BACKGROUND Decreased serum magnesium(Mg2+)is commonly seen in critically ill patients.Hypomagnesemia is significantly more frequent in patients with severe acute pancreatitis.Acute kidney injury(AKI)in patients with a...BACKGROUND Decreased serum magnesium(Mg2+)is commonly seen in critically ill patients.Hypomagnesemia is significantly more frequent in patients with severe acute pancreatitis.Acute kidney injury(AKI)in patients with acute pancreatitis(AP)is associated with an extremely high mortality.The association underlying serum Mg2+and AKI in AP has not been elucidated.AIM To explore the association between serum Mg2+on admission and AKI in patients with AP.METHODS A retrospective observational study was conducted in a cohort of patients(n=233)with AP without any renal injury before admission to our center from August 2015 to February 2019.Demographic characteristics on admission,severity score,laboratory values and in-hospital mortality were compared between patients with and without AKI.RESULTS A total of 233 patients were included for analysis,including 85 with AKI.Compared to patients without AKI,serum Mg2+level was significantly lower in patients with AKI at admission[OR=6.070,95%CI:3.374-10.921,P<0.001].Multivariate logistic analysis showed that lower serum Mg2+was an independent risk factor for AKI[OR=8.47,95%CI:3.02-23.72,P<0.001].CONCLUSION Our analysis indicates that serum Mg2+level at admission is independently associated with the development of AKI in patients with AP and may be a potential prognostic factor.展开更多
BACKGROUND The epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)patients have been widely reported,but the assessment of doseresponse relationships and risk factors for mortality and s...BACKGROUND The epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)patients have been widely reported,but the assessment of doseresponse relationships and risk factors for mortality and severe cases and clinical outcomes remain unclear.AIM To determine the dose-response relationship between risk factors and incidence of COVID-19.METHODS In this retrospective,multicenter cohort study,we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6,2020.We used multivariable logistic regression and Cox proportional hazard models to determine the dose-response relationship between risk factors and incidence of COVID-19.RESULTS It clarified that increasing risk of in-hospital death were associated with older age(HR:1.04,95%CI:1.01-1.09),higher lactate dehydrogenase[HR:1.04,95%confidence interval(CI):1.01-1.10],C-reactive protein(HR:1.10,95%CI:1.01-1.23),and procalcitonin(natural log-transformed HR:1.88,95%CI:1.22-2.88),and D-dimer greater than 1μg/m L at admission(natural log transformed HR:1.63,95%CI:1.03-2.58)by multivariable regression.D-dimer and procalcitonin were logarithmically correlated with COVID-19 mortality risk,while there was a linear dose-response correlation between age,lactate dehydrogenase,D-dimer and procalcitonin,independent of established risk factors.CONCLUSION Higher lactate dehydrogenase,D-dimer,and procalcitonin levels were independently associated with a dose-response increased risk of COVID-19 mortality.展开更多
Diabetes is a condition of persistent hyperglycemia caused by the endocrine disorder of the pancreas.Therefore,all pancreatic diseases have the risk of diabetes.In particular,increasing attention has been paid recentl...Diabetes is a condition of persistent hyperglycemia caused by the endocrine disorder of the pancreas.Therefore,all pancreatic diseases have the risk of diabetes.In particular,increasing attention has been paid recently to new-onset diabetes secondary to acute pancreatitis(AP).The complications of secondary diabetes have caused a lot of trouble for patients and have garnered increasing attention.At present,the pathophysiological mechanism of new-onset diabetes caused by AP is not clear.This review summarizes the current understanding of new-onset diabetes secondary to AP.展开更多
妊娠期急性胰腺炎(acute pancreatitis in pregnancy,APIP)是妊娠期较少见却病情凶险的妊娠合并症,具有起病快、进展急、并发症多、病死率高等特点.据相关研究报道,APIP发病率约为1/10000-1/1000,且随胎龄的增加而升高.由于亚洲人群与...妊娠期急性胰腺炎(acute pancreatitis in pregnancy,APIP)是妊娠期较少见却病情凶险的妊娠合并症,具有起病快、进展急、并发症多、病死率高等特点.据相关研究报道,APIP发病率约为1/10000-1/1000,且随胎龄的增加而升高.由于亚洲人群与欧美人群基因背景以及饮食生活习惯的差异,我国APIP的发病率高达1.14‰-2.27‰,显著高于西方国家.APIP的临床症状缺乏特异性,容易导致误诊或漏诊,极大增加了诊疗的难度.尽管对APIP的研究不断深入,然而其发病机制仍不明确.本文将对APIP的综合现状进行综述.展开更多
基金National Natural Science Foundation of China,No.82070669.
