Studies have confirmed that low-frequency repetitive transcranial magnetic stimulation can decrease the activity of cortical neurons, and high-frequency repetitive transcranial magnetic stimulation can increase the ex...Studies have confirmed that low-frequency repetitive transcranial magnetic stimulation can decrease the activity of cortical neurons, and high-frequency repetitive transcranial magnetic stimulation can increase the excitability of cortical neurons. However, there are few studies concerning the use of different frequencies of repetitive transcranial magnetic stimulation on the recovery of upper-limb motor function after cerebral infarction. We hypothesized that different frequencies of repetitive transcranial magnetic stimulation in patients with cerebral infarction would produce different effects on the recovery of upper-limb motor function. This study enrolled 127 patients with upper-limb dysfunction during the subacute phase of cerebral infarction. These patients were randomly assigned to three groups. The low-frequency group comprised 42 patients who were treated with 1 Hz repetitive transcranial magnetic stimulation on the contralateral hemisphere primary motor cortex （M1）. The high-frequency group comprised 43 patients who were treated with 10 Hz repetitive transcranial magnetic stimulation on ipsilateral M1. Finally, the sham group comprised 42 patients who were treated with 10 Hz of false stimulation on ipsilateral M1. A total of 135 seconds of stimulation was applied in the sham group and high-frequency group. At 2 weeks after treatment, cortical latency of motor-evoked potentials and central motor conduction time were significantly lower compared with before treatment. Moreover, motor function scores were significantly improved. The above indices for the low- and high-frequency groups were significantly different compared with the sham group. However, there was no significant difference between the low- and high-frequency groups. The results show that low- and high-frequency repetitive transcranial magnetic stimulation can similarly improve upper-limb motor function in patients with cerebral infarction.展开更多
MXene has shown distinctive advantages as anode materials of lithium-ion batteries. However, local surface chemistry, which was confirmed that can block ion transfer and limit redox reaction, has a significant effect ...MXene has shown distinctive advantages as anode materials of lithium-ion batteries. However, local surface chemistry, which was confirmed that can block ion transfer and limit redox reaction, has a significant effect on electrochemical performance. Herein, annealing MXene under hydrogen was employed for removing-F and turning-OH to-O terminations. We demonstrate that it improves the kinetics of Li-ion transport between the electrolyte and electrode. As a result, a lower interfacial charge transfer impedance was obtained. The electrochemical measurement exhibited that a nearly 2-fold increase of specific capacity was achieved for the annealed MXene.展开更多
AIM:To investigate the effect of hydrogen sulfide(H2S)on smooth muscle motility in the gastric fundus.METHODS:The expression of cystathionineβ-synthase(CBS)and cystathionineγ-lyase(CSE)in cultured smooth muscle cell...AIM:To investigate the effect of hydrogen sulfide(H2S)on smooth muscle motility in the gastric fundus.METHODS:The expression of cystathionineβ-synthase(CBS)and cystathionineγ-lyase(CSE)in cultured smooth muscle cells from the gastric fundus was examined by the immunocytochemistry technique.The tension of the gastric fundus smooth muscle was recorded by an isometric force transducer under the condition of isometric contraction with each end of the smooth muscle strip tied with a silk thread.Intracellular recording was used to identify whether hydrogen sulfide affects the resting membrane potential of the gastric fundus in vitro.Cells were freshly separated from the gastric fundus of mice using a variety of enzyme digestion methods and whole-cell patch-clamp technique was used to find the effects of hydrogen sulfide on voltage-dependent potassium channel and calcium channel.Calcium imaging with fura-3AM loading was used to investigate the mechanism by which hydrogen sulfide regulates gastric fundus motility in cultured smooth muscle cells.RESULTS:We found that both CBS and CSE were expressed in the cul tured smooth muscle cel ls from the gastric fundus and that H2S increased the smooth muscle tension of the gastric fundus in mice at low concentrations.In addition,nicardipine and aminooxyacetic acid(AOAA),a CBS inhibitor,reduced the tension,whereas Nω-nitro-L-arginine methyl ester,a nonspecific nitric oxide synthase,increased the tension.The AOAA-induced relaxation was significantly recovered by H2S,and the Na HS-induced increase in tonic contraction was blocked by 5 mmol/L4-aminopyridine and 1μmol/L nicardipine.Na HS significantly depolarized the membrane potential and inhibited the voltage-dependent potassium currents.Moreover,Na HS increased L-type Ca2+currents and caused an elevation in intracellular calcium([Ca2+]i).CONCLUSION:These findings suggest that H2S may be an excitatory modulator in the gastric fundus in mice.The excitatory effect is mediated by voltagedependent potassium and L-type calcium channels.展开更多
AIM: To investigate the relationship between neuronal nitric oxide synthase (nNOS) expression and the natriuretic peptide signaling pathway in the gastric fundus of streptozotocin (STZ)-induced diabetic mice.
