Cation additives can efficiently enhance the total electrochemical capabilities of zinc-ion hybrid capacitors (ZHCs).However their energy storage mechanisms in zinc-based systems are still under debate.Herein,we modul...Cation additives can efficiently enhance the total electrochemical capabilities of zinc-ion hybrid capacitors (ZHCs).However their energy storage mechanisms in zinc-based systems are still under debate.Herein,we modulate the electrolyte and achieve dual-ion storage by adding magnesium ions.And we assemble several Zn//activated carbon devices with different electrolyte concentrations and investigate their electrochemical reaction dynamic behaviors.The zinc-ion capacitor with Mg^(2+)mixed solution delivers 82 mAh·g^(-1)capacity at 1 A·g^(-1) and maintains 91%of the original capacitance after 10000 cycling.It is superior to the other assembled zinc-ion devices in single-component electrolytes.The finding demonstrates that the double-ion storage mechanism enables the superior rate performance and long cycle lifetime of ZHCs.展开更多
BACKGROUND A solitary fibrous tumor(SFT)is often located in the pleura,while SFT of the pancreas is extremely rare.Here,we report a case of SFT of the pancreas and discuss imaging,histopathology,and immunohistochemist...BACKGROUND A solitary fibrous tumor(SFT)is often located in the pleura,while SFT of the pancreas is extremely rare.Here,we report a case of SFT of the pancreas and discuss imaging,histopathology,and immunohistochemistry for accurate diagnosis and treatment.CASE SUMMARY A 54-year-old man presented to our hospital with pancreatic occupancy for over a month.There were no previous complaints of discomfort.His blood pressure was normal.Blood glucose,tumor markers,and enhanced computed tomography(CT)suggested a malignant tumor.Because the CT appearance of pancreatic cancer varies,we could not confirm the diagnosis;therefore,we performed endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB).Pathology and immunohistochemistry were consistent with SFT of the pancreas.The posto-perative pathology and immunohistochemistry were consistent with the puncture results.The patient presented for a follow-up examination one month after discharge with no adverse effects.CONCLUSION Other diseases must be excluded in patients with a pancreatic mass that cannot be diagnosed.CT and pathological histology have diagnostic value for pancreatic tumors.Endoscopic puncture biopsy under ultrasound can help diagnose pancreatic masses that cannot be diagnosed preoperatively.Surgery is an effective treatment for SFT of the pancreas;however,long-term follow-up is strongly recommended because of the possibility of malignant transformation of the tumor.展开更多
With the rise of aqueous multivalent rechargeable batteries,inorganic-organic hybrid cathodes have attracted more and more attention due to the complement of each other’s advantages.Herein,a strategy of designing hyb...With the rise of aqueous multivalent rechargeable batteries,inorganic-organic hybrid cathodes have attracted more and more attention due to the complement of each other’s advantages.Herein,a strategy of designing hybrid cathode is adopted for high efficient aqueous zinc-ion batteries(AZIBs).Methylene blue(MB)intercalated vanadium oxide(HVO-MB)was synthesized through sol-gel and ion exchange method.Compared with other organic-inorganic intercalation cathode,not only can the MB intercalation enlarge the HVO interlayer spacing to improve ion mobility,but also provide coordination reactions with the Zn^(2+)to enhance the intrinsic electrochemical reaction kinetics of the hybrid electrode.As a key component for the cathode of AZIBs,HVO-MB contributes a specific capacity of 418 mA h g^(-1) at 0.1 A g^(-1),high rate capability(243 mA h g^(-1) at 5 A g^(-1))and extraordinary stability(88%of capacity retention after 2000cycles at a high current density of 5 A g^(-1))in 3 M Zn(CF_(3)SO_(3))_(2) aqueous electrolyte.The electrochemical kinetics reveals HVO-MB characterized with large pseudocapacitance charge storage behavior due to the fast ion migration provided by the coordination reaction and expanded interlayer distance.Furthermore,a mixed energy storage mechanism involving Zn^(2+)insertion and coordination reaction is confirmed by various ex-situ characterization.Thus,this work opens up a new path for constructing the high performance cathode of AZIBs through organic-inorganic hybridization.展开更多
