Carbohydrates have gained a lot of appreciation in the past few decades due to their important roles in numerous biological events.Acquiring a structurally well-defined carbohydrate compound is essential for the under...Carbohydrates have gained a lot of appreciation in the past few decades due to their important roles in numerous biological events.Acquiring a structurally well-defined carbohydrate compound is essential for the understanding of its functions.Although some innovative methods have been developed for the synthesis of complex oligosaccharides,glycan synthesis is in general still a time-consuming and difficult work.Herein,we will introduce the preactivation-based glycosylation strategy,which is an efficient protocol independent of the reactivity of glycosyl donor.This review will focus on summarizing the versatile applications of preactivation strategy in stereoselective glycosylation and one-pot assembly of biologically important oligosaccharides and even polysaccharides。展开更多
基金the National Key Research and Development Program of China(Grant No.2018YFA0507602)the National Natural Science Foundation of China(Grant Nos.81821004,21738001)the National Science and Technology Major Project of China(Grant No.2019ZX09301106).
文摘Carbohydrates have gained a lot of appreciation in the past few decades due to their important roles in numerous biological events.Acquiring a structurally well-defined carbohydrate compound is essential for the understanding of its functions.Although some innovative methods have been developed for the synthesis of complex oligosaccharides,glycan synthesis is in general still a time-consuming and difficult work.Herein,we will introduce the preactivation-based glycosylation strategy,which is an efficient protocol independent of the reactivity of glycosyl donor.This review will focus on summarizing the versatile applications of preactivation strategy in stereoselective glycosylation and one-pot assembly of biologically important oligosaccharides and even polysaccharides。
