The Rural Minimum Living Standard Guarantee(Rural Dibao)is an important unconditional cash transfer program to alleviate poverty in rural China.Despite the importance of children’s nutrition in breaking poverty cycle...The Rural Minimum Living Standard Guarantee(Rural Dibao)is an important unconditional cash transfer program to alleviate poverty in rural China.Despite the importance of children’s nutrition in breaking poverty cycles,little is known about the impact of Rural Dibao on child nutrition outcomes.Using China Family Panel Studies(CFPS),this paper examines the effects of Rural Dibao on child nutrition outcomes and investigates potential pathways and heterogeneous effects.We exploit propensity score matching and difference-in-differences techniques to evaluate the effects of the Rural Dibao program on child nutrition outcomes.Our results suggest that Rural Dibao significantly impacts the nutrition outcomes of children up to 15 years of age.Specifically,our results suggest that Rural Dibao improves child height-to-age z-scores by 1.05 standard deviations and lowers the probability of stunting by 11.9 percentage points.Additional analyses suggest that increased protein intake is the main pathway through which Rural Dibao participation contributes to better nutrition outcomes.We also find that the effect of the program is more pronounced among girls,children who are non-left-behind or live with highly educated mothers,and those from low-income families and poor areas.Our findings suggest that Rural Dibao participation helps improve child nutrition outcomes through improving diet quality.展开更多
The impacts of dexamethasone(Dex)and thyroid hormone T3 on the insulin-stimulated Srebp-1c expression were studied in primary rat hepatocytes. Primary hepatocytes from Sprague-Dawley rats were isolated, cultured and t...The impacts of dexamethasone(Dex)and thyroid hormone T3 on the insulin-stimulated Srebp-1c expression were studied in primary rat hepatocytes. Primary hepatocytes from Sprague-Dawley rats were isolated, cultured and treated with insulin in the presence or absence of the indicated reagents over time. The mRNA levels of indicated genes were determined using real-time PCR. Insulin treatment induced the Srebp-1c expression and suppressed the Pck1 expression in a time-dependent manner. Dex treatment alone reduced the Srebp-1c expression, whereas potentiated the insulin-induced its expression, which reached to a level that was higher than the insulin alone group. On the other hand, insulin treatment completely suppressed the Dex-induced Pck1 expression in the same cells. T3 treatment did not affect the expressions of Srebp-1c and Pck1 alone or in the presence of absence of insulin or Dex. Interestingly, insulin treatment induced the Rxrg m RNA expression level in the absence or presence of T0901317, a specific agonist for the liver X receptor. Dex and insulin mutually affect each other's ability to regulate the expression levels of hepatic genes involved in glucose and fatty acid metabolism. Insulin induced Rxrg expression in primary hepatocytes, which may contribute to the induction of Srebp-1c expression in the same cells.展开更多
Introduction: Parkinson’s Disease (PD) is a devastating neurodegenerative disease that significantly influences motor performance. Recent studies suggest expressive language deficits may also exist among individuals ...Introduction: Parkinson’s Disease (PD) is a devastating neurodegenerative disease that significantly influences motor performance. Recent studies suggest expressive language deficits may also exist among individuals with PD even though the condition is primarily known for changes in motor skills. The purpose of this pilot study was to examine the influence of early stage PD on global coherence or the ability to maintain consistency of a theme or topic. Methods: Discourse samples were collected from eleven individuals with PD and compared to eleven matched controls to examine measures of global coherence. Two-minute speech samples describing a “typical day” were transcribed and rated on mean global coherence and percentage high global coherence. Results: Greater declines in global coherence were observed among individuals with PD, however, comparisons of both mean global coherence ratings and percentage high global coherence were not statistically significant between the two groups. A significant downward linear trend was observed for both mean global coherence ratings and percentage high coherence among all participants indicating decreases in global coherence over time. Conclusion: Approaches to the study of global coherence as a measure of expressive language performance should consider the temporal changes especially among neurological conditions known to reduce expressive language ability.展开更多