Sensors play an important role in shaping and monitoring human health.Exploration of methods to use Fiber Bragg Grating(FBG)with enhanced sensitivity has attracted great interest in the field of medical research.In th...Sensors play an important role in shaping and monitoring human health.Exploration of methods to use Fiber Bragg Grating(FBG)with enhanced sensitivity has attracted great interest in the field of medical research.In this paper,a novel apodization function is proposed and performance evaluation and optimization of the same have been made.A comparison was conducted between various existing apodization functions and the proposed one based on optical characteristics and sensor parameters.The results evince the implementation of the proposed apodization function for vital sign measurement.The optical characteristics considered for evaluation are Peak Resonance Reflectivity level,Side Lobes Reflectivity level and FullWidth HalfMaximum(FWHM).The proposed novel apodization novel function has better FWHM,which is narrower than the FWHM of uniform FBG.Sensor characteristics like a quality parameter,detection accuracy and sensitivity also show improvement.The proposed novel apodization function is demonstrated to have a better shift in wavelength in terms of temperature and pulse measurement than the existing functions.The sensitivity of the proposed apodized function is enhanced with a Poly-dimethylsiloxane coating of varying thickness,which is 6 times and 5.14 times greater than uniform Fiber Bragg grating and FBG with the proposed novel apodization function,respectively,enhancing its utilization in the field of medicine.展开更多
Vanadium oxides have attracted one’s wide attention due to their diverse valences and spatial structure as cathode for aqueous zinc ion batteries.However,a strong electrostatic interaction exists between Zn ions and ...Vanadium oxides have attracted one’s wide attention due to their diverse valences and spatial structure as cathode for aqueous zinc ion batteries.However,a strong electrostatic interaction exists between Zn ions and host materials,which leads to their sluggish reaction kinetics and inferior structural stability.Herein,we design a kind of vanadium-based electrode materials with abundant phase boundaries and oxygen defects.The assembled Zn//V_(6)O_(13)/VO_(2) batteries deliver a specific capacity of 498.3 mA h g^(-1)at 0.2 A g^(-1) and retain a capacity of 485.8 mA h g^(-1)after 100 cycles.Moreover,they achieve a retention rate of 96.8% after 5000 cycles at 10 A g^(-1).The soft pack cells also show excellent mechanical stability at different folding conditions.展开更多
Mining the core value of Industrial Internet of Things(IIoT)data safely and reducing the risk of malicious attacks are the inherent requirements of industrial data visualization.Visualization technology has become the...Mining the core value of Industrial Internet of Things(IIoT)data safely and reducing the risk of malicious attacks are the inherent requirements of industrial data visualization.Visualization technology has become the main tool for data aggregation,mining and analysis of IIoT data through graphical representation.However,visualization technology still has two shortcomings in big data calculation and analysis scenarios.On the one hand,visual results will lead to the disclosure of sensitive privacy.On the other hand,most visualization tools can't provide an interactive framework for users to select the suitable solutions.To address these problems,we present an open accessible Visual framework based on Differential Privacy theory(VisDP),which provides Multi-index Quantitative comprehensive Evaluation technology(MQE)for data mining results.Considering the advantages of interactive mechanism,VisDP provides rich optional schemes,including the operating web,calling API and the downloading SDK.Finally,we verify the availability and privacy of MQE through mathematical proofs,analyze the hospital medical waste detection system that actually applies the framework,and the experimental results have showed the effectiveness and practicality of the proposed platform.展开更多
