Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals,including dogs and cats.Obesity occurs with multiple comorbidities,such as diabetes,hypertension,heart d...Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals,including dogs and cats.Obesity occurs with multiple comorbidities,such as diabetes,hypertension,heart disease and osteoarthritis in dogs and cats.A direct link between lipid metabolism dysregulation and obesity-associated diseases has been implicated.However,the understanding of such pathophysiology in companion animals is lim-ited.This review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity,emphasizing the involvement of the gut microbiota.Furthermore,we also discuss the management of obesity,including approaches like nutritional interventions,thus providing novel insights into obesity prevention and treatment for canines and felines.展开更多
Chrysanthemum Fusarium wilt is a soil-borne disease that causes serious economic losses to the chrysanthemum industry.However,the molecular mechanism underlying the response of chrysanthemum WRKY to Fusarium oxysporum...Chrysanthemum Fusarium wilt is a soil-borne disease that causes serious economic losses to the chrysanthemum industry.However,the molecular mechanism underlying the response of chrysanthemum WRKY to Fusarium oxysporum infection remains largely unknown.In this study,we isolated CmWRKY6–1 from chrysanthemum‘Jinba’and identified it as a transcriptional repressor localized in the nucleus via subcellular localization and transcriptional activation assays.We found that CmWRKY6–1 negatively regulated resistance to F.oxysporum and affected reactive oxygen species(ROS)and salicylic acid(SA)pathways using transgenic experiments and transcriptomic analysis.Moreover,CmWRKY6–1 bound to the W-box element on the CmWRKY15-like promoter and inhibited its expression.Additionally,we observed that CmWRKY15-like silencing in chrysanthemum reduced its resistance to F.oxysporum via transgenic experiments.In conclusion,we revealed the mechanism underlying the CmWRKY6–1–CmWRKY15-like cascade response to F.oxysporum infection in chrysanthemum and demonstrated that CmWRKY6–1 and CmWRKY15-like regulates the immune system.展开更多
Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard ...Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase(GOx) and carboxylated cisplatin(Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide(NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment.展开更多
Dear Editor,Dogs were long considered refractory to influenza viruses until the equine-origin H3N8 canine influenza virus(CIV)was first isolated in the United States of America(U.S.A)in 2004(Crawford et al.2005).Since...Dear Editor,Dogs were long considered refractory to influenza viruses until the equine-origin H3N8 canine influenza virus(CIV)was first isolated in the United States of America(U.S.A)in 2004(Crawford et al.2005).Since then,H3N8 CIV of equine-origin strains has been circulating in dogs in the U.S.A.In 2006,another CIV of avian origin H3N2 subtype was isolated from dogs in China(Li et al.2010).Recently,H3N2 CIV strains have become endemic in dog populations in China,South Korea,and North America(Borland et al.2020).展开更多
基金funded by research grants from the Jiangsu Provincial Double-Innovation Team Program(JSSCTD202147)Nutrition and Care of Maternal and Child Research Fund Project of the Biostime Institute of Nutrition and Care(Grant No.2022BINCMCF006)+1 种基金the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_3527)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Obesity is a prevalent chronic disease that has significant negative impacts on humans and our companion animals,including dogs and cats.Obesity occurs with multiple comorbidities,such as diabetes,hypertension,heart disease and osteoarthritis in dogs and cats.A direct link between lipid metabolism dysregulation and obesity-associated diseases has been implicated.However,the understanding of such pathophysiology in companion animals is lim-ited.This review aims to address the role of lipid metabolism in various metabolic disorders associated with obesity,emphasizing the involvement of the gut microbiota.Furthermore,we also discuss the management of obesity,including approaches like nutritional interventions,thus providing novel insights into obesity prevention and treatment for canines and felines.
基金This research was supported by National Natural Science Foundation of China(32072603)China Agriculture Research System(CARS-23-A18)+1 种基金The JBGS Project of Seed Industry Revitalization in Jiangsu Province[JBGS(2021)094]Jiangsu Agriculture Science and Technology Innovation Fund[CX(22)2033].
文摘Chrysanthemum Fusarium wilt is a soil-borne disease that causes serious economic losses to the chrysanthemum industry.However,the molecular mechanism underlying the response of chrysanthemum WRKY to Fusarium oxysporum infection remains largely unknown.In this study,we isolated CmWRKY6–1 from chrysanthemum‘Jinba’and identified it as a transcriptional repressor localized in the nucleus via subcellular localization and transcriptional activation assays.We found that CmWRKY6–1 negatively regulated resistance to F.oxysporum and affected reactive oxygen species(ROS)and salicylic acid(SA)pathways using transgenic experiments and transcriptomic analysis.Moreover,CmWRKY6–1 bound to the W-box element on the CmWRKY15-like promoter and inhibited its expression.Additionally,we observed that CmWRKY15-like silencing in chrysanthemum reduced its resistance to F.oxysporum via transgenic experiments.In conclusion,we revealed the mechanism underlying the CmWRKY6–1–CmWRKY15-like cascade response to F.oxysporum infection in chrysanthemum and demonstrated that CmWRKY6–1 and CmWRKY15-like regulates the immune system.
基金supported by the National Natural Science Foundation of China(22175096,22275095)the Social Development Project of Jiangsu Natural Science Foundation(BE2019744)+3 种基金the Qinglan Project Foundation of Colleges and Universities of Jiangsu Provincethe Jiangsu Collaborative Innovation Center of Biomedical Functional Materialsthe Priority Academic Program Development of Jiangsu Higher Education Institutionthe Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX22_1545)。
文摘Glioblastoma(GBM) is the most aggressive malignant brain tumor. Due to the infiltration and heterogeneity of GBM, the obstruction of the blood-brain barrier(BBB) and the unique immunosuppressive mechanism, it is hard to achieve significant effects of GBM treatment. Here, a kind of chemotactic nanomotor that loaded with glucose oxidase(GOx) and carboxylated cisplatin(Pt(IV)) prodrug on the L-arginine-derived polymer is proposed. The nanomotors are driven by catalysis of glucose decomposition and the positive chemotaxis towards the GBM microenvironment where inducible nitric oxide synthase and reactive oxygen species are highly expressed. This facilitates the BBB crossing and GBM targeting of the nanomotors. In addition, the released nitric oxide(NO) during propulsion as well as the loaded GOx and Pt(IV) can exert combined NO/starvation/chemotherapy. Meanwhile, it is able to induce and enhance the immune response through multiple pathways, thus better coping with the complexities of GBM treatment.
基金supported in part by the National Natural Science Foundation of China(31802204,31872454)the Natural Science Foundation of Guangdong Province,China(2018B030311037,2018A030313633)。
文摘Dear Editor,Dogs were long considered refractory to influenza viruses until the equine-origin H3N8 canine influenza virus(CIV)was first isolated in the United States of America(U.S.A)in 2004(Crawford et al.2005).Since then,H3N8 CIV of equine-origin strains has been circulating in dogs in the U.S.A.In 2006,another CIV of avian origin H3N2 subtype was isolated from dogs in China(Li et al.2010).Recently,H3N2 CIV strains have become endemic in dog populations in China,South Korea,and North America(Borland et al.2020).
