BACKGROUND Pulmonary mucoepidermoid carcinoma(PMEC)is a rare malignancy that arises from minor salivary glands within the tracheobronchial tree.The clear cell variant of PMEC is exceptionally uncommon and presents not...BACKGROUND Pulmonary mucoepidermoid carcinoma(PMEC)is a rare malignancy that arises from minor salivary glands within the tracheobronchial tree.The clear cell variant of PMEC is exceptionally uncommon and presents notable diagnostic challenges,primarily attributable to its morphological similarity to other tumors containing clear cells.CASE SUMMARY A 22-year-old male,formerly in good health,came in with a two-month duration of persistent cough and production of sputum.Subsequent imaging and bronchoscopy examinations revealed a 2 cm tumor in the distal left main bronchus,which resulted in complete atelectasis of the left lung.Further assessment via positron emission tomography/computed tomography scans and endoscopic biopsy confirmed the primary malignant nature of the tumor,charac-terized by clear cell morphology in most of the tumor cells.The patient underwent a left lower lobe sleeve resection accompanied by systematic mediastinal lymph node dissection.Molecular pathology analysis subsequently revealed a CRTC3-MAML2 gene fusion,leading to a definitive pathological diagnosis of the clear cell variant of PMEC,staged as T2N0M0.After surgery,the patient experienced a smooth recovery and exhibited no signs of recurrence during the one-and-a-half-year follow-up period.CONCLUSION This article describes an unusual case of a clear cell variant of PMEC characterized by the presence of a CRTC3-MAML2 gene fusion in a 22-year-old male.The patient underwent successful left lower lobe sleeve resection.This case underscores the distinctive challenges associated with diagnosing and treating this uncommon malignancy,underscoring the importance of precise diagnosis and personalized treatment strategies.展开更多
BACKGROUND Pulmonary mucormycosis is a rare but life-threatening invasive fungal infection that mostly affects immunocompromised patients.This disease usually develops acutely and progresses rapidly,often leading to a...BACKGROUND Pulmonary mucormycosis is a rare but life-threatening invasive fungal infection that mostly affects immunocompromised patients.This disease usually develops acutely and progresses rapidly,often leading to a poor clinical prognosis.Chronic pulmonary mucormycosis is highly unusual in immunocompetent patients.CASE SUMMARY A 43-year-old man,who was a house improvement worker with a long history of occupational dust exposure,presented with an irritating cough that had lasted for two months.The patient was previously in good health,without dysglycemia or any known immunodeficiencies.Chest computed tomography revealed a mass in the left lower lobe,measuring approximately 6 cm in diameter,which was suspected to be primary lung carcinoma complicated with obstructive pneumonia.Thoracoscopic-assisted left lower lobectomy was performed,and metagenomic next-generation sequencing detection,along with special pathological staining of surgical specimens,suggested Rhizopus microsporus infection.Postoperatively,the patient’s respiratory symptoms were relieved,and no signs of recurrence were found during the six-month follow-up.CONCLUSION This article reports a rare case of chronic pulmonary mucormycosis caused by Rhizopus microsporus in a middle-aged male without dysglycemia or immunodeficiency.The patient’s surgical outcome was excellent,reaffirming that surgery remains the cornerstone of pulmonary mucormycosis treatment.展开更多
Background:Oral ulcer is the most common and easily recurrent disease in stomatology,which influence the patients’communication,normal dietary,and sleep.Evodia rutaecarpa(ER)is a traditional Chinese herbal medicine r...Background:Oral ulcer is the most common and easily recurrent disease in stomatology,which influence the patients’communication,normal dietary,and sleep.Evodia rutaecarpa(ER)is a traditional Chinese herbal medicine recorded in ancient Chinese medical books,which has a medicinal history of more than 2,000 years.Clinically,the application of ER at plantar Yongquan point(KI1)is effective in the treatment of oral ulcer.The purpose of this study was to combine the modern transdermal drug delivery system with traditional Chinese medicine to develop the transdermal absorption patch of ER and apply it to the treatment of oral ulcer at Yongquan point of plantar.Methods:Firstly,the medicinal materials of ER were extracted and the extracted materials were prepared into dispersed ER patch.The formulation and preparation process were screened by orthogonal design method and single factor investigation method.The adhesive and transdermal properties of the patch were used as the evaluation index of the preparation.Secondly,Wistar rats were used as experimental animals to establish a rat model of mouth ulcers.Wistar rats were randomly divided into normal group,model group(A),model group(B),low dose group,medium dose group and high dose group.the efficacy of ER on rat’s oral ulcer model was evaluated through three aspect such as apparent index,pathological index and biochemical index.Results:The patch had suitable adhesion and good skin penetration,which was an effective treatment for oral ulcer.In vivo pharmacodynamic studies,compared with the normal group,the body mass and food intake of rats in each group after modeling decreased,the amount of drinking water increased,the tissue structure of oral mucosa was damaged,and the levels of inflammatory factors(TNF-α,IL-6)and malondialdehyde increased,the levels of anti-inflammatory factors(IL-10),cell growth factor(epidermal growth factor,TGF-β_(1))and superoxide dismutase decreased.Compared with the model group,the body weight and food intake of each dosing group increased,water consumption decreased,the oral mucosal tissue structure was more complete,the levels of TNF-α,IL-6 and malondialdehyde decreased,the levels of IL-10,epidermal growth factor,TGF-β1 and superoxide dismutase increased,and the changes of various indexes were dose-related.Conclusion:ER patch can inhibit inflammatory reaction,enhance the antioxidant defense ability of the body,and promote the repair of damaged oral mucosa,so as to play an effective role in the treatment of oral ulcer.展开更多
