Extensive research attentions have been devoted to studying cooperative cognitive radio networks(CCRNs),where secondary users(SU)providing cooperative transmissions can be permitted by primary users(PU)to use spectrum...Extensive research attentions have been devoted to studying cooperative cognitive radio networks(CCRNs),where secondary users(SU)providing cooperative transmissions can be permitted by primary users(PU)to use spectrum.In order to maximize SU’s utility,SU may transmit its own information during the period of cooperative transmission,which stimulates the use of covert transmission against PU’s monitoring.For this sake,this article reviews the motivations of studying covert communications in CCRN.In particular,three intelligent covert transmission approaches are developed for maximizing SU’s utility in CCRNs,namely,intelligent parasitic covert transmission(IPCT),intelligent jammer aided covert transmission(IJCT)and intelligent reflecting surface assisted covert transmission(IRSC).Further,some raw performance evaluations are discussed,and a range of potential research directions are also provided.展开更多
Myc belongs to a family of proto-oncogenes that encode transcription factors.The overexpression of c-Myc causes many types of cancers.Recently,we established a system for screening c-Myc inhibitors and identified anti...Myc belongs to a family of proto-oncogenes that encode transcription factors.The overexpression of c-Myc causes many types of cancers.Recently,we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical library.The specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be explained.In this study,we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces sp.RK19-A0402 strongly inhibits c-Myc transcriptional activity.After purification of the hit broth,we identified compounds closely related to the aglycone of cytovaricin and had a structure similar to that of oligomycin A.Similar to oligomycin A,the hit compounds inhibited mitochondrial complex V.The mitochondria dysfunction caused by the compounds induced the production of reactive oxygen species(ROS),and the ROS activated GSK3α/βthat phosphorylated c-Myc for ubiquitination.This study provides a successful screening strategy for identifying natural products as potential c-Myc inhibitors as potential anticancer agents.展开更多
β-transducin repeat-containing protein(β-TrCP)is an F-box protein subunit of the E3 Skp1-Cullin-F box(SCF)type ubiquitin-ligase complex,and provides the substrate specificity for the ligase.To find potent ligands of...β-transducin repeat-containing protein(β-TrCP)is an F-box protein subunit of the E3 Skp1-Cullin-F box(SCF)type ubiquitin-ligase complex,and provides the substrate specificity for the ligase.To find potent ligands ofβ-TrCP useful for the proteolysis targeting chimera(PROTAC)system usingβ-TrCP in the future,we developed a high-throughput screening system for small moleculeβ-TrCP ligands.We screened the chemical library utilizing the system and obtained several hit compounds.The effects of the hit compounds on in vitro ubiquitination activity of SCFβ-TrCP1 and on downstream signaling pathways were examined.Hit compounds NPD5943,NPL62020-01,and NPL42040-01 inhibited the TNFα-induced degradation of IκBαand its phosphorylated form.Hence,they inhibited the activation of the transcription activity of NF-κB,indicating the effective inhibition ofβ-TrCP by the hit compounds in cells.Next,we performed an in silico analysis of the hit compounds to determine the important moieties of the hit compounds.Carboxyl groups of NPL62020-01 and NPL42040-01 and hydroxyl groups of NPD5943 created hydrogen bonds withβ-TrCP similar to those created by intrinsic target phosphopeptides ofβ-TrCP.Our findings enhance our knowledge of useful small molecule ligands ofβ-TrCP and the importance of residues that can be ligands ofβ-TrCP.展开更多
There is limited understanding regarding the formation of multiple tropical cyclones(MTCs).This study explores the environmental conditions conducive to MTC formation by objectively determining the atmospheric circula...There is limited understanding regarding the formation of multiple tropical cyclones(MTCs).This study explores the environmental conditions conducive to MTC formation by objectively determining the atmospheric circulation patterns favorable for MTC formation over the western North Pacific.Based on 199 MTC events occurring from June to October 1980–2020,four distinct circulation patterns are identified:the monsoon trough(MT)pattern,accounting for 40.3%of occurrences,the confluence zone(CON)pattern at 26.2%,the easterly wave(EW)pattern at 17.8%,and the monsoon gyre(MG)pattern at 15.7%.The MT pattern mainly arises from the interaction between the subtropical high and the monsoon trough,with MTCs forming along the monsoon trough and its flanks.The CON pattern is affected by the subtropical high,the South Asian high,and the monsoon trough,with MTCs emerging at the confluence zone where the prevailing southwesterly and southeasterly flows converge.The EW pattern is dominated by easterly flows,with MTCs developing along the easterly wave train.MTCs in the MG pattern arise within a monsoon vortex characterized by strong southwesterly flows.A quantitative analysis further indicates that MTC formation in the MT pattern is primarily governed by mid-level vertical velocity and low-level vorticity,while mid-level humidity and vertical velocity are significantly important in the other patterns.The meridional shear and convergence of zonal winds are essential in converting barotropic energy from the basic flows to disturbance kinetic energy,acting as the primary source for eddy kinetic energy growth.展开更多
The accuracy of laser-induced breakdown spectroscopy(LIBS) quantitative method is greatly dependent on the amount of certified standard samples used for training. However, in practical applications, only limited stand...The accuracy of laser-induced breakdown spectroscopy(LIBS) quantitative method is greatly dependent on the amount of certified standard samples used for training. However, in practical applications, only limited standard samples with labeled certified concentrations are available. A novel semi-supervised LIBS quantitative analysis method is proposed, based on co-training regression model with selection of effective unlabeled samples. The main idea of the proposed method is to obtain better regression performance by adding effective unlabeled samples in semisupervised learning. First, effective unlabeled samples are selected according to the testing samples by Euclidean metric. Two original regression models based on least squares support vector machine with different parameters are trained by the labeled samples separately, and then the effective unlabeled samples predicted by the two models are used to enlarge the training dataset based on labeling confidence estimation. The final predictions of the proposed method on the testing samples will be determined by weighted combinations of the predictions of two updated regression models. Chromium concentration analysis experiments of 23 certified standard high-alloy steel samples were carried out, in which 5 samples with labeled concentrations and 11 unlabeled samples were used to train the regression models and the remaining 7 samples were used for testing. With the numbers of effective unlabeled samples increasing, the root mean square error of the proposed method went down from 1.80% to 0.84% and the relative prediction error was reduced from 9.15% to 4.04%.展开更多
