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Succinylation modification:a potential therapeutic target in stroke
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作者 Jie Lian wenwu liu +1 位作者 Qin Hu Xiaohua Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第4期781-787,共7页
Stroke is a leading cause of mortality and disability worldwide.Ischemic cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain injury.Imp... Stroke is a leading cause of mortality and disability worldwide.Ischemic cell death triggered by the compromised supply of blood oxygen and glucose is one of the major pathophysiology of strokeinduced brain injury.Impaired mitochondrial energy metabolism is observed minutes after stroke and is closely associated with the progression of neuropathology.Recently,a new type of posttranslational modification,known as lysine succinylation,has been recognized to play a significant role in mitochondrial energy metabolism after ischemia.However,the role of succinylation modification in cell metabolism after stroke and its regulation are not well understood.We aimed to review the effects of succinylation on energy metabolism,reactive oxygen species generation,and neuroinflammation,as well as Sirtuin 5 mediated desuccinylation after stroke.We also highlight the potential of targeting succinylation/desuccinylation as a promising strategy for the treatment of stroke.The succinylation level is dynamically regulated by the nonenzymatic or enzymatic transfer of a succinyl group to a protein on lysine residues and the removal of succinyl catalyzed by desuccinylases.Mounting evidence has suggested that succinylation can regulate the metabolic pathway through modulating the activity or stability of metabolic enzymes.Sirtuins,especially Sirtuin 5,are characterized for their desuccinylation activity and have been recognized as a critical regulator of metabolism through desuccinylating numerous metabolic enzymes.Imbalance between succinylation and desuccinylation has been implicated in the pathophysiology of stroke.Pharmacological agents that enhance the activity of Sirtuin 5 have been employed to promote desuccinylation and improve mitochondrial metabolism,and neuroprotective effects of these agents have been observed in experimental stroke studies.However,their therapeutic efficacy in stroke patients should be validated. 展开更多
关键词 mitochondria metabolism NEUROPROTECTION sirtuin 5 STROKE succinylation modification
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Selenium-doped cathode materials with polyaniline skeleton for lithium-organosulfur batteries
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作者 Rong Zou wenwu liu Fen Ran 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第4期148-157,共10页
Sulfur-containing polymer(SCP)is considered as an outstanding cathode material for lithium-sulfur batteries.However,undesirable soluble polysulfides may shuttle in electrolyte,concluding long-chain Li_(2)S_(n)(n>4)... Sulfur-containing polymer(SCP)is considered as an outstanding cathode material for lithium-sulfur batteries.However,undesirable soluble polysulfides may shuttle in electrolyte,concluding long-chain Li_(2)S_(n)(n>4)and short-chain Li2Sn(n≤4),as well as the sluggish conversion kinetics are yet to be solved to enhance the performance of lithium-sulfur batteries.Here Se-doped sulfurized polyaniline with adjusted sulfur-chain-S_(x)-(x≤6)contribute to ensure the absence of long-chain polysulfides,and the skeleton with quinoid imine can endow strongly adsorption towards short-chain polysulfides by the reversible transition between deprotonated/protonated imine(-NH^(+)=and-N=),which offer double insurance against suppressing“shuttle effect”.Furthermore,Se atoms are doped into sulfurized polysulfides to accelerate the redox conversion and take a frontier orbital theory-oriented view into catalytic mechanism.Se-doped sulfurized polyaniline as active materials for lithium-organosulfur batteries delivers good electrochemical performance,including high rate,reversible specific capacity(680 mA h g^(-1)at 0.1 A g^(-1)),and lower capacity decay rate only of 0.15%with near 100%coulomb efficiency during long-term cycle.This work provides a valuable guiding ideology and promising solution for the chemistry-oriented structure design and practical application for lithium-organosulfur batteries. 展开更多