Non-layered two-dimensional(2D)lead sulfide(PbS)has attracted growing interest recently due to its direct narrow bandgap(0.4 eV)and broad spectral detection from visible to mid-IR region,which lead to remarkable elect...Non-layered two-dimensional(2D)lead sulfide(PbS)has attracted growing interest recently due to its direct narrow bandgap(0.4 eV)and broad spectral detection from visible to mid-IR region,which lead to remarkable electronic and optoelectronic properties promising for real applications.We report the chemical vapor deposition growth of highly crystalline 2D PbS crystals on mica substrates.The high quality and uniformity of 2D PbS nanoplates are confirmed by atomic force microscopy,x-ray powder diffraction,transmission electron microscopy and x-ray photoelectron spectroscopy.The morphology and lateral size are controllable by different growth temperatures.Photodetectors made from 2D PbS nanoplates reveal good stability,high photoresponsivity,and fast response time,which indicates their promising applications for ultrathin optoelectronics.展开更多
Objective:To explore the therapeutic effect of the fire needling with the three-edged needle and the cupping on popliteal cyst.Methods:A total of 60 patients of popliteal cyst were divided into two groups,30 cases in ...Objective:To explore the therapeutic effect of the fire needling with the three-edged needle and the cupping on popliteal cyst.Methods:A total of 60 patients of popliteal cyst were divided into two groups,30 cases in each one according to the random number table.In the fire needling group,the burnt-red three-edged needle was inserted to the deep layer of the cyst.After the fluid was squeezed out,the cupping was exerted.The treatment was given 1 to 2 times a week,for 4 weeks totally.In the western medication group,prednisolone acetate 25 mg was injected in the cyst capsule,once a week,for 4 weeks totally.The effective rate,recurrence rate and Rauschning-Lindgren grading were evaluated before and after treatment.Results:The total effective rate was 80.0%in the fire needling group and was 83.3%in the western medication group,without statistical significance in comparison(P>0.05).The recurrence rate was 6.7%in the fire needling group and was 30%in the western medication group.The recurrence rate in the fire needling group was lower than that in the western medication group,indicating the statistical significance(P<0.05).After treatment,Rauschning-Lindgren grade was different statistically as compared with that before treatment in either group(both P<0.05).Rauschning-Lindgren grade was distributed in 0 to I in the fire needling group after treatment,which was different significantly as compared with the western medication group(P<0.05).Conclusion:The combined treatment with the fire needling combined with cupping therapy achieves the satisfactory effect on popliteal cyst and the very low recurrence rate and it is easy in operation and deserves to be promoted in primary care.展开更多
基金several colleague therapists of the Rehabilitation Medicine Department of the Affiliated Hospital of Qingdao University of China for their support and selfless help
文摘Studies have confirmed that low-frequency repetitive transcranial magnetic stimulation can decrease the activity of cortical neurons, and high-frequency repetitive transcranial magnetic stimulation can increase the excitability of cortical neurons. However, there are few studies concerning the use of different frequencies of repetitive transcranial magnetic stimulation on the recovery of upper-limb motor function after cerebral infarction. We hypothesized that different frequencies of repetitive transcranial magnetic stimulation in patients with cerebral infarction would produce different effects on the recovery of upper-limb motor function. This study enrolled 127 patients with upper-limb dysfunction during the subacute phase of cerebral infarction. These patients were randomly assigned to three groups. The low-frequency group comprised 42 patients who were treated with 1 Hz repetitive transcranial magnetic stimulation on the contralateral hemisphere primary motor cortex （M1）. The high-frequency group comprised 43 patients who were treated with 10 Hz repetitive transcranial magnetic stimulation on ipsilateral M1. Finally, the sham group comprised 42 patients who were treated with 10 Hz of false stimulation on ipsilateral M1. A total of 135 seconds of stimulation was applied in the sham group and high-frequency group. At 2 weeks after treatment, cortical latency of motor-evoked potentials and central motor conduction time were significantly lower compared with before treatment. Moreover, motor function scores were significantly improved. The above indices for the low- and high-frequency groups were significantly different compared with the sham group. However, there was no significant difference between the low- and high-frequency groups. The results show that low- and high-frequency repetitive transcranial magnetic stimulation can similarly improve upper-limb motor function in patients with cerebral infarction.
基金financial support provided by the National Key R&D Program of China (2016YFA0200400)the Jilin Province/Jilin University co-Construction Project-Funds for New Materials (SXGJSF2017-3, Branch-2/440050316A36)+4 种基金the National Natural Science Foundation of China (Grant nos. 91545119, 21761132025, 21773269 and 51372095)the Youth Innovation Promotion Association CAS (Grant no. 2015152)Strategic Priority Research Program of the Chinese Academy of Sciences Chinese Academy of Sciences (Grant nos. XDA09030103 and XDA09040203)the Program for JLU Science and Technology Innovative Research Team (JLUSTIRT)"Double-First Class" Discipline for Materials Science & Engineering
文摘MXene has shown distinctive advantages as anode materials of lithium-ion batteries. However, local surface chemistry, which was confirmed that can block ion transfer and limit redox reaction, has a significant effect on electrochemical performance. Herein, annealing MXene under hydrogen was employed for removing-F and turning-OH to-O terminations. We demonstrate that it improves the kinetics of Li-ion transport between the electrolyte and electrode. As a result, a lower interfacial charge transfer impedance was obtained. The electrochemical measurement exhibited that a nearly 2-fold increase of specific capacity was achieved for the annealed MXene.