The development of tin-based devices with low toxicity is critical for the commercial viability of perovskite solar cells.However because tin halide is a stronger Lewis acid,its crystallization rate is extremely fast,...The development of tin-based devices with low toxicity is critical for the commercial viability of perovskite solar cells.However because tin halide is a stronger Lewis acid,its crystallization rate is extremely fast,resulting in the formation of numerous defects that affect the device performance of tin-based perovskite solar cells.Herein,propylamine hydrobromide(PABr)was added to the perovskite precursor solution as an additive to passivate defects and fabricate more uniform and dense perovskite films.Because propylamine cations are too large to enter the perovskite lattices,they only exist at the grain boundary to passivate surface defects and promote crystal growth in a preferred orientation.The PABr additive raises the average short-circuit current density from 19.45 to 25.47 mA·cm^(-2)by reducing carrier recombination induced by defects.Furthermore,the device’s long-term illumination stability is improved after optimization,and the hysteresis effect is negligible.The addition of PABr results in a power conversion efficiency of 9.35%.展开更多
The biosecurity hazards caused by pathogenic fungus have been widely concerned.Given the long-term coexistence of eukaryotic pathogens and quorum sensing bacteria in different habitats in environments,we hypothesized ...The biosecurity hazards caused by pathogenic fungus have been widely concerned.Given the long-term coexistence of eukaryotic pathogens and quorum sensing bacteria in different habitats in environments,we hypothesized that they have social interactions via signal molecules.In this work,we firstly discovered the well-known bacterial signal molecules play an adverse role in the cell morphology and metabolism in a model pathogen Trichosporon asahii.N-Tetradecanoyl-L-homoserine lactone(C14-HSL)was discovered to increase pathogen hazards of T.asahii,which limited mycelium by 52%,but enhanced cell aggregation by 93%.Higher fluorescence intensity of tryptophan(59%)and aromatic protein(2-fold)contents after the treatment of C14-HSL,indicating that aromatic proteins helped aggregate Trichosporon and showed hydrophobicity.Transcriptome analysis revealed that C14-HSL upregulated the shikimate pathway(above1-fold)located in downstream of tricarboxylic acid cycle,which contributed to the synthesis of more aromatic proteins and the formation of larger flocs.The limited mycelial growth of T.asahii attributed to the up-regulated expressions of cell cycle process.The fungal transboundary response to bacterial C14-HSL was controlled by signal transduction pathways.This study provides new insights into the co-evolution of bacterial and pathogenic fungi in microecosystems.展开更多
Salt and saline-alkaline stress seriously threaten crop production and food security worldwide(Yang and Guo,2018).Identifying genes that confer tolerance to these conditions without yield penalty would help mitigate t...Salt and saline-alkaline stress seriously threaten crop production and food security worldwide(Yang and Guo,2018).Identifying genes that confer tolerance to these conditions without yield penalty would help mitigate this problem through molecular breeding(Liang et al.,2023;Sahu and Liu,2023).Although numerous stress-tolerance genes have been identified,their application potential in molecular breeding has rarely been confirmed through multi-year and multi-site field trials.展开更多
Porta hepatis tuberculous lymphadenopathy(TL)is rare,and the clinical and imaging manifestations often mimic tumors.To offer a bet-ter understanding of porta hepatis TL and thus improve its diagnosis and treatment,her...Porta hepatis tuberculous lymphadenopathy(TL)is rare,and the clinical and imaging manifestations often mimic tumors.To offer a bet-ter understanding of porta hepatis TL and thus improve its diagnosis and treatment,here,we retrospectively reviewed and analyzed 10 porta hepatis TL cases between May 2017 and November 2022.In this study,porta hepatis TL occurred predominantly in women(70%),with a mean age of 43.1 years(range,16-70 years).Among the patients,60%were initially suspected of malignancy(metastatic lymphadenopathy and lymphoma).The clinical manifestations were nonspecific,such as fever and weight loss,without overt abdominal malaise.Many patients showed high concentrations of serum C-reactive protein,erythrocyte sedimentation rate,alkaline phosphatase,γ-glutamyl transpeptidase and carbohydrate antigen 125.Peripheral rim-like enhancement was a characteristic finding on contrast-enhanced CT for all the patients.Pathological examination confirmed the diagnosis in 90%of patients with caseous granulo-matous inflammation and positive results of Xpert MTB/RIF,quantitative real-time PCR and/or metagenomic next-generation sequenc-ing assays.All patients underwent antituberculosis therapy with a median treatment duration of 13.5 months(range,1-43 months).They all showed satisfactory therapeutic responses with improved symptoms and resolution on imaging after treatment.Pathological examination by biopsy remains the primary diagnostic method.A combination of the characteristic epidemiologic,clinical,imaging fea-tures and lesion biopsy for histopathology are essential for the diagnosis and treatment of TL.展开更多
Collective cells are organized to form specific patterns which play important roles in various physiological and pathological processes, such as tissue morphogenesis, wound healing, and cancer invasion. Compared to si...Collective cells are organized to form specific patterns which play important roles in various physiological and pathological processes, such as tissue morphogenesis, wound healing, and cancer invasion. Compared to single cell behaviors, which has been intensively studied from many aspects (cell migration, adhesion, polarization, proliferation, etc.) and at various scales (molecular, subcellular, and cellular), the multiple cell behaviors are relatively less understood, particularly in a quantitative manner. In this paper, we will present our recent studies of collective polarization and orientation of multiple cells through both experimental measurement and theoretical modeling, including those cell behaviors on/in 2D and 3D substrate/tissue. We find that the collective cell behaviors, including polarization, alignment and migration are closely related to local stress states in cell layer or tissue, which demonstrate the crucial roles of mechanical forces in the living organisms. Specifically, the cells prefer to polarize and align along the maximum principal stress in the cell layer, and the aspect ratio of cell increases with the in-plane maximum shear stress, suggesting that the maximum shear stress is the underlying driving force of cell polarization and orientation. This theory of stress-driven cell behaviors of polarization and orientation provides a new perspective for understanding cell behaviors in living organisms and the guideline for tissue engineering in biomedical applications.展开更多