关键词 Lithium-organosulfur batteries Selenium-doped Cathode materials Sulfur-containing polymer Frontier orbital theory
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Bifurcation Analysis of a Stage-Structured Prey-Predator System with Discrete and Continuous Delays 被引量:1
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作者 Shunyi Li wenwu liu Xiangui Xue 《Applied Mathematics》 2013年第7期1059-1064,共6页
A three-stage-structured prey-predator model with discrete and continuous time delays is studied. The characteristic equations and the stability of the boundary and positive equilibrium are analyzed. The conditions fo... A three-stage-structured prey-predator model with discrete and continuous time delays is studied. The characteristic equations and the stability of the boundary and positive equilibrium are analyzed. The conditions for the positive equilibrium occurring Hopf bifurcation are given, by applying the theorem of Hopf bifurcation. Finally, numerical simulation and brief conclusion are given. 展开更多
关键词 Three-Stage-Structured PREY-PREDATOR Model Time DELAY HOPF BIFURCATION
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肝癌切除术后的长间隔与短间隔随访:一项回顾性队列研究
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作者 Wei He Yun Zheng +9 位作者 Ruhai Zou Jingxian Shen Junping Yang Jiliang Qiu Qiang Tao wenwu liu Zhiwen Yang Yuanping Zhang Binkui Li Yunfei Yuan 《癌症》 SCIE CAS CSCD 2018年第12期533-544,共12页
背景与目的由于缺乏证据证明肝细胞癌(hepatocellular carcinoma,HCC)切除术后的最佳随访间隔,术后患者接受随访的平均时间间隔不同。我们的目的是比较长间隔随访和短间隔随访与生存和复发的相关性在不同风险分层肝癌患者中的差异。方... 背景与目的由于缺乏证据证明肝细胞癌(hepatocellular carcinoma,HCC)切除术后的最佳随访间隔,术后患者接受随访的平均时间间隔不同。我们的目的是比较长间隔随访和短间隔随访与生存和复发的相关性在不同风险分层肝癌患者中的差异。方法我们在2007年至2014年期间进行了一项回顾性队列研究。共有1227例巴塞罗那临床肝癌分期A期或B期的患者接受了根治性切除术。根据最小绝对收缩和选择操作算法为基础的预后因素分析,我们将患者分层为有低风险(n=865)或高风险(n=362)早期复发(切除术后2年内)的2组。根据切除术后2年内的随访情况,患者进一步分为长间隔(每4–6个月)随访和短期间隔(每2–4个月)随访的亚组(低风险,长期vs.短期:n=390 vs. n=475;高风险,长期vs.短期:n=149 vs. n=213)。结果不管在低风险[风险比(hazard ratio,HR)=1.152;95%置信区间(confidenceinterval,CI):0.720–1.843]还是高风险(HR=1.213;95%CI:0.702–2.094)患者中,短间隔随访没有延长患者的总生存期。401例患者出现早期复发。在高风险患者中,与长间隔随访组相比,短间隔组肝内复发肿瘤较小(2.6 cm vs. 3.5 cm,P=0.045)。但是,对于巴塞罗临床肝癌分期0/A期,长间隔与短间隔随访不管在低风险还是高风险患者中复发率(63.1%vs. 68.2%,P=0.580;31.3%vs. 41.5%,P=0.280)差异均无统计学意义。类似的,根治性切除术后,长间隔或短间隔随访分别在低风险和高风险患者中的复发率(34.5%vs. 39.7%,P=0.430;14.6%vs. 20.3%,P=0.388)差异也均无统计学意义。结论对于巴塞罗那临床肝癌分期A期或B期的患者,在接受了根治性切除术后的前2年内,将随访时间从4–6月缩短为2–4个月并不能增加根治性切除术的成功率或延长患者生存时间。 展开更多
关键词 肝细胞癌 肝切除术 预后 监测 复发
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Kinematic Characteristics Analysis and Parametric Solving of Snow Melting Agent Throwing Mechanism with Variable Crank Length
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作者 wenwu liu Nianli Lu Hongxin liu 《Journal of Harbin Institute of Technology(New Series)》 CAS 2021年第4期60-66,共7页
Variable crank length cam⁃linkage mechanism has attracted much attention due to its compact overall structure when realizing complex motion laws.According to the special trajectory requirements,the kinematic character... Variable crank length cam⁃linkage mechanism has attracted much attention due to its compact overall structure when realizing complex motion laws.According to the special trajectory requirements,the kinematic characteristics and parameters of the mechanism have been analyzed and solved,which lays foundation for the implementation of the variable crank length snow melting agent throwing mechanism designed in this paper.Based on the trajectory equation of the point,the mathematical model of the throwing mechanism was established,and the theoretical trajectory of the end point of the throwing mechanism was obtained by programming.The parametric modeling and trajectory drawing were carried out by computer aided three⁃dimensional interactive application(CATIA),and the correctness of the mathematical model was verified by comparison.The regional trajectory distribution characteristics of the end points of the throwing mechanism were studied by using the trajectory region location