Because of the continuous improvement of the quality of life,the population of gout patients is also increasing,which seriously affects the quality of life of patients.Traditional Chinese medicine compound has a long ...Because of the continuous improvement of the quality of life,the population of gout patients is also increasing,which seriously affects the quality of life of patients.Traditional Chinese medicine compound has a long history and remarkable clinical effect in treating gout patients,and has been widely used.Intestinal flora and its metabolites are the focus of current research,which can promote intestinal mucosal barrier,improve immunity and improve metabolism.The regulation of intestinal flora can reduce serum uric acid and inhibit inflammation to fight gouty arthritis.Moreover,the mechanism of intestinal flora is related to the spleen in Chinese medicine theory.Therefore,this study discusses the research mechanism and clinical application of traditional Chinese medicine compound in treating gout by regulating intestinal flora,and provides theoretical basis for the clinical application of traditional Chinese medicine and the expansion of new dosage forms.展开更多
The diamond anvil cell-based high-pressure technique is a unique tool for creating new states of matter and for understanding the physics underlying some exotic phenomena.In situ sensing of spin and charge properties ...The diamond anvil cell-based high-pressure technique is a unique tool for creating new states of matter and for understanding the physics underlying some exotic phenomena.In situ sensing of spin and charge properties under high pressure is crucially important but remains technically challenging.While the nitrogen-vacancy(NV)center in diamond is a promising quantum sensor under extreme conditions,its spin dynamics and the quantum control of its spin states under high pressure remain elusive.In this study,we demonstrate coherent control,spin relaxation,and spin dephasing measurements for ensemble NV centers up to 32.8 GPa.With this in situ quantum sensor,we investigate the pressure-induced magnetic phase transition of a micron-size permanent magnet Nd2Fe14B sample in a diamond anvil cell,with a spatial resolution of ~2μm,and sensitivity of ~20 μT/Hz1/2. This scheme could be generalized to measure other parameters such as temperature,pressure and their gradients under extreme conditions.This will be beneficial for frontier research of condensed matter physics and geophysics.展开更多
The Qian-Gorlos earthquake, which occurred in the Songliao basin in Jilin Province in 1119 AD, was the largest earthquake to occur in NE China before the 1975 Haicheng earthquake. Based on historical records and surfa...The Qian-Gorlos earthquake, which occurred in the Songliao basin in Jilin Province in 1119 AD, was the largest earthquake to occur in NE China before the 1975 Haicheng earthquake. Based on historical records and surface geological investigations, it has been suggested previously that the earthquake epicenter was in the Longkeng area. However, other workers have considered the epicenter to be in the Halamaodu area based on the landslides and faults found in this region. No seismogenic structure has yet been found in either of these two regions.We tried to detect active faults in the urban areas of Songyuan City, where the historical earthquake was probably located. One of the aims of this work was to clarify the seismogenic structure so that the seismic risk in the city could be more accurately evaluated. The area was investigated and analyzed using information from remote sensing and topographic surveys, seismic data from petroleum exploration, shallow seismic profiles, exploratory geological trenches on fault outcrops, and borehole data. The geophysical data did not reveal any evidence of faults cutting through Cretaceous or later strata under the Longkeng scarp, which has been suggested to be structural evidence of the Qian-Gorlos earthquake. The continuous fault surfaces on the back edge of terraces in theHalamaodu area stretch for [3.5 km and were probably formed by tectonic activity. However, results from shallow seismic profiles showed that the faults did not extend downward, with the corresponding deep structure being identified as a gentle kink band. A new reverse fault was found to the west of the two suggested epicenters, which presented as a curvilinear fault extending to the west, and was formed by two groups of NE- and NW-trending faults intersecting the Gudian fault. Three-dimensional seismic and shallow seismic data from petroleum exploration revealed its distinct spatial distribution and showed that the fault may cut through Late Quaternary strata. Exploration boreholes and later geomorphological studies provided further proof of this. Based on these results and analysis,the Gudian fault was confirmed as having been an active fault since the Late Quaternary, with the possibility of earthquakes of magnitude [7 in the future. The QianGorlos earthquake was most probably the result of breakage on one or two sections of this 66-km-long fault.展开更多
We report a comprehensive high-pressure study on the monoclinic TIFeSe2 single crystal,which is an antiferromagnetic jnsulator with quasi-one-dimensional crystal structure at ambient pressure.It is found that TIFeSe2 ...We report a comprehensive high-pressure study on the monoclinic TIFeSe2 single crystal,which is an antiferromagnetic jnsulator with quasi-one-dimensional crystal structure at ambient pressure.It is found that TIFeSe2 undergoes a pressure-induced structural transformation from the monoclinic phase to an orthorhombic structure above Pc≈13 GPa,accompanied with a large volume collapse of ΔV/V0=8.3%.In the low-pressure monoclinic phase,the insulating state is easily metallized at pressures above 2 GPa;while possible superconductivity with Tconset^2 K is found to emerge above 30 GPa in the high-pressure phase.Such a great tunability of TIFeSe2 under pressure indicates that the ternary AFeSe2 system(A=Tl,K,Cs,Rb) should be taken as an important platform for explorations of interesting phenomena such as insulator-metal transition,dimensionality crossover,and superconductivity.展开更多
