Objective:Postpartum depression and postoperative pain affect postpartum physical and psychological rehabilitation.Esketamine,as a dexer of ketamine,has analgesic and antidepressant effects.This study was to investiga...Objective:Postpartum depression and postoperative pain affect postpartum physical and psychological rehabilitation.Esketamine,as a dexer of ketamine,has analgesic and antidepressant effects.This study was to investigate the effect of intravenous infusion of esmololone on postoperative analgesia and postpartum depression in parturients undergoing cesarean section.Methods:435 parturients undergoing cesarean section under combined spinal and epidural anesthesia were randomly divided into three groups.All of the subjects were given continuous intravenous infusion 5 minutes after delivery of the fetus.HE:0.4 mg/kg esketamine;LE:0.2 mg/kg esketamine;C:saline.Intraoperative records of MAP and HR at entry operating room(T0),skin resection(T1),beginning of test drug pumping(T2),10 min of pumping(T3)20min of pumping(T4),end of pumping(T5),end of operation(T6)and the adverse reactions before leaving the room were recorded.Postoperative analgesia with intravenous analgesia pump:2.5 ug/kg Sufentanil+8 mg Ondansetron+100 mL Saline.VAS score and sufentanil consumption and adverse reactions were recorded at 2 h(T0’)4 h(T1’)、8 h(T2’)、12 h(T3’)、24 h(T4’)after operation.The Edinburgh Postpartum Depression Scale(EPDS)was used to evaluate the depression status of pregnant women 1 day before operation,1 d,3 d,1 w and 6 w after operation.Result:There was no significant difference in mean arterial pressure(MAP)and heart rate(HR)among the three groups(P>0.05).Compared with C,the incidence of dizziness and diplopia was higher in HE and LE(P<0.05).Compared with C,VAS scores,the sufentanil dosage,and EPDS scores decreased at 1 and 3d postoperatively in both the HE and LE.(P<0.05).Conclusion:The analgesic effect of esketamine after cesarean section is remarkable,which can reduce the use of opioids and improve the short-term depression of pregnant women.展开更多
通过静态吸附-解吸试验从5种大孔树脂筛中筛选出D-101大孔树脂对紫玉米穗轴花青素进行纯化,结果表明:D-101的静态吸附率(94.17±1.31)%,解吸率(90.83±1.33)%,为最佳纯化材料。通过动态吸附-解吸试验确定最佳纯化工艺条件:上柱...通过静态吸附-解吸试验从5种大孔树脂筛中筛选出D-101大孔树脂对紫玉米穗轴花青素进行纯化,结果表明:D-101的静态吸附率(94.17±1.31)%,解吸率(90.83±1.33)%,为最佳纯化材料。通过动态吸附-解吸试验确定最佳纯化工艺条件:上柱体积9 BV、上样流速1.5 m L/min、洗脱剂为体积分数70%乙醇与体积分数0.02%盐酸的混合液(体积比100∶1)、洗脱流速1.5 m L/min、洗脱体积8 BV。在此条件下,获得穗轴花青素纯度为29.76%,相比于原料花青素纯度0.74%,提高了约40倍。展开更多
基金Clinical Application Research and Medical Training Fund Project(No.2021SQCJ2065)。
文摘Objective:Postpartum depression and postoperative pain affect postpartum physical and psychological rehabilitation.Esketamine,as a dexer of ketamine,has analgesic and antidepressant effects.This study was to investigate the effect of intravenous infusion of esmololone on postoperative analgesia and postpartum depression in parturients undergoing cesarean section.Methods:435 parturients undergoing cesarean section under combined spinal and epidural anesthesia were randomly divided into three groups.All of the subjects were given continuous intravenous infusion 5 minutes after delivery of the fetus.HE:0.4 mg/kg esketamine;LE:0.2 mg/kg esketamine;C:saline.Intraoperative records of MAP and HR at entry operating room(T0),skin resection(T1),beginning of test drug pumping(T2),10 min of pumping(T3)20min of pumping(T4),end of pumping(T5),end of operation(T6)and the adverse reactions before leaving the room were recorded.Postoperative analgesia with intravenous analgesia pump:2.5 ug/kg Sufentanil+8 mg Ondansetron+100 mL Saline.VAS score and sufentanil consumption and adverse reactions were recorded at 2 h(T0’)4 h(T1’)、8 h(T2’)、12 h(T3’)、24 h(T4’)after operation.The Edinburgh Postpartum Depression Scale(EPDS)was used to evaluate the depression status of pregnant women 1 day before operation,1 d,3 d,1 w and 6 w after operation.Result:There was no significant difference in mean arterial pressure(MAP)and heart rate(HR)among the three groups(P>0.05).Compared with C,the incidence of dizziness and diplopia was higher in HE and LE(P<0.05).Compared with C,VAS scores,the sufentanil dosage,and EPDS scores decreased at 1 and 3d postoperatively in both the HE and LE.(P<0.05).Conclusion:The analgesic effect of esketamine after cesarean section is remarkable,which can reduce the use of opioids and improve the short-term depression of pregnant women.
文摘通过静态吸附-解吸试验从5种大孔树脂筛中筛选出D-101大孔树脂对紫玉米穗轴花青素进行纯化,结果表明:D-101的静态吸附率(94.17±1.31)%,解吸率(90.83±1.33)%,为最佳纯化材料。通过动态吸附-解吸试验确定最佳纯化工艺条件:上柱体积9 BV、上样流速1.5 m L/min、洗脱剂为体积分数70%乙醇与体积分数0.02%盐酸的混合液(体积比100∶1)、洗脱流速1.5 m L/min、洗脱体积8 BV。在此条件下,获得穗轴花青素纯度为29.76%,相比于原料花青素纯度0.74%,提高了约40倍。
