Fischer indole cyclization of phenylhydrazine and various ketones using carboxyl-functionalized ionic liquid, 1-carboxymethyl- 3-methylimidazolium tetrafluoroborate （abbreviated as [crnmim] [BF4]） as catalyst was su...Fischer indole cyclization of phenylhydrazine and various ketones using carboxyl-functionalized ionic liquid, 1-carboxymethyl- 3-methylimidazolium tetrafluoroborate （abbreviated as [crnmim] [BF4]） as catalyst was successfully performed. The yields of the target compounds were 80-92%, the purities were 96-98%. The catalyst could be recovered and reused for at least six times without significant loss in activity.展开更多
Canrenone（1） was biotransformed into 11α-hydroxycanrenone（2） and a main byproduct（3） by Aspergillus ochraceus SIT34205.Compound 3 was separated and purified using silica gel column chromatography,and its struct...Canrenone（1） was biotransformed into 11α-hydroxycanrenone（2） and a main byproduct（3） by Aspergillus ochraceus SIT34205.Compound 3 was separated and purified using silica gel column chromatography,and its structure was characterized via MS and NMR methods.These results indicated that 3 was 1β,11α-dihydroxycanrenone and the product of further hydroxylation of 2.Thus,investigating the structure and synthesis of 3 may be a promising method to improve the efficiency and purity of 2.展开更多
基金the Key Project of Shanghai Educational Committee(No.06ZZ82)
文摘Fischer indole cyclization of phenylhydrazine and various ketones using carboxyl-functionalized ionic liquid, 1-carboxymethyl- 3-methylimidazolium tetrafluoroborate （abbreviated as [crnmim] [BF4]） as catalyst was successfully performed. The yields of the target compounds were 80-92%, the purities were 96-98%. The catalyst could be recovered and reused for at least six times without significant loss in activity.
文摘Canrenone（1） was biotransformed into 11α-hydroxycanrenone（2） and a main byproduct（3） by Aspergillus ochraceus SIT34205.Compound 3 was separated and purified using silica gel column chromatography,and its structure was characterized via MS and NMR methods.These results indicated that 3 was 1β,11α-dihydroxycanrenone and the product of further hydroxylation of 2.Thus,investigating the structure and synthesis of 3 may be a promising method to improve the efficiency and purity of 2.