The prolonged mei-yu/baiu system with anomalous precipitation in the year 2020 has swollen many rivers and lakes,caused flash flooding,urban flooding and landslides,and consistently wreaked havoc across large swathes ...The prolonged mei-yu/baiu system with anomalous precipitation in the year 2020 has swollen many rivers and lakes,caused flash flooding,urban flooding and landslides,and consistently wreaked havoc across large swathes of China,particularly in the Yangtze River basin.Significant precipitation and flooding anomalies have already been seen in magnitude and extension so far this year,which have been exerting much higher pressure on emergency responses in flood control and mitigation than in other years,even though a rainy season with multiple ongoing serious flood events in different provinces is not that uncommon in China.Instead of delving into the causes of the uniqueness of this year’s extreme precipitation-flooding situation,which certainly warrants in-depth exploration,in this article we provide a short view toward a more general hydrometeorological solution to this annual nationwide problem.A“glocal”(global to local)hydrometeorological solution for floods(GHS-F)is considered to be critical for better preparedness,mitigation,and management of different types of significant precipitation-caused flooding,which happen extensively almost every year in many countries such as China,India and the United States.Such a GHS-F model is necessary from both scientific and operational perspectives,with the strength in providing spatially consistent flood definitions and spatially distributed flood risk classification considering the heterogeneity in vulnerability and resilience across the entire domain.Priorities in the development of such a GHS-F are suggested,emphasizing the user’s requirements and needs according to practical experiences with various flood response agencies.展开更多
Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration(nAMD).Myofibroblasts originated from retinal pigment epithelial(RPE)cells through epithe...Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration(nAMD).Myofibroblasts originated from retinal pigment epithelial(RPE)cells through epithelial-mesenchymal transition(EMT)contribute to the fibrosis formation.N^(6)-Methyladenosine(m^(6)A)modification has been implicated in the EMT process and multiple fibrotic diseases.The role of m^(6)A modification in EMT-related subretinal fibrosis has not yet been elucidated.In this study,we found that during subretinal fibrosis in the mouse model of laser-induced choroidal neovascularization,METTL3 was upregulated in RPE cells.Through m^(6)A epitranscriptomic microarray and further verification,high-mobility group AT-hook 2(HMGA2)was identified as thekey downstream target of METTL3,subsequently activating potent EMT-inducing transcription factor SNAIL.Finally,by subretinal injections of adeno-associated virus vectors,we confirmed that METTL3 deficiency in RPE cells could efficiently attenuate subretinal fibrosis in vivo.In conclusion,our present research identified an epigenetic mechanism of METTL3-m^(6)A-HMGA2 in subretinal fibrosis and EMT of RPE cells,providing a novel therapeutic target for subretinal fibrosis secondary to nAMD.展开更多
We report on a new type of amperometric glucose biosensor that was made by integration of glucose oxidase (GOD) with palladium nanoparticles/reduce graphene oxide (Pd/RGO) nanocomposite. The Pd/RGO was prepared by a o...We report on a new type of amperometric glucose biosensor that was made by integration of glucose oxidase (GOD) with palladium nanoparticles/reduce graphene oxide (Pd/RGO) nanocomposite. The Pd/RGO was prepared by a one-step reduction method in which the palladium nanoparticles and the reduced graphene oxide (RGO) were simultaneously accomplished from the reduction of dispersed solution of PdCl2 and graphite oxide (GO) with hydrazine. The asprepared nanocomposite exhibits favorable electrocatalytic activities towards the oxidation of H2O2, which makes it a good platform for the construction of the glucose biosensor. The analytical performance of the glucose biosensor is fully evaluated. It shows good analytical properties in terms of a short response time (3 s), high sensitivity (14.1 μA/mM), and low detection limit (0.034 mM). In addition, the effects of pH value, applied potential, electroactive interference and the stability of the biosensor were discussed as well.展开更多
A series of high-k[(Na_(0.5)Bi_(0.5))_(x)Bi_(1-x)](W_(x)V_(1-x))O_(4)(abbreviated as NBWV(x value))solid solution ceramics with a scheelite-like structure are synthesized by a modified solid-state reaction method at t...A series of high-k[(Na_(0.5)Bi_(0.5))_(x)Bi_(1-x)](W_(x)V_(1-x))O_(4)(abbreviated as NBWV(x value))solid solution ceramics with a scheelite-like structure are synthesized by a modified solid-state reaction method at the temperature range of 680-760 C.A monoclinic(0≤x<0.09)to tetragonal scheelite(0.09≤x≤1.0)structural phase transition is confirmed by X-ray difraction(XRD),Raman,and infrared(IR)analyses.The effect of structural deformation and order-disorder caused by Na^(+)/Bi^(3+)/W^(6+) complex substitution on microwave dielectric properties is investigated in deail.The compositional series possess a wide range of variable relative permittivity(er=24.8-80)and temperature coefficient of resonant frequency(TCF value,-271.9-188.9 ppm/℃).The maximum permittivity of 80 and a high Qxf value of~10,000 GHz are obtained near the phase boundary at x=0.09.Furthermore,the temperature-stable dielectric ceramics sintered at 680 C with excellent microwave dielectric properties of ε_(r)=80.7,Qxf=9400 GHz(at 4.1 GHz),and TCF value=-3.8 ppm/℃ are designed by mixing the components of x=0.07 and 0.08.In summary,similar sinterability and structural compatibility of scheelite-like solid solution systems make it potential for low-temperature co-fired ceramic(LTCC)applications.展开更多
Anas poecilorhyncha is one of improved variety of mallards, which was the protected bird species listed by International Union for Conservation of Nature （1UCN）. Little is known until now about behavioral characteri...Anas poecilorhyncha is one of improved variety of mallards, which was the protected bird species listed by International Union for Conservation of Nature （1UCN）. Little is known until now about behavioral characteristics of the mallard. The objective of this study was to compare the behavioral differentials between A. poecilorhyncha and domestic duck in order to make a strategy to manage A. poecilorhyncha under the condition of animal welfare. A total of 180 birds were distributed into six groups with 30 birds for each group. They were placed in a room of 3 m ~ 4 m and fed for one year old. Sansui ducks, a kind of native domestic duck （Sansui laying duck） were used for behavioral comparison. Two different rooms in the same building were applied, one room for A. poecilorhyncha and another one for Sansui ducks. All behaviors for A. poecilorhyncha and Sansui ducks were coded using the program The Observer XT 11.5 （Noldus Information Technology, Beijing）. The duration of observation was from 8：00 am to 18：00 pm daily and lasted 5 d. The results showed that there were similar behavioral percentages between A. poecilorhyncha and domestic duck. Percentages of standing activity spent for A. poecilorhyncha and Sansui duck were 34.59% and 30.25%, respectively. Accordingly, the activities, such as wing plugging, preening and head stretching, were more than 5.51%. The other activities, including walking, drinking and tail wagging, occupied less proportions （〈 3%）. While the specific behaviors, like aggression, alerting, wing dithering, clawing, nodding, pendulum clawing and crawling, took less than 1% of percentage. There were large differences between A. poecilorhyncha and domestic duck when comparing eight behavioral peaks. Lag sequential analysis was used to calculate frequency of transition between a pair of activities. Some parameters were very significant, like the frequency value from foraging converted to drinking in Sansui duck was 369-515, but 37-65 in A. poecilorhyncha. The best explaining could be given that Sansui duck was better domesticated than spot-billed duck. This study provides the basic data to study and develop spot-billed duck.展开更多