Sepsis,a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection,is a leading contributor to mortality in intensive care units.Sepsis-related deaths have been reported to accou...Sepsis,a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection,is a leading contributor to mortality in intensive care units.Sepsis-related deaths have been reported to account for 19.7%of all global deaths.However,no effective and specific therapeutic for clinical sepsis management is available due to the complex pathogenesis.Concurrently eliminating infections and restoring immune homeostasis are regarded as the core strategies to manage sepsis.Sophisticated nanoplatforms guided by supramolecular and medicinal chemistry,targeting infection and/or imbalanced immune responses,have emerged as potent tools to combat sepsis by supporting more accurate diagnosis and precision treatment.Nanoplatforms can overcome the barriers faced by clinical strategies,including delayed diagnosis,drug resistance and incapacity to manage immune disorders.Here,we present a comprehensive review highlighting the pathogenetic characteristics of sepsis and future therapeutic concepts,summarizing the progress of these well-designed nanoplatforms in sepsis management and discussing the ongoing challenges and perspectives regarding future potential therapies.Based on these state-of-the-art studies,this review will advance multidisciplinary collaboration and drive clinical translation to remedy sepsis.展开更多
In two articles published in Science online in September 2020,Zhang et al.[1]and Bastard et al.[2]elucidated a key factor in the progression to severe COVID-19;namely,a deficiency in interferon,especially type I inter...In two articles published in Science online in September 2020,Zhang et al.[1]and Bastard et al.[2]elucidated a key factor in the progression to severe COVID-19;namely,a deficiency in interferon,especially type I interferon(IFN D).This deficiency might be caused by diverse reasons such as genetic mutations of genes encoding key antiviral signaling molecules,or the'neutralization'of IFN I by endogenous antibodies.How does IFN I deficiency cause severe,life-threatening COVID-19?The most straightforward explanation is that such deficiency allows uncontrolled virus replication and spread.IFN I deficiency may also have other impacts on immune system function.Individuals with mutations in the IFN-I-induced signaling pathways may benefit from interferon therapies.In addition,individuals with neutralizing antibodies against IFN-a and IFN-C may also benefit from other types of interferons provided in the therapy,such as IFN-β and IFN-λ.展开更多
基金The authors are grateful for support from the National Social Science Fund of China(21AJL015).
文摘The Rural Minimum Living Standard Guarantee(Rural Dibao)is an important unconditional cash transfer program to alleviate poverty in rural China.Despite the importance of children’s nutrition in breaking poverty cycles,little is known about the impact of Rural Dibao on child nutrition outcomes.Using China Family Panel Studies(CFPS),this paper examines the effects of Rural Dibao on child nutrition outcomes and investigates potential pathways and heterogeneous effects.We exploit propensity score matching and difference-in-differences techniques to evaluate the effects of the Rural Dibao program on child nutrition outcomes.Our results suggest that Rural Dibao significantly impacts the nutrition outcomes of children up to 15 years of age.Specifically,our results suggest that Rural Dibao improves child height-to-age z-scores by 1.05 standard deviations and lowers the probability of stunting by 11.9 percentage points.Additional analyses suggest that increased protein intake is the main pathway through which Rural Dibao participation contributes to better nutrition outcomes.We also find that the effect of the program is more pronounced among girls,children who are non-left-behind or live with highly educated mothers,and those from low-income families and poor areas.Our findings suggest that Rural Dibao participation helps improve child nutrition outcomes through improving diet quality.