While the Bushen Yizhi Formula can treat Alzheimer’s disease(AD),the yet to be ascertained specific mechanism of action was explored in this work.Methods:Different concentrations of the Bushen Yizhi Formula and amylo...While the Bushen Yizhi Formula can treat Alzheimer’s disease(AD),the yet to be ascertained specific mechanism of action was explored in this work.Methods:Different concentrations of the Bushen Yizhi Formula and amyloid-beta peptide(Aβ)were used to treat rat pheochromocytoma cells(P12)and human neuroblastoma cells(SH-SY5Y).Cell morphological changes were observed to determine the in vitro cell damage.Cell Counting Kit(CCK)-8 assay and flow cytometry were employed to identify cell viability and apoptosis/cell cycle,respectively.Western blotting and immunohistochemistry were employed to measure the expressions of endoplasmic reticulum stress(ERS)-related proteins(GRP78 and CHOP),p-IRE1α,IRE1α,ASK1,p-JNK,JNK,Bax,Bcl-2,XBP-1,and Bim.Fura 2-acetoxymethyl ester(Fura-2/AM)was used to determine the intracellular calcium(Ca^(2+))concentration.Also,an AD model was constructed by injecting Aβinto the CA1 area of the hippocampus in Sprague Dawley rats.AD model rats were gavaged with different concentrations of Bushen Yizhi Formula for 14 consecutive days.The Morris water maze experiment was conducted to test the learning and memory of rats.Hematoxylin&Eosin(H&E)and Terminal-deoxynucleotidyl Transferase(TdT)-mediated dUTP Nick-End Labeling(TUNEL)staining were done to determine histopathological changes in the brain.Results:Bushen Yizhi Formula relieved the Aβ-induced effects including cell injury,decreased viability,increased apoptosis,G0/G1 phase cell cycle arrest,upregulation of GRP78,CHOP,p-IRE1α,p-JNK,Bax,XBP-1 and Bim,as well as down-regulation of Bcl-2.These results were also seen with IRE1αsilencing.While Aβsuppressed the learning and memory abilities of rats,the Bushen Yizhi Formula alleviated these effects of Aβ.Brain nerve cell injury induced by Aβcould also be treated with Bushen Yizhi Formula.Conclusion:Bushen Yizhi Formula could influence ERS through the IRE1αsignaling pathway to achieve its therapeutic effects on AD.展开更多
基金financially supported by the National Natural Science Foundation of China (No.52172218)。
文摘Cation additives can efficiently enhance the total electrochemical capabilities of zinc-ion hybrid capacitors (ZHCs).However their energy storage mechanisms in zinc-based systems are still under debate.Herein,we modulate the electrolyte and achieve dual-ion storage by adding magnesium ions.And we assemble several Zn//activated carbon devices with different electrolyte concentrations and investigate their electrochemical reaction dynamic behaviors.The zinc-ion capacitor with Mg^(2+)mixed solution delivers 82 mAh·g^(-1)capacity at 1 A·g^(-1) and maintains 91%of the original capacitance after 10000 cycling.It is superior to the other assembled zinc-ion devices in single-component electrolytes.The finding demonstrates that the double-ion storage mechanism enables the superior rate performance and long cycle lifetime of ZHCs.
文摘BACKGROUND A solitary fibrous tumor(SFT)is often located in the pleura,while SFT of the pancreas is extremely rare.Here,we report a case of SFT of the pancreas and discuss imaging,histopathology,and immunohistochemistry for accurate diagnosis and treatment.CASE SUMMARY A 54-year-old man presented to our hospital with pancreatic occupancy for over a month.There were no previous complaints of discomfort.His blood pressure was normal.Blood glucose,tumor markers,and enhanced computed tomography(CT)suggested a malignant tumor.Because the CT appearance of pancreatic cancer varies,we could not confirm the diagnosis;therefore,we performed endoscopic ultrasound-guided fine-needle biopsy(EUS-FNB).Pathology and immunohistochemistry were consistent with SFT of the pancreas.The posto-perative pathology and immunohistochemistry were consistent with the puncture results.The patient presented for a follow-up examination one month after discharge with no adverse effects.CONCLUSION Other diseases must be excluded in patients with a pancreatic mass that cannot be diagnosed.CT and pathological histology have diagnostic value for pancreatic tumors.Endoscopic puncture biopsy under ultrasound can help diagnose pancreatic masses that cannot be diagnosed preoperatively.Surgery is an effective treatment for SFT of the pancreas;however,long-term follow-up is strongly recommended because of the possibility of malignant transformation of the tumor.
