BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface barrier.Notably,these enzymes p...BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface barrier.Notably,these enzymes play a significant role in the development of diverse tumors.AIM To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression Omnibus.The study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and PLA2G12B.Gene Set Enrichment Analysis was utilized to pinpoint associated pathways.Moreover,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was evaluated.RESULTS PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy individuals.Elevated expression of PLA2G2A was correlated with poorer overall survival in CCA patients.Additionally,the study delineated pathways and miRNAs associated with these genes.CONCLUSION Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for CCA.The increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.展开更多
The advent of single-cell RNA sequencing(scRNA-seq)has provided insight into the tumour immune microenvironment(TIME).This review focuses on the application of scRNA-seq in investigation of the TIME.Over time,scRNA-se...The advent of single-cell RNA sequencing(scRNA-seq)has provided insight into the tumour immune microenvironment(TIME).This review focuses on the application of scRNA-seq in investigation of the TIME.Over time,scRNA-seq methods have evolved,and components of the TIME have been deciphered with high resolution.In this review,we first introduced the principle of scRNA-seq and compared different sequencing approaches.Novel cell types in the TIME,a continuous transitional state,and mutual intercommunication among TIME components present potential targets for prognosis prediction and treatment in cancer.Thus,we concluded novel cell clusters of cancerassociated fibroblasts(CAFs),T cells,tumour-associated macrophages(TAMs)and dendritic cells(DCs)discovered after the application of scRNA-seq in TIME.We also proposed the development of TAMs and exhausted T cells,as well as the possible targets to interrupt the process.In addition,the therapeutic interventions based on cellular interactions in TIME were also summarized.For decades,quantification of the TIME components has been adopted in clinical practice to predict patient survival and response to therapy and is expected to play an important role in the precise treatment of cancer.Summarizing the current findings,we believe that advances in technology and wide application of single-cell analysis can lead to the discovery of novel perspectives on cancer therapy,which can subsequently be implemented in the clinic.Finally,we propose some future directions in the field of TIME studies that can be aided by scRNA-seq technology.展开更多
Background:In this study,we investigated whether prophylactic treatment with Guizhi-Shaoyao-Zhimu decoction(GSZ)could delay the onset of rheumatoid arthritis by targeting mast cells.Methods:Collagen-induced arthritis ...Background:In this study,we investigated whether prophylactic treatment with Guizhi-Shaoyao-Zhimu decoction(GSZ)could delay the onset of rheumatoid arthritis by targeting mast cells.Methods:Collagen-induced arthritis was used to evaluate the effect of GSZ in preventing arthritis and joint destruction.Immunohistochemical staining revealed the accumulation of histamine H4 receptor and tryptase alpha/beta-1 in the ankle joint of the model.Then,we explored the effect of GSZ serum on fibroblast-like synoviocytes using standard transwell invasion and migration assays.Real-time quantitative polymerase chain reaction and western blot were used to detect the expression of toll-like receptor 4(TLR4)/myeloid differentiationfactor 88(MyD88)/nuclear factor-κB p65(NF-κB p65).Results:The results showed that pre-rheumatoid arthritis treatment with GSZ could reduce inflammation and maintain cartilage structure in the collagen-induced arthritis model.Moreover,GSZ significantly blocked mast cell degranulation and inhibited the TLR4/MyD88/NF-κB p65 pathway.Since the combined activation of mast cells via TLR4 and immune complexes enhances inflammation in synovial tissue,we concluded that GSZ may block mast cell degranulation by inhibiting the TLR4/MyD88/NF-κB p65 pathway and thus influence rheumatoid arthritis onset.Conclusion:Taken together,our data suggested that GSZ may be a promising therapeutic decoction for the prophylactic treatment of rheumatoid arthritis.展开更多
Rechargeable zinc(Zn)metal batteries have long been plagued by dendrite growth and parasitic reactions due to the absence of a stable Zn-ion conductive solid-electrolyte interphase(SEI).Although the current strategies...Rechargeable zinc(Zn)metal batteries have long been plagued by dendrite growth and parasitic reactions due to the absence of a stable Zn-ion conductive solid-electrolyte interphase(SEI).Although the current strategies assist in suppressing dendritic Zn growth,it is still a challenge to obtain the operation-stability of Zn anode with high Coulombic efficiency(CE)required to implement a sustainable and long-cycling life of Zn metal batteries.In this perspective,we summarize the advantages of the functional gradient interphase(FGI)and try to fundamentally understand the transport behaviors of Zn ions,based on recently an article understanding Zn chemistry.The correlation between the function-orientated design of gradient interphase and key challenges of Zn metal anodes in accelerating Zn2+transport kinetics,improving electrode reversibility,and inhibiting Zn dendrite growth and side reactions was particularly emphasized.Finally,the rational design and innovative directions are provided for the development and application of functional gradient interphase in rechargeable Zn metal battery systems.展开更多
Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental e...Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure.展开更多
In the long history of traditional Chinese medicine(TCM),meridians play essential roles as the critical network to regulate the normal physiological functions of the human body.They are regarded to be the channels con...In the long history of traditional Chinese medicine(TCM),meridians play essential roles as the critical network to regulate the normal physiological functions of the human body.They are regarded to be the channels connecting the internal organs with the body surface and various parts of the body.Although there are many studies and doctrines trying to reveal the nature of meridians for their validation in TCM,the mechanism underlying the meridians remains unclear.Herein,based on our macroscopic quantum state concept of ion channels(i.e.,sub-nanometer scale channels),we propose a quantum principle of meridians.The acupoints and organ symptom are in a macroscopic coherence state of the ion channels in meridians.By applying TCM treatments(e.g.,TCM massage,acupuncture,moxibustion,and electroacupuncture)on the acupoint,the corresponding organ symptom could be well regulated with help of quantum meridian state.展开更多
Coupling low-grade heat(LGH)with salinity gradient is an effective approach to increase the efficiency of the nanofluidic-membrane-based power generator.However,it is a challenge to fabricate membranes with high charg...Coupling low-grade heat(LGH)with salinity gradient is an effective approach to increase the efficiency of the nanofluidic-membrane-based power generator.However,it is a challenge to fabricate membranes with high charge density that ensures ion permselectivity,while maintaining chemical and mechanical stability in this composite environment.Here,we develop a bis[2-(methacryloyloxy)ethyl]phosphate(BMAP)hydrogel membrane with good thermal stability and anti-swelling property through self-crosslinking of the selected monomer.By taking advantage of negative space charge and three-dimensional(3D)interconnected nanochannels,salinity gradient energy conversion efficiency is substantially enhanced by temperature difference.Theoretical and experimental results verify that LGH can largely weaken the concentration polarization,promoting transmembrane ion transport.As a result,such a hydrogel membrane delivers high-performance energy conversion with a power density of 11.53 W·m^(−2)under a negative temperature difference(NTD),showing a 193%increase compared with that without NTD.展开更多
Harvesting clean energy such as solar energy and salinity gradient energy directly from the surrounding environment has attracted great attention.A promising proof-of-concept combination of cation-selective membrane-b...Harvesting clean energy such as solar energy and salinity gradient energy directly from the surrounding environment has attracted great attention.A promising proof-of-concept combination of cation-selective membrane-based osmotic energy with photoelectrochemical-based solar energy has been developed,highlighting the great potential for the direct conversion of osmotic energy to hydrogen energy.With the help of a 50-fold concentration gradient,the MXene-CdSe quantum dots system exhibits the highest photocurrent enhancement ratio(Δ/_(L-H)/Δ/_(L-L)),and the hydrogen production is increased by about 33%at a bias of 0 V versus reversible hydrogen electrode.Directly converting osmotic energy and solar energy into hydrogen energy suggests the possibility of coupling osmotic energy with other renewable energy sources.展开更多
This paper considers the problem of delay-dependent robust stability for uncertain systems with interval time-varying delays. By using the direct Lyapunov method, a new Lyapunov-Krasovskii(L-K) functional is introduce...This paper considers the problem of delay-dependent robust stability for uncertain systems with interval time-varying delays. By using the direct Lyapunov method, a new Lyapunov-Krasovskii(L-K) functional is introduced based on decomposition approach, when dealing with the time derivative of L-K functional, a new tight integral inequality is adopted for bounding the cross terms. Then, a new less conservative delay-dependent stability criterion is formulated in terms of linear matrix inequalities(LMIs),which can be easily solved by optimization algorithms. Numerical examples are given to show the effectiveness and the benefits of the proposed method.展开更多
Simulation of open quantum dynamics for various Hamiltonians and spectral densities are ubiquitous for studying various quantum systems.On a quantum computer,only log2N qubits are required for the simulation of an N-d...Simulation of open quantum dynamics for various Hamiltonians and spectral densities are ubiquitous for studying various quantum systems.On a quantum computer,only log2N qubits are required for the simulation of an N-dimensional quantum system,hence simulation in a quantum computer can greatly reduce the computational complexity compared with classical methods.Recently,a quantum simulation approach was proposed for studying photosynthetic light harvesting[npj Quantum Inf.4,52(2018)].In this paper,we apply the approach to simulate the open quantum dynamics of various photosynthetic systems.We show that for Drude—Lorentz spectral density,the dimerized geometries with strong couplings within the donor and acceptor clusters respectively exhibit significantly improved efficiency.We also demonstrate that the overall energy transfer can be optimized when the energy gap between the donor and acceptor clusters matches the optimum of the spectral density.The effects of different types of baths,e.g.,Ohmic,sub-Ohmic,and super-Ohmic spectral densities are also studied.The present investigations demonstrate that the proposed approach is universal for simulating the exact quantum dynamics of photosynthetic systems.展开更多
