As important messengers of intercellular communication,exosomes can regulate local and distant cellular communication by transporting specific exosomal con-tents and can also promote or suppress the development and pr...As important messengers of intercellular communication,exosomes can regulate local and distant cellular communication by transporting specific exosomal con-tents and can also promote or suppress the development and progression of gas-tric cancer(GC)by regulating the growth and proliferation of tumor cells,the tumor-related immune response and tumor angiogenesis.Exosomes transport bioactive molecules including DNA,proteins,and RNA(coding and noncoding)from donor cells to recipient cells,causing reprogramming of the target cells.In this review,we will describe how exosomes regulate the cellular immune respon-se,tumor angiogenesis,proliferation and metastasis of GC cells,and the role and mechanism of exosome-based therapy in human cancer.We will also discuss the potential application value of exosomes as biomarkers in the diagnosis and treat-ment of GC and their relationship with drug resistance.展开更多
Gastroesophageal reflux disease(GERD)is a common chronic disease of the gastrointestinal tract that occurs in 3.1%of the Chinese population[1].Heartburn,acid regurgitation and epigastric pain are typical clinical symp...Gastroesophageal reflux disease(GERD)is a common chronic disease of the gastrointestinal tract that occurs in 3.1%of the Chinese population[1].Heartburn,acid regurgitation and epigastric pain are typical clinical symptoms of GERD.These symptoms can affect patients'work productivity,sleep,diet and daily activities,thus resulting in a reduced quality of life(QOL)[2].Although patient QOL is increasingly being considered as a medical outcome index in the evaluation of the impact of GERD symptoms on patients'health status,measuring patient QOL in clinical trials can be challenging due to the lack of a standard assessment tool.Therefore,we aim to review the commonly used generic,disease-specific and hybrid QOL questionnaires to evaluate patients with GERD to provide a reference for clinical nursing work.展开更多
文摘As important messengers of intercellular communication,exosomes can regulate local and distant cellular communication by transporting specific exosomal con-tents and can also promote or suppress the development and progression of gas-tric cancer(GC)by regulating the growth and proliferation of tumor cells,the tumor-related immune response and tumor angiogenesis.Exosomes transport bioactive molecules including DNA,proteins,and RNA(coding and noncoding)from donor cells to recipient cells,causing reprogramming of the target cells.In this review,we will describe how exosomes regulate the cellular immune respon-se,tumor angiogenesis,proliferation and metastasis of GC cells,and the role and mechanism of exosome-based therapy in human cancer.We will also discuss the potential application value of exosomes as biomarkers in the diagnosis and treat-ment of GC and their relationship with drug resistance.
文摘Gastroesophageal reflux disease(GERD)is a common chronic disease of the gastrointestinal tract that occurs in 3.1%of the Chinese population[1].Heartburn,acid regurgitation and epigastric pain are typical clinical symptoms of GERD.These symptoms can affect patients'work productivity,sleep,diet and daily activities,thus resulting in a reduced quality of life(QOL)[2].Although patient QOL is increasingly being considered as a medical outcome index in the evaluation of the impact of GERD symptoms on patients'health status,measuring patient QOL in clinical trials can be challenging due to the lack of a standard assessment tool.Therefore,we aim to review the commonly used generic,disease-specific and hybrid QOL questionnaires to evaluate patients with GERD to provide a reference for clinical nursing work.