BACKGROUND Thyroxine-binding globulin(TBG;the gene product of SERPINA7)is the main transporter of thyroid hormones in humans.Mutations in the TBG gene may lead to inherited TBG deficiency.There have been 28 reported m...BACKGROUND Thyroxine-binding globulin(TBG;the gene product of SERPINA7)is the main transporter of thyroid hormones in humans.Mutations in the TBG gene may lead to inherited TBG deficiency.There have been 28 reported mutations that associate with complete TBG deficiency(TBG-CD).Here we identified a novel frameshift mutation causing early termination of the TBG protein and TBG-CD in a Chinese family.CASE SUMMARY A 46-year-old Chinese man was referred to our hospital with normal free thyroxine,free triiodothyronine,thyrotropin,but lower total thyroxine and total triiodothyronine,and undetectable serum TBG,indicative of TBG-CD.Blood samples were obtained from the patient’s family members and thyroid function and serum TBG were evaluated.Genomic DNA from peripheral blood was sequenced to detect possible TBG mutation(s).Quantitative PCR high-resolution melting curve analysis was used to screen TBG-Poly(L283F)among 117 Chinese men.A novel mutation of TBG(p.Phe135Alafs*21),a 19-nucleotide insertion in exon 1,was identified,which resulted in a truncated TBG protein product and caused TBG-CD.The other mutation,identified in the proband’s father,is a known polymorphism,TBG-Poly(L283F).The frequency of the TBG-Poly allele among 117 unrelated Han Chinese men from northeast China was 21.37%.CONCLUSION A novel mutation in the TBG gene associated with the TBG-CD phenotype was identified in a Chinese family.Additionally,it was found that 21.37%of Chinese males had TBG-Poly(L283F).展开更多
Megabar pressures are of crucial importance for cutting-edge studies of condensed matter physics and geophysics.With the development of diamond anvil cell(DAC),laboratory studies of high pressure have entered the mega...Megabar pressures are of crucial importance for cutting-edge studies of condensed matter physics and geophysics.With the development of diamond anvil cell(DAC),laboratory studies of high pressure have entered the megabar era for decades.However,it is still challenging to implement in situ magnetic sensing under ultrahigh pressures.In this work,we demonstrate optically detected magnetic resonance and coherent quantum control of diamond nitrogen-vacancy(NV)center,a promising quantum sensor inside the DAC,up to 1.4 Mbar.The pressure dependence of optical and spin properties of NV centers in diamond are quantified,and the evolution of an external magnetic field has been successfully tracked at about 80 GPa.These results shed new light on our understanding of diamond NV centers and pave the way for quantum sensing under extreme conditions.展开更多
Pretibial myxedema(PTM), an uncommon manifestation of Graves' disease(GD), is a local autoimmune reaction in the cutaneous tissue. The treatment of PTM is a clinical challenge. We herein report on a patient with P...Pretibial myxedema(PTM), an uncommon manifestation of Graves' disease(GD), is a local autoimmune reaction in the cutaneous tissue. The treatment of PTM is a clinical challenge. We herein report on a patient with PTM who achieved complete remission by multipoint subcutaneous injections of a long-acting glucocorticoid and topical glucocorticoid ointment application for a self-controlled study. A 53-year-old male presented with a history of GD for 3.5 years and a history of PTM for 1.5 years. Physical examination revealed slight exophthalmos, a diffusely enlarged thyroid gland, and PTM of both lower extremities. One milliliter of triamcinolone acetonide(40 mg) was mixed well with 9 mL of 2% lidocaine in a 10 mL syringe. Multipoint intralesional injections into the skin lesions of the right lower extremity were conducted with 0.5 mL of the premixed solution. A halometasone ointment was used once daily for PTM of the left lower extremity until the PTM had remitted completely. The patient's PTM achieved complete remission in both legs afteran approximately 5-mo period of therpy that included triamcinolone injections once a week for 8 wk and then once a month for 2 mo for the right lower extremity and halometasone ointment application once daily for8 wk and then once 3-5 d for 2 mo for the left lower extremity. The total dosage of triamcinolone acetonide for the right leg was 200 mg. Our experience with this patient suggests that multipoint subcutaneous injections of a long-acting glucocorticoid and topical glucocorticoid ointment application are safe, effective,and convenient treatments. However, the topical application of a glucocorticoid ointment is a more convenient treatment for patients with PTM.展开更多
As one of important members of refractory materials,tungsten phosphide(WP)holds great potential for fundamental study and industrial applications in many fields of science and technology,due to its excellent propertie...As one of important members of refractory materials,tungsten phosphide(WP)holds great potential for fundamental study and industrial applications in many fields of science and technology,due to its excellent properties such as superconductivity and as-predicted topological band structure.However,synthesis of high-quality WP crystals is still a challenge by using tradition synthetic methods,because the synthesis temperature for growing its large crystals is very stringently required to be as high as 3000℃,which is far beyond the temperature capability of most laboratory-based devices for crystal growth.In addition,high temperature often induces the decomposition of metal phosphides,leading to off-stoichiometric samples based on which the materials'intrinsic properties cannot be explored.In this work,we report a high-pressure synthesis of single-crystal WP through a direct crystallization from cooling the congruent W-P melts at 5 GPa and^3200℃.In combination of x-ray diffraction,electron microscope,and thermal analysis,the crystal structure,morphology,and stability of recovered sample are well investigated.The final product is phase-pure and nearly stoichiometric WP in a single-crystal form with a large grain size,in excess of one millimeter,thus making it feasible to implement most experimental measurements,especially,for the case where a large crystal is required.Success in synthesis of high-quality WP crystals at high pressure can offer great opportunities for determining their intrinsic properties and also making more efforts to study the family of transition-metal phosphides.展开更多
This work⑴was additionally supported by the National Key R&D Program of China under Grant No 2018YFA0305700.The financial acknowledgment section should be corrected as follows:Supported by the National Basic Rese...This work⑴was additionally supported by the National Key R&D Program of China under Grant No 2018YFA0305700.The financial acknowledgment section should be corrected as follows:Supported by the National Basic Research Program of China under Grant No 2015CB921103,the National Key R&D Program of China under Grant Nos 2016YFA0401503 and 2018YFA0305700,the Strategic Priority Research Program of Chinese Academy of Sciences under Grant No XDB28000000.展开更多