Quantum state transfer in optical microcavities plays an important role in quantum information processing and is essential in many optical devices such as optical frequency converters and diodes.Existing schemes are e...Quantum state transfer in optical microcavities plays an important role in quantum information processing and is essential in many optical devices such as optical frequency converters and diodes.Existing schemes are effective and realized by tuning the coupling strengths between modes.However,such approaches are severely restricted due to the small amount of strength that can be tuned and the difficulty performing the tuning in some situations,such as in an on-chip microcavity system.Here we propose a novel approach that realizes the state transfer between different modes in optical microcavities by tuning the frequency of an intermediate mode.We show that for typical functions of frequency tuning,such as linear and periodic functions,the state transfer can be realized successfully with different features.To optimize the process,we use the gradient descent technique to find an optimal tuning function for a fast and perfect state transfer.We also showed that our approach has significant nonreciprocity with appropriate tuning variables,where one can unidirectionally transfer a state from one mode to another,but the inverse direction transfer is forbidden.This work provides an effective method for controlling the multimode interactions in on-chip optical microcavities via simple operations,and it has practical applications in all-optical devices.展开更多
Osmotic energy between river water and seawater has attracted interest as a new source of sustainable energy.Nanofluidic membranes in a reverse electrodialysis configuration can capture energy from salinity gradients....Osmotic energy between river water and seawater has attracted interest as a new source of sustainable energy.Nanofluidic membranes in a reverse electrodialysis configuration can capture energy from salinity gradients.However,current membrane materials suffer from high resistances,low stabilities,and low charge densities,which limit their further application.Here,we designed a high-performance nanofluidic membrane using carboxylic cellulose nanofibers functionalized with graphene oxide nanolamellas with cement-and-pebble microstructures and stable skeletons for enhanced ion transmembrane transport.By mixing artificial river water and seawater,the composite membrane achieved a high output power density up to 5.26 W m^(−2).Additionally,the membrane had an excellent acid resistance,which enabled long-term use with over 67 W m^(−2) of power density.The performance of this composite membrane benefited from the mechanically strong cellulose fibers and the bonding between nanofibers and nanolamellas.In this work,we highlight promising directions in industrial waste treatment using energy extracted from chemical potential gradients.展开更多
This paper considers the problem of delay-dependent non-fragile H∞control for a class of linear systems with interval time-varying delay. Based on the direct Lyapunov method, an appropriate Lyapunov-Krasovskii functi...This paper considers the problem of delay-dependent non-fragile H∞control for a class of linear systems with interval time-varying delay. Based on the direct Lyapunov method, an appropriate Lyapunov-Krasovskii functional(LKF) with triple-integral terms and augment terms is introduced. Then, by using the integral inequalities and convex combination technique, an improved H∞performance analysis criterion and non-fragile H∞controller are formulated in terms of linear matrix inequalities(LMIs), which can be easily solved by using standard numerical packages. At last, two numerical examples are provided to demonstrate the effectiveness of the obtained results.展开更多
Osmotic energy from the ocean,also called blue energy,serves as a clean,renewable,and vast energy source for the energy demands of the world.Reverse electrodialysis-based blue energy harvesting via ion-selective membr...Osmotic energy from the ocean,also called blue energy,serves as a clean,renewable,and vast energy source for the energy demands of the world.Reverse electrodialysis-based blue energy harvesting via ion-selective membranes,by the regulation and manipulation of directional ion transport,has been greatly developed recently.In particular,light has been employed to enhance directional ion transport for energy conversion through an increase in photo-induced surface charge.Here,the authors demonstrate a novel nanofluidic regulation strategy based on the phenomenon of light-induced heat-driven active ion transport through the lamellar MXene membrane.Due to the great light-induced heat effect,a temperature gradient appears as soon as illumination is applied to an off-center position,inducing an actively temperature gradient-driven ionic species transport.By employing this phenomenon,the authors conducted light-induced heat-enhanced osmotic energy conversion and doubled the osmotic energy conversion power density.This study has extended the scope of light-enhanced osmotic energy conversion and could further bring other photothermal materials into this field.Furthermore,the proposed system provides a new avenue of light-controlled ionic transport for ion gathering,desalination,and energy conversion applications.展开更多