基金supported by the National Natural Science Foundation of China(21965027 and 22065030)the Natural Science Foundation of Ningxia Province(2022AAC03109)the National First-rate Discipline Construction Project of Ningxia:Chemical Engineering and Technology(NXY-LXK2017A04)。
文摘With the rise of aqueous multivalent rechargeable batteries,inorganic-organic hybrid cathodes have attracted more and more attention due to the complement of each other’s advantages.Herein,a strategy of designing hybrid cathode is adopted for high efficient aqueous zinc-ion batteries(AZIBs).Methylene blue(MB)intercalated vanadium oxide(HVO-MB)was synthesized through sol-gel and ion exchange method.Compared with other organic-inorganic intercalation cathode,not only can the MB intercalation enlarge the HVO interlayer spacing to improve ion mobility,but also provide coordination reactions with the Zn^(2+)to enhance the intrinsic electrochemical reaction kinetics of the hybrid electrode.As a key component for the cathode of AZIBs,HVO-MB contributes a specific capacity of 418 mA h g^(-1) at 0.1 A g^(-1),high rate capability(243 mA h g^(-1) at 5 A g^(-1))and extraordinary stability(88%of capacity retention after 2000cycles at a high current density of 5 A g^(-1))in 3 M Zn(CF_(3)SO_(3))_(2) aqueous electrolyte.The electrochemical kinetics reveals HVO-MB characterized with large pseudocapacitance charge storage behavior due to the fast ion migration provided by the coordination reaction and expanded interlayer distance.Furthermore,a mixed energy storage mechanism involving Zn^(2+)insertion and coordination reaction is confirmed by various ex-situ characterization.Thus,this work opens up a new path for constructing the high performance cathode of AZIBs through organic-inorganic hybridization.
基金supported in part by Universiti Malaya,and ACU UK under Project No.IF063-2021.
文摘Sensors play an important role in shaping and monitoring human health.Exploration of methods to use Fiber Bragg Grating(FBG)with enhanced sensitivity has attracted great interest in the field of medical research.In this paper,a novel apodization function is proposed and performance evaluation and optimization of the same have been made.A comparison was conducted between various existing apodization functions and the proposed one based on optical characteristics and sensor parameters.The results evince the implementation of the proposed apodization function for vital sign measurement.The optical characteristics considered for evaluation are Peak Resonance Reflectivity level,Side Lobes Reflectivity level and FullWidth HalfMaximum(FWHM).The proposed novel apodization novel function has better FWHM,which is narrower than the FWHM of uniform FBG.Sensor characteristics like a quality parameter,detection accuracy and sensitivity also show improvement.The proposed novel apodization function is demonstrated to have a better shift in wavelength in terms of temperature and pulse measurement than the existing functions.The sensitivity of the proposed apodized function is enhanced with a Poly-dimethylsiloxane coating of varying thickness,which is 6 times and 5.14 times greater than uniform Fiber Bragg grating and FBG with the proposed novel apodization function,respectively,enhancing its utilization in the field of medicine.
基金supported by the National Natural Science Foundation of China (No. 52172218)。
文摘Vanadium oxides have attracted one’s wide attention due to their diverse valences and spatial structure as cathode for aqueous zinc ion batteries.However,a strong electrostatic interaction exists between Zn ions and host materials,which leads to their sluggish reaction kinetics and inferior structural stability.Herein,we design a kind of vanadium-based electrode materials with abundant phase boundaries and oxygen defects.The assembled Zn//V_(6)O_(13)/VO_(2) batteries deliver a specific capacity of 498.3 mA h g^(-1)at 0.2 A g^(-1) and retain a capacity of 485.8 mA h g^(-1)after 100 cycles.Moreover,they achieve a retention rate of 96.8% after 5000 cycles at 10 A g^(-1).The soft pack cells also show excellent mechanical stability at different folding conditions.