Methane clathrate hydrate(MCH)is a promising energy resource,but controllable extraction of CH4 from MCH remains a challenge.Gradually replacing CH4 in MCH with CO2 is an attractive scheme,as it is cost efficient and ...Methane clathrate hydrate(MCH)is a promising energy resource,but controllable extraction of CH4 from MCH remains a challenge.Gradually replacing CH4 in MCH with CO2 is an attractive scheme,as it is cost efficient and mitigates the environmentally harmful effects of CO2 by sequestration.However,the practicable implementation of this method has not yet been achieved.In this study,using in situ neutron diffraction,we confirm that CH4 in the 51262 cages of bulk structure-I(si)MCH can be substituted by gaseous CO2 under high pressure and low temperature with a high substitution ratio(~44%)while conserving the structure of the hydrate framework.First-principles calculations indicate that CO2 binds more strongly to the 51262 cages than methane does,and that the diffusion barrier for CH4 is significantly lowered by an intermediate state in which one hydrate cage is doubly occupied by CH4 and CO2.Therefore,exchange of CO2 for CH4 in MCH is not only energetically favorable but also kinetically feasible.Experimental and theoretical studies of CH4/CO2 substitution elucidate a method to harness energy from these combustible ice resources.展开更多
Since the outbreak of COVID-19,with the emergence of a series of novel coronavirus variants of different types,COVID-19 has continued to spread across the globe,posing a huge threat to the lives and health of people a...Since the outbreak of COVID-19,with the emergence of a series of novel coronavirus variants of different types,COVID-19 has continued to spread across the globe,posing a huge threat to the lives and health of people around the world and posing a severe challenge to global public health security.Recently,the World Health Organization(WHO)announced that novel coronavirus variant strain"Omicron"subtype variant strain BA.2 has been found in 57 countries and regions.It has higher vaccine and antibody tolerance and is more infectious than omicron(B.1.1.529).In this paper,we briefly review the recent studies on the omicron subtype variant strain BA.2.展开更多
Since the outbreak of Novel coronavirus pneumonia(COVID-19),Novel coronavirus has undergone evolution and variation in the process of transmission,and has formed many variant strains.There are five variants of concern...Since the outbreak of Novel coronavirus pneumonia(COVID-19),Novel coronavirus has undergone evolution and variation in the process of transmission,and has formed many variant strains.There are five variants of concern,Alpha,Beta,Gamma,Delta and Omicron.In November 9,2021,South Africa firstly detected a variant strain(B.1.1.529)from a sample of cases.In November 26,the World Health Organization named it"Omicron variant strain",Currently,the Omicron variant strain has become the main epidemic variant strain in the world.Omicron variant strain consists of several subtypes,including BA.1,BA.2 and BA.3.The subtypes of Omicron variant strain have different mutation and infectivity.This article reviews the characteristics and immune escape mechanisms of each Omicron variant strain subtype.展开更多
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)poses a serious threat to human life and health as well as social and economic development.In order to deal with this public h...The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)poses a serious threat to human life and health as well as social and economic development.In order to deal with this public health event,scientific research institutions around the world have rapidly developed and put vaccines into urgent use,bringing hope to the victory over the epidemic.However,as the Novel Coronavirus continues to spread throughout the world,the virus genome has mutated to form a variety of variants.Among them,the Alpha,Beta,Gamma,Delta and Omicron variants show higher infectivity and higher resistance to vaccines and neutralizing antibodies,posing new challenges to the prevention and treatment of COVID-19.At present,the effect of variants on the effectiveness of developed vaccines has become a hot topic of global discussion.In this paper,we briefly review the new progress of novel Coronavirus variants and their effects on vaccine immune protection.展开更多
With the increasing number of COVID-19 patients cured and discharged,the emergence of associated sequelae has become a new global health crisis following acute infection.The sequela of COVID-19 involves many systems s...With the increasing number of COVID-19 patients cured and discharged,the emergence of associated sequelae has become a new global health crisis following acute infection.The sequela of COVID-19 involves many systems such as respiration,circulation,nerve,digestion,psychological cognition,and so on,with varying duration and severity,seriously affecting people's physical and mental health,as well as the development of society.This paper summarizes the clinical characteristics and research progress of COVID-19 sequelae through extensive review of relevant domestic and foreign literature,in order to provide reference for the development of a comprehensive and systematic management system.展开更多
Coronavirus disease 2019(COVID-19)that broke out at the end of December 2019 has been raging for 3 years,bringing unpredictable harm to the physical and mental health of all mankind and global economic development.The...Coronavirus disease 2019(COVID-19)that broke out at the end of December 2019 has been raging for 3 years,bringing unpredictable harm to the physical and mental health of all mankind and global economic development.The new type of coronavirus pneumonia is a new type of respiratory infectious disease with a high incidence and fatality rate caused by SARS-CoV-2.Up to now,hundreds of millions of people have been infected with new coronary pneumonia worldwide,and millions of people have died.Due to the specificity of the new coronavirus itself and its high mutation rate,a series of different new coronavirus variants have appeared,which has caused the new crown pneumonia epidemic to repeat.Recently,the World Health Organization(WHO)announced a new variant"omicron"(omicron,B.1.1.529),and declared that the mutant strain may be highly infectious,antibody tolerant and highly resistant to vaccines.This article briefly reviews the latest research progress of the"omicron"variants.展开更多
基金Hunan Provincial Natural Science Foundation of China,No.2022JJ40246The Hunan Cancer Hospital Climb Plan,No.2021NSFC-B005.
