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Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology 被引量:16
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作者 jun Cui Dong Hua Yang +1 位作者 xiang jun bi Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2001年第1期136-139,共4页
INTRODUCTIONThe mechanism that DNA hypomethylation leads toactivation of oncogene and occurrence of malignantneoplasm is being increasingly recognized byresearchers. Normal DNA methylation playsimportant role in stabi... INTRODUCTIONThe mechanism that DNA hypomethylation leads toactivation of oncogene and occurrence of malignantneoplasm is being increasingly recognized byresearchers. Normal DNA methylation playsimportant role in stabilizing the phenotype of cell.DNA methylation status reduction and/or patternalteration are related to activation and abnormallyhigh expression of some oncogenes and cellularmalignancy[1-6]. c-fms oncogene encodes for colonystimulating factor 1 receptor (CSF-1R)[7], c-fms/CSF-1R was highly expressed in hepatocellularcarcinoma (HCC) tissue, but the mechanismremained obscure[8,9]. 展开更多
关键词 Adult Aged Blotting Southern Carcinoma Hepatocellular DNA Methylation Female Gene Expression Regulation Neoplastic Humans Liver Liver Neoplasms Male Middle Aged Phenotype Receptor Macrophage Colony-Stimulating Factor Research Support Non-U.S. Gov't
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