基金the Scientific Research Project of Wuhan Municipal Health Commission for research support to Y. Zhang (WX19Y09)。
文摘The impacts of dexamethasone(Dex)and thyroid hormone T3 on the insulin-stimulated Srebp-1c expression were studied in primary rat hepatocytes. Primary hepatocytes from Sprague-Dawley rats were isolated, cultured and treated with insulin in the presence or absence of the indicated reagents over time. The mRNA levels of indicated genes were determined using real-time PCR. Insulin treatment induced the Srebp-1c expression and suppressed the Pck1 expression in a time-dependent manner. Dex treatment alone reduced the Srebp-1c expression, whereas potentiated the insulin-induced its expression, which reached to a level that was higher than the insulin alone group. On the other hand, insulin treatment completely suppressed the Dex-induced Pck1 expression in the same cells. T3 treatment did not affect the expressions of Srebp-1c and Pck1 alone or in the presence of absence of insulin or Dex. Interestingly, insulin treatment induced the Rxrg m RNA expression level in the absence or presence of T0901317, a specific agonist for the liver X receptor. Dex and insulin mutually affect each other's ability to regulate the expression levels of hepatic genes involved in glucose and fatty acid metabolism. Insulin induced Rxrg expression in primary hepatocytes, which may contribute to the induction of Srebp-1c expression in the same cells.
文摘Introduction: Parkinson’s Disease (PD) is a devastating neurodegenerative disease that significantly influences motor performance. Recent studies suggest expressive language deficits may also exist among individuals with PD even though the condition is primarily known for changes in motor skills. The purpose of this pilot study was to examine the influence of early stage PD on global coherence or the ability to maintain consistency of a theme or topic. Methods: Discourse samples were collected from eleven individuals with PD and compared to eleven matched controls to examine measures of global coherence. Two-minute speech samples describing a “typical day” were transcribed and rated on mean global coherence and percentage high global coherence. Results: Greater declines in global coherence were observed among individuals with PD, however, comparisons of both mean global coherence ratings and percentage high global coherence were not statistically significant between the two groups. A significant downward linear trend was observed for both mean global coherence ratings and percentage high coherence among all participants indicating decreases in global coherence over time. Conclusion: Approaches to the study of global coherence as a measure of expressive language performance should consider the temporal changes especially among neurological conditions known to reduce expressive language ability.
基金the National Key Research and Development Program of China(Grant No.2018YFC2001904).
文摘Sepsis,a highly life-threatening organ dysfunction caused by uncontrollable immune responses to infection,is a leading contributor to mortality in intensive care units.Sepsis-related deaths have been reported to account for 19.7%of all global deaths.However,no effective and specific therapeutic for clinical sepsis management is available due to the complex pathogenesis.Concurrently eliminating infections and restoring immune homeostasis are regarded as the core strategies to manage sepsis.Sophisticated nanoplatforms guided by supramolecular and medicinal chemistry,targeting infection and/or imbalanced immune responses,have emerged as potent tools to combat sepsis by supporting more accurate diagnosis and precision treatment.Nanoplatforms can overcome the barriers faced by clinical strategies,including delayed diagnosis,drug resistance and incapacity to manage immune disorders.Here,we present a comprehensive review highlighting the pathogenetic characteristics of sepsis and future therapeutic concepts,summarizing the progress of these well-designed nanoplatforms in sepsis management and discussing the ongoing challenges and perspectives regarding future potential therapies.Based on these state-of-the-art studies,this review will advance multidisciplinary collaboration and drive clinical translation to remedy sepsis.
文摘In two articles published in Science online in September 2020,Zhang et al.[1]and Bastard et al.[2]elucidated a key factor in the progression to severe COVID-19;namely,a deficiency in interferon,especially type I interferon(IFN D).This deficiency might be caused by diverse reasons such as genetic mutations of genes encoding key antiviral signaling molecules,or the'neutralization'of IFN I by endogenous antibodies.How does IFN I deficiency cause severe,life-threatening COVID-19?The most straightforward explanation is that such deficiency allows uncontrolled virus replication and spread.IFN I deficiency may also have other impacts on immune system function.Individuals with mutations in the IFN-I-induced signaling pathways may benefit from interferon therapies.In addition,individuals with neutralizing antibodies against IFN-a and IFN-C may also benefit from other types of interferons provided in the therapy,such as IFN-β and IFN-λ.
