Background:Early recurrence has been reported to be predictive of a poor prognosis for patients with perihilar cholangiocarcinoma(pCCA)after resection.The objective of our study was to construct a useful scoring syste...Background:Early recurrence has been reported to be predictive of a poor prognosis for patients with perihilar cholangiocarcinoma(pCCA)after resection.The objective of our study was to construct a useful scoring system to predict early recurrence for Bismuth–Corlette type IV pCCA patients in clinic and to investigate the value of early recurrence in directing post-operative surveillance and adjuvant therapy.Methods:In total,244 patients who underwent radical resection for type IV pCCA were included.Data on clinicopathological characteristics,perioperative details and survival outcomes were analyzed.Survival curves were generated using the Kaplan–Meier method.Univariate and multivariate logistic-regression models were used to identify factors associated with early recurrence.Results:Twenty-one months was defined as the cutoff point to distinguish between early and late recurrence.Univariate and multivariate analysis revealed that CA19-9 level>200 U/mL,R1 resection margin,higher N category and positive lymphovascular invasion were independent predictors of early recurrence.The scoring system was constructed accordingly.The early-recurrence rates of patients with scores of 0,1,2,3,4,and 5 were 23.9%,38.7%,60.0%,78.6%,83.4%,and 100%,respectively.Adjuvant therapy was significantly associated with higher overall survival rate for patients with early recurrence,but not for those with late recurrence.Patients in the early-recurrence group with scores2 had better prognoses after adjuvant therapy.Conclusions:A simple scoring system using CA19-9 level,N category,resection margin and lymphovascular invasion status could predict early recurrence,and thus might direct post-operative surveillance and adjuvant therapy for patients with type IV pCCA.展开更多
基金This work was supported by the grants from the Science and Technology Support Project of Sichuan Province[No.2018SZ0170 and No.2018SZ0195].
文摘Background:Early recurrence has been reported to be predictive of a poor prognosis for patients with perihilar cholangiocarcinoma(pCCA)after resection.The objective of our study was to construct a useful scoring system to predict early recurrence for Bismuth–Corlette type IV pCCA patients in clinic and to investigate the value of early recurrence in directing post-operative surveillance and adjuvant therapy.Methods:In total,244 patients who underwent radical resection for type IV pCCA were included.Data on clinicopathological characteristics,perioperative details and survival outcomes were analyzed.Survival curves were generated using the Kaplan–Meier method.Univariate and multivariate logistic-regression models were used to identify factors associated with early recurrence.Results:Twenty-one months was defined as the cutoff point to distinguish between early and late recurrence.Univariate and multivariate analysis revealed that CA19-9 level>200 U/mL,R1 resection margin,higher N category and positive lymphovascular invasion were independent predictors of early recurrence.The scoring system was constructed accordingly.The early-recurrence rates of patients with scores of 0,1,2,3,4,and 5 were 23.9%,38.7%,60.0%,78.6%,83.4%,and 100%,respectively.Adjuvant therapy was significantly associated with higher overall survival rate for patients with early recurrence,but not for those with late recurrence.Patients in the early-recurrence group with scores2 had better prognoses after adjuvant therapy.Conclusions:A simple scoring system using CA19-9 level,N category,resection margin and lymphovascular invasion status could predict early recurrence,and thus might direct post-operative surveillance and adjuvant therapy for patients with type IV pCCA.
