BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ...BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to ferroptosis.Our previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 integrins.MFG-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated autophagy.AIM To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy flux.METHODS SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus lipopolysaccharide.mfge8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver injury.Cilengitide,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of MFG-E8.RESULTS The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of ferroptosis.Exogenous MFG-E8 reduced SAP-induced liver injury in a dose-dependent manner.Mechanistically,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver cells.Cilengitide abolished MFG-E8’s beneficial effects in SAP-induced liver injury.CONCLUSION MFG-E8 acts as an endogenous protective mediator in SAP-induced liver injury.MFG-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5.展开更多
BACKGROUND Acute pancreatitis(AP)is often associated with intestinal injury,which in turn exaggerates the progression of AP.Our recent study has shown that a low level of serum irisin,a novel exercise-induced hormone,...BACKGROUND Acute pancreatitis(AP)is often associated with intestinal injury,which in turn exaggerates the progression of AP.Our recent study has shown that a low level of serum irisin,a novel exercise-induced hormone,is associated with poor outcomes in patients with AP and irisin administration protects against experimental AP.However,the role of irisin in intestinal injury in AP has not been evaluated.AIM To investigate the effect of irisin administration on intestinal injury in experimental AP.METHODS AP was induced in male adult mice by two hourly intraperitoneal injections of Larginine.At 2 h after the last injection of L-arginine,irisin(50 or 250μg/kg body weight)or 1 mL normal saline(vehicle)was administered through intraperitoneal injection.The animals were sacrificed at 72 h after the induction of AP.Intestinal injury,apoptosis,oxidative and endoplasmic reticulum(ER)stress were evaluated.RESULTS Administration of irisin significantly mitigated intestinal damage,reduced apoptosis,and attenuated oxidative and ER stress in AP mice.In addition,irisin treatment also effectively downregulated serum tumor necrosis factor-alpha and interleukin-6 levels and alleviated injury in the pancreas,liver and lung of AP mice.CONCLUSION Irisin-mediated multiple physiological events attenuate intestinal injury following an episode of AP.Irisin has a great potential to be further developed as an effective treatment for patients with AP.展开更多
BACKGROUND Whether to use a T-tube for biliary anastomosis during orthotopic liver transplantation(OLT)remains a debatable question.Some surgeons chose to use a T-tube because they believed that it reduces the inciden...BACKGROUND Whether to use a T-tube for biliary anastomosis during orthotopic liver transplantation(OLT)remains a debatable question.Some surgeons chose to use a T-tube because they believed that it reduces the incidence of biliary strictures.Advances in surgical techniques during the last decades have significantly decreased the overall incidence of postoperative biliary complications.Whether using a T-tube during OLT is still associated with the reduced incidence of biliary strictures needs to be re-evaluated.AIM To provide an updated systematic review and meta-analysis on using a T-tube during adult OLT.METHODS In the electronic databases MEDLINE,PubMed,Scopus,ClinicalTrials.gov,the Cochrane Library,the Cochrane Hepato-Biliary Group Controlled Trails Register,and the Cochrane Central Register of Controlled Trials,we identified 17 studies(eight randomized controlled trials and nine comparative studies)from January 1995 to October 2020.The data of the studies before and after 2010 were separately extracted.We chose the overall biliary complications,bile leaks or fistulas,biliary strictures(anastomotic or non-anastomotic),and cholangitis as outcomes.Odds ratios(ORs)with 95%confidence intervals(CIs)were calculated to describe the results of the outcomes.Furthermore,the test for overall effect(Z)was used to test the difference between OR and 1,where P≤0.05 indicated a significant difference between OR value and 1.RESULTS A total of 1053 subjects before 2010 and 1346 subjects after 2010 were included in this meta-analysis.The pooled results showed that using a T-tube reduced the incidence of postoperative biliary strictures in studies before 2010(P=0.012,OR=0.62,95%CI:0.42-0.90),while the same benefit was not seen in studies after 2010(P=0.60,OR=0.76,95%CI:0.27-2.12).No significant difference in the incidence of overall biliary complications(P=0.37,OR=1.41,95%CI:0.66-2.98),bile leaks(P=0.89,OR=1.04,95%CI:0.63-1.70),and cholangitis(P=0.27,OR=2.00,95%CI:0.59-6.84)was observed between using and not using a T-tube before 2010.However,using a T-tube appeared to increase the incidence of overall biliary