Biological ion channels, as fundamental units participating in various daily behaviors with incredible mass transportation and signal transmission, triggered booming researches on manufacturing their artificial protot...Biological ion channels, as fundamental units participating in various daily behaviors with incredible mass transportation and signal transmission, triggered booming researches on manufacturing their artificial prototypes. Biomimetic ion channel with the nanometer scale for smart responding functions has been successfully realized in sorts of materials by employing state-of-art nanotechnology. Ion track-etching technology, as crucial branches of fabricating solid-state nanochannels, exhibits outstanding advantages, such as easy fabrication, low cost, and high customization. To endow the nanochannel with smart responsibility, various modification methods are developed, including chemical grafting, non-covalent adsorption, and electrochemical deposition, enriching the reservoir of accessible stimuli-responses combinations, whereas were limited by their relatively lengthy and complex procedure. Here, based on the electric field induced self-assembly of polyelectrolytes, a universal customizable modifying strategy has been proposed, which exhibits superiorities in their functionalization with convenience and compatibility. By using this protocol, the channels’ ionic transport behaviors could be easily tuned, and even the specific ionic or molecular responding could be realized with superior performance. This strategy surely accelerates the nanochannels functionalization into fast preparing, high efficiency, and large-scale application scenarios.展开更多
Controlling ions transport across the membrane at different pH environments is essential for the physiological process and artificial systems.Many efforts have been devoted to pH-responsive ion gating,while rarely sys...Controlling ions transport across the membrane at different pH environments is essential for the physiological process and artificial systems.Many efforts have been devoted to pH-responsive ion gating,while rarely systems can maintain the rectification in pH-changing environments.Here,a composite nanochannel system is fabricated,which shows unidirectional rectification with high performance in a wide pH range.In the system,block copolymer(BCP) and polyethylene te rephthalate(PET) are employed for the amphoteric nanochannels fabrication.Based on the composite system,a model is built for the theoretical simulation.Thereafter,rectification mapping is conducted on the system,which can provide abundant info rmation about the relations between charge distribution and ions transport prope rties.The proposed rectification mapping can definitely help to design new materials with special ion transport properties,such as high-performance membranes used in the salinity gradient power generation field.展开更多
Principal/minor component analysis(PCA/MCA),generalized principal/minor component analysis(GPCA/GMCA),and singular value decomposition(SVD)algorithms are important techniques for feature extraction.In the convergence ...Principal/minor component analysis(PCA/MCA),generalized principal/minor component analysis(GPCA/GMCA),and singular value decomposition(SVD)algorithms are important techniques for feature extraction.In the convergence analysis of these algorithms,the deterministic discrete-time(DDT)method can reveal the dynamic behavior of PCA/MCA and GPCA/GMCA algorithms effectively.However,the dynamic behavior of SVD algorithms has not been studied quantitatively because of their special structure.In this paper,for the first time,we utilize the advantages of the DDT method in PCA algorithms analysis to study the dynamics of SVD algorithms.First,taking the cross-coupled Hebbian algorithm as an example,by concatenating the two cross-coupled variables into a single vector,we successfully get a PCA-like DDT system.Second,we analyze the discrete-time dynamic behavior and stability of the PCA-like DDT system in detail based on the DDT method,and obtain the boundedness of the weight vectors and learning rate.Moreover,further discussion shows the universality of the proposed method for analyzing other SVD algorithms.As a result,the proposed method provides a new way to study the dynamical convergence properties of SVD algorithms.展开更多
基金Supported by the Key Specialty Construction Project of Shanghai Pudong New Area Health Commission,No.PWZzk2022-17Shanghai East Hospital Clinical Research Project,No.DFLC2022019and the Featured Clinical Discipline Project of Shanghai Pudong District,No.PWYts2021-06.
文摘BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface barrier.Notably,these enzymes play a significant role in the development of diverse tumors.AIM To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression Omnibus.The study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and PLA2G12B.Gene Set Enrichment Analysis was utilized to pinpoint associated pathways.Moreover,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was evaluated.RESULTS PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy individuals.Elevated expression of PLA2G2A was correlated with poorer overall survival in CCA patients.Additionally,the study delineated pathways and miRNAs associated with these genes.CONCLUSION Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for CCA.The increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.