method,and the influence of various parameters on the trajectory was investigated by using the numerical cycle comparison method.The human⁃computer interaction system of snow melting agent throwing mechanism with variable crank length was constructed by using Microsoft Visual Basic(VB)software.Based on the restriction conditions,the optimum combination of structural adjustment parameters and operational parameters suitable for Harbin first⁃class roads was obtained by using orthogonal test table,which provides an effective method to solve the parameters of the variable crank length cam mechanism with smooth impulse trajectory. 展开更多
关键词 throwing mechanism variable crank length cam mechanism mathematical model kinematic characteristics parametric solving
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The predictive role of the neutrophil-lymphocyte ratio in the prognosis of adult patients with stroke 被引量:6
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作者 Jinzhao Wan Xiaoxiong Wang +7 位作者 Yunbo Zhen Xin Chen Penglei Yao wenwu liu Enzhou Lu Yiming Du Huailei liu Shiguang Zhao 《Chinese Neurosurgical Journal》 CSCD 2020年第3期161-170,共10页
Our study aimed to determine the effect of the neutrophil-lymphocyte ratio on the prognosis of adult patients with acute stroke.We searched the Web of Science,PubMed,Embase,Cochrane Library,and China National Knowledg... Our study aimed to determine the effect of the neutrophil-lymphocyte ratio on the prognosis of adult patients with acute stroke.We searched the Web of Science,PubMed,Embase,Cochrane Library,and China National Knowledge Infrastructure databases and selected all of the potentially eligible studies.From the included studies,we extracted characteristics such as the stroke type and acquisition time until routine blood collection and the odds ratios across studies.The 95%confidence intervals and odds ratios were pooled to calculate the effect size for the neutrophil-lymphocyte ratio in acute stroke patients.We defined poor function outcomes according to the modified Rankin Scale≥3 or Glasgow Outcome Scale<3.Thirteen studies with 4443 patients were included in our analysis,including 7 ischemic and 6 hemorrhagic stroke studies.The pooled odds ratios for poor functional outcome at 3 months with a higher neutrophil-lymphocyte ratio in acute ischemic and hemorrhagic patients were 1.689(95%CI=1.184-2.409,p<0.001)and 1.125(95%CI=1.022-1.239,p<0.001),respectively,and the overall pooled odds ratio for poor functional outcome following stroke was 1.257(95%CI=1.146-1.379,p<0.001).At the same time,the overall combined odds ratio for death at 3 months was 1.632(95%CI=1.155-2.306,p<0.001).The neutrophil-lymphocyte ratio,an easily calculated marker,plays a predictive role in the short-term outcomes of adult patients(mean age≥50 years)following acute ischemic and hemorrhagic stroke. 展开更多
关键词 Prognosis of stroke adult patients with stroke Neutrophil-lymphocyte ratio Acute stroke Predictive role
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Long- versus short-interval follow-up after resection of hepatocellular carcinoma: a retrospective cohort study 被引量:2
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作者 Wei He Yun Zheng +9 位作者 Ruhai Zou Jingxian Shen Junping Yang Jiliang Qiu Qiang Tao wenwu liu Zhiwen Yang Yuanping Zhang Binkui Li Yunfei Yuan 《Cancer Communications》 SCIE 2018年第1期280-290,共11页
Background:Average postoperative follow-up intervals vary in patients undergoing hepatocellular carcinoma(HCC)resection because of limited evidence regarding the optimal interval.We aimed to compare the associations o... Background:Average postoperative follow-up intervals vary in patients undergoing hepatocellular carcinoma(HCC)resection because of limited evidence regarding the optimal interval.We aimed to compare the associations of long-versus short-interval follow-up with survival and recurrence in risk-stratified HCC patients.Methods:We performed a retrospective cohort study between 2007 and 2014.In total,1227 patients treated by curative resection of Barcelona Clinic Liver Cancer stage A or B HCC were stratified as having a low(n=865)or high(n=362)risk of early