complications(P=0.049,OR=1.49,95%CI:1.00-2.22),bile leaks(P=0.048,OR=1.91,95%CI:1.01-3.64),and cholangitis(P=0.02,OR=7.21,95%CI:1.37-38.00)after 2010.A random-effects model was used in biliary strictures(after 2010),overall biliary complications(before 2010),and cholangitis(before 2010)due to their heterogeneity(I2=62.3%,85.4%,and 53.6%,respectively).In the sensitivity analysis(only RCTs included),bile leak(P=0.66)lost the significance after 2010 and a random-effects model was used in overall biliary complications(before 2010),cholangitis(before 2010),bile leaks(after 2010),and biliary strictures(after 2010)because of their heterogeneity(I2=92.2%,65.6%,50.9%,and 80.3%,respectively).CONCLUSION In conclusion,the evidence gathered in our updated meta-analysis showed that the studies published in the last decade did not provide enough evidence to support the routine use of T-tube in adults during OLT.展开更多
We theoretically study optomechanically induced transparency in a spinning Kerr-nonlinear resonator.The interplay between the optical Kerr effect and the Sagnac effect provides a flexible tool for modifying the optome...We theoretically study optomechanically induced transparency in a spinning Kerr-nonlinear resonator.The interplay between the optical Kerr effect and the Sagnac effect provides a flexible tool for modifying the optomechanically induced transparency windows of the signal comparing to the system of a single spinning resonator.It is found that the system will exhibit distinct transparency phenomenon and fast-to-slow light effects.More importantly,a symmetric transparency window appears by adjusting the rotation-induced Sagnac frequency shift to compensate for the Kerr-induced frequency shift.These results open up a new way to explore novel light propagation of optomechanically induced transparency devices in spinning resonators with Kerr nonlinearity.展开更多
We investigate the itinerant ferromagnetism in a dipolar Fermi atomic system with the anisotropic spin–orbit coupling(SOC),which is traditionally explored with isotropic contact interaction.We first study the ferroma...We investigate the itinerant ferromagnetism in a dipolar Fermi atomic system with the anisotropic spin–orbit coupling(SOC),which is traditionally explored with isotropic contact interaction.We first study the ferromagnetism transition boundaries and the properties of the ground states through the density and spin-flip distribution in momentum space,and we find that both the anisotropy and the magnitude of the SOC play an important role in this process.We propose a helpful scheme and a quantum control method which can be applied to conquering the difficulties of previous experimental observation of itinerant ferromagnetism.Our further study reveals that exotic Fermi surfaces and an abnormal phase region can exist in this system by controlling the anisotropy of SOC,which can provide constructive suggestions for the research and the application of a dipolar Fermi gas.Furthermore,we also calculate the ferromagnetism transition temperature and novel distributions in momentum space at finite temperature beyond the ground states from the perspective of experiment.展开更多
How to improve charging processes and suppress self-discharging processes has always been one of the key issues to achieve quantum batteries with high performance.Although a quantum battery is inevitably influenced by...How to improve charging processes and suppress self-discharging processes has always been one of the key issues to achieve quantum batteries with high performance.Although a quantum battery is inevitably influenced by composite environments,this situation is still little understood,particularly regarding the influence of the memory effect of the composite environments and the coupling between composite environments.In this work,we investigate the effects of the composite environments,composed of two identical parts each containing a single cavity mode decaying to a reservoir,on the charging and self-discharging processes of a quantum battery.We show that increasing the two-mode coupling can effectively enhance the charging performance(i.e.,the stored energy,the charging power,ergotropy)and restrain the self-discharging process(i.e.,suppressing the process of dissipating the energy).However,different from the effect of two-mode coupling,we reveal that the memory effect of the reservoir in this composite environment is unfavorable to the charging process of the quantum battery,which is in sharp contrast to previous studies where the memory effect can significantly improve the charging performance of a quantum battery.Our results may benefit to the realization of quantum batteries with high performance under the actual complex environmental noise.展开更多
基金Supported by the National Natural Science Foundation of China,No.82100685the Scientific Research Fund of Xi’an Health Commission,No.2021yb08+1 种基金Scientific Research Fund of Xi’an Central Hospital,No.2022QN07Innovation Capability Support Plan of Xi’an Science and Technology Bureau,No.23YXYJ0097.