文摘BACKGROUND Decreased serum magnesium(Mg2+)is commonly seen in critically ill patients.Hypomagnesemia is significantly more frequent in patients with severe acute pancreatitis.Acute kidney injury(AKI)in patients with acute pancreatitis(AP)is associated with an extremely high mortality.The association underlying serum Mg2+and AKI in AP has not been elucidated.AIM To explore the association between serum Mg2+on admission and AKI in patients with AP.METHODS A retrospective observational study was conducted in a cohort of patients(n=233)with AP without any renal injury before admission to our center from August 2015 to February 2019.Demographic characteristics on admission,severity score,laboratory values and in-hospital mortality were compared between patients with and without AKI.RESULTS A total of 233 patients were included for analysis,including 85 with AKI.Compared to patients without AKI,serum Mg2+level was significantly lower in patients with AKI at admission[OR=6.070,95%CI:3.374-10.921,P<0.001].Multivariate logistic analysis showed that lower serum Mg2+was an independent risk factor for AKI[OR=8.47,95%CI:3.02-23.72,P<0.001].CONCLUSION Our analysis indicates that serum Mg2+level at admission is independently associated with the development of AKI in patients with AP and may be a potential prognostic factor.
文摘BACKGROUND The epidemiological and clinical characteristics of coronavirus disease 2019(COVID-19)patients have been widely reported,but the assessment of doseresponse relationships and risk factors for mortality and severe cases and clinical outcomes remain unclear.AIM To determine the dose-response relationship between risk factors and incidence of COVID-19.METHODS In this retrospective,multicenter cohort study,we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6,2020.We used multivariable logistic regression and Cox proportional hazard models to determine the dose-response relationship between risk factors and incidence of COVID-19.RESULTS It clarified that increasing risk of in-hospital death were associated with older age(HR:1.04,95%CI:1.01-1.09),higher lactate dehydrogenase[HR:1.04,95%confidence interval(CI):1.01-1.10],C-reactive protein(HR:1.10,95%CI:1.01-1.23),and procalcitonin(natural log-transformed HR:1.88,95%CI:1.22-2.88),and D-dimer greater than 1μg/m L at admission(natural log transformed HR:1.63,95%CI:1.03-2.58)by multivariable regression.D-dimer and procalcitonin were logarithmically correlated with COVID-19 mortality risk,while there was a linear dose-response correlation between age,lactate dehydrogenase,D-dimer and procalcitonin,independent of established risk factors.CONCLUSION Higher lactate dehydrogenase,D-dimer,and procalcitonin levels were independently associated with a dose-response increased risk of COVID-19 mortality.
文摘Diabetes is a condition of persistent hyperglycemia caused by the endocrine disorder of the pancreas.Therefore,all pancreatic diseases have the risk of diabetes.In particular,increasing attention has been paid recently to new-onset diabetes secondary to acute pancreatitis(AP).The complications of secondary diabetes have caused a lot of trouble for patients and have garnered increasing attention.At present,the pathophysiological mechanism of new-onset diabetes caused by AP is not clear.This review summarizes the current understanding of new-onset diabetes secondary to AP.
文摘妊娠期急性胰腺炎(acute pancreatitis in pregnancy,APIP)是妊娠期较少见却病情凶险的妊娠合并症,具有起病快、进展急、并发症多、病死率高等特点.据相关研究报道,APIP发病率约为1/10000-1/1000,且随胎龄的增加而升高.由于亚洲人群与欧美人群基因背景以及饮食生活习惯的差异,我国APIP的发病率高达1.14‰-2.27‰,显著高于西方国家.APIP的临床症状缺乏特异性,容易导致误诊或漏诊,极大增加了诊疗的难度.尽管对APIP的研究不断深入,然而其发病机制仍不明确.本文将对APIP的综合现状进行综述.