基金supported by the National Key Research Development Program of China(2021YFA1301203)the National Natural Science Foundation of China(82103031,82103918,81973408)+6 种基金the Clinical Research Incubation Project,West China Hospital,Sichuan University(22HXFH019)the China Postdoctoral Science Foundation(2019 M653416)the International Cooperation Project of Chengdu Municipal Science and Technology Bureau(2020-GH02-00017-HZ)the“1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University”(ZYJC18035,ZYJC18025,ZYYC20003,ZYJC18003)the GIST Research Institute(GRI)IIBR grants funded by the GISTthe National Research Foundation of Korea funded by the Korean government(MSIP)(2019R1C1C1005403,2019R1A4A1028802 and2021M3H9A2097520)the Post-Doctor Research Project,West China Hospital,Sichuan University(2021HXBH054)。
文摘The advent of single-cell RNA sequencing(scRNA-seq)has provided insight into the tumour immune microenvironment(TIME).This review focuses on the application of scRNA-seq in investigation of the TIME.Over time,scRNA-seq methods have evolved,and components of the TIME have been deciphered with high resolution.In this review,we first introduced the principle of scRNA-seq and compared different sequencing approaches.Novel cell types in the TIME,a continuous transitional state,and mutual intercommunication among TIME components present potential targets for prognosis prediction and treatment in cancer.Thus,we concluded novel cell clusters of cancerassociated fibroblasts(CAFs),T cells,tumour-associated macrophages(TAMs)and dendritic cells(DCs)discovered after the application of scRNA-seq in TIME.We also proposed the development of TAMs and exhausted T cells,as well as the possible targets to interrupt the process.In addition,the therapeutic interventions based on cellular interactions in TIME were also summarized.For decades,quantification of the TIME components has been adopted in clinical practice to predict patient survival and response to therapy and is expected to play an important role in the precise treatment of cancer.Summarizing the current findings,we believe that advances in technology and wide application of single-cell analysis can lead to the discovery of novel perspectives on cancer therapy,which can subsequently be implemented in the clinic.Finally,we propose some future directions in the field of TIME studies that can be aided by scRNA-seq technology.
基金funded by Zhejiang Nature Science Foundation(LQ20H270006)National Key R&D Program of China(No.2018YFC1705500).
文摘Background:In this study,we investigated whether prophylactic treatment with Guizhi-Shaoyao-Zhimu decoction(GSZ)could delay the onset of rheumatoid arthritis by targeting mast cells.Methods:Collagen-induced arthritis was used to evaluate the effect of GSZ in preventing arthritis and joint destruction.Immunohistochemical staining revealed the accumulation of histamine H4 receptor and tryptase alpha/beta-1 in the ankle joint of the model.Then,we explored the effect of GSZ serum on fibroblast-like synoviocytes using standard transwell invasion and migration assays.Real-time quantitative polymerase chain reaction and western blot were used to detect the expression of toll-like receptor 4(TLR4)/myeloid differentiationfactor 88(MyD88)/nuclear factor-κB p65(NF-κB p65).Results:The results showed that pre-rheumatoid arthritis treatment with GSZ could reduce inflammation and maintain cartilage structure in the collagen-induced arthritis model.Moreover,GSZ significantly blocked mast cell degranulation and inhibited the TLR4/MyD88/NF-κB p65 pathway.Since the combined activation of mast cells via TLR4 and immune complexes enhances inflammation in synovial tissue,we concluded that GSZ may block mast cell degranulation by inhibiting the TLR4/MyD88/NF-κB p65 pathway and thus influence rheumatoid arthritis onset.Conclusion:Taken together,our data suggested that GSZ may be a promising therapeutic decoction for the prophylactic treatment of rheumatoid arthritis.
基金the National Key R&D Program of China(Nos.2022YFB3805904 and 2022YFB3805900)the National Natural Science Foundation of China(Nos.22122207 and 21988102)CAS Project for Young Scientists in Basic Research(YSBR-039)。
文摘Rechargeable zinc(Zn)metal batteries have long been plagued by dendrite growth and parasitic reactions due to the absence of a stable Zn-ion conductive solid-electrolyte interphase(SEI).Although the current strategies assist in suppressing dendritic Zn growth,it is still a challenge to obtain the operation-stability of Zn anode with high Coulombic efficiency(CE)required to implement a sustainable and long-cycling life of Zn metal batteries.In this perspective,we summarize the advantages of the functional gradient interphase(FGI)and try to fundamentally understand the transport behaviors of Zn ions,based on recently an article understanding Zn chemistry.The correlation between the function-orientated design of gradient interphase and key challenges of Zn metal anodes in accelerating Zn2+transport kinetics,improving electrode reversibility,and inhibiting Zn dendrite growth and side reactions was particularly emphasized.Finally,the rational design and innovative directions are provided for the development and application of functional gradient interphase in rechargeable Zn metal battery systems.
基金We thank the National Key R&D Program of China(No.2020YFA0710401)the National Natural Science Foundation of China(Nos.82225012,81922019,82071161,81991505,22122207,21988102,and 52075138)+1 种基金the Young Elite Scientist Sponsorship Program by CAST(No.2020QNRC001)the Beijing Nova Program(No.211100002121013).