Chronic liver disease(CLD)entails elevated risk of COVID-19 severity and mortality.The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear.Th...Chronic liver disease(CLD)entails elevated risk of COVID-19 severity and mortality.The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear.Therefore,we conducted a cross-sectional study involving 237 adult CLD patients and 170 healthy controls(HC)to analyze neutralizing antibodies(NAbs)against SARS-CoV-2 prototype and BA.4/5 variant,anti-receptor binding domain(RBD)IgG,and total anti-SARS-CoV-2 antibodies.Serum levels of the total anti-SARS-CoV-2 antibodies,anti-RBD IgG and inhibition efficacy of NAbs were significantly elevated in CLD patients after the booster dose compared with the pre-booster dose,but were relatively lower than those of HCs.Induced humoral responses decreased over time after booster vaccination.The neutralization efficiency of the serum against BA.4/5 increased but remained below the inhibition threshold.All four SARS-CoV-2 antibodies,including total anti-SARS-CoV-2 antibodies,anti-RBD IgG and NAbs against prototype and BA.4/5,were lower in patients with severe CLD than those with non-severe CLD.After booster shot,age and time after the last vaccine were the risk factors for seropositivity of NAb against BA.4/5 in CLD patients.Additionally,white blood cell counts and hepatitis B core antibodies were the protective factors,and severe liver disease was the risk factor associated with seropositivity of total anti-SARS-CoV-2 antibodies.Overall,our data uncovered that antibody responses were improved in CLD patients and peaked at 120 days after the booster vaccines.All antibodies excepting total anti-SARS-CoV-2 antibodies declined after peak.CLD patients exhibited impaired immunologic responses to vaccination and weakened NAbs against BA.4/5,which hindered the protective effect of the booster shot against Omicron prevalence.Cellular immune responses should be further evaluated to determine the optimal vaccine regimen for CLD patients.展开更多
Strain modulation is crucial for heteroepitaxy such as GaN on foreign substrates.Here,the epitaxy of strain-relaxed GaN films on graphene/SiC substrates by metal-organic chemical vapor deposition is demonstrated.Graph...Strain modulation is crucial for heteroepitaxy such as GaN on foreign substrates.Here,the epitaxy of strain-relaxed GaN films on graphene/SiC substrates by metal-organic chemical vapor deposition is demonstrated.Graphene was directly prepared on SiC substrates by thermal decomposition.Its pre-treatment with nitrogen-plasma can introduce C–N dangling bonds,which provides nucleation sites for subsequent epitaxial growth.The scanning transmission electron microscopy measurements confirm that part of graphene surface was etched by nitrogen-plasma.We study the growth behavior on different areas of graphene surface after pre-treatment,and propose a growth model to explain the epitaxial growth mechanism of GaN films on graphene.Significantly,graphene is found to be effective to reduce the biaxial stress in GaN films and the strain relaxation improves indium-atom incorporation in InGaN/GaN multiple quantum wells(MQWs)active region,which results in the obvious red-shift of light-emitting wavelength of InGaN/GaN MQWs.This work opens up a new way for the fabrication of GaN-based long wavelength light-emitting diodes.展开更多
A silk fibroin/poly(vinyl alcohol)porous scaffold with a water vapor transmission rate of 21256464 g/m^(2)/day has been developed via thermally induced phase separation(gelation)and freeze-drying process.A hierarchica...A silk fibroin/poly(vinyl alcohol)porous scaffold with a water vapor transmission rate of 21256464 g/m^(2)/day has been developed via thermally induced phase separation(gelation)and freeze-drying process.A hierarchical architecture of micropores and nanofibers was observed inside the scaffolds,and the related structures were analyzed.The viability and proliferation of 3T3 fibroblasts were examined,which indicated that the scaffolds exerted low cytotoxicity.After loading curcumin,the scaffolds can suppress the growth of 3T3 fibroblasts.The release behavior of curcumin from the scaffolds was investigated.At pH=7.2,the release profiles showed no significant difference for the loading amounts of 0.5mg and 0.25mg per sample.Meanwhile,the cumulative amount of released drug at pH=5.7 was significantly more than that in neutral solution due to more degradation of the scaffolds.It was suggested that the silk fibroin/poly(vinyl alcohol)blend scaffolds could be potentially used as wound dressing materials.展开更多
A terminal sliding mode （TSM） control with self-tuning gain algorithm is proposed for the synchronization of coronary artery system under the existence of the unmodeled dynamics and the external disturbance. Conside...A terminal sliding mode （TSM） control with self-tuning gain algorithm is proposed for the synchronization of coronary artery system under the existence of the unmodeled dynamics and the external disturbance. Considering the sliding mode dynamics of sys- tem, a criterion of selecting the parameters is derived to reach the point of equilibrium in the finite time. The theoretic analysis based on Lyapunov theory proved that the systems with the proposed TSM control with self-tuning scheme could be stabilized in finite time. The proposed method shows that the drive and response systems are synchronized and states of the response system track the states of the drive system in finite time. This information about the bound of unmodeled dynamics and the external disturbance is not needed in advance through self-tuning the gains of controller. The results for coronary artery system synchronization simulation show that the proposed TSM controller with self-tuning achieves better robustness and adaptation against unmodeled dynamics and the external disturbance, which offer the theory basis on curing myocardial infarction.展开更多
基金supported by the National Natural Science Foundation of China under Grant 61825104, in part by the National Natural Science Foundation of China under Grants 61801518, 62201582in part by the National Key R&D Program of China under Grant 2022YFC3301300+3 种基金in part by the Key Research and Development Program of Shaanxi under Grant 2022KW-03in part by the Young Talent fund of University Association for Science and Technology in Shaanxi under Grant 20210111in part by the Natural Science Basic Research Program of Shaanxi under Grant 2022JQ-632in part by Innovative Cultivation Project of School of Information and Communication of National University of Defense Technology under Grant YJKT-ZD-2202
文摘Extensive research attentions have been devoted to studying cooperative cognitive radio networks(CCRNs),where secondary users(SU)providing cooperative transmissions can be permitted by primary users(PU)to use spectrum.In order to maximize SU’s utility,SU may transmit its own information during the period of cooperative transmission,which stimulates the use of covert transmission against PU’s monitoring.For this sake,this article reviews the motivations of studying covert communications in CCRN.In particular,three intelligent covert transmission approaches are developed for maximizing SU’s utility in CCRNs,namely,intelligent parasitic covert transmission(IPCT),intelligent jammer aided covert transmission(IJCT)and intelligent reflecting surface assisted covert transmission(IRSC).Further,some raw performance evaluations are discussed,and a range of potential research directions are also provided.