文摘BACKGROUND Pulmonary mucoepidermoid carcinoma(PMEC)is a rare malignancy that arises from minor salivary glands within the tracheobronchial tree.The clear cell variant of PMEC is exceptionally uncommon and presents notable diagnostic challenges,primarily attributable to its morphological similarity to other tumors containing clear cells.CASE SUMMARY A 22-year-old male,formerly in good health,came in with a two-month duration of persistent cough and production of sputum.Subsequent imaging and bronchoscopy examinations revealed a 2 cm tumor in the distal left main bronchus,which resulted in complete atelectasis of the left lung.Further assessment via positron emission tomography/computed tomography scans and endoscopic biopsy confirmed the primary malignant nature of the tumor,charac-terized by clear cell morphology in most of the tumor cells.The patient underwent a left lower lobe sleeve resection accompanied by systematic mediastinal lymph node dissection.Molecular pathology analysis subsequently revealed a CRTC3-MAML2 gene fusion,leading to a definitive pathological diagnosis of the clear cell variant of PMEC,staged as T2N0M0.After surgery,the patient experienced a smooth recovery and exhibited no signs of recurrence during the one-and-a-half-year follow-up period.CONCLUSION This article describes an unusual case of a clear cell variant of PMEC characterized by the presence of a CRTC3-MAML2 gene fusion in a 22-year-old male.The patient underwent successful left lower lobe sleeve resection.This case underscores the distinctive challenges associated with diagnosing and treating this uncommon malignancy,underscoring the importance of precise diagnosis and personalized treatment strategies.
基金Supported by Hunan Provincial Natural Science Foundation of China,No.2022JJ40247,No.2022JJ40256。
文摘BACKGROUND Pulmonary mucormycosis is a rare but life-threatening invasive fungal infection that mostly affects immunocompromised patients.This disease usually develops acutely and progresses rapidly,often leading to a poor clinical prognosis.Chronic pulmonary mucormycosis is highly unusual in immunocompetent patients.CASE SUMMARY A 43-year-old man,who was a house improvement worker with a long history of occupational dust exposure,presented with an irritating cough that had lasted for two months.The patient was previously in good health,without dysglycemia or any known immunodeficiencies.Chest computed tomography revealed a mass in the left lower lobe,measuring approximately 6 cm in diameter,which was suspected to be primary lung carcinoma complicated with obstructive pneumonia.Thoracoscopic-assisted left lower lobectomy was performed,and metagenomic next-generation sequencing detection,along with special pathological staining of surgical specimens,suggested Rhizopus microsporus infection.Postoperatively,the patient’s respiratory symptoms were relieved,and no signs of recurrence were found during the six-month follow-up.CONCLUSION This article reports a rare case of chronic pulmonary mucormycosis caused by Rhizopus microsporus in a middle-aged male without dysglycemia or immunodeficiency.The patient’s surgical outcome was excellent,reaffirming that surgery remains the cornerstone of pulmonary mucormycosis treatment.
基金This work was supported by the Scientific Research Project of Liaoning Province Education Department(2020LJC16).
文摘Background:Oral ulcer is the most common and easily recurrent disease in stomatology,which influence the patients’communication,normal dietary,and sleep.Evodia rutaecarpa(ER)is a traditional Chinese herbal medicine recorded in ancient Chinese medical books,which has a medicinal history of more than 2,000 years.Clinically,the application of ER at plantar Yongquan point(KI1)is effective in the treatment of oral ulcer.The purpose of this study was to combine the modern transdermal drug delivery system with traditional Chinese medicine to develop the transdermal absorption patch of ER and apply it to the treatment of oral ulcer at Yongquan point of plantar.Methods:Firstly,the medicinal materials of ER were extracted and the extracted materials were prepared into dispersed ER patch.The formulation and preparation process were screened by orthogonal design method and single factor investigation method.The adhesive and transdermal properties of the patch were used as the evaluation index of the preparation.Secondly,Wistar rats were used as experimental animals to establish a rat model of mouth ulcers.Wistar rats were randomly divided into normal group,model group(A),model group(B),low dose group,medium dose group and high dose group.the efficacy of ER on rat’s oral ulcer model was evaluated through three aspect such as apparent index,pathological index and biochemical index.Results:The patch had suitable adhesion and good skin penetration,which was an effective treatment for oral ulcer.In vivo pharmacodynamic studies,compared with the normal group,the body mass and food intake of rats in each group after modeling decreased,the amount of drinking water increased,the tissue structure of oral mucosa was damaged,and the levels of inflammatory factors(TNF-α,IL-6)and malondialdehyde increased,the levels of anti-inflammatory factors(IL-10),cell growth factor(epidermal growth factor,TGF-β_(1))and superoxide dismutase decreased.Compared with the model group,the body weight and food intake of each dosing group increased,water consumption decreased,the oral mucosal tissue structure was more complete,the levels of TNF-α,IL-6 and malondialdehyde decreased,the levels of IL-10,epidermal growth factor,TGF-β1 and superoxide dismutase increased,and the changes of various indexes were dose-related.Conclusion:ER patch can inhibit inflammatory reaction,enhance the antioxidant defense ability of the body,and promote the repair of damaged oral mucosa,so as to play an effective role in the treatment of oral ulcer.
文摘Because of the continuous improvement of the quality of life,the population of gout patients is also increasing,which seriously affects the quality of life of patients.Traditional Chinese medicine compound has a long history and remarkable clinical effect in treating gout patients,and has been widely used.Intestinal flora and its metabolites are the focus of current research,which can promote intestinal mucosal barrier,improve immunity and improve metabolism.The regulation of intestinal flora can reduce serum uric acid and inhibit inflammation to fight gouty arthritis.Moreover,the mechanism of intestinal flora is related to the spleen in Chinese medicine theory.Therefore,this study discusses the research mechanism and clinical application of traditional Chinese medicine compound in treating gout by regulating intestinal flora,and provides theoretical basis for the clinical application of traditional Chinese medicine and the expansion of new dosage forms.
