To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of th...To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement.展开更多
This research explored the application potential of PUM thin-overlay technology on airport rapid maintenance.The rapid curing process of polyurethane binder determines the limited time window for mixing and constructi...This research explored the application potential of PUM thin-overlay technology on airport rapid maintenance.The rapid curing process of polyurethane binder determines the limited time window for mixing and construction of polyurethane-bonded mixture(PUM),which presents significant difference with hot-mix asphalt(HMA)technology.Therefore,this research investigated and optimized the mix design of PUM for airport thin-overlay technology based on its thermosetting characteristics.First,limestone and basalt were comprehensively compared as an aggregate for PUM.Then,the effects of molding and curing conditions were studied in terms of mixing time,molding method,molding parameters and curing temperature.Statistical analysis was also conducted to evaluate the effects of gradation and particle size on PUM performances based on gray relational analysis(GRA),thus determining the key particle size to control PUM performances.Finally,the internal structural details of PUM were captured by X-ray CT scan test.The results demonstrated that it only took 12 hours to reach 75%of maximum strength at a curing temperature of 50°C,indicating an efficient curing process and in turn allowing short traffic delay.The internal structural details of PUM presented distribution of tiny pores with few connective voids,guaranteeing waterproof property and high strength.展开更多
基金supported by grants from the National Key Research and Development Program of China(2016YFC1306700 to ZJZ,2016YFC1306704 to HXZ)the National Natural Science Key Foundation of China(81830040 to ZJZ)+2 种基金Science and Technology Program of Guangdong(2018B030334001 to ZJZ)Program of Excellent Talents in Medical Science of Jiangsu Province(JCRCA2016006 to ZJZ)the Program for Innovative Research Team in Science and Technology in University of Henan Province(18IRTSTHN025 to HXZ)。
文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement.
基金This study was supported by the National Natural Science Foundation of China under Grant number of 51861145402.
文摘This research explored the application potential of PUM thin-overlay technology on airport rapid maintenance.The rapid curing process of polyurethane binder determines the limited time window for mixing and construction of polyurethane-bonded mixture(PUM),which presents significant difference with hot-mix asphalt(HMA)technology.Therefore,this research investigated and optimized the mix design of PUM for airport thin-overlay technology based on its thermosetting characteristics.First,limestone and basalt were comprehensively compared as an aggregate for PUM.Then,the effects of molding and curing conditions were studied in terms of mixing time,molding method,molding parameters and curing temperature.Statistical analysis was also conducted to evaluate the effects of gradation and particle size on PUM performances based on gray relational analysis(GRA),thus determining the key particle size to control PUM performances.Finally,the internal structural details of PUM were captured by X-ray CT scan test.The results demonstrated that it only took 12 hours to reach 75%of maximum strength at a curing temperature of 50°C,indicating an efficient curing process and in turn allowing short traffic delay.The internal structural details of PUM presented distribution of tiny pores with few connective voids,guaranteeing waterproof property and high strength.