基金supported by grants from JSPS/MEXT KAKENHI(JP19H05302 and JP21H00295 to N.W.)the MOST-RIKEN Collaboration Project(2021YFE0108000 to J.L.and N.W.)Translation Research Programs from Fukushima Prefecture(to K.S.).
文摘Myc belongs to a family of proto-oncogenes that encode transcription factors.The overexpression of c-Myc causes many types of cancers.Recently,we established a system for screening c-Myc inhibitors and identified antimycin A by screening the RIKEN NPDepo chemical library.The specific mechanism of promoting tumor cell metastasis by high c-Myc expression remains to be explained.In this study,we screened approximately 5,600 microbial extracts using this system and identified a broth prepared from Streptomyces sp.RK19-A0402 strongly inhibits c-Myc transcriptional activity.After purification of the hit broth,we identified compounds closely related to the aglycone of cytovaricin and had a structure similar to that of oligomycin A.Similar to oligomycin A,the hit compounds inhibited mitochondrial complex V.The mitochondria dysfunction caused by the compounds induced the production of reactive oxygen species(ROS),and the ROS activated GSK3α/βthat phosphorylated c-Myc for ubiquitination.This study provides a successful screening strategy for identifying natural products as potential c-Myc inhibitors as potential anticancer agents.
基金supported by research grants from the JSPS/MEXT KAKENHI(JP19H05302 and JP21H00295 to N.W.)the MOSTRIKEN Collaboration Project(2021YFE0108000 to J.L.and N.W.).
文摘β-transducin repeat-containing protein(β-TrCP)is an F-box protein subunit of the E3 Skp1-Cullin-F box(SCF)type ubiquitin-ligase complex,and provides the substrate specificity for the ligase.To find potent ligands ofβ-TrCP useful for the proteolysis targeting chimera(PROTAC)system usingβ-TrCP in the future,we developed a high-throughput screening system for small moleculeβ-TrCP ligands.We screened the chemical library utilizing the system and obtained several hit compounds.The effects of the hit compounds on in vitro ubiquitination activity of SCFβ-TrCP1 and on downstream signaling pathways were examined.Hit compounds NPD5943,NPL62020-01,and NPL42040-01 inhibited the TNFα-induced degradation of IκBαand its phosphorylated form.Hence,they inhibited the activation of the transcription activity of NF-κB,indicating the effective inhibition ofβ-TrCP by the hit compounds in cells.Next,we performed an in silico analysis of the hit compounds to determine the important moieties of the hit compounds.Carboxyl groups of NPL62020-01 and NPL42040-01 and hydroxyl groups of NPD5943 created hydrogen bonds withβ-TrCP similar to those created by intrinsic target phosphopeptides ofβ-TrCP.Our findings enhance our knowledge of useful small molecule ligands ofβ-TrCP and the importance of residues that can be ligands ofβ-TrCP.
基金supported by the National Natural Science Foundation of China(Grant No.42075015)the Science and Technology Commission of Shanghai Municipality,China(23DZ1204703).
文摘There is limited understanding regarding the formation of multiple tropical cyclones(MTCs).This study explores the environmental conditions conducive to MTC formation by objectively determining the atmospheric circulation patterns favorable for MTC formation over the western North Pacific.Based on 199 MTC events occurring from June to October 1980–2020,four distinct circulation patterns are identified:the monsoon trough(MT)pattern,accounting for 40.3%of occurrences,the confluence zone(CON)pattern at 26.2%,the easterly wave(EW)pattern at 17.8%,and the monsoon gyre(MG)pattern at 15.7%.The MT pattern mainly arises from the interaction between the subtropical high and the monsoon trough,with MTCs forming along the monsoon trough and its flanks.The CON pattern is affected by the subtropical high,the South Asian high,and the monsoon trough,with MTCs emerging at the confluence zone where the prevailing southwesterly and southeasterly flows converge.The EW pattern is dominated by easterly flows,with MTCs developing along the easterly wave train.MTCs in the MG pattern arise within a monsoon vortex characterized by strong southwesterly flows.A quantitative analysis further indicates that MTC formation in the MT pattern is primarily governed by mid-level vertical velocity and low-level vorticity,while mid-level humidity and vertical velocity are significantly important in the other patterns.The meridional shear and convergence of zonal winds are essential in converting barotropic energy from the basic flows to disturbance kinetic energy,acting as the primary source for eddy kinetic energy growth.
基金supported by National Natural Science Foundation of China (No. 51674032)
文摘The accuracy of laser-induced breakdown spectroscopy(LIBS) quantitative method is greatly dependent on the amount of certified standard samples used for training. However, in practical applications, only limited standard samples with labeled certified concentrations are available. A novel semi-supervised LIBS quantitative analysis method is proposed, based on co-training regression model with selection of effective unlabeled samples. The main idea of the proposed method is to obtain better regression performance by adding effective unlabeled samples in semisupervised learning. First, effective unlabeled samples are selected according to the testing samples by Euclidean metric. Two original regression models based on least squares support vector machine with different parameters are trained by the labeled samples separately, and then the effective unlabeled samples predicted by the two models are used to enlarge the training dataset based on labeling confidence estimation. The final predictions of the proposed method on the testing samples will be determined by weighted combinations of the predictions of two updated regression models. Chromium concentration analysis experiments of 23 certified standard high-alloy steel samples were carried out, in which 5 samples with labeled concentrations and 11 unlabeled samples were used to train the regression models and the remaining 7 samples were used for testing. With the numbers of effective unlabeled samples increasing, the root mean square error of the proposed method went down from 1.80% to 0.84% and the relative prediction error was reduced from 9.15% to 4.04%.
