BACKGROUND We invented Endoscopic Ruler,a new endoscopic device to measure the size of varices in patients with cirrhosis and portal hypertension.AIM To assess the feasibility and safety of Endoscopic Ruler,and evalua...BACKGROUND We invented Endoscopic Ruler,a new endoscopic device to measure the size of varices in patients with cirrhosis and portal hypertension.AIM To assess the feasibility and safety of Endoscopic Ruler,and evaluate the agreement on identifying large oesophageal varices(OV)between Endoscopic Ruler and the endoscopists,as well as the interobserver agreement on diagnosing large OV using Endoscopic Ruler.METHODS We prospectively and consecutively enrolled patients with cirrhosis from 11 hospitals,all of whom got esophagogastroduodenoscopy(EGD)with Endoscopic Ruler.The primary study outcome was a successful measurement of the size of varices using Endoscopic Ruler.The secondary outcomes included adverse events,operation time,the agreement of identifying large OV between the objective measurement of Endoscopic Ruler and the empirical reading of endoscopists,together with the interobserver agreement on diagnosing large OV by Endoscopic Ruler.RESULTS From November 2020 to April 2022,a total of 120 eligible patients with cirrhosis were recruited and all of them underwent EGD examinations with Endoscopic Ruler successfully without any adverse event.The median operation time of Endoscopic Ruler was 3.00 min[interquartile range(IQR):3.00 min].The kappa value between Endoscopic Ruler and the endoscopists while detecting large OV was 0.52,demonstrating a moderate agreement.The kappa value for diagnosing large OV using Endoscopic Ruler among the six independent observers was 0.77,demonstrating a substantial agreement.CONCLUSION The data demonstrates that Endoscopic Ruler is feasible and safe for measuring the size of varices in patients with cirrhosis and portal hypertension.Endoscopic Ruler is potential to promote the clinical practice of the two-grade classification system of OV.展开更多
Abstract The effects of mass asymmetry on the production of superheavy nuclei(SHN),within the dinuclear system model,are investigated in this study.It is observed that the fusion probability decreases with decreasing ...Abstract The effects of mass asymmetry on the production of superheavy nuclei(SHN),within the dinuclear system model,are investigated in this study.It is observed that the fusion probability decreases with decreasing mass asymmetry.A total of 192 possible combinations of projectiles from O to Ti and targets with half-lives longer than30 days for producing SHN^(264)Db,^(265)Db,^(267)Sg,^(268)Bh,268Sg,^(269)Bh,^(271)Hs,^(271)Mt,^(272)Hs,^(272)Mt,^(273)Mt,^(274)Ds,275Ds,^(275)Rg,^(276)Ds,^(276)Rg,^(277)Rg,^(278)Cn,^(279)Cn,and^(280)Cn are examined.Further,the optimal combinations and incident energies for synthesizing these nuclei are predicted.Most of the cross sections for production of SHNare larger than 10 pb;therefore,the process can be carried out with the available experimental equipment.展开更多
INTRODUCTIONRotator cuffinjuries are common in all athletic. Of all rotator cuff injuries, the supraspinatus tendon involves mostly. Severe supraspinatus tendon injury may affect the patient＇s quality of life. Howeve...INTRODUCTIONRotator cuffinjuries are common in all athletic. Of all rotator cuff injuries, the supraspinatus tendon involves mostly. Severe supraspinatus tendon injury may affect the patient＇s quality of life. However, supraspinatus tendon injury can be relatively asymptomatic in some cases and may require sonographic examination for diagnosis, With continued improvement in shoulder arthroscopy, surgical treatment for supraspinatus tendon injury has become more effective and less invasive.展开更多
基金This study is registered at https://www.clinicaltrials.gov/.The registration identification number is NCT04639323.
文摘BACKGROUND We invented Endoscopic Ruler,a new endoscopic device to measure the size of varices in patients with cirrhosis and portal hypertension.AIM To assess the feasibility and safety of Endoscopic Ruler,and evaluate the agreement on identifying large oesophageal varices(OV)between Endoscopic Ruler and the endoscopists,as well as the interobserver agreement on diagnosing large OV using Endoscopic Ruler.METHODS We prospectively and consecutively enrolled patients with cirrhosis from 11 hospitals,all of whom got esophagogastroduodenoscopy(EGD)with Endoscopic Ruler.The primary study outcome was a successful measurement of the size of varices using Endoscopic Ruler.The secondary outcomes included adverse events,operation time,the agreement of identifying large OV between the objective measurement of Endoscopic Ruler and the empirical reading of endoscopists,together with the interobserver agreement on diagnosing large OV by Endoscopic Ruler.RESULTS From November 2020 to April 2022,a total of 120 eligible patients with cirrhosis were recruited and all of them underwent EGD examinations with Endoscopic Ruler successfully without any adverse event.The median operation time of Endoscopic Ruler was 3.00 min[interquartile range(IQR):3.00 min].The kappa value between Endoscopic Ruler and the endoscopists while detecting large OV was 0.52,demonstrating a moderate agreement.The kappa value for diagnosing large OV using Endoscopic Ruler among the six independent observers was 0.77,demonstrating a substantial agreement.CONCLUSION The data demonstrates that Endoscopic Ruler is feasible and safe for measuring the size of varices in patients with cirrhosis and portal hypertension.Endoscopic Ruler is potential to promote the clinical practice of the two-grade classification system of OV.
基金supported by the National Natural Science Foundation of China under Grant No.11605296the Natural Science Foundation of Guangdong Province,China(Grant No.2016A030310208)the National Natural Science Foundation of China under Grant Nos.11875328,11405278 and 11605270
文摘Abstract The effects of mass asymmetry on the production of superheavy nuclei(SHN),within the dinuclear system model,are investigated in this study.It is observed that the fusion probability decreases with decreasing mass asymmetry.A total of 192 possible combinations of projectiles from O to Ti and targets with half-lives longer than30 days for producing SHN^(264)Db,^(265)Db,^(267)Sg,^(268)Bh,268Sg,^(269)Bh,^(271)Hs,^(271)Mt,^(272)Hs,^(272)Mt,^(273)Mt,^(274)Ds,275Ds,^(275)Rg,^(276)Ds,^(276)Rg,^(277)Rg,^(278)Cn,^(279)Cn,and^(280)Cn are examined.Further,the optimal combinations and incident energies for synthesizing these nuclei are predicted.Most of the cross sections for production of SHNare larger than 10 pb;therefore,the process can be carried out with the available experimental equipment.
文摘INTRODUCTIONRotator cuffinjuries are common in all athletic. Of all rotator cuff injuries, the supraspinatus tendon involves mostly. Severe supraspinatus tendon injury may affect the patient＇s quality of life. However, supraspinatus tendon injury can be relatively asymptomatic in some cases and may require sonographic examination for diagnosis, With continued improvement in shoulder arthroscopy, surgical treatment for supraspinatus tendon injury has become more effective and less invasive.