文摘BACKGROUND Liver injury is common in severe acute pancreatitis(SAP).Excessive autophagy often leads to an imbalance of homeostasis in hepatocytes,which induces lipid peroxidation and mitochondrial iron deposition and ultimately leads to ferroptosis.Our previous study found that milk fat globule epidermal growth factor 8(MFG-E8)alleviates acinar cell damage during SAP via binding toαvβ3/5 integrins.MFG-E8 also seems to mitigate pancreatic fibrosis via inhibiting chaperone-mediated autophagy.AIM To speculate whether MFG-E8 could also alleviate SAP induced liver injury by restoring the abnormal autophagy flux.METHODS SAP was induced in mice by 2 hly intraperitoneal injections of 4.0 g/kg L-arginine or 7 hly injections of 50μg/kg cerulein plus lipopolysaccharide.mfge8-knockout mice were used to study the effect of MFG-E8 deficiency on SAPinduced liver injury.Cilengitide,a specificαvβ3/5 integrin inhibitor,was used to investigate the possible mechanism of MFG-E8.RESULTS The results showed that MFG-E8 deficiency aggravated SAP-induced liver injury in mice,enhanced autophagy flux in hepatocyte,and worsened the degree of ferroptosis.Exogenous MFG-E8 reduced SAP-induced liver injury in a dose-dependent manner.Mechanistically,MFG-E8 mitigated excessive autophagy and inhibited ferroptosis in liver cells.Cilengitide abolished MFG-E8’s beneficial effects in SAP-induced liver injury.CONCLUSION MFG-E8 acts as an endogenous protective mediator in SAP-induced liver injury.MFG-E8 alleviates the excessive autophagy and inhibits ferroptosis in hepatocytes by binding to integrinαVβ3/5.
基金Supported by the National Natural Science Foundation of China,No.81770491
文摘BACKGROUND Acute pancreatitis(AP)is often associated with intestinal injury,which in turn exaggerates the progression of AP.Our recent study has shown that a low level of serum irisin,a novel exercise-induced hormone,is associated with poor outcomes in patients with AP and irisin administration protects against experimental AP.However,the role of irisin in intestinal injury in AP has not been evaluated.AIM To investigate the effect of irisin administration on intestinal injury in experimental AP.METHODS AP was induced in male adult mice by two hourly intraperitoneal injections of Larginine.At 2 h after the last injection of L-arginine,irisin(50 or 250μg/kg body weight)or 1 mL normal saline(vehicle)was administered through intraperitoneal injection.The animals were sacrificed at 72 h after the induction of AP.Intestinal injury,apoptosis,oxidative and endoplasmic reticulum(ER)stress were evaluated.RESULTS Administration of irisin significantly mitigated intestinal damage,reduced apoptosis,and attenuated oxidative and ER stress in AP mice.In addition,irisin treatment also effectively downregulated serum tumor necrosis factor-alpha and interleukin-6 levels and alleviated injury in the pancreas,liver and lung of AP mice.CONCLUSION Irisin-mediated multiple physiological events attenuate intestinal injury following an episode of AP.Irisin has a great potential to be further developed as an effective treatment for patients with AP.
基金National Natural Science Foundation of China,No.81770491The Innovation Capacity Support Plan of Shaanxi Province,No.2020TD-040.
文摘BACKGROUND Whether to use a T-tube for biliary anastomosis during orthotopic liver transplantation(OLT)remains a debatable question.Some surgeons chose to use a T-tube because they believed that it reduces the incidence of biliary strictures.Advances in surgical techniques during the last decades have significantly decreased the overall incidence of postoperative biliary complications.Whether using a T-tube during OLT is still associated with the reduced incidence of biliary strictures needs to be re-evaluated.AIM To provide an updated systematic review and meta-analysis on using a T-tube during adult OLT.METHODS In the electronic databases MEDLINE,PubMed,Scopus,ClinicalTrials.gov,the Cochrane Library,the Cochrane Hepato-Biliary Group Controlled Trails Register,and the Cochrane Central Register of Controlled Trials,we identified 17 studies(eight randomized controlled trials and nine comparative studies)from January 1995 to October 2020.The data of the studies before and after 2010 were separately extracted.We chose the overall biliary complications,bile leaks or fistulas,biliary strictures(anastomotic or non-anastomotic),and cholangitis as outcomes.Odds ratios(ORs)with 95%confidence intervals(CIs)were calculated to describe the results of the outcomes.Furthermore,the test for overall effect(Z)was used to test the difference between OR and 1,where P≤0.05 indicated a significant difference between OR value and 1.RESULTS A total of 1053 subjects before 2010 and 1346 subjects after 2010 were included in this meta-analysis.The pooled results showed that using a T-tube reduced the incidence of postoperative biliary strictures in studies before 2010(P=0.012,OR=0.62,95%CI:0.42-0.90),while the same benefit was not seen in studies after 2010(P=0.60,OR=0.76,95%CI:0.27-2.12).No significant difference in the incidence of overall biliary complications(P=0.37,OR=1.41,95%CI:0.66-2.98),bile leaks(P=0.89,OR=1.04,95%CI:0.63-1.70),and cholangitis(P=0.27,OR=2.00,95%CI:0.59-6.84)was observed between using and not using a T-tube before 2010.However,using a T-tube appeared to increase the incidence of overall biliary complications(P=0.049,OR=1.49,95%CI:1.00-2.22),bile leaks(P=0.048,OR=1.91,95%CI:1.01-3.64),and cholangitis(P=0.02,OR=7.21,95%CI:1.37-38.00)after 2010.A random-effects model was used in biliary strictures(after 2010),overall biliary complications(before 2010),and cholangitis(before 2010)due to their heterogeneity(I2=62.3%,85.4%,and 53.6%,respectively).In the sensitivity analysis(only RCTs included),bile leak(P=0.66)lost the significance after 2010 and a random-effects model was used in overall biliary complications(before 2010),cholangitis(before 2010),bile leaks(after 2010),and biliary strictures(after 2010)because of their heterogeneity(I2=92.2%,65.6%,50.9%,and 80.3%,respectively).CONCLUSION In conclusion,the evidence gathered in our updated meta-analysis showed that the studies published in the last decade did not provide enough evidence to support the routine use of T-tube in adults during OLT.