基金Supported by National Natural Science Foundation of China,No.31171107,No.31071011 and No.31271236
文摘AIM:To investigate the effect of hydrogen sulfide(H2S)on smooth muscle motility in the gastric fundus.METHODS:The expression of cystathionineβ-synthase(CBS)and cystathionineγ-lyase(CSE)in cultured smooth muscle cells from the gastric fundus was examined by the immunocytochemistry technique.The tension of the gastric fundus smooth muscle was recorded by an isometric force transducer under the condition of isometric contraction with each end of the smooth muscle strip tied with a silk thread.Intracellular recording was used to identify whether hydrogen sulfide affects the resting membrane potential of the gastric fundus in vitro.Cells were freshly separated from the gastric fundus of mice using a variety of enzyme digestion methods and whole-cell patch-clamp technique was used to find the effects of hydrogen sulfide on voltage-dependent potassium channel and calcium channel.Calcium imaging with fura-3AM loading was used to investigate the mechanism by which hydrogen sulfide regulates gastric fundus motility in cultured smooth muscle cells.RESULTS:We found that both CBS and CSE were expressed in the cul tured smooth muscle cel ls from the gastric fundus and that H2S increased the smooth muscle tension of the gastric fundus in mice at low concentrations.In addition,nicardipine and aminooxyacetic acid(AOAA),a CBS inhibitor,reduced the tension,whereas Nω-nitro-L-arginine methyl ester,a nonspecific nitric oxide synthase,increased the tension.The AOAA-induced relaxation was significantly recovered by H2S,and the Na HS-induced increase in tonic contraction was blocked by 5 mmol/L4-aminopyridine and 1μmol/L nicardipine.Na HS significantly depolarized the membrane potential and inhibited the voltage-dependent potassium currents.Moreover,Na HS increased L-type Ca2+currents and caused an elevation in intracellular calcium([Ca2+]i).CONCLUSION:These findings suggest that H2S may be an excitatory modulator in the gastric fundus in mice.The excitatory effect is mediated by voltagedependent potassium and L-type calcium channels.
基金Supported by The National Natural Science Foundation of China,No.31071011No.31171107the Shanghai Natural Science Foundation,No.13ZR1423100
文摘AIM: To investigate the relationship between neuronal nitric oxide synthase (nNOS) expression and the natriuretic peptide signaling pathway in the gastric fundus of streptozotocin (STZ)-induced diabetic mice.
基金Supported by the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDA09040203)the National Natural Science Foundation of China(Grant No.11704389).
文摘Non-layered two-dimensional(2D)lead sulfide(PbS)has attracted growing interest recently due to its direct narrow bandgap(0.4 eV)and broad spectral detection from visible to mid-IR region,which lead to remarkable electronic and optoelectronic properties promising for real applications.We report the chemical vapor deposition growth of highly crystalline 2D PbS crystals on mica substrates.The high quality and uniformity of 2D PbS nanoplates are confirmed by atomic force microscopy,x-ray powder diffraction,transmission electron microscopy and x-ray photoelectron spectroscopy.The morphology and lateral size are controllable by different growth temperatures.Photodetectors made from 2D PbS nanoplates reveal good stability,high photoresponsivity,and fast response time,which indicates their promising applications for ultrathin optoelectronics.
文摘Objective:To explore the therapeutic effect of the fire needling with the three-edged needle and the cupping on popliteal cyst.Methods:A total of 60 patients of popliteal cyst were divided into two groups,30 cases in each one according to the random number table.In the fire needling group,the burnt-red three-edged needle was inserted to the deep layer of the cyst.After the fluid was squeezed out,the cupping was exerted.The treatment was given 1 to 2 times a week,for 4 weeks totally.In the western medication group,prednisolone acetate 25 mg was injected in the cyst capsule,once a week,for 4 weeks totally.The effective rate,recurrence rate and Rauschning-Lindgren grading were evaluated before and after treatment.Results:The total effective rate was 80.0%in the fire needling group and was 83.3%in the western medication group,without statistical significance in comparison(P>0.05).The recurrence rate was 6.7%in the fire needling group and was 30%in the western medication group.The recurrence rate in the fire needling group was lower than that in the western medication group,indicating the statistical significance(P<0.05).After treatment,Rauschning-Lindgren grade was different statistically as compared with that before treatment in either group(both P<0.05).Rauschning-Lindgren grade was distributed in 0 to I in the fire needling group after treatment,which was different significantly as compared with the western medication group(P<0.05).Conclusion:The combined treatment with the fire needling combined with cupping therapy achieves the satisfactory effect on popliteal cyst and the very low recurrence rate and it is easy in operation and deserves to be promoted in primary care.
