To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanica...To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanical stress.Piezo1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron gatekeeper.Furthermore,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical stress.Moreover,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.展开更多
We report a one‐pot surfactant‐free wet‐chemical reduction approach to the synthesis of palladium/titanium nitride(Pd/TiN)and Pd/carbon(Pd/C)composites,in which^5 nm Pd NPs were uniformly dispersed on TiN or C.In t...We report a one‐pot surfactant‐free wet‐chemical reduction approach to the synthesis of palladium/titanium nitride(Pd/TiN)and Pd/carbon(Pd/C)composites,in which^5 nm Pd NPs were uniformly dispersed on TiN or C.In terms of catalytic performance,Pd/TiN showed enhanced efficiency and stability compared with those of Pd/C and bare TiN in the electrocatalytic hydrodechlorination(EHDC)reaction of 2,4‐dichlorophenol(2,4‐DCP)in aqueous solution.The superior performance of Pd/TiN arises from the promotion effect of TiN.Strong metal‐support interactions modified the electronic structure of Pd,which optimized generation of H*ads and 2,4‐DCP adsorption/activation.The cathode potential plays a vital role in controlling the EHDC efficiency and the product distribution.A working potential of?0.80 V was shown to be optimal for achieving the highest EHDC efficiency and maximizing conversion of 2,4‐DCP to phenol(P).Our studies of the reaction pathway show that EHDC of 2,4‐DCP on Pd/TiN proceeded by 2,4‐DCP→p‐chlorophenol(p‐CP),o‐chlorophenol(o‐CP)→P;however,Pd/TiN presented little selectivity for cleavage of p‐C‐Cl vs o‐C‐Cl.This work presents a new approach to enhancing Pd performance towards EHDC through the effects of a support.The strategy demonstrated here could also be extended to design highly efficient catalysts for other hydrogenation reactions.展开更多
An ultra-efficient electro-Fenton catalyst with porous carbon coated Fe-Mo metal(FeMo@PC),was prepared by calcining MIL-53(Fe)@MoO_(3).This FeMo@PC-2 exhibited impressive catalytic performance for sulfamethazine(SMT)d...An ultra-efficient electro-Fenton catalyst with porous carbon coated Fe-Mo metal(FeMo@PC),was prepared by calcining MIL-53(Fe)@MoO_(3).This FeMo@PC-2 exhibited impressive catalytic performance for sulfamethazine(SMT)degradation with a high turnover frequency value(7.89 L/(g·min)),much better than most of reported catalysts.The mineralization current efficiency and electric energy consumption were 83.2%and 0.03 kWh/gTOC,respectively,at lowcurrent(5mA)and small dosage of catalyst(25.0mg/L).The removal rate of heterogeneous electro-Fenton(Hetero-EF)process catalyzed by FeMo@PC-2 was 4.58 times that of Fe@PC/Hetero-EF process.Because the internal-micro-electrolysis occurred between PC and Fe0,while the co-catalysis of Mo accelerated the rate-limiting step of the Fe^(3+)/Fe^(2+) cycle and greatly improved the H_(2)O_(2)utilization efficiency.The results of radical scavenger experiments and electron paramagnetic resonance confirmed the main role of surface-bound hydroxyl radical oxidation.This process was feasible to remove diverse organic contaminants such as phenol,2,4-dichlorophenoxyacetic acid,carbamazepine and SMT.This paper enlightened the importance of the doped Mo,which could greatly improve the activity of the iron-carbon heterogeneous catalyst derived from metal-organic frameworks in EF process for efficient removal of organic contaminants.展开更多
基金supported in part by the National Nature Science Foundation(81874022 and 82172483 to Xinyu Liu,82102522 to Lianlei Wang,82072478 to Yunpeng Zhao,82072435 to Qiang Yang,82073437 to Weiwei Li,81930070 to Shiqing Feng,82272548 to Lei Cheng)Key R&D Project of Shandong Province(2022CXGC010503 to Xinyu Liu)+1 种基金Shandong Natural Science Foundation(ZR202102210113 to Lianlei Wang,ZR2020YQ54 to Yunpeng Zhao)Shandong Province Taishan Scholar Project(tsqn202211317 to Lianlei Wang).The authors thank the Translational Medicine Core Facility of Shandong University for the consultation and instrument availability that supported this work.