基金supported by the Doctoral Scientific Research Foundation of Henan Normal University(Grant No.20210397)the Henan Province Key Scientific Research Project Plan of Colleges and Universities(Grant No.23A140001)+1 种基金the National Natural Science Foundation of China(Grant Nos.11704103,12074106,61835013,and 12074105)the National Key R&D Program of China(Grant Nos.2021YFA1400900,2021YFA0718300,and 2021YFA1400243)。
文摘We theoretically study optomechanically induced transparency in a spinning Kerr-nonlinear resonator.The interplay between the optical Kerr effect and the Sagnac effect provides a flexible tool for modifying the optomechanically induced transparency windows of the signal comparing to the system of a single spinning resonator.It is found that the system will exhibit distinct transparency phenomenon and fast-to-slow light effects.More importantly,a symmetric transparency window appears by adjusting the rotation-induced Sagnac frequency shift to compensate for the Kerr-induced frequency shift.These results open up a new way to explore novel light propagation of optomechanically induced transparency devices in spinning resonators with Kerr nonlinearity.
基金supported by the National Key R&D Program of China(Grant Nos.2021YFA1400900,2021YFA0718300,and 2021YFA1400243)the Key Scientific Research Project of colleges and Universities in Henan Province(Nos.20A140018 and 23A140001)+1 种基金the National Natural Science Foundatiion of China(Grant Nos.12074105,12074106,12074120,12247146,12104135,and 61835013)the Natural Science Foundation of Shanghai(Grant No.20ZR1418500).
文摘We investigate the itinerant ferromagnetism in a dipolar Fermi atomic system with the anisotropic spin–orbit coupling(SOC),which is traditionally explored with isotropic contact interaction.We first study the ferromagnetism transition boundaries and the properties of the ground states through the density and spin-flip distribution in momentum space,and we find that both the anisotropy and the magnitude of the SOC play an important role in this process.We propose a helpful scheme and a quantum control method which can be applied to conquering the difficulties of previous experimental observation of itinerant ferromagnetism.Our further study reveals that exotic Fermi surfaces and an abnormal phase region can exist in this system by controlling the anisotropy of SOC,which can provide constructive suggestions for the research and the application of a dipolar Fermi gas.Furthermore,we also calculate the ferromagnetism transition temperature and novel distributions in momentum space at finite temperature beyond the ground states from the perspective of experiment.
基金supported by the National Natural Science Foundation of China under grant Nos.12204348,12074027,11434015,61227902,61835013,11611530676,and KZ201610005011the National Key R&D Program of China under grant No.2016YFA0301500SPRPCAS under grant Nos.XDB01020300 and XDB21030300.
文摘How to improve charging processes and suppress self-discharging processes has always been one of the key issues to achieve quantum batteries with high performance.Although a quantum battery is inevitably influenced by composite environments,this situation is still little understood,particularly regarding the influence of the memory effect of the composite environments and the coupling between composite environments.In this work,we investigate the effects of the composite environments,composed of two identical parts each containing a single cavity mode decaying to a reservoir,on the charging and self-discharging processes of a quantum battery.We show that increasing the two-mode coupling can effectively enhance the charging performance(i.e.,the stored energy,the charging power,ergotropy)and restrain the self-discharging process(i.e.,suppressing the process of dissipating the energy).However,different from the effect of two-mode coupling,we reveal that the memory effect of the reservoir in this composite environment is unfavorable to the charging process of the quantum battery,which is in sharp contrast to previous studies where the memory effect can significantly improve the charging performance of a quantum battery.Our results may benefit to the realization of quantum batteries with high performance under the actual complex environmental noise.
