Objective:To explore the correlation between genotypes of Orientia(O.)tsutsugamushi and clinical characteristics of scrub typhus patients.Methods:Clinical data of patients with scrub typhus admitted to different types...Objective:To explore the correlation between genotypes of Orientia(O.)tsutsugamushi and clinical characteristics of scrub typhus patients.Methods:Clinical data of patients with scrub typhus admitted to different types of medical institutions in Guangzhou from September 2012 to December 2016 were collected using medical records.Demographic data,clinical manifestations,as well as hematological and biochemical indicators of patients infected with different genotypes were analyzed and compared.Results:A total of 192 patients were included in this study,including 121 patients with Karp genotype of O.tsutsugamushi infection(63.0%),36 patients with Gilliam genotype(19.0%),23 patients with Kato genotype(12.0%),and 12 patients with TA763 genotype(6.0%)infection.The median value of albumin in patients with Karp genotype infection was significantly lower than that of Gilliam-infected patients(P=0.032).Patients with Karp genotype infection had a significantly longer hospital stay(9 days)than those with Gilliam genotype(7 days)(P=0.009)and Kato genotype infection(6 days)(P=0.005).Karp-infected patients also represented for the largest number of patients with complicated organ involvement(88/133,66.2%).Furthermore,Karp-infected patients had higher risk of developing multiple organ dysfunction syndrome(18.2%)and requiring intensive care unit treatment(15.9%).Besides,patients with Gilliam genotype(8 days)and TA763 genotype infection(7.5 days)had shorter fever duration than those with Karp genotype(9 days)and Kato genotype(9 days)infection,respectively.Conclusions:Genotypes of Orientia tsutsugamushi were associated with varying clinical manifestations,organ involvement,and treatment outcomes,suggesting that genotypes ranged in virulence.展开更多
目的探究在高血压脑出血微创术后采取通腑醒神汤治疗的效果。方法选取2021年2月—2023年2月曲阜市中医院收治的88例高血压脑出血患者为研究对象,按术后用药方法的不同分为对照组、观察组,各44例。两组患者均行微创手术,对照组在术后使...目的探究在高血压脑出血微创术后采取通腑醒神汤治疗的效果。方法选取2021年2月—2023年2月曲阜市中医院收治的88例高血压脑出血患者为研究对象,按术后用药方法的不同分为对照组、观察组,各44例。两组患者均行微创手术,对照组在术后使用依达拉奉注射液治疗,观察组在对照组基础上结合通腑醒神汤治疗。对比两组治疗总有效率、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、巴塞尔指数(Barthel Index,BI)、炎性因子水平及不良反应发生情况。结果对照组治疗总有效率为81.82%(36/44),低于观察组的95.45%(42/44),差异有统计学意义(χ^(2)=4.062,P<0.05)。治疗后,对照组NIHSS评分高于观察组,BI评分低于观察组,差异有统计学意义(P均<0.05)。对照组C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平均高于观察组,差异有统计学意义(P均<0.05)。对照组不良反应总发生率高于观察组,差异有统计学意义(P<0.05)。结论接受微创手术的高血压脑出血患者服用通腑醒神汤具有明显的治疗效果,能够有效促进神经系统恢复,改善炎症反应,且不良反应较少。展开更多
文摘为探索长期连作状态下烟草根系分泌物内含有的化感物质组成成分,设置石英砂栽培和连作土壤栽培2种烟草培养处理,对2种烟草不同生长时期的根系分泌物进行提取,利用超高效液相色谱串联质谱(ultra-high performance liquid chromatography tandem mass spectrometry,UHPLC-MS/MS)对提取的根系分泌物进行分析,通过数据库比对、差异分析和时间聚类分析等方法筛选连作烟草根系分泌物中潜在的化感物质。结果表明,共筛选出11类潜在化感物质,分别为生物碱、萜类、胺类、有机酸、苯酸及其衍生物、脂肪酸、酚类、氨基酸和多肽、香豆素、肉桂酸及其衍生物和其他。生物碱、萜类、胺类和有机酸4类化合物相对含量占所有化合物的73.3%。L-烟碱、熊果酸、β-氨基丙腈、5-羟基吲哚乙酸、早熟素Ⅱ、单乙基己基邻苯二甲酸、己内酰胺、姜酚、L-乳酸、邻苯二甲酸二乙酯和2,3-二氢-3,5-二羟基-2-氧代-3-吲哚乙酸甲酯是连作烟草根系分泌物中相对含量较高的潜在化感物质。研究结果为烟草根系化感物质的化感作用研究及缓解烟草连作障碍方法研究提供理论基础。
基金supported by the Science and Technology Plan Grant of Guangzhou(grant number 202102080035)the Guangzhou Health and Family Planning Science and Technology Project Western Medicine-general Guidance Project(20221A011067)+2 种基金the Basic Research Project of Key Laboratory of Guangzhou(grant number 202102100001)the Key Project of Medicine Discipline of Guangzhou(grant number 2021-2023-12)the Guangzhou Health Science and Technology Project(grant number 20221A011066).