文摘Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains unclear.The long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain processes.However,no experimental evidence supports the statements.Here,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine hypersensitivity.The in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine hypersensitivity.Furthermore,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine hypersensitivity.Therefore,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical applications.The proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure.
基金supported by the National Natural Science Foundation of China(Nos.21988102,22122207,T224100002,and 62101017)the National Key R&D Program of China(No.2021YFA1200404)+1 种基金the Innovation Program for Quantum Science and Technology(No.2021ZD0300500)the Development and Application of Ultra-Weak Magnetic Measurement Technology based on Atomic Magnetometer(No.2022-189-181).
文摘In the long history of traditional Chinese medicine(TCM),meridians play essential roles as the critical network to regulate the normal physiological functions of the human body.They are regarded to be the channels connecting the internal organs with the body surface and various parts of the body.Although there are many studies and doctrines trying to reveal the nature of meridians for their validation in TCM,the mechanism underlying the meridians remains unclear.Herein,based on our macroscopic quantum state concept of ion channels(i.e.,sub-nanometer scale channels),we propose a quantum principle of meridians.The acupoints and organ symptom are in a macroscopic coherence state of the ion channels in meridians.By applying TCM treatments(e.g.,TCM massage,acupuncture,moxibustion,and electroacupuncture)on the acupoint,the corresponding organ symptom could be well regulated with help of quantum meridian state.
基金supported by the National Key R&D Program of China(Nos.2022YFB3805904,2022YFB3805900,and 2020YFA0710401)the National Natural Science Foundation of China(Nos.22122207,21988102,and 52075138)+2 种基金CAS Key Laboratory of Bio-inspired Materials and Interfacial Science,Technical Institute of Physics and Chemistry(No.BMIS202102)China Postdoctoral Science Foundation(Nos.2022TQ0345,2022M723229,and 2022M713226)Postdoctoral International Exchange Talent-Introducing Program(No.YJ20220199).
文摘Coupling low-grade heat(LGH)with salinity gradient is an effective approach to increase the efficiency of the nanofluidic-membrane-based power generator.However,it is a challenge to fabricate membranes with high charge density that ensures ion permselectivity,while maintaining chemical and mechanical stability in this composite environment.Here,we develop a bis[2-(methacryloyloxy)ethyl]phosphate(BMAP)hydrogel membrane with good thermal stability and anti-swelling property through self-crosslinking of the selected monomer.By taking advantage of negative space charge and three-dimensional(3D)interconnected nanochannels,salinity gradient energy conversion efficiency is substantially enhanced by temperature difference.Theoretical and experimental results verify that LGH can largely weaken the concentration polarization,promoting transmembrane ion transport.As a result,such a hydrogel membrane delivers high-performance energy conversion with a power density of 11.53 W·m^(−2)under a negative temperature difference(NTD),showing a 193%increase compared with that without NTD.
基金supported by the National Key R&D Program of China(grant nos.2017YFA02-06900,2017YFA0206904,2017YFA0206903,and 2021YFA1500800)the National Natural Science Foundation of China(grant nos.21625303,22122207,21905287,21988102,22088102,and 21971251).
文摘Harvesting clean energy such as solar energy and salinity gradient energy directly from the surrounding environment has attracted great attention.A promising proof-of-concept combination of cation-selective membrane-based osmotic energy with photoelectrochemical-based solar energy has been developed,highlighting the great potential for the direct conversion of osmotic energy to hydrogen energy.With the help of a 50-fold concentration gradient,the MXene-CdSe quantum dots system exhibits the highest photocurrent enhancement ratio(Δ/_(L-H)/Δ/_(L-L)),and the hydrogen production is increased by about 33%at a bias of 0 V versus reversible hydrogen electrode.Directly converting osmotic energy and solar energy into hydrogen energy suggests the possibility of coupling osmotic energy with other renewable energy sources.
基金supported by National Natural Science Foundation of China(No.61074072)
文摘This paper considers the problem of delay-dependent robust stability for uncertain systems with interval time-varying delays. By using the direct Lyapunov method, a new Lyapunov-Krasovskii(L-K) functional is introduced based on decomposition approach, when dealing with the time derivative of L-K functional, a new tight integral inequality is adopted for bounding the cross terms. Then, a new less conservative delay-dependent stability criterion is formulated in terms of linear matrix inequalities(LMIs),which can be easily solved by optimization algorithms. Numerical examples are given to show the effectiveness and the benefits of the proposed method.
基金This work was supported by the National Natural Science Foundation of China under Grant Nos.11674033,11474026,and 11505007Beijing Natural Science Foundation under Grant No.1202017N.L.acknowledges partial support from JST PRESTO through Grant No.JPMJPR18GC.