文摘To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be elucidated.Here,Piezo1 channel was identified as a key iron transporter in response to mechanical stress.Piezo1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron gatekeeper.Furthermore,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical stress.Moreover,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.
基金supported by the National Natural Science Foundation of China(51508055,51502277)Chongqing Postdoctoral Science Foundation(Xm2016020)+2 种基金China Postdoctoral Science Foundation(2016M602660)Natural Science Foundation of Chongqing Science and Technology Commission(cstc2016jcyjA0154)Innovative Research Team of Chongqing(CXTDG201602014)~~
文摘We report a one‐pot surfactant‐free wet‐chemical reduction approach to the synthesis of palladium/titanium nitride(Pd/TiN)and Pd/carbon(Pd/C)composites,in which^5 nm Pd NPs were uniformly dispersed on TiN or C.In terms of catalytic performance,Pd/TiN showed enhanced efficiency and stability compared with those of Pd/C and bare TiN in the electrocatalytic hydrodechlorination(EHDC)reaction of 2,4‐dichlorophenol(2,4‐DCP)in aqueous solution.The superior performance of Pd/TiN arises from the promotion effect of TiN.Strong metal‐support interactions modified the electronic structure of Pd,which optimized generation of H*ads and 2,4‐DCP adsorption/activation.The cathode potential plays a vital role in controlling the EHDC efficiency and the product distribution.A working potential of?0.80 V was shown to be optimal for achieving the highest EHDC efficiency and maximizing conversion of 2,4‐DCP to phenol(P).Our studies of the reaction pathway show that EHDC of 2,4‐DCP on Pd/TiN proceeded by 2,4‐DCP→p‐chlorophenol(p‐CP),o‐chlorophenol(o‐CP)→P;however,Pd/TiN presented little selectivity for cleavage of p‐C‐Cl vs o‐C‐Cl.This work presents a new approach to enhancing Pd performance towards EHDC through the effects of a support.The strategy demonstrated here could also be extended to design highly efficient catalysts for other hydrogenation reactions.
基金supported by National Key R&D Program International Cooperation Project(No.2021YFE0106500)Natural Science Foundation of China(Nos.52170085 and 21976096)+2 种基金Tianjin Development Program for Innovation and Entrepreneurship,Key Project of Natural Science Foundation of Tianjin(No.21JCZDJC00320)Tianjin Post-graduate Students Research and Innovation Project(No.2019YJSB075)Fundamental Research Funds for the Central Universities,Nankai University(No.63221313).
文摘An ultra-efficient electro-Fenton catalyst with porous carbon coated Fe-Mo metal(FeMo@PC),was prepared by calcining MIL-53(Fe)@MoO_(3).This FeMo@PC-2 exhibited impressive catalytic performance for sulfamethazine(SMT)degradation with a high turnover frequency value(7.89 L/(g·min)),much better than most of reported catalysts.The mineralization current efficiency and electric energy consumption were 83.2%and 0.03 kWh/gTOC,respectively,at lowcurrent(5mA)and small dosage of catalyst(25.0mg/L).The removal rate of heterogeneous electro-Fenton(Hetero-EF)process catalyzed by FeMo@PC-2 was 4.58 times that of Fe@PC/Hetero-EF process.Because the internal-micro-electrolysis occurred between PC and Fe0,while the co-catalysis of Mo accelerated the rate-limiting step of the Fe^(3+)/Fe^(2+) cycle and greatly improved the H_(2)O_(2)utilization efficiency.The results of radical scavenger experiments and electron paramagnetic resonance confirmed the main role of surface-bound hydroxyl radical oxidation.This process was feasible to remove diverse organic contaminants such as phenol,2,4-dichlorophenoxyacetic acid,carbamazepine and SMT.This paper enlightened the importance of the doped Mo,which could greatly improve the activity of the iron-carbon heterogeneous catalyst derived from metal-organic frameworks in EF process for efficient removal of organic contaminants.
