BACKGROUND Leukemia is a broad term for blood cell cancer.Leukemia is divided into acute or chronic,depending on cell differentiation.Leukemia patients are prone to adverse reactions during chemotherapy,such as anxiet...BACKGROUND Leukemia is a broad term for blood cell cancer.Leukemia is divided into acute or chronic,depending on cell differentiation.Leukemia patients are prone to adverse reactions during chemotherapy,such as anxiety,depression,and even suicide,affecting prognosis.As a nursing model developed by three well-known cognitive psychologists,empathetic nursing with mindfulness cognitive therapy(ENMCT)can effectively reduce anxiety and depression and improve the quality of life in patients with chronic disease.AIM To explore the effect of ENMCT on cancer-induced fatigue,hope level,and negative emotions in patients with long-term leukemia chemotherapy.METHODS A total of 103 patients with long-term leukemia chemotherapy diagnosed and treated in our hospital from July 2017 to October 2019 were enrolled and randomly assigned to observation and control groups using the random number table approach.Fifty-one patients in the control group received routine nursing,while 52 patients in the observation group received empathic nursing with mindfulness cognitive therapy.After three months of nursing care,cancerinduced fatigue was measured with the Piper Fatigue Scale(PFS),hope level with the Herth Hope Index(HHI),and negative emotion with the Hamilton Anxiety Scale(HAMA)/Hamilton Depression Scale(HAMD).Self-management(Chinese Strategies Used by People to Promote Health)was also recorded.RESULTS The observation group’s total scores in behavior,cognition,emotion,feeling,and PFS were lower than the control group after the intervention(P<0.05).Keeping close contact with others,the attitude of taking positive actions,the attitude toward reality and future,and the total HHI score were higher in the observation group than the control group(P<0.05).The observation group’s HAMA and HAMD scores were lower than the control group(P<0.05).The observation group’s positive attitude,self-decision,and self-relief scores were greater than the control group(P<0.05).CONCLUSION Empathetic nursing with cognitive mindfulness therapy is beneficial in improving cancer-related fatigue,negative emotions,expectation level,and self-management ability in patients with longterm leukemia chemotherapy.展开更多
Objective: To explore the therapeutic effect of elemene combined with S-1 / oxaliplatin (SOX) in the treatment of advanced metastatic gastric cancer, and to analyze and evaluate the safety of the chemotherapy, so as t...Objective: To explore the therapeutic effect of elemene combined with S-1 / oxaliplatin (SOX) in the treatment of advanced metastatic gastric cancer, and to analyze and evaluate the safety of the chemotherapy, so as to provide new ideas for clinical treatment. Methods: 71 patients with advanced metastatic gastric cancer from April 2015 to April 2018 were randomly divided into two groups: the control group treated with SOX alone and the observation group treated with elemene combined SOX. The short-term and long-term therapeutic effects of the two groups were compared by the RECIST1.1 score and survival curve, and the differences of tumor markers, serological indicators and adverse reactions between the two groups were compared. Results: the objective remission rate (ORR) and clinical benefit rate (CBR) of the observation group were significantly higher than those of the control group (χ2=5.161, P=0.031;χ2=5.124, P=0.037);after treatment, the serum CEA, CA-199, IGF-1, MMP-9, IL-2 and IFN-γ levels of the observation group were significantly improved compared with those of the control group (P<0.05);compared with the two groups, the incidence of leucopenia, anemia, asthenia, nausea and vomiting in the observation group were significantly lower than that in the control group (P<0.05);the median tumor progression time (7.1 months, 95%CI=4.037-10.248) and median total survival time (8.8 months, 95%CI=6.634-10.907) in the observation group were significantly higher than that in the control group (4.9 months, 95%CI=2.324-6.839) and median total survival time (6.5 months, 95%CI=5.007-7.638), and the difference was statistically significant (P=0.001, P=0.026). Conclusion: elemene combined with SOX has a high short-term and long-term efficacy in patients with advanced metastatic gastric cancer, and its side effects are less, and its safety is higher, which has a certain clinical significance.展开更多
文摘BACKGROUND Leukemia is a broad term for blood cell cancer.Leukemia is divided into acute or chronic,depending on cell differentiation.Leukemia patients are prone to adverse reactions during chemotherapy,such as anxiety,depression,and even suicide,affecting prognosis.As a nursing model developed by three well-known cognitive psychologists,empathetic nursing with mindfulness cognitive therapy(ENMCT)can effectively reduce anxiety and depression and improve the quality of life in patients with chronic disease.AIM To explore the effect of ENMCT on cancer-induced fatigue,hope level,and negative emotions in patients with long-term leukemia chemotherapy.METHODS A total of 103 patients with long-term leukemia chemotherapy diagnosed and treated in our hospital from July 2017 to October 2019 were enrolled and randomly assigned to observation and control groups using the random number table approach.Fifty-one patients in the control group received routine nursing,while 52 patients in the observation group received empathic nursing with mindfulness cognitive therapy.After three months of nursing care,cancerinduced fatigue was measured with the Piper Fatigue Scale(PFS),hope level with the Herth Hope Index(HHI),and negative emotion with the Hamilton Anxiety Scale(HAMA)/Hamilton Depression Scale(HAMD).Self-management(Chinese Strategies Used by People to Promote Health)was also recorded.RESULTS The observation group’s total scores in behavior,cognition,emotion,feeling,and PFS were lower than the control group after the intervention(P<0.05).Keeping close contact with others,the attitude of taking positive actions,the attitude toward reality and future,and the total HHI score were higher in the observation group than the control group(P<0.05).The observation group’s HAMA and HAMD scores were lower than the control group(P<0.05).The observation group’s positive attitude,self-decision,and self-relief scores were greater than the control group(P<0.05).CONCLUSION Empathetic nursing with cognitive mindfulness therapy is beneficial in improving cancer-related fatigue,negative emotions,expectation level,and self-management ability in patients with longterm leukemia chemotherapy.
基金Wu Jieping medical foundation project (320.3750.18075)
文摘Objective: To explore the therapeutic effect of elemene combined with S-1 / oxaliplatin (SOX) in the treatment of advanced metastatic gastric cancer, and to analyze and evaluate the safety of the chemotherapy, so as to provide new ideas for clinical treatment. Methods: 71 patients with advanced metastatic gastric cancer from April 2015 to April 2018 were randomly divided into two groups: the control group treated with SOX alone and the observation group treated with elemene combined SOX. The short-term and long-term therapeutic effects of the two groups were compared by the RECIST1.1 score and survival curve, and the differences of tumor markers, serological indicators and adverse reactions between the two groups were compared. Results: the objective remission rate (ORR) and clinical benefit rate (CBR) of the observation group were significantly higher than those of the control group (χ2=5.161, P=0.031;χ2=5.124, P=0.037);after treatment, the serum CEA, CA-199, IGF-1, MMP-9, IL-2 and IFN-γ levels of the observation group were significantly improved compared with those of the control group (P<0.05);compared with the two groups, the incidence of leucopenia, anemia, asthenia, nausea and vomiting in the observation group were significantly lower than that in the control group (P<0.05);the median tumor progression time (7.1 months, 95%CI=4.037-10.248) and median total survival time (8.8 months, 95%CI=6.634-10.907) in the observation group were significantly higher than that in the control group (4.9 months, 95%CI=2.324-6.839) and median total survival time (6.5 months, 95%CI=5.007-7.638), and the difference was statistically significant (P=0.001, P=0.026). Conclusion: elemene combined with SOX has a high short-term and long-term efficacy in patients with advanced metastatic gastric cancer, and its side effects are less, and its safety is higher, which has a certain clinical significance.
