Regional agricultural sustainable development is the basement and important component of sustainable development system. In view of the relationship between population and regional agricultural sustainable development...Regional agricultural sustainable development is the basement and important component of sustainable development system. In view of the relationship between population and regional agricultural sustainable development, this paper proposes some countermeasures on coordination development between population and sustainable agriculture in Hebei Province.展开更多
With the economic development, the income disparity between towns＇ residents and rural residents in China shows an enlarging trend. This phenomenon becomes a hot issue of the whole society. The income disparity betwe...With the economic development, the income disparity between towns＇ residents and rural residents in China shows an enlarging trend. This phenomenon becomes a hot issue of the whole society. The income disparity between towns＇ residents and rural residents in Hebei province also shows an enlarging trend. The authors study this problem with the positive analysis method from the situation, the developing trend in the future, the reasons of the income disparity between towns＇ residents and rural residents in Hebei, and put forward proposals about how to reduce the income disparity.展开更多
T cell immunoglobulin- and mucin-domain-containing molecule-3 （Tim-3） has been reported to participate in the pathogenesis of inflammatory diseases. However, whether Tim-3 is involved in hepatitis B virus （HBV） in...T cell immunoglobulin- and mucin-domain-containing molecule-3 （Tim-3） has been reported to participate in the pathogenesis of inflammatory diseases. However, whether Tim-3 is involved in hepatitis B virus （HBV） infection remains unknown. Here, we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes, especially on CD8^＋ T cells, was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs, significantly increased IFN-γ production from hepatic CD8^＋ T cells in HBV model mice was observed. Very interestingly, we found Tim-3 expression on CD8^＋ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover, Tim-3 knockdown influenced anti-HBs production in vivo. Collectively, our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. Cellular ＆ Molecular Immunology.展开更多
Natural gas is extensively used as a clean energy source in cities and industries;consequently,there are associ-ated risks of accidental explosions.To reduce the hazards associated with natural gas explosions,it is im...Natural gas is extensively used as a clean energy source in cities and industries;consequently,there are associ-ated risks of accidental explosions.To reduce the hazards associated with natural gas explosions,it is important to study the inherent laws of natural gas blast loads in unconfined spaces and establish load models.Using ex-periments on natural gas explosions in unconfined spaces,this study demonstrates the influence of natural gas concentrations,propagation distances,and gas volumes upon explosion loads.A new load model was proposed for the overpressure-time history curves of natural-gas explosions in an unconfined space.A comparison with the empirical model indicated that the predictive effect was superior to that of previous models,such as the TNT equivalent model and the TNO multi-energy model.展开更多
CD28 is one of the costimulatory molecules crucial for T-cell activation and thus has become an attractive target for therapeutic immunomodulation. Conventional strategies for blocking CD28 activity using monoclonal a...CD28 is one of the costimulatory molecules crucial for T-cell activation and thus has become an attractive target for therapeutic immunomodulation. Conventional strategies for blocking CD28 activity using monoclonal antibodies, Fab fragments, antagonistic peptide and fusion proteins, have apparent disadvantages such as inherent immunogenicity, unwanted Fc signaling, poor tissue penetration and bioinstability. Recent research has been directed toward the creation of non-natural, sequence-specific biomimetic oligomers with bioinspired structures that capture the amino-acid interface of the targeted proteins. One such family of molecules is the poly-N-substituted glycines or peptoids, which have close structural similarity to peptides but are essentially invulnerable to protease degradation. To screen for peptoids that specifically target CD28, we first designed and chemically synthesized 19 candidate peptoids based on molecular modeling and docking. Using the phage-displaying system that expresses the extracellular domain of the CD28 homodimer and contains the core B7-binding motif, a peptoid （No. 9） with a molecular formula of C21H29N307, was identified to display the highest binding activity to CD28. This peptoid not only inhibited the lymphocyte proliferation in vitro, but suppressed immunoresponses against alloantigens in vivo, and attenuated the graft-versus-host disease in a mouse bone-marrow transplantation model. These results suggested that peptoids targeting CD28 are effective agents for blocking the CD28-mediated costimulation and suitable for development of novel therapeutic approaches for diseases involving this pathway.展开更多
文摘Regional agricultural sustainable development is the basement and important component of sustainable development system. In view of the relationship between population and regional agricultural sustainable development, this paper proposes some countermeasures on coordination development between population and sustainable agriculture in Hebei Province.
