Four new monoterpenoid indole alkaloids,bousmekines A-D(1-4),and one new pyranopyridine alkaloid,bousmekine E(5),were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis.Their stru...Four new monoterpenoid indole alkaloids,bousmekines A-D(1-4),and one new pyranopyridine alkaloid,bousmekine E(5),were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis.Their structures including absolute configurations were elucidated by a combination of MS,NMR,ECD calculation,and single-crystal X-ray diffraction analysis.Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety.Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC50 values of 0.8-7.4μM.展开更多
基金This work was financially supported by Yunnan Applied Basic Research Projects(2018FA049)Top Young Talent of the Ten Thousand Talents Program of Yunnan(to Y.Zhang).
文摘Four new monoterpenoid indole alkaloids,bousmekines A-D(1-4),and one new pyranopyridine alkaloid,bousmekine E(5),were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis.Their structures including absolute configurations were elucidated by a combination of MS,NMR,ECD calculation,and single-crystal X-ray diffraction analysis.Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety.Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC50 values of 0.8-7.4μM.