基金Supported by the National Basic Research Program of China under Grant No 2015CB921103the National Key R&D Program of China under Grant No 2016YFA0401503+2 种基金the Strategic Priority Research Program of Chinese Academy of Sciences under Grant No XDB28000000the National Natural Science Foundation of China under Grant Nos 11574386,11575288 and 51402350the Youth Innovation Promotion Association of Chinese Academy of Sciences under Grant No 2016006
文摘The diamond anvil cell-based high-pressure technique is a unique tool for creating new states of matter and for understanding the physics underlying some exotic phenomena.In situ sensing of spin and charge properties under high pressure is crucially important but remains technically challenging.While the nitrogen-vacancy(NV)center in diamond is a promising quantum sensor under extreme conditions,its spin dynamics and the quantum control of its spin states under high pressure remain elusive.In this study,we demonstrate coherent control,spin relaxation,and spin dephasing measurements for ensemble NV centers up to 32.8 GPa.With this in situ quantum sensor,we investigate the pressure-induced magnetic phase transition of a micron-size permanent magnet Nd2Fe14B sample in a diamond anvil cell,with a spatial resolution of ~2μm,and sensitivity of ~20 μT/Hz1/2. This scheme could be generalized to measure other parameters such as temperature,pressure and their gradients under extreme conditions.This will be beneficial for frontier research of condensed matter physics and geophysics.
基金supported by the National Natural Science Foundation of China under Grant No.41372216the Major Projects of the Ministry of Finance under Grant No.201108001+1 种基金the Fundamental Research Funds of the Central Universities under Grant No.20120102 and No.ZY20150303the Teachers Fund of China Earthquake Administration under Grant No.2012001
文摘The Qian-Gorlos earthquake, which occurred in the Songliao basin in Jilin Province in 1119 AD, was the largest earthquake to occur in NE China before the 1975 Haicheng earthquake. Based on historical records and surface geological investigations, it has been suggested previously that the earthquake epicenter was in the Longkeng area. However, other workers have considered the epicenter to be in the Halamaodu area based on the landslides and faults found in this region. No seismogenic structure has yet been found in either of these two regions.We tried to detect active faults in the urban areas of Songyuan City, where the historical earthquake was probably located. One of the aims of this work was to clarify the seismogenic structure so that the seismic risk in the city could be more accurately evaluated. The area was investigated and analyzed using information from remote sensing and topographic surveys, seismic data from petroleum exploration, shallow seismic profiles, exploratory geological trenches on fault outcrops, and borehole data. The geophysical data did not reveal any evidence of faults cutting through Cretaceous or later strata under the Longkeng scarp, which has been suggested to be structural evidence of the Qian-Gorlos earthquake. The continuous fault surfaces on the back edge of terraces in theHalamaodu area stretch for [3.5 km and were probably formed by tectonic activity. However, results from shallow seismic profiles showed that the faults did not extend downward, with the corresponding deep structure being identified as a gentle kink band. A new reverse fault was found to the west of the two suggested epicenters, which presented as a curvilinear fault extending to the west, and was formed by two groups of NE- and NW-trending faults intersecting the Gudian fault. Three-dimensional seismic and shallow seismic data from petroleum exploration revealed its distinct spatial distribution and showed that the fault may cut through Late Quaternary strata. Exploration boreholes and later geomorphological studies provided further proof of this. Based on these results and analysis,the Gudian fault was confirmed as having been an active fault since the Late Quaternary, with the possibility of earthquakes of magnitude [7 in the future. The QianGorlos earthquake was most probably the result of breakage on one or two sections of this 66-km-long fault.
基金Supported by the National Key R&D Program of China(2018YFA0305700)the National Natural Science Foundation of China(11904391,11834016,11874400,11888101,11921004)+3 种基金the Beijing Natural Science Foundation(Z190008)the Strategic Priority Research Program and the Key Research Program of Frontier Sciences of the Chinese Academy of Sciences(XDB25000000,QYZDB-SSW-SLH013)the CAS Interdisciplinary Innovation Team(JCTD-2019-01)JPS acknowledges the support from the China Postdoctoral Science Foundation and the Postdoctoral Innovative Talent Program.
文摘We report a comprehensive high-pressure study on the monoclinic TIFeSe2 single crystal,which is an antiferromagnetic jnsulator with quasi-one-dimensional crystal structure at ambient pressure.It is found that TIFeSe2 undergoes a pressure-induced structural transformation from the monoclinic phase to an orthorhombic structure above Pc≈13 GPa,accompanied with a large volume collapse of ΔV/V0=8.3%.In the low-pressure monoclinic phase,the insulating state is easily metallized at pressures above 2 GPa;while possible superconductivity with Tconset^2 K is found to emerge above 30 GPa in the high-pressure phase.Such a great tunability of TIFeSe2 under pressure indicates that the ternary AFeSe2 system(A=Tl,K,Cs,Rb) should be taken as an important platform for explorations of interesting phenomena such as insulator-metal transition,dimensionality crossover,and superconductivity.
基金Supported by the National Natural Science Foundation of China,No.81570711National Clinical Key College Fund and the Key Platform Foundation of Science and Technology for the Universities in Liaoning Province,No.16010
文摘BACKGROUND Thyroxine-binding globulin(TBG;the gene product of SERPINA7)is the main transporter of thyroid hormones in humans.Mutations in the TBG gene may lead to inherited TBG deficiency.There have been 28 reported mutations that associate with complete TBG deficiency(TBG-CD).Here we identified a novel frameshift mutation causing early termination of the TBG protein and TBG-CD in a Chinese family.CASE SUMMARY A 46-year-old Chinese man was referred to our hospital with normal free thyroxine,free triiodothyronine,thyrotropin,but lower total thyroxine and total triiodothyronine,and undetectable serum TBG,indicative of TBG-CD.Blood samples were obtained from the patient’s family members and thyroid function and serum TBG were evaluated.Genomic DNA from peripheral blood was sequenced to detect possible TBG mutation(s).Quantitative PCR high-resolution melting curve analysis was used to screen TBG-Poly(L283F)among 117 Chinese men.A novel mutation of TBG(p.Phe135Alafs*21),a 19-nucleotide insertion in exon 1,was identified,which resulted in a truncated TBG protein product and caused TBG-CD.The other mutation,identified in the proband’s father,is a known polymorphism,TBG-Poly(L283F).The frequency of the TBG-Poly allele among 117 unrelated Han Chinese men from northeast China was 21.37%.CONCLUSION A novel mutation in the TBG gene associated with the TBG-CD phenotype was identified in a Chinese family.Additionally,it was found that 21.37%of Chinese males had TBG-Poly(L283F).