基金supported by the Talent Fund of Beijing Jiaotong University (No.2019RC058)the National Natural Science Foundation of China (Nos.62205013,62075009,62275013,and 12274020)。
文摘The development of tin-based devices with low toxicity is critical for the commercial viability of perovskite solar cells.However because tin halide is a stronger Lewis acid,its crystallization rate is extremely fast,resulting in the formation of numerous defects that affect the device performance of tin-based perovskite solar cells.Herein,propylamine hydrobromide(PABr)was added to the perovskite precursor solution as an additive to passivate defects and fabricate more uniform and dense perovskite films.Because propylamine cations are too large to enter the perovskite lattices,they only exist at the grain boundary to passivate surface defects and promote crystal growth in a preferred orientation.The PABr additive raises the average short-circuit current density from 19.45 to 25.47 mA·cm^(-2)by reducing carrier recombination induced by defects.Furthermore,the device’s long-term illumination stability is improved after optimization,and the hysteresis effect is negligible.The addition of PABr results in a power conversion efficiency of 9.35%.
基金the National Natural Science Foundation of China(Nos.52070036,U20A20322)the Fundamental Research Funds for the Central Universities(No.2412018ZD042)for their financial support。
文摘The biosecurity hazards caused by pathogenic fungus have been widely concerned.Given the long-term coexistence of eukaryotic pathogens and quorum sensing bacteria in different habitats in environments,we hypothesized that they have social interactions via signal molecules.In this work,we firstly discovered the well-known bacterial signal molecules play an adverse role in the cell morphology and metabolism in a model pathogen Trichosporon asahii.N-Tetradecanoyl-L-homoserine lactone(C14-HSL)was discovered to increase pathogen hazards of T.asahii,which limited mycelium by 52%,but enhanced cell aggregation by 93%.Higher fluorescence intensity of tryptophan(59%)and aromatic protein(2-fold)contents after the treatment of C14-HSL,indicating that aromatic proteins helped aggregate Trichosporon and showed hydrophobicity.Transcriptome analysis revealed that C14-HSL upregulated the shikimate pathway(above1-fold)located in downstream of tricarboxylic acid cycle,which contributed to the synthesis of more aromatic proteins and the formation of larger flocs.The limited mycelial growth of T.asahii attributed to the up-regulated expressions of cell cycle process.The fungal transboundary response to bacterial C14-HSL was controlled by signal transduction pathways.This study provides new insights into the co-evolution of bacterial and pathogenic fungi in microecosystems.
基金supported by Key Project of Natural Science Foundation of Shandong(ZR202105200003)National Natural Science Foundation of China(31870242)National Transgene Project(2020ZX08009-11B,2016ZX08002002-003)。
文摘Salt and saline-alkaline stress seriously threaten crop production and food security worldwide(Yang and Guo,2018).Identifying genes that confer tolerance to these conditions without yield penalty would help mitigate this problem through molecular breeding(Liang et al.,2023;Sahu and Liu,2023).Although numerous stress-tolerance genes have been identified,their application potential in molecular breeding has rarely been confirmed through multi-year and multi-site field trials.
基金supported by the National key research and development program(2021YFC2301800)。
文摘Porta hepatis tuberculous lymphadenopathy(TL)is rare,and the clinical and imaging manifestations often mimic tumors.To offer a bet-ter understanding of porta hepatis TL and thus improve its diagnosis and treatment,here,we retrospectively reviewed and analyzed 10 porta hepatis TL cases between May 2017 and November 2022.In this study,porta hepatis TL occurred predominantly in women(70%),with a mean age of 43.1 years(range,16-70 years).Among the patients,60%were initially suspected of malignancy(metastatic lymphadenopathy and lymphoma).The clinical manifestations were nonspecific,such as fever and weight loss,without overt abdominal malaise.Many patients showed high concentrations of serum C-reactive protein,erythrocyte sedimentation rate,alkaline phosphatase,γ-glutamyl transpeptidase and carbohydrate antigen 125.Peripheral rim-like enhancement was a characteristic finding on contrast-enhanced CT for all the patients.Pathological examination confirmed the diagnosis in 90%of patients with caseous granulo-matous inflammation and positive results of Xpert MTB/RIF,quantitative real-time PCR and/or metagenomic next-generation sequenc-ing assays.All patients underwent antituberculosis therapy with a median treatment duration of 13.5 months(range,1-43 months).They all showed satisfactory therapeutic responses with improved symptoms and resolution on imaging after treatment.Pathological examination by biopsy remains the primary diagnostic method.A combination of the characteristic epidemiologic,clinical,imaging fea-tures and lesion biopsy for histopathology are essential for the diagnosis and treatment of TL.
基金the National Natural Science Foundation of China (Grants 11772055, 11532009, 11521062, 11372042).
文摘Collective cells are organized to form specific patterns which play important roles in various physiological and pathological processes, such as tissue morphogenesis, wound healing, and cancer invasion. Compared to single cell behaviors, which has been intensively studied from many aspects (cell migration, adhesion, polarization, proliferation, etc.) and at various scales (molecular, subcellular, and cellular), the multiple cell behaviors are relatively less understood, particularly in a quantitative manner. In this paper, we will present our recent studies of collective polarization and orientation of multiple cells through both experimental measurement and theoretical modeling, including those cell behaviors on/in 2D and 3D substrate/tissue. We find that the collective cell behaviors, including polarization, alignment and migration are closely related to local stress states in cell layer or tissue, which demonstrate the crucial roles of mechanical forces in the living organisms. Specifically, the cells prefer to polarize and align along the maximum principal stress in the cell layer, and the aspect ratio of cell increases with the in-plane maximum shear stress, suggesting that the maximum shear stress is the underlying driving force of cell polarization and orientation. This theory of stress-driven cell behaviors of polarization and orientation provides a new perspective for understanding cell behaviors in living organisms and the guideline for tissue engineering in biomedical applications.
基金This study was supported by the National Key R&D Program of China(Grant No.2017YFA0604300)the National Natural Science Foundation of China(Grant Nos.41861144014,41775106 and U1811464)+1 种基金the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(Grant No.2017ZT07X355)the project of the Chinese Ministry of Emergency Management on“Catastrophe Evaluation Modeling Study”.