文摘Simulation of open quantum dynamics for various Hamiltonians and spectral densities are ubiquitous for studying various quantum systems.On a quantum computer,only log2N qubits are required for the simulation of an N-dimensional quantum system,hence simulation in a quantum computer can greatly reduce the computational complexity compared with classical methods.Recently,a quantum simulation approach was proposed for studying photosynthetic light harvesting[npj Quantum Inf.4,52(2018)].In this paper,we apply the approach to simulate the open quantum dynamics of various photosynthetic systems.We show that for Drude—Lorentz spectral density,the dimerized geometries with strong couplings within the donor and acceptor clusters respectively exhibit significantly improved efficiency.We also demonstrate that the overall energy transfer can be optimized when the energy gap between the donor and acceptor clusters matches the optimum of the spectral density.The effects of different types of baths,e.g.,Ohmic,sub-Ohmic,and super-Ohmic spectral densities are also studied.The present investigations demonstrate that the proposed approach is universal for simulating the exact quantum dynamics of photosynthetic systems.
基金National Natural Science Foundation of China(61727801)National Key Research and Development Program of China(2017YFA0303700)+2 种基金China Postdoctoral Science Foundation(2019M6506202019M660605)Beijing Innovation Center for Future Chip。
文摘Quantum state transfer in optical microcavities plays an important role in quantum information processing and is essential in many optical devices such as optical frequency converters and diodes.Existing schemes are effective and realized by tuning the coupling strengths between modes.However,such approaches are severely restricted due to the small amount of strength that can be tuned and the difficulty performing the tuning in some situations,such as in an on-chip microcavity system.Here we propose a novel approach that realizes the state transfer between different modes in optical microcavities by tuning the frequency of an intermediate mode.We show that for typical functions of frequency tuning,such as linear and periodic functions,the state transfer can be realized successfully with different features.To optimize the process,we use the gradient descent technique to find an optimal tuning function for a fast and perfect state transfer.We also showed that our approach has significant nonreciprocity with appropriate tuning variables,where one can unidirectionally transfer a state from one mode to another,but the inverse direction transfer is forbidden.This work provides an effective method for controlling the multimode interactions in on-chip optical microcavities via simple operations,and it has practical applications in all-optical devices.
基金supported by the National Key R&D Program of China(2017YFA0206904 and 2017YFA0206900)the National Natural Science Foundation of China(21625303,22122207,2190528721988102)。
文摘Osmotic energy between river water and seawater has attracted interest as a new source of sustainable energy.Nanofluidic membranes in a reverse electrodialysis configuration can capture energy from salinity gradients.However,current membrane materials suffer from high resistances,low stabilities,and low charge densities,which limit their further application.Here,we designed a high-performance nanofluidic membrane using carboxylic cellulose nanofibers functionalized with graphene oxide nanolamellas with cement-and-pebble microstructures and stable skeletons for enhanced ion transmembrane transport.By mixing artificial river water and seawater,the composite membrane achieved a high output power density up to 5.26 W m^(−2).Additionally,the membrane had an excellent acid resistance,which enabled long-term use with over 67 W m^(−2) of power density.The performance of this composite membrane benefited from the mechanically strong cellulose fibers and the bonding between nanofibers and nanolamellas.In this work,we highlight promising directions in industrial waste treatment using energy extracted from chemical potential gradients.
基金supported by National Natural Science Foundation of China(Nos.61074072 and 61374120)
文摘This paper considers the problem of delay-dependent non-fragile H∞control for a class of linear systems with interval time-varying delay. Based on the direct Lyapunov method, an appropriate Lyapunov-Krasovskii functional(LKF) with triple-integral terms and augment terms is introduced. Then, by using the integral inequalities and convex combination technique, an improved H∞performance analysis criterion and non-fragile H∞controller are formulated in terms of linear matrix inequalities(LMIs), which can be easily solved by using standard numerical packages. At last, two numerical examples are provided to demonstrate the effectiveness of the obtained results.
基金This study was supported by the National Key R&D Program of China(nos.2017YFA0206904 and 2017YFA0206900)the National Natural Science Foundation of China(nos.21625303,21905287,51673206,and 21988102)+2 种基金the Beijing Natural Science Foundation(no.2194088)the Strategic Priority Research Program of the Chinese Academy of Science(no.XDA21010213)the Key Research Program of the Chinese Academy of Sciences(no.QYZDY-SSW-SLH014).