基金supported by the Beijing Natural Science Foundation(Grant No.Z200009)Chinese Academy of Sciences(Grant Nos.YJKYYQ20190082,XDB28000000,XDB33000000,XDB25000000,and QYZDBSSW-SLH013)+2 种基金the National Natural Science Foundation of China(Grant Nos.11974020,12022509,12074422,11934018,and T2121001)the National Key Research and Development Program of China(Grant Nos.2019YFA0308100,2021YFA1400300,and 2018YFA0305700)the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.202003)。
文摘Megabar pressures are of crucial importance for cutting-edge studies of condensed matter physics and geophysics.With the development of diamond anvil cell(DAC),laboratory studies of high pressure have entered the megabar era for decades.However,it is still challenging to implement in situ magnetic sensing under ultrahigh pressures.In this work,we demonstrate optically detected magnetic resonance and coherent quantum control of diamond nitrogen-vacancy(NV)center,a promising quantum sensor inside the DAC,up to 1.4 Mbar.The pressure dependence of optical and spin properties of NV centers in diamond are quantified,and the evolution of an external magnetic field has been successfully tracked at about 80 GPa.These results shed new light on our understanding of diamond NV centers and pave the way for quantum sensing under extreme conditions.
文摘Pretibial myxedema(PTM), an uncommon manifestation of Graves' disease(GD), is a local autoimmune reaction in the cutaneous tissue. The treatment of PTM is a clinical challenge. We herein report on a patient with PTM who achieved complete remission by multipoint subcutaneous injections of a long-acting glucocorticoid and topical glucocorticoid ointment application for a self-controlled study. A 53-year-old male presented with a history of GD for 3.5 years and a history of PTM for 1.5 years. Physical examination revealed slight exophthalmos, a diffusely enlarged thyroid gland, and PTM of both lower extremities. One milliliter of triamcinolone acetonide(40 mg) was mixed well with 9 mL of 2% lidocaine in a 10 mL syringe. Multipoint intralesional injections into the skin lesions of the right lower extremity were conducted with 0.5 mL of the premixed solution. A halometasone ointment was used once daily for PTM of the left lower extremity until the PTM had remitted completely. The patient's PTM achieved complete remission in both legs afteran approximately 5-mo period of therpy that included triamcinolone injections once a week for 8 wk and then once a month for 2 mo for the right lower extremity and halometasone ointment application once daily for8 wk and then once 3-5 d for 2 mo for the left lower extremity. The total dosage of triamcinolone acetonide for the right leg was 200 mg. Our experience with this patient suggests that multipoint subcutaneous injections of a long-acting glucocorticoid and topical glucocorticoid ointment application are safe, effective,and convenient treatments. However, the topical application of a glucocorticoid ointment is a more convenient treatment for patients with PTM.
基金the National Key Research and Development Program of China(Grant Nos.2016YFA0401503 and 2018YFA0305700)the National Natural Science Foundation of China(Grant No.11575288)+4 种基金the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2016006)the Key Research Platforms and Research Projects of Universities in Guangdong Province,China(Grant No.2018KZDXM062)the Guangdong Innovative&Entrepreneurial Research Team Program,China(Grant No.2016ZT06C279)the Shenzhen Peacock Plan,China(Grant No.KQTD2016053019134356)the Shenzhen Development&Reform Commission Foundation for Novel Nano-Material Sciences,China,the Research Platform for Crystal Growth&Thin-Film Preparation at SUST,China,and the Shenzhen Development and Reform Commission Foundation for Shenzhen Engineering Research Center for Frontier Materials Synthesis at High Pressure,China.
文摘As one of important members of refractory materials,tungsten phosphide(WP)holds great potential for fundamental study and industrial applications in many fields of science and technology,due to its excellent properties such as superconductivity and as-predicted topological band structure.However,synthesis of high-quality WP crystals is still a challenge by using tradition synthetic methods,because the synthesis temperature for growing its large crystals is very stringently required to be as high as 3000℃,which is far beyond the temperature capability of most laboratory-based devices for crystal growth.In addition,high temperature often induces the decomposition of metal phosphides,leading to off-stoichiometric samples based on which the materials'intrinsic properties cannot be explored.In this work,we report a high-pressure synthesis of single-crystal WP through a direct crystallization from cooling the congruent W-P melts at 5 GPa and^3200℃.In combination of x-ray diffraction,electron microscope,and thermal analysis,the crystal structure,morphology,and stability of recovered sample are well investigated.The final product is phase-pure and nearly stoichiometric WP in a single-crystal form with a large grain size,in excess of one millimeter,thus making it feasible to implement most experimental measurements,especially,for the case where a large crystal is required.Success in synthesis of high-quality WP crystals at high pressure can offer great opportunities for determining their intrinsic properties and also making more efforts to study the family of transition-metal phosphides.
文摘This work⑴was additionally supported by the National Key R&D Program of China under Grant No 2018YFA0305700.The financial acknowledgment section should be corrected as follows:Supported by the National Basic Research Program of China under Grant No 2015CB921103,the National Key R&D Program of China under Grant Nos 2016YFA0401503 and 2018YFA0305700,the Strategic Priority Research Program of Chinese Academy of Sciences under Grant No XDB28000000.