文摘The prolonged mei-yu/baiu system with anomalous precipitation in the year 2020 has swollen many rivers and lakes,caused flash flooding,urban flooding and landslides,and consistently wreaked havoc across large swathes of China,particularly in the Yangtze River basin.Significant precipitation and flooding anomalies have already been seen in magnitude and extension so far this year,which have been exerting much higher pressure on emergency responses in flood control and mitigation than in other years,even though a rainy season with multiple ongoing serious flood events in different provinces is not that uncommon in China.Instead of delving into the causes of the uniqueness of this year’s extreme precipitation-flooding situation,which certainly warrants in-depth exploration,in this article we provide a short view toward a more general hydrometeorological solution to this annual nationwide problem.A“glocal”(global to local)hydrometeorological solution for floods(GHS-F)is considered to be critical for better preparedness,mitigation,and management of different types of significant precipitation-caused flooding,which happen extensively almost every year in many countries such as China,India and the United States.Such a GHS-F model is necessary from both scientific and operational perspectives,with the strength in providing spatially consistent flood definitions and spatially distributed flood risk classification considering the heterogeneity in vulnerability and resilience across the entire domain.Priorities in the development of such a GHS-F are suggested,emphasizing the user’s requirements and needs according to practical experiences with various flood response agencies.
基金supported by grants from the National Natural Science Foundation of China(81730026)National Key Technologies R&D Program(2017YFA0105301)Shanghai Hospital Development Center(SHDC2020CR2040B and SHDC2020CR5014).
文摘Subretinal fibrosis is a major cause of the poor visual prognosis for patients with neovascular age-related macular degeneration(nAMD).Myofibroblasts originated from retinal pigment epithelial(RPE)cells through epithelial-mesenchymal transition(EMT)contribute to the fibrosis formation.N^(6)-Methyladenosine(m^(6)A)modification has been implicated in the EMT process and multiple fibrotic diseases.The role of m^(6)A modification in EMT-related subretinal fibrosis has not yet been elucidated.In this study,we found that during subretinal fibrosis in the mouse model of laser-induced choroidal neovascularization,METTL3 was upregulated in RPE cells.Through m^(6)A epitranscriptomic microarray and further verification,high-mobility group AT-hook 2(HMGA2)was identified as thekey downstream target of METTL3,subsequently activating potent EMT-inducing transcription factor SNAIL.Finally,by subretinal injections of adeno-associated virus vectors,we confirmed that METTL3 deficiency in RPE cells could efficiently attenuate subretinal fibrosis in vivo.In conclusion,our present research identified an epigenetic mechanism of METTL3-m^(6)A-HMGA2 in subretinal fibrosis and EMT of RPE cells,providing a novel therapeutic target for subretinal fibrosis secondary to nAMD.
文摘We report on a new type of amperometric glucose biosensor that was made by integration of glucose oxidase (GOD) with palladium nanoparticles/reduce graphene oxide (Pd/RGO) nanocomposite. The Pd/RGO was prepared by a one-step reduction method in which the palladium nanoparticles and the reduced graphene oxide (RGO) were simultaneously accomplished from the reduction of dispersed solution of PdCl2 and graphite oxide (GO) with hydrazine. The asprepared nanocomposite exhibits favorable electrocatalytic activities towards the oxidation of H2O2, which makes it a good platform for the construction of the glucose biosensor. The analytical performance of the glucose biosensor is fully evaluated. It shows good analytical properties in terms of a short response time (3 s), high sensitivity (14.1 μA/mM), and low detection limit (0.034 mM). In addition, the effects of pH value, applied potential, electroactive interference and the stability of the biosensor were discussed as well.
基金supported by the National Natural Science Foundation of China(Grant Nos.61631166004 and 51902245)Hong Wang acknowledged the support of Shenzhen Science and Technology Program(Nos.KQTD20180411143514543 and JSGGZD20220822095603006)。
文摘A series of high-k[(Na_(0.5)Bi_(0.5))_(x)Bi_(1-x)](W_(x)V_(1-x))O_(4)(abbreviated as NBWV(x value))solid solution ceramics with a scheelite-like structure are synthesized by a modified solid-state reaction method at the temperature range of 680-760 C.A monoclinic(0≤x<0.09)to tetragonal scheelite(0.09≤x≤1.0)structural phase transition is confirmed by X-ray difraction(XRD),Raman,and infrared(IR)analyses.The effect of structural deformation and order-disorder caused by Na^(+)/Bi^(3+)/W^(6+) complex substitution on microwave dielectric properties is investigated in deail.The compositional series possess a wide range of variable relative permittivity(er=24.8-80)and temperature coefficient of resonant frequency(TCF value,-271.9-188.9 ppm/℃).The maximum permittivity of 80 and a high Qxf value of~10,000 GHz are obtained near the phase boundary at x=0.09.Furthermore,the temperature-stable dielectric ceramics sintered at 680 C with excellent microwave dielectric properties of ε_(r)=80.7,Qxf=9400 GHz(at 4.1 GHz),and TCF value=-3.8 ppm/℃ are designed by mixing the components of x=0.07 and 0.08.In summary,similar sinterability and structural compatibility of scheelite-like solid solution systems make it potential for low-temperature co-fired ceramic(LTCC)applications.
文摘Anas poecilorhyncha is one of improved variety of mallards, which was the protected bird species listed by International Union for Conservation of Nature （1UCN）. Little is known until now about behavioral characteristics of the mallard. The objective of this study was to compare the behavioral differentials between A. poecilorhyncha and domestic duck in order to make a strategy to manage A. poecilorhyncha under the condition of animal welfare. A total of 180 birds were distributed into six groups with 30 birds for each group. They were placed in a room of 3 m ~ 4 m and fed for one year old. Sansui ducks, a kind of native domestic duck （Sansui laying duck） were used for behavioral comparison. Two different rooms in the same building were applied, one room for A. poecilorhyncha and another one for Sansui ducks. All behaviors for A. poecilorhyncha and Sansui ducks were coded using the program The Observer XT 11.5 （Noldus Information Technology, Beijing）. The duration of observation was from 8：00 am to 18：00 pm daily and lasted 5 d. The results showed that there were similar behavioral percentages between A. poecilorhyncha and domestic duck. Percentages of standing activity spent for A. poecilorhyncha and Sansui duck were 34.59% and 30.25%, respectively. Accordingly, the activities, such as wing plugging, preening and head stretching, were more than 5.51%. The other activities, including walking, drinking and tail wagging, occupied less proportions （〈 3%）. While the specific behaviors, like aggression, alerting, wing dithering, clawing, nodding, pendulum clawing and crawling, took less than 1% of percentage. There were large differences between A. poecilorhyncha and domestic duck when comparing eight behavioral peaks. Lag sequential analysis was used to calculate frequency of transition between a pair of activities. Some parameters were very significant, like the frequency value from foraging converted to drinking in Sansui duck was 369-515, but 37-65 in A. poecilorhyncha. The best explaining could be given that Sansui duck was better domesticated than spot-billed duck. This study provides the basic data to study and develop spot-billed duck.
