目的对比无创间歇期雾化与无创同时雾化对慢性阻塞性肺疾病急性加重患者雾化过程中经皮二氧化碳分压(PtCO_(2))动态变化及治疗效果的影响。方法采用随机平行对照试验方法,便利抽样选取2021年10月至2022年9月常州市第一人民医院收治慢性...目的对比无创间歇期雾化与无创同时雾化对慢性阻塞性肺疾病急性加重患者雾化过程中经皮二氧化碳分压(PtCO_(2))动态变化及治疗效果的影响。方法采用随机平行对照试验方法,便利抽样选取2021年10月至2022年9月常州市第一人民医院收治慢性阻塞性肺疾病急性加重患者70例,根据随机数字表法分为对照组和试验组各35例,对照组给予无创间歇期雾化吸入,试验组给予无创同时雾化吸入,观察2组雾化0、5、10、15 min(雾化结束点)的PtCO_(2)数值,记录每日的动脉血气分析指标(主要包括PaCO_(2)、PaO_(2)、pH),记录治疗前、治疗第4天、治疗第7天临床肺部感染评分和慢性阻塞性肺疾病患者自我评估评分。结果最终纳入对照组和试验组各33例患者。对照组男25例,女8例,年龄(75.33±8.24)岁;试验组男25例,女8例,年龄(72.39±8.56)岁。对照组患者雾化0、5、10、15 min PtCO_(2)数值分别为(63.83±12.47)、(64.40±12.57)、(65.42±13.77)、(66.62±14.59)mmHg(1 mmHg=0.133 kPa),各时间点PtCO_(2)之间总体上差异有统计学意义(F=8.05,P<0.01),进一步采用Sidak法两两比较显示雾化15 min与雾化0、5、10 min的PtCO_(2)差异均有统计学意义(均P<0.05),试验组雾化0、5、10、15 min PtCO_(2)数值分别为(67.62±11.89)、(67.15±12.12)、(67.82±12.22)、(68.15±12.09)mmHg,各时间点PtCO_(2)之间总体上差异无统计学意义(F=2.00,P>0.05);2组患者PaCO_(2)和pH值均随治疗时间好转,但对照组最早在治疗第4天开始与治疗前比较差异有统计学意义(P<0.05),而试验组在治疗第2天开始与治疗前比较差异有统计学意义(P<0.05)。结论2种雾化方式均取得良好的治疗效果,但无创同时雾化在雾化过程中更能维持PtCO_(2)的平稳,安全性更高,且能够更早改善患者动脉血气指标PaCO_(2)和pH值,是无创通气与雾化治疗联合运用尤其是患者伴有高碳酸血症时更宜选择的雾化方式。展开更多
目的:建立高效液相色谱法(HPLC)测定复方薄荷涂剂中樟脑的含量。方法:采用Waters Symmetry C 18色谱柱(4.6mm×250mm,5μm),以甲醇-水(75∶25)为流动相,检测波长:288nm,流速:1.0mL·min^-1,柱温:30℃,进样量:25μL。结果:樟脑在...目的:建立高效液相色谱法(HPLC)测定复方薄荷涂剂中樟脑的含量。方法:采用Waters Symmetry C 18色谱柱(4.6mm×250mm,5μm),以甲醇-水(75∶25)为流动相,检测波长:288nm,流速:1.0mL·min^-1,柱温:30℃,进样量:25μL。结果:樟脑在0.05~1.0mg·mL-1的浓度范围内有良好的线性关系(r=0.9999)。以加样回收率试验对准确度进行验证,平均回收率为100.36%(RSD=0.73%)。结论:本文建立的方法简便,结果准确可靠,适用于复方薄荷涂剂中樟脑的含量测定。展开更多
Photoelectrochemical sensor is a new kind of developing analytical device based on the photoelectrochemical properties of materials.Because of its remarkable sensitivity,inherent miniaturization,portability and easy i...Photoelectrochemical sensor is a new kind of developing analytical device based on the photoelectrochemical properties of materials.Because of its remarkable sensitivity,inherent miniaturization,portability and easy integration,photoelectrochemical analysis is becoming a promising analytical technique.This review focuses on the basic principles,classification,characteristics,and research progress of photoelectrochemical sensors with 94 references.The prospect of the development of photoelectrochemical sensors is also evaluated and discussed.展开更多
Nanofluidics is a recent appearing research field, introduced in 1995 as an analogue of the field of microfluidics, and has been becoming popular in the past few years. The proximity of the channel dimension, the Deby...Nanofluidics is a recent appearing research field, introduced in 1995 as an analogue of the field of microfluidics, and has been becoming popular in the past few years. The proximity of the channel dimension, the Debye length, and the size of biomolecules such as DNA and proteins gives the unique features of nanofluidic devices. Of various unique properties of the nanofluidics, mass transport in nanochannel plays determining roles in fundamental reaches and practical applications of nanofluidic device. Thus, much work including numerical and experimental researches has been performed to investigate the mass transport behaviors in nanofluidic devices. This review summarizes the fabrication technologies for nanofluidic devices, the mass transport behaviors in nanochannel, and their applications in bioanalysis. The main focus will be laid on the effects of nanochannel size and surface charge on mass transport including electrokinetic transport of charged analytes, diffusion of electric neutral molecules, ionic current rectification, concentration polarization, nonlinear electrokinetic flow at the micro-nanofluidic interfaces.展开更多