基金Supported by the National Key R&D Program of China under Grant Nos 2016YFA0401503 and 2018YFA0305700the National Natural Science Foundation of China under Grant Nos 11575288,11775011,21703006,21773005+1 种基金the Youth Innovation Promotion Association of Chinese Academy of Sciences under Grant No 2016006.J.Zhu was supported by the National Thousand-Young-Talents Program and the National Science Associated Funding Grant U1530402The experimental work has benefited from the use of the neutron source at Los Alamos Neutron Science Center(LANSCE),which is funded by the U.S.Department of Energy’s Office of Basic Energy Sciences.
文摘Methane clathrate hydrate(MCH)is a promising energy resource,but controllable extraction of CH4 from MCH remains a challenge.Gradually replacing CH4 in MCH with CO2 is an attractive scheme,as it is cost efficient and mitigates the environmentally harmful effects of CO2 by sequestration.However,the practicable implementation of this method has not yet been achieved.In this study,using in situ neutron diffraction,we confirm that CH4 in the 51262 cages of bulk structure-I(si)MCH can be substituted by gaseous CO2 under high pressure and low temperature with a high substitution ratio(~44%)while conserving the structure of the hydrate framework.First-principles calculations indicate that CO2 binds more strongly to the 51262 cages than methane does,and that the diffusion barrier for CH4 is significantly lowered by an intermediate state in which one hydrate cage is doubly occupied by CH4 and CO2.Therefore,exchange of CO2 for CH4 in MCH is not only energetically favorable but also kinetically feasible.Experimental and theoretical studies of CH4/CO2 substitution elucidate a method to harness energy from these combustible ice resources.
基金The 940th Hospital Intra-Hospital Fund Project(No.20yjky020)the Huoshenshan Hospital Research Fund General Project(No.HSS-217)。
文摘Since the outbreak of COVID-19,with the emergence of a series of novel coronavirus variants of different types,COVID-19 has continued to spread across the globe,posing a huge threat to the lives and health of people around the world and posing a severe challenge to global public health security.Recently,the World Health Organization(WHO)announced that novel coronavirus variant strain"Omicron"subtype variant strain BA.2 has been found in 57 countries and regions.It has higher vaccine and antibody tolerance and is more infectious than omicron(B.1.1.529).In this paper,we briefly review the recent studies on the omicron subtype variant strain BA.2.
基金COVID-19 Emergency Medical Research Project of 940 Hospital(No.20yjky020)General Project of Huoshenshan Hospital Scientific Research Fund(No.HSS-217)。
文摘Since the outbreak of Novel coronavirus pneumonia(COVID-19),Novel coronavirus has undergone evolution and variation in the process of transmission,and has formed many variant strains.There are five variants of concern,Alpha,Beta,Gamma,Delta and Omicron.In November 9,2021,South Africa firstly detected a variant strain(B.1.1.529)from a sample of cases.In November 26,the World Health Organization named it"Omicron variant strain",Currently,the Omicron variant strain has become the main epidemic variant strain in the world.Omicron variant strain consists of several subtypes,including BA.1,BA.2 and BA.3.The subtypes of Omicron variant strain have different mutation and infectivity.This article reviews the characteristics and immune escape mechanisms of each Omicron variant strain subtype.
基金General Project of Huoshenshan Hospital Scientific Research Fund(No.HSS 217)Intra hospital COVID 19 Fund Project of Hospital No.940(No.20yjky020)。
文摘The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)poses a serious threat to human life and health as well as social and economic development.In order to deal with this public health event,scientific research institutions around the world have rapidly developed and put vaccines into urgent use,bringing hope to the victory over the epidemic.However,as the Novel Coronavirus continues to spread throughout the world,the virus genome has mutated to form a variety of variants.Among them,the Alpha,Beta,Gamma,Delta and Omicron variants show higher infectivity and higher resistance to vaccines and neutralizing antibodies,posing new challenges to the prevention and treatment of COVID-19.At present,the effect of variants on the effectiveness of developed vaccines has become a hot topic of global discussion.In this paper,we briefly review the new progress of novel Coronavirus variants and their effects on vaccine immune protection.
基金Hospital Fund Project of 940 Hospital(No.20yjky020)General Project of Scientific Research Foundation of Huoshenshan Hospital(No.HSS-217)。
文摘With the increasing number of COVID-19 patients cured and discharged,the emergence of associated sequelae has become a new global health crisis following acute infection.The sequela of COVID-19 involves many systems such as respiration,circulation,nerve,digestion,psychological cognition,and so on,with varying duration and severity,seriously affecting people's physical and mental health,as well as the development of society.This paper summarizes the clinical characteristics and research progress of COVID-19 sequelae through extensive review of relevant domestic and foreign literature,in order to provide reference for the development of a comprehensive and systematic management system.
基金940 Hospital COVID-19 Emergency Medical Research Project(No.20yjky020)Huoshenshan Hospital Research Fund General Project(No.HSS-217)。
文摘Coronavirus disease 2019(COVID-19)that broke out at the end of December 2019 has been raging for 3 years,bringing unpredictable harm to the physical and mental health of all mankind and global economic development.The new type of coronavirus pneumonia is a new type of respiratory infectious disease with a high incidence and fatality rate caused by SARS-CoV-2.Up to now,hundreds of millions of people have been infected with new coronary pneumonia worldwide,and millions of people have died.Due to the specificity of the new coronavirus itself and its high mutation rate,a series of different new coronavirus variants have appeared,which has caused the new crown pneumonia epidemic to repeat.Recently,the World Health Organization(WHO)announced a new variant"omicron"(omicron,B.1.1.529),and declared that the mutant strain may be highly infectious,antibody tolerant and highly resistant to vaccines.This article briefly reviews the latest research progress of the"omicron"variants.