文摘With the economic development, the income disparity between towns＇ residents and rural residents in China shows an enlarging trend. This phenomenon becomes a hot issue of the whole society. The income disparity between towns＇ residents and rural residents in Hebei province also shows an enlarging trend. The authors study this problem with the positive analysis method from the situation, the developing trend in the future, the reasons of the income disparity between towns＇ residents and rural residents in Hebei, and put forward proposals about how to reduce the income disparity.
基金supported in part by grants from the National Nature Science Foundation of China (No. 30670966)the National Basic Research Program (No. 2009CB521900)+1 种基金the Taishan Scholar Programthe Scientific Foundation of Innovative Research Team in Shandong University.
文摘T cell immunoglobulin- and mucin-domain-containing molecule-3 （Tim-3） has been reported to participate in the pathogenesis of inflammatory diseases. However, whether Tim-3 is involved in hepatitis B virus （HBV） infection remains unknown. Here, we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes, especially on CD8^＋ T cells, was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs, significantly increased IFN-γ production from hepatic CD8^＋ T cells in HBV model mice was observed. Very interestingly, we found Tim-3 expression on CD8^＋ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover, Tim-3 knockdown influenced anti-HBs production in vivo. Collectively, our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. Cellular ＆ Molecular Immunology.
基金support from the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20180081)the National Key R&D Program of China(Great No.2020YFB2103300)the National Basic Research Program of China(973 Program)(Grant No.2015CB058000).
文摘Natural gas is extensively used as a clean energy source in cities and industries;consequently,there are associ-ated risks of accidental explosions.To reduce the hazards associated with natural gas explosions,it is important to study the inherent laws of natural gas blast loads in unconfined spaces and establish load models.Using ex-periments on natural gas explosions in unconfined spaces,this study demonstrates the influence of natural gas concentrations,propagation distances,and gas volumes upon explosion loads.A new load model was proposed for the overpressure-time history curves of natural-gas explosions in an unconfined space.A comparison with the empirical model indicated that the predictive effect was superior to that of previous models,such as the TNT equivalent model and the TNO multi-energy model.
文摘CD28 is one of the costimulatory molecules crucial for T-cell activation and thus has become an attractive target for therapeutic immunomodulation. Conventional strategies for blocking CD28 activity using monoclonal antibodies, Fab fragments, antagonistic peptide and fusion proteins, have apparent disadvantages such as inherent immunogenicity, unwanted Fc signaling, poor tissue penetration and bioinstability. Recent research has been directed toward the creation of non-natural, sequence-specific biomimetic oligomers with bioinspired structures that capture the amino-acid interface of the targeted proteins. One such family of molecules is the poly-N-substituted glycines or peptoids, which have close structural similarity to peptides but are essentially invulnerable to protease degradation. To screen for peptoids that specifically target CD28, we first designed and chemically synthesized 19 candidate peptoids based on molecular modeling and docking. Using the phage-displaying system that expresses the extracellular domain of the CD28 homodimer and contains the core B7-binding motif, a peptoid （No. 9） with a molecular formula of C21H29N307, was identified to display the highest binding activity to CD28. This peptoid not only inhibited the lymphocyte proliferation in vitro, but suppressed immunoresponses against alloantigens in vivo, and attenuated the graft-versus-host disease in a mouse bone-marrow transplantation model. These results suggested that peptoids targeting CD28 are effective agents for blocking the CD28-mediated costimulation and suitable for development of novel therapeutic approaches for diseases involving this pathway.