基金This work was supported by the Beijing Natural Science Foundation(M23008)the National Key Research and Development Program of China(2018YFE0207300)+2 种基金Beijing Municipal Science&Technology Commission(Z211100002521021)the National High Level Hospital Clinical Research Funding(2022-PUMCH-B-124)Key Research and Development Plan of Hebei Province,Special Health Innovation Project(22377744D).
文摘Chronic liver disease(CLD)entails elevated risk of COVID-19 severity and mortality.The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear.Therefore,we conducted a cross-sectional study involving 237 adult CLD patients and 170 healthy controls(HC)to analyze neutralizing antibodies(NAbs)against SARS-CoV-2 prototype and BA.4/5 variant,anti-receptor binding domain(RBD)IgG,and total anti-SARS-CoV-2 antibodies.Serum levels of the total anti-SARS-CoV-2 antibodies,anti-RBD IgG and inhibition efficacy of NAbs were significantly elevated in CLD patients after the booster dose compared with the pre-booster dose,but were relatively lower than those of HCs.Induced humoral responses decreased over time after booster vaccination.The neutralization efficiency of the serum against BA.4/5 increased but remained below the inhibition threshold.All four SARS-CoV-2 antibodies,including total anti-SARS-CoV-2 antibodies,anti-RBD IgG and NAbs against prototype and BA.4/5,were lower in patients with severe CLD than those with non-severe CLD.After booster shot,age and time after the last vaccine were the risk factors for seropositivity of NAb against BA.4/5 in CLD patients.Additionally,white blood cell counts and hepatitis B core antibodies were the protective factors,and severe liver disease was the risk factor associated with seropositivity of total anti-SARS-CoV-2 antibodies.Overall,our data uncovered that antibody responses were improved in CLD patients and peaked at 120 days after the booster vaccines.All antibodies excepting total anti-SARS-CoV-2 antibodies declined after peak.CLD patients exhibited impaired immunologic responses to vaccination and weakened NAbs against BA.4/5,which hindered the protective effect of the booster shot against Omicron prevalence.Cellular immune responses should be further evaluated to determine the optimal vaccine regimen for CLD patients.
基金supported by the National Key Research and Development Program(No.2018YFB0406703)the National Natural Science Foundation of China(Nos.61734001 and 62074069)+1 种基金the Science and Technology Developing Project of Jilin Province(No.20200801013GH)the Program for JLU Science and Technology Innovative Research Team(JLUSTIRT,2021TD-39).
文摘Strain modulation is crucial for heteroepitaxy such as GaN on foreign substrates.Here,the epitaxy of strain-relaxed GaN films on graphene/SiC substrates by metal-organic chemical vapor deposition is demonstrated.Graphene was directly prepared on SiC substrates by thermal decomposition.Its pre-treatment with nitrogen-plasma can introduce C–N dangling bonds,which provides nucleation sites for subsequent epitaxial growth.The scanning transmission electron microscopy measurements confirm that part of graphene surface was etched by nitrogen-plasma.We study the growth behavior on different areas of graphene surface after pre-treatment,and propose a growth model to explain the epitaxial growth mechanism of GaN films on graphene.Significantly,graphene is found to be effective to reduce the biaxial stress in GaN films and the strain relaxation improves indium-atom incorporation in InGaN/GaN multiple quantum wells(MQWs)active region,which results in the obvious red-shift of light-emitting wavelength of InGaN/GaN MQWs.This work opens up a new way for the fabrication of GaN-based long wavelength light-emitting diodes.
基金This work was supported by the National Basic Research Program of China[grant number 2012CB933601]the National Natural Science Foundation of China[grant number 51202075]the Fundamental Research Funds for the Central Universities[grant number 2014QN121].
文摘A silk fibroin/poly(vinyl alcohol)porous scaffold with a water vapor transmission rate of 21256464 g/m^(2)/day has been developed via thermally induced phase separation(gelation)and freeze-drying process.A hierarchical architecture of micropores and nanofibers was observed inside the scaffolds,and the related structures were analyzed.The viability and proliferation of 3T3 fibroblasts were examined,which indicated that the scaffolds exerted low cytotoxicity.After loading curcumin,the scaffolds can suppress the growth of 3T3 fibroblasts.The release behavior of curcumin from the scaffolds was investigated.At pH=7.2,the release profiles showed no significant difference for the loading amounts of 0.5mg and 0.25mg per sample.Meanwhile,the cumulative amount of released drug at pH=5.7 was significantly more than that in neutral solution due to more degradation of the scaffolds.It was suggested that the silk fibroin/poly(vinyl alcohol)blend scaffolds could be potentially used as wound dressing materials.
基金This work is partially supported by National Natural Science Foundation of China under Grant Nos. 61503280, 61403278 and 61471243. The authors also gratefully acknowledge the anonymous reviewers for their valuable comments.
文摘A terminal sliding mode （TSM） control with self-tuning gain algorithm is proposed for the synchronization of coronary artery system under the existence of the unmodeled dynamics and the external disturbance. Considering the sliding mode dynamics of sys- tem, a criterion of selecting the parameters is derived to reach the point of equilibrium in the finite time. The theoretic analysis based on Lyapunov theory proved that the systems with the proposed TSM control with self-tuning scheme could be stabilized in finite time. The proposed method shows that the drive and response systems are synchronized and states of the response system track the states of the drive system in finite time. This information about the bound of unmodeled dynamics and the external disturbance is not needed in advance through self-tuning the gains of controller. The results for coronary artery system synchronization simulation show that the proposed TSM controller with self-tuning achieves better robustness and adaptation against unmodeled dynamics and the external disturbance, which offer the theory basis on curing myocardial infarction.