recurrence(within the first 2 years after resection)based on prognostic factors identified by the least absolute shrinkage and selection operation algorithm.Patients were further classified into long-interval(every 4-6 months)and short-interval(every 2-4 months)follow-up subgroups based on follow-up within 2 years after resection(low risk,long vs.short:n=390 vs.n=475;high-risk,long vs.short:n=149 vs.n=213).Results:The short-interval follow-up did not prolong overall survival in either the low-risk(hazard ratio[HR]=1.152;95%confidence interval[CI]0.720-1.843)or high-risk(HR=1.213;95%CI 0.702-2.094)patients.Early recurrence occurred in 401 patients.For high-risk patients,the short-interval follow-up subgroup exhibited smaller intrahepatic recurrence than did the long-interval group(2.6 vs.3.5 cm,respectively,P=0.045).However,no significant difference in the rate of Barcelona Clinic Liver Cancer stage 0/A recurrence was found between the long-and short-interval follow-up groups in either low-or high-risk patients(63.1%vs.68.2%,respectively,P=0.580;31.3%vs.41.5%,respec-tively,P=0.280).The rate of curative intent treatment for recurrence(34.5%vs.39.7%,respectively,P=0.430;14.6%vs.20.3%,respectively,P=0.388)was also similar between the follow-up groups for low-and high-risk patients.Conclusions:Shortening the postoperative follow-up interval from every 4-6 months to every 2-4 months within the first 2 years after resection did not increase the rate of curative intent treatment or prolong the overall survival of patients with Barcelona Clinic Liver Cancer stage A or B HCC. 展开更多
关键词 Hepatocellular carcinoma HEPATECTOMY Prognosis SURVEILLANCE RECURRENCE
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Sulfur-containing polymer cathode materials: From energy storage mechanism to energy density
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作者 Rong Zou wenwu liu Fen Ran 《InfoMat》 SCIE CAS 2022年第8期1-24,共24页
Besides lithium-ion batteries, it is imperative to develop new battery energystorage system with high energy density. In conjunction with the developmentof Li-S batteries, emerging sulfur-containing polymers with tuna... Besides lithium-ion batteries, it is imperative to develop new battery energystorage system with high energy density. In conjunction with the developmentof Li-S batteries, emerging sulfur-containing polymers with tunable sulfur-chain length and organic groups gradually attract much attention as cathodematerials. This can avoid the problems that are impeding the development ofthe typical Li-S batteries, such as volume expansion, active material dissolu-tion, shuttle effect, and so on. This review aims to generalize the type ofsulfur-containing polymers and the working principles in Li-S batteries. Thesulfur-containing polymers (R-Sn-R) with different sulfur-chain length (n > 6,n ≤ 2, and 3 ≤ n ≤ 6) are summarized. It also discusses several organic groupssuch as phenyl rings, N-heterocycles, and unique structure with cross-linkednetworks and multi-micropores skeleton. This review also explores other strat-egies of sulfur-containing polymers in the rest of Li-S batteries, providing asummary of the advantages of sulfur-containing polymers, recent develop-ment, in-depth discussion of the mechanism in Li-S batteries, and organicgroup-structure-performance relationship. This review would have guidelinesfor future development of sulfur-containing polymers in Li-S batteries. 展开更多
关键词 cathode materials energy density energy storage mechanism Li-S batteries sulfur-containing polymer
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潜艇失事脱险艇员的分类救治探讨——以北约分类救治为例
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作者 刘文武 闫硕 +4 位作者 陈杰 李慈 徐佳骏 俞旭华 王世锋 《中华航海医学与高气压医学杂志》 CAS CSCD 2022年第3期281-284,共4页
我国目前尚缺乏针对援潜救生伤病员的分类救治系统。北约针对援潜救生过程中的伤病员情况进行分类救治。该分类系统基于病情危重程度,将疾病分为4类(T1、T2、T3和T4);根据是否需要加压治疗,将疾病分为2类(C1和C2)。另外,将救治场地分为... 我国目前尚缺乏针对援潜救生伤病员的分类救治系统。北约针对援潜救生过程中的伤病员情况进行分类救治。该分类系统基于病情危重程度,将疾病分为4类(T1、T2、T3和T4);根据是否需要加压治疗,将疾病分为2类(C1和C2)。另外,将救治场地分为5个区:分类区、一级治疗区、二级治疗区、三级治疗区和T4治疗区。笔者基于前期援潜救生的教学体会,对该分类救治系统存在的问题提出一些建议,为后期制定我国援潜救生分类救治系统提供借鉴。 展开更多
关键词 援潜救生 分类救治 后送 潜水疾病
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