文摘Objective:To explore the correlation between genotypes of Orientia(O.)tsutsugamushi and clinical characteristics of scrub typhus patients.Methods:Clinical data of patients with scrub typhus admitted to different types of medical institutions in Guangzhou from September 2012 to December 2016 were collected using medical records.Demographic data,clinical manifestations,as well as hematological and biochemical indicators of patients infected with different genotypes were analyzed and compared.Results:A total of 192 patients were included in this study,including 121 patients with Karp genotype of O.tsutsugamushi infection(63.0%),36 patients with Gilliam genotype(19.0%),23 patients with Kato genotype(12.0%),and 12 patients with TA763 genotype(6.0%)infection.The median value of albumin in patients with Karp genotype infection was significantly lower than that of Gilliam-infected patients(P=0.032).Patients with Karp genotype infection had a significantly longer hospital stay(9 days)than those with Gilliam genotype(7 days)(P=0.009)and Kato genotype infection(6 days)(P=0.005).Karp-infected patients also represented for the largest number of patients with complicated organ involvement(88/133,66.2%).Furthermore,Karp-infected patients had higher risk of developing multiple organ dysfunction syndrome(18.2%)and requiring intensive care unit treatment(15.9%).Besides,patients with Gilliam genotype(8 days)and TA763 genotype infection(7.5 days)had shorter fever duration than those with Karp genotype(9 days)and Kato genotype(9 days)infection,respectively.Conclusions:Genotypes of Orientia tsutsugamushi were associated with varying clinical manifestations,organ involvement,and treatment outcomes,suggesting that genotypes ranged in virulence.
文摘目的探究在高血压脑出血微创术后采取通腑醒神汤治疗的效果。方法选取2021年2月—2023年2月曲阜市中医院收治的88例高血压脑出血患者为研究对象,按术后用药方法的不同分为对照组、观察组,各44例。两组患者均行微创手术,对照组在术后使用依达拉奉注射液治疗,观察组在对照组基础上结合通腑醒神汤治疗。对比两组治疗总有效率、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、巴塞尔指数(Barthel Index,BI)、炎性因子水平及不良反应发生情况。结果对照组治疗总有效率为81.82%(36/44),低于观察组的95.45%(42/44),差异有统计学意义(χ^(2)=4.062,P<0.05)。治疗后,对照组NIHSS评分高于观察组,BI评分低于观察组,差异有统计学意义(P均<0.05)。对照组C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平均高于观察组,差异有统计学意义(P均<0.05)。对照组不良反应总发生率高于观察组,差异有统计学意义(P<0.05)。结论接受微创手术的高血压脑出血患者服用通腑醒神汤具有明显的治疗效果,能够有效促进神经系统恢复,改善炎症反应,且不良反应较少。
