are jointly built and shared by the whole people.Yancheng Yellow Sea Wetland is a characteristic natural resource and the name card of Yancheng City,and also an important part of the natural education of teenagers in Yancheng.As one of the main resources of nature education in Yancheng,the Yellow Sea Wetland World Natural Heritage resources play a more important role in the cultivation of youth ecological civilization values and legal awareness of environmental protection.Based on the protection and utilization of the Yellow Sea Wetland World Natural Heritage resources,this paper explores the methods and approaches of nature education for teenagers in Yancheng. 展开更多
关键词 Nature education Yellow sea wetland World natural heritage
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Deep structure of the Kumkol basin in the northern Tibetan Plateau and its resource environmental implications
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作者 wenhui li Zhanwu LU +4 位作者 Rui GAO Xiaofan DENG Jingyuan li Guangwen WANG Zhanxuan SUN 《Science China Earth Sciences》 SCIE EI CAS CSCD 2024年第11期3421-3435,共15页
The Kumkol basin is located in the northern Tibetan Plateau and is a closed plateau basin with an average altitude of>4000 m and an area of nearly 20000 km^(2). Its boundaries are limited by the Altyn Tagh fault, E... The Kumkol basin is located in the northern Tibetan Plateau and is a closed plateau basin with an average altitude of>4000 m and an area of nearly 20000 km^(2). Its boundaries are limited by the Altyn Tagh fault, East Kunlun orogen and Qimantag orogen. Studying the deep structure of the Kumkol basin reveals 2 significant implications:(1) the basin has developed a large thickness of >7000 m Cenozoic continental sediments, recording the uplift history of the northern Tibetan Plateau, and(2)preliminary work indicates that the basin is likely to have oil and gas prospects. However, owing to the adverse natural conditions of the area and the strong tectonic activity in the Cenozoic, the latter of which was not conducive to hydrocarbon preservation,only regional geological mapping and petroleum exploration route surveys have been carried out, and there is no consensus on strata, structure and tectonic evolution. From 2021 to 2022, a deep seismic reflection profile implemented by the Second Tibetan Plateau Scientific Expedition and Research(STEP) project was the first high-resolution geophysical survey across the Kumkol basin. This study uses seismic reflection migration profiles, first-arrival wave tomographic imaging and previous research results to analyze the deep structure of the basin. The final merged model contains many features of tectonic and resource significance:(1) The Kumkol basin is ~90 km wide from north to south, with a basement depth of >9000 m. The main component is the Cenozoic continental deposits, which are divided into two major parts: the southern composite basin and the northern faulted basin. Owing to the later compression, the southern composite basin experienced significant deformation, but most parts still preserved their original sedimentary formations.(2) The structural deformation characteristics of the basin reveal a two-stage tectonic evolution process of the northern Tibetan Plateau in the Cenozoic: from the Oligocene to the Pliocene, the main mechanism was vertical differential uplift and subsidence, and after the Pliocene, it transformed to north-south compression and shortened deformation.(3) The strata, formation time, and source-reservoir-cap conditions of the Kumkol basin are similar to those of the Qaidam basin. If a breakthrough can be achieved, it is expected to expand the production capacity of the oil field in the Qaidam basin with a low-cost investment. Thus, further exploration is recommended. 展开更多
关键词 Kumkol basin Seismic reflection TOMOGRAPHY Northern Tibetan Plateau Oil and gas prospect
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New taxa of Berberis (Berberidaceae) with greenish flowers from a biodiversity hotspot in Sichuan Province, China 被引量:3
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作者 Xinhua li licun Zhang +2 位作者 wenhui li Xiaoming Yin Sen Yuan 《Plant Diversity》 SCIE CAS CSCD 北大核心 2017年第2期94-103,共10页
A new species,Berberis viridiflora X.H.Li,and a new variety,Berberis sanguinea Franch.var.viridisepala X.H.Li,L.C.Zhang & W.H.Li are described and illustrated from Baoxing County,a biodiversity hotspot located on ... A new species,Berberis viridiflora X.H.Li,and a new variety,Berberis sanguinea Franch.var.viridisepala X.H.Li,L.C.Zhang & W.H.Li are described and illustrated from Baoxing County,a biodiversity hotspot located on the eastern edge of Hengduan Mountains in Sichuan Province,Southwest China,Both new taxa resemble B.sanguinea Franch.var.sanguinea,but B.viridiflora differs by the greenish flowers,and the petals being truncate,obtuse,or undulate at apex;while B.sanguinea var.viridisepala differs by the greenish or yellowish green flowers.Morphological features of the pollen grains of B.sanguinea and the two new taxa are revealed by scanning election microscope.B.sanguinea var.sanguinea displays obvious similarities with a sympatric congener,Berberis multiovula T.S.Ying in the morphology of flowers,stems and leaves,especially its ovule number varies greatly from 2 to 9,thus,B.multiovula characterized by the5-ovuled ovary is reduced to a synonymy of B.sanguinea var.sanguinea.On the basis of field surveys and study of herbarium specimens,a total of 16 species and varieties of Berberis are recorded from Baoxing County,and a key is provided.Among the 16 taxa,most phenotypic variations in Chinese Berberis can be displayed,including the habit of plants,most morphological variations of stems,branches and leaves,all types of inflorescences,all color types of flowers,and nearly all types of the shape and color of fruits.Baoxing County and its adjacent Sichuan Giant Panda Sanctuaries possibly constitute an active diversification center of Berberis in eastern Hengduan Mountains of China. 展开更多
关键词 BERBERIS Greenish flowers Purplish red flowers Bicolored flowers Ovule number Baoxing County
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