基金supported by the National Key Research and Development Program of China under Grant No.2020YFC2006600the National Natural Science Foundation of China under Grant No.62003291the National Science and Technology Foundation Project under Grant No.2019FY100100,and the QingLan Project.
文摘Mining the core value of Industrial Internet of Things(IIoT)data safely and reducing the risk of malicious attacks are the inherent requirements of industrial data visualization.Visualization technology has become the main tool for data aggregation,mining and analysis of IIoT data through graphical representation.However,visualization technology still has two shortcomings in big data calculation and analysis scenarios.On the one hand,visual results will lead to the disclosure of sensitive privacy.On the other hand,most visualization tools can't provide an interactive framework for users to select the suitable solutions.To address these problems,we present an open accessible Visual framework based on Differential Privacy theory(VisDP),which provides Multi-index Quantitative comprehensive Evaluation technology(MQE)for data mining results.Considering the advantages of interactive mechanism,VisDP provides rich optional schemes,including the operating web,calling API and the downloading SDK.Finally,we verify the availability and privacy of MQE through mathematical proofs,analyze the hospital medical waste detection system that actually applies the framework,and the experimental results have showed the effectiveness and practicality of the proposed platform.
基金supported by the National Natural Science Foundation of China[81904266,82004309].
文摘While the Bushen Yizhi Formula can treat Alzheimer’s disease(AD),the yet to be ascertained specific mechanism of action was explored in this work.Methods:Different concentrations of the Bushen Yizhi Formula and amyloid-beta peptide(Aβ)were used to treat rat pheochromocytoma cells(P12)and human neuroblastoma cells(SH-SY5Y).Cell morphological changes were observed to determine the in vitro cell damage.Cell Counting Kit(CCK)-8 assay and flow cytometry were employed to identify cell viability and apoptosis/cell cycle,respectively.Western blotting and immunohistochemistry were employed to measure the expressions of endoplasmic reticulum stress(ERS)-related proteins(GRP78 and CHOP),p-IRE1α,IRE1α,ASK1,p-JNK,JNK,Bax,Bcl-2,XBP-1,and Bim.Fura 2-acetoxymethyl ester(Fura-2/AM)was used to determine the intracellular calcium(Ca^(2+))concentration.Also,an AD model was constructed by injecting Aβinto the CA1 area of the hippocampus in Sprague Dawley rats.AD model rats were gavaged with different concentrations of Bushen Yizhi Formula for 14 consecutive days.The Morris water maze experiment was conducted to test the learning and memory of rats.Hematoxylin&Eosin(H&E)and Terminal-deoxynucleotidyl Transferase(TdT)-mediated dUTP Nick-End Labeling(TUNEL)staining were done to determine histopathological changes in the brain.Results:Bushen Yizhi Formula relieved the Aβ-induced effects including cell injury,decreased viability,increased apoptosis,G0/G1 phase cell cycle arrest,upregulation of GRP78,CHOP,p-IRE1α,p-JNK,Bax,XBP-1 and Bim,as well as down-regulation of Bcl-2.These results were also seen with IRE1αsilencing.While Aβsuppressed the learning and memory abilities of rats,the Bushen Yizhi Formula alleviated these effects of Aβ.Brain nerve cell injury induced by Aβcould also be treated with Bushen Yizhi Formula.Conclusion:Bushen Yizhi Formula could influence ERS through the IRE1αsignaling pathway to achieve its therapeutic effects on AD.
基金Project(CXZZ20140506150310438) supported by the Science and Technology Program of Shenzhen,ChinaProject(2017GK2261) supported by the Science and Technology Program of Hunan Province,China