文摘Osmotic energy from the ocean,also called blue energy,serves as a clean,renewable,and vast energy source for the energy demands of the world.Reverse electrodialysis-based blue energy harvesting via ion-selective membranes,by the regulation and manipulation of directional ion transport,has been greatly developed recently.In particular,light has been employed to enhance directional ion transport for energy conversion through an increase in photo-induced surface charge.Here,the authors demonstrate a novel nanofluidic regulation strategy based on the phenomenon of light-induced heat-driven active ion transport through the lamellar MXene membrane.Due to the great light-induced heat effect,a temperature gradient appears as soon as illumination is applied to an off-center position,inducing an actively temperature gradient-driven ionic species transport.By employing this phenomenon,the authors conducted light-induced heat-enhanced osmotic energy conversion and doubled the osmotic energy conversion power density.This study has extended the scope of light-enhanced osmotic energy conversion and could further bring other photothermal materials into this field.Furthermore,the proposed system provides a new avenue of light-controlled ionic transport for ion gathering,desalination,and energy conversion applications.
基金We thank Yihui Xu and the service station of CAS key laboratory of infection and immunity for technical support during the revision of this manuscript.This work was supported by the National Key R&D Program of China(Nos.2017YFA0206904 and 2017YFA0206900)the National Natural Science Foundation of China(Nos.21625303,21905287,51673206,and 21988102)+2 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA21010213)Beijing Natural Science Foundation(No.2194088)the Key Research Program of the Chinese Academy of Sciences(No.QYZDY-SSW-SLH014).
文摘Biological ion channels, as fundamental units participating in various daily behaviors with incredible mass transportation and signal transmission, triggered booming researches on manufacturing their artificial prototypes. Biomimetic ion channel with the nanometer scale for smart responding functions has been successfully realized in sorts of materials by employing state-of-art nanotechnology. Ion track-etching technology, as crucial branches of fabricating solid-state nanochannels, exhibits outstanding advantages, such as easy fabrication, low cost, and high customization. To endow the nanochannel with smart responsibility, various modification methods are developed, including chemical grafting, non-covalent adsorption, and electrochemical deposition, enriching the reservoir of accessible stimuli-responses combinations, whereas were limited by their relatively lengthy and complex procedure. Here, based on the electric field induced self-assembly of polyelectrolytes, a universal customizable modifying strategy has been proposed, which exhibits superiorities in their functionalization with convenience and compatibility. By using this protocol, the channels’ ionic transport behaviors could be easily tuned, and even the specific ionic or molecular responding could be realized with superior performance. This strategy surely accelerates the nanochannels functionalization into fast preparing, high efficiency, and large-scale application scenarios.
基金financially supported by the Beijing Natural Science Foundation (No.2194088)the National Natural Science Foundation of China (Nos.21905287,21625303, 51673206,21988102,81972488,81701836)。
文摘Controlling ions transport across the membrane at different pH environments is essential for the physiological process and artificial systems.Many efforts have been devoted to pH-responsive ion gating,while rarely systems can maintain the rectification in pH-changing environments.Here,a composite nanochannel system is fabricated,which shows unidirectional rectification with high performance in a wide pH range.In the system,block copolymer(BCP) and polyethylene te rephthalate(PET) are employed for the amphoteric nanochannels fabrication.Based on the composite system,a model is built for the theoretical simulation.Thereafter,rectification mapping is conducted on the system,which can provide abundant info rmation about the relations between charge distribution and ions transport prope rties.The proposed rectification mapping can definitely help to design new materials with special ion transport properties,such as high-performance membranes used in the salinity gradient power generation field.
基金supported by the National Natural Science Foundation of China under Grant Nos.61903375,61673387 and 61773389the Natural Science Foundation of Shaanxi Province of China under Grant Nos.2020JM-356 and 2020JQ-298the Postdoctoral Science Foundation of China under Grant No.2019M663635.
文摘Principal/minor component analysis(PCA/MCA),generalized principal/minor component analysis(GPCA/GMCA),and singular value decomposition(SVD)algorithms are important techniques for feature extraction.In the convergence analysis of these algorithms,the deterministic discrete-time(DDT)method can reveal the dynamic behavior of PCA/MCA and GPCA/GMCA algorithms effectively.However,the dynamic behavior of SVD algorithms has not been studied quantitatively because of their special structure.In this paper,for the first time,we utilize the advantages of the DDT method in PCA algorithms analysis to study the dynamics of SVD algorithms.First,taking the cross-coupled Hebbian algorithm as an example,by concatenating the two cross-coupled variables into a single vector,we successfully get a PCA-like DDT system.Second,we analyze the discrete-time dynamic behavior and stability of the PCA-like DDT system in detail based on the DDT method,and obtain the boundedness of the weight vectors and learning rate.Moreover,further discussion shows the universality of the proposed method for analyzing other SVD algorithms.As a result,the proposed method provides a new way to study the dynamical convergence properties of SVD algorithms.