文摘目的对比无创间歇期雾化与无创同时雾化对慢性阻塞性肺疾病急性加重患者雾化过程中经皮二氧化碳分压(PtCO_(2))动态变化及治疗效果的影响。方法采用随机平行对照试验方法,便利抽样选取2021年10月至2022年9月常州市第一人民医院收治慢性阻塞性肺疾病急性加重患者70例,根据随机数字表法分为对照组和试验组各35例,对照组给予无创间歇期雾化吸入,试验组给予无创同时雾化吸入,观察2组雾化0、5、10、15 min(雾化结束点)的PtCO_(2)数值,记录每日的动脉血气分析指标(主要包括PaCO_(2)、PaO_(2)、pH),记录治疗前、治疗第4天、治疗第7天临床肺部感染评分和慢性阻塞性肺疾病患者自我评估评分。结果最终纳入对照组和试验组各33例患者。对照组男25例,女8例,年龄(75.33±8.24)岁;试验组男25例,女8例,年龄(72.39±8.56)岁。对照组患者雾化0、5、10、15 min PtCO_(2)数值分别为(63.83±12.47)、(64.40±12.57)、(65.42±13.77)、(66.62±14.59)mmHg(1 mmHg=0.133 kPa),各时间点PtCO_(2)之间总体上差异有统计学意义(F=8.05,P<0.01),进一步采用Sidak法两两比较显示雾化15 min与雾化0、5、10 min的PtCO_(2)差异均有统计学意义(均P<0.05),试验组雾化0、5、10、15 min PtCO_(2)数值分别为(67.62±11.89)、(67.15±12.12)、(67.82±12.22)、(68.15±12.09)mmHg,各时间点PtCO_(2)之间总体上差异无统计学意义(F=2.00,P>0.05);2组患者PaCO_(2)和pH值均随治疗时间好转,但对照组最早在治疗第4天开始与治疗前比较差异有统计学意义(P<0.05),而试验组在治疗第2天开始与治疗前比较差异有统计学意义(P<0.05)。结论2种雾化方式均取得良好的治疗效果,但无创同时雾化在雾化过程中更能维持PtCO_(2)的平稳,安全性更高,且能够更早改善患者动脉血气指标PaCO_(2)和pH值,是无创通气与雾化治疗联合运用尤其是患者伴有高碳酸血症时更宜选择的雾化方式。
文摘目的:建立高效液相色谱法(HPLC)测定复方薄荷涂剂中樟脑的含量。方法:采用Waters Symmetry C 18色谱柱(4.6mm×250mm,5μm),以甲醇-水(75∶25)为流动相,检测波长:288nm,流速:1.0mL·min^-1,柱温:30℃,进样量:25μL。结果:樟脑在0.05~1.0mg·mL-1的浓度范围内有良好的线性关系(r=0.9999)。以加样回收率试验对准确度进行验证,平均回收率为100.36%(RSD=0.73%)。结论:本文建立的方法简便,结果准确可靠,适用于复方薄荷涂剂中樟脑的含量测定。
基金Supported by the National Natural Science Foundation of China (Grant No. 20890021)the 973 Program (2007CB936404)
文摘Photoelectrochemical sensor is a new kind of developing analytical device based on the photoelectrochemical properties of materials.Because of its remarkable sensitivity,inherent miniaturization,portability and easy integration,photoelectrochemical analysis is becoming a promising analytical technique.This review focuses on the basic principles,classification,characteristics,and research progress of photoelectrochemical sensors with 94 references.The prospect of the development of photoelectrochemical sensors is also evaluated and discussed.
基金supported by the National Basic Research Program (2012CB933804)the National Natural Science Foundation of China (20890020, 20975047, 21035002)+2 种基金the National Science Fund for Creative Research Groups (21121091)Specialized Research Fund for the Doctoral Program of Higher Fducation (200802840012)the Natural Science Foundation of Jiangsu Province (BK2010009)
文摘Nanofluidics is a recent appearing research field, introduced in 1995 as an analogue of the field of microfluidics, and has been becoming popular in the past few years. The proximity of the channel dimension, the Debye length, and the size of biomolecules such as DNA and proteins gives the unique features of nanofluidic devices. Of various unique properties of the nanofluidics, mass transport in nanochannel plays determining roles in fundamental reaches and practical applications of nanofluidic device. Thus, much work including numerical and experimental researches has been performed to investigate the mass transport behaviors in nanofluidic devices. This review summarizes the fabrication technologies for nanofluidic devices, the mass transport behaviors in nanochannel, and their applications in bioanalysis. The main focus will be laid on the effects of nanochannel size and surface charge on mass transport including electrokinetic transport of charged analytes, diffusion of electric neutral molecules, ionic current rectification, concentration polarization, nonlinear electrokinetic flow at the micro-nanofluidic